B Meunier

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Second-site reversion analysis is not a reliable method to determine distances in membrane proteins: an assessment using mutations in yeast cytochrome c oxidase subunits I and II
    B Meunier
    Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK
    J Mol Biol 283:727-30. 1998
  2. pmc Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase
    B Meunier
    Department of Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 354:407-12. 2001
  3. ncbi Mutations of cytochrome c oxidase subunits 1 and 3 in Saccharomyces cerevisiae: assembly defect and compensation
    Brigitte Meunier
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1554:101-7. 2002
  4. ncbi Effects of mutation of the conserved glutamic acid-286 in subunit I of cytochrome c oxidase from Rhodobacter sphaeroides
    S Jünemann
    Glynn Laboratory of Bioenergetics, Department of Biology, University College, London, U K
    Biochemistry 38:5248-55. 1999
  5. ncbi Effects of mutations in mitochondrial cytochrome b in yeast and man. Deficiency, compensation and disease
    N Fisher
    Department of Biology, University College London, UK
    Eur J Biochem 268:1155-62. 2001
  6. pmc Analysis of COX2 mutants reveals cytochrome oxidase subassemblies in yeast
    Susannah Horan
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 390:703-8. 2005
  7. doi Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex
    Giancarlo A Biagini
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Mol Pharmacol 73:1347-55. 2008
  8. pmc Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci
    Philip Hill
    Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
    Antimicrob Agents Chemother 47:2725-31. 2003
  9. ncbi Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models
    Melyssa Bratton
    Department of Biochemistry, University of Mississippi Medical Center, USA
    Eur J Biochem 270:1222-30. 2003
  10. doi Is cytochrome b glutamic acid 272 a quinol binding residue in the bc1 complex of Saccharomyces cerevisiae?
    Nadir Seddiki
    Laboratoire de Bioenergetique et Ingenierie des Proteines, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochemistry 47:2357-68. 2008

Collaborators

  • P R Rich
  • S Jünemann
  • Jan Willem Taanman
  • C Hunte
  • P Hellwig
  • Giancarlo A Biagini
  • Gael Brasseur
  • Nicholas Fisher
  • Ingrid Bourges
  • Jacques J Kessl
  • Philip Hill
  • Susannah Horan
  • Bernard L Trumpower
  • Tina Wenz
  • Benjamin B Lange
  • Nadir Seddiki
  • Fraser MacMillan
  • Emma L Blakely
  • Steven R Meshnick
  • C Kate Castleden
  • Melyssa Bratton
  • N Fisher
  • Danielle Lemesle-Meunier
  • Raul Covian
  • Margaret J Jackson
  • Douglass M Turnbull
  • Andrew M Schaefer
  • Kevin H Ha
  • Robert W Taylor
  • Leo G Nijtmans
  • Anne K Merritt
  • Anna L Mitchell
  • Genevieve Dujardin
  • Graham Sexton
  • Alison Cook
  • John Windass
  • Amanda C Brown
  • Klaus Zwicker
  • Hildur Palsdottir
  • Torsten Merbitz-Zahradnik
  • Steve Meshnick
  • Jonathan Hosler
  • Steven Meshnick
  • Denize Mills
  • Jacques Kessl

