J S Metcalf

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi request reprint Cyanobacteria, neurotoxins and water resources: are there implications for human neurodegenerative disease?
    James S Metcalf
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, UK
    Amyotroph Lateral Scler 10:74-8. 2009
  2. ncbi request reprint Inhibition of plant protein synthesis by the cyanobacterial hepatotoxin, cylindrospermopsin
    James S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, Scotland, UK
    FEMS Microbiol Lett 235:125-9. 2004
  3. ncbi request reprint Effects of organic solvents on the high performance liquid chromatographic analysis of the cyanobacterial toxin cylindrospermopsin and its recovery from environmental eutrophic waters by solid phase extraction
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, DD1 4HN, Dundee, UK
    FEMS Microbiol Lett 216:159-64. 2002
  4. doi request reprint Co-occurrence of beta-N-methylamino-L-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies, 1990-2004
    James S Metcalf
    Division of Molecular and Environmental Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Environ Microbiol 10:702-8. 2008
  5. ncbi request reprint Legal and security requirements for the air transportation of cyanotoxins and toxigenic cyanobacterial cells for legitimate research and analytical purposes
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicol Lett 163:85-90. 2006
  6. ncbi request reprint Analysis of cyanobacterial toxins by physicochemical and biochemical methods
    G A Codd
    University of Dundee, Department of Biological Sciences, UK
    J AOAC Int 84:1626-35. 2001
  7. ncbi request reprint Protection against the toxicity of microcystin-LR and cylindrospermopsin in Artemia salina and Daphnia spp. by pre-treatment with cyanobacterial lipopolysaccharide (LPS)
    J Lindsay
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicon 48:995-1001. 2006
  8. ncbi request reprint Toxicity of cylindrospermopsin to the brine shrimp Artemia salina: comparisons with protein synthesis inhibitors and microcystins
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee, DD1 4HN, UK
    Toxicon 40:1115-120. 2002
  9. ncbi request reprint Effects of adsorption to plastics and solvent conditions in the analysis of the cyanobacterial toxin microcystin-LR by high performance liquid chromatography
    P Hyenstrand
    Department of Biological Sciences, University of Dundee, UK
    Water Res 35:3508-11. 2001
  10. doi request reprint Cyanotoxins in desert environments may present a risk to human health
    J S Metcalf
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Sci Total Environ 421:118-23. 2012