Detail Information

Publications23

  1. ncbi Second-site reversion analysis is not a reliable method to determine distances in membrane proteins: an assessment using mutations in yeast cytochrome c oxidase subunits I and II
    B Meunier
    Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK
    J Mol Biol 283:727-30. 1998
    ..However, the reversions are not randomly located in the structure but reveal regions essential for assembly or functional units...
  2. pmc Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase
    B Meunier
    Department of Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 354:407-12. 2001
    ..However, mutations Met-273-->Thr and Ile-280-->Thr were mildly deleterious, decreased cytochrome oxidase activity and slightly perturbed the properties of the binuclear centre...
  3. ncbi Mutations of cytochrome c oxidase subunits 1 and 3 in Saccharomyces cerevisiae: assembly defect and compensation
    Brigitte Meunier
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1554:101-7. 2002
    ..Surprisingly, the introduction of the 'human' mutation A224S and of a more drastic change A224F had no effect on the yeast enzyme. This might be explained by differences in local folding in the two enzymes...
  4. ncbi Effects of mutation of the conserved glutamic acid-286 in subunit I of cytochrome c oxidase from Rhodobacter sphaeroides
    S Jünemann
    Glynn Laboratory of Bioenergetics, Department of Biology, University College, London, U K
    Biochemistry 38:5248-55. 1999
    ..We propose that the glutamate is implicated in several steps in the catalytic cycle, O --> R, P --> F, and, possibly, F --> O. The results are discussed in relation to the "glutamate trap" model for proton translocation...
  5. ncbi Effects of mutations in mitochondrial cytochrome b in yeast and man. Deficiency, compensation and disease
    N Fisher
    Department of Biology, University College London, UK
    Eur J Biochem 268:1155-62. 2001
    ..In this paper, we re-examine the mutations in the light of the atomic structure of the complex, and discuss the possible effect, at enzyme level, of the human cytochrome b mutations and the correcting effect of the reversions...
  6. pmc Analysis of COX2 mutants reveals cytochrome oxidase subassemblies in yeast
    Susannah Horan
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 390:703-8. 2005
    ..The identification of these novel cytochrome oxidase subcomplexes should encourage the reexamination of other yeast mutants...
  7. doi Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex
    Giancarlo A Biagini
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Mol Pharmacol 73:1347-55. 2008
    ..falciparum bc(1) Q(o). Dihydroacridinediones represent an entirely new class of bc(1) inhibitors and the potential of these compounds as novel antimalarial drugs is discussed...
  8. pmc Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci
    Philip Hill
    Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
    Antimicrob Agents Chemother 47:2725-31. 2003
    ..S. cerevisiae thus provides an easy-to-use system to characterize in vivo and in vitro cytochrome b mutations reported in pathogens and to assess their role in drug resistance...
  9. ncbi Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models
    Melyssa Bratton
    Department of Biochemistry, University of Mississippi Medical Center, USA
    Eur J Biochem 270:1222-30. 2003
    ..The bacterial system allows detailed biochemical analysis of the effect of the mutations on the function and assembly of the catalytic core of the enzyme...
  10. doi Is cytochrome b glutamic acid 272 a quinol binding residue in the bc1 complex of Saccharomyces cerevisiae?
    Nadir Seddiki
    Laboratoire de Bioenergetique et Ingenierie des Proteines, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochemistry 47:2357-68. 2008
    ..The observed suppressor mutations introduced polar residues serine and threonine at position 272. The data lead us to suggest that E272 may be involved in a later step on the proton exit pathway via the interaction with a water molecule...
  11. ncbi Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex III
    Tina Wenz
    Department Molecular Membrane Biology, Max Planck Institute of Biophysics, D 60438 Frankfurt am Main, Germany
    J Biol Chem 282:3977-88. 2007
    ..Altered center N kinetics and activation of ubiquinol oxidation by binding of cytochrome c in the Y132F and E272D enzymes indicate long range effects of these mutations...
  12. ncbi Probing the role of E272 in quinol oxidation of mitochondrial complex III
    Tina Wenz
    Department Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany
    Biochemistry 45:9042-52. 2006
    ..The conserved glutamate appears to influence the accurate formation of the enzyme-substrate complex and to govern the efficiency of catalysis...
  13. ncbi Transcriptional response to nitrosative stress in Saccharomyces cerevisiae
    Susannah Horan
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Yeast 23:519-35. 2006
    ..We showed also that Msn2/4p and Yap1p, key regulators of the response to general stress and oxidative stress, respectively, played a role in mediating the RNS-induced response...
  14. ncbi A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast
    Emma L Blakely
    Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, UK
    FEBS J 272:3583-92. 2005
    ..Biochemical studies of the equivalent amino-acid substitution (Lys319Pro) in the yeast enzyme showed a loss of enzyme activity and decrease in the steady-state level of bc1 complex in the mutant confirming pathogenicity...
  15. ncbi Effect of inhibition of the bc1 complex on gene expression profile in yeast
    Ingrid Bourges
    Wolfson Institute for Biomedical Research, University College London, UK
    J Biol Chem 280:29743-9. 2005
    ....
  16. ncbi Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae
    Jacques J Kessl
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 279:2817-24. 2004
    ..Modeling of the changes in cytochrome b structure and atovaquone binding with the mutated bc(1) complexes provides the first quantitative explanation for the molecular basis of atovaquone resistance...
  17. ncbi Re-examination of inhibitor resistance conferred by Qo-site mutations in cytochrome b using yeast as a model system
    Nicholas Fisher
    The Wolfson Institute for Biomedical Research, UCL, Gower Street, London, WC1E 6BT, UK
    Pest Manag Sci 61:973-8. 2005
    ..Site-directed mutagenesis was also used to model selected regions of the mammalian Qo site in yeast cytochrome b in order to further understand the differential efficacy of these QoI in the mammalian and pathogen bc1 complexes...
  18. ncbi Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae
    Jacques J Kessl
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 280:17142-8. 2005
    ..By modeling the variations in cytochrome b structure and atovaquone binding with the mutated bc1 complexes, we obtained the first quantitative explanation for the molecular basis of atovaquone resistance in malaria parasites...
  19. ncbi Modeling the Qo site of crop pathogens in Saccharomyces cerevisiae cytochrome b
    Nicholas Fisher
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Biochem 271:2264-71. 2004
    ..If so, this could contribute to observed differences in the rates of evolution of QoI resistance in fungal and oomycete pathogens...
  20. ncbi Molecular basis for atovaquone binding to the cytochrome bc1 complex
    Jacques J Kessl
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 278:31312-8. 2003
    ..These results provide the first molecular description of how atovaquone binds to the bc1 complex and explain the differential inhibition of the fungal versus mammalian enzymes...
  21. ncbi Disruption of the interaction between the Rieske iron-sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b
    Nicholas Fisher
    Wolfson Institute for Biomedical Research, University College London, UK
    Eur J Biochem 271:1292-8. 2004
    ....
  22. ncbi Human disease-related mutations in cytochrome b studied in yeast
    Nicholas Fisher
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 279:12951-8. 2004
    ..Thus by using yeast as a model system, we identified the molecular basis of the respiratory defect caused by the disease mutations in cytochrome b...
  23. ncbi QO site deficiency can be compensated by extragenic mutations in the hinge region of the iron-sulfur protein in the bc1 complex of Saccharomyces cerevisiae
    Gael Brasseur
    Laboratoire de Bioenergetique et Ingenierie des Proteines, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biol Chem 279:24203-11. 2004
    ....