Detail Information

Publications31

  1. doi request reprint Cyanobacteria, neurotoxins and water resources: are there implications for human neurodegenerative disease?
    James S Metcalf
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, UK
    Amyotroph Lateral Scler 10:74-8. 2009
    ..An understanding of the risks presented by waterborne BMAA and of available mitigation strategies to reduce this potential exposure is needed...
  2. ncbi request reprint Inhibition of plant protein synthesis by the cyanobacterial hepatotoxin, cylindrospermopsin
    James S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, Scotland, UK
    FEMS Microbiol Lett 235:125-9. 2004
    ..Implications of these observations for current spray-irrigation practices are discussed...
  3. ncbi request reprint Effects of organic solvents on the high performance liquid chromatographic analysis of the cyanobacterial toxin cylindrospermopsin and its recovery from environmental eutrophic waters by solid phase extraction
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, DD1 4HN, Dundee, UK
    FEMS Microbiol Lett 216:159-64. 2002
    ..Using C18 and polygraphite carbon cartridges in series, 100% recoveries of cylindrospermopsin were achieved for lake waters spiked at 1 micro g l(-1)...
  4. doi request reprint Co-occurrence of beta-N-methylamino-L-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies, 1990-2004
    James S Metcalf
    Division of Molecular and Environmental Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Environ Microbiol 10:702-8. 2008
    ..Furthermore, samples collected over several years shows that BMAA can co-occur with other known cyanotoxins in such waterbodies. Health risk assessment of cyanobacterial BMAA in waterbodies is suggested...
  5. ncbi request reprint Legal and security requirements for the air transportation of cyanotoxins and toxigenic cyanobacterial cells for legitimate research and analytical purposes
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicol Lett 163:85-90. 2006
    ..Implications of the regulations for the packaging and air-transport of dangerous goods, as they apply to cyanotoxins and toxigenic cyanobacteria, are discussed...
  6. ncbi request reprint Analysis of cyanobacterial toxins by physicochemical and biochemical methods
    G A Codd
    University of Dundee, Department of Biological Sciences, UK
    J AOAC Int 84:1626-35. 2001
    ..Analytical requirements are considered with reference to recently derived guideline levels for the protection of health and to the availability, or otherwise, of purified, quantitative cyanobacterial toxin standards...
  7. ncbi request reprint Protection against the toxicity of microcystin-LR and cylindrospermopsin in Artemia salina and Daphnia spp. by pre-treatment with cyanobacterial lipopolysaccharide (LPS)
    J Lindsay
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicon 48:995-1001. 2006
    ....
  8. ncbi request reprint Toxicity of cylindrospermopsin to the brine shrimp Artemia salina: comparisons with protein synthesis inhibitors and microcystins
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee, DD1 4HN, UK
    Toxicon 40:1115-120. 2002
    ..salina and the LC(50) concentration for these strains over time was greater than the LC(50) for purified cylindrospermopsin, with the exception of C. raciborskii strain CR1...
  9. ncbi request reprint Effects of adsorption to plastics and solvent conditions in the analysis of the cyanobacterial toxin microcystin-LR by high performance liquid chromatography
    P Hyenstrand
    Department of Biological Sciences, University of Dundee, UK
    Water Res 35:3508-11. 2001
    ..Furthermore, dilutions of microcystin-LR in varying concentrations of methanol and acetonitrile influenced the quantification of the microcystin-LR concentration by high performance liquid chromatography...
  10. doi request reprint Cyanotoxins in desert environments may present a risk to human health
    J S Metcalf
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Sci Total Environ 421:118-23. 2012
    ..Further studies are required to monitor desert dust storms for the presence of cyanotoxins. An understanding of the risks of inhaling particles containing cyanotoxins is also warranted...
  11. ncbi request reprint Retention of Microcystis aeruginosa and microcystin by salad lettuce (Lactuca sativa) after spray irrigation with water containing cyanobacteria
    G A Codd
    Department of Biological Sciences, University of Dundee, UK
    Toxicon 37:1181-5. 1999
    ..These findings are discussed in terms of crop spray irrigation with water containing cyanobacteria and potential human exposure to cyanobacterial toxins via plant foods grown in such circumstances...
  12. ncbi request reprint Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio)
    J H Best
    Division of Applied and Environmental Biology, School of Life Sciences, University of Dundee, DD1 4HN, Dundee, UK
    Aquat Toxicol 60:223-31. 2002
    ..rerio to detoxicate microcystins. The results presented here have wide ranging implications for both animal and human health...
  13. doi request reprint Toxicity of the cyanobacterial neurotoxin beta-N-methylamino-L-alanine to three aquatic animal species
    Esme L Purdie
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, UK
    Amyotroph Lateral Scler 10:67-70. 2009
    ..rerio), loss of phototaxis (A. salina) and mortalities (all species). These systems offer potential to further understand BMAA toxicity and the bioaccumulation and fates of BMAA in aquatic food chains leading to potential human exposure...
  14. ncbi request reprint Production of antibodies against microcystin-RR for the assessment of purified microcystins and cyanobacterial environmental samples
    Fiona M Young
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicon 48:295-306. 2006
    ..MC-RR antisera are useful for screening samples containing multiple MCs, and particularly for samples primarily containing MC-RR variants...
  15. ncbi request reprint Immunogold localisation of microcystins in cryosectioned cells of Microcystis
    Fiona M Young
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DDI 4HN, UK
    J Struct Biol 151:208-14. 2005
    ..Cryosectioning is a useful technique since it reduces the extraction of microcystins during sample preparation for electron microscopy...
  16. ncbi request reprint Cyanobacterial toxins: risk management for health protection
    Geoffrey A Codd
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicol Appl Pharmacol 203:264-72. 2005
    ....
  17. ncbi request reprint Analysis of cyanobacterial toxins by immunological methods
    J S Metcalf
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee, DD1 4HN, United Kingdom
    Chem Res Toxicol 16:103-12. 2003
  18. ncbi request reprint Laboratory studies of dissolved radiolabelled microcystin-LR in lake water
    Per Hyenstrand
    University of Dundee, School of Life Sciences, Division of Environmental and Applied Biology, DD1 4HN Dundee, UK
    Water Res 37:3299-306. 2003
    ..The study demonstrated that biodegradation of dissolved microcystin-LR occurred in water collected at a lake surface with carbon dioxide as a major end-product...
  19. doi request reprint Amino acid neurotoxins in feathers of the Lesser Flamingo, Phoeniconaias minor
    J S Metcalf
    Institute for Ethnomedicine, Box 3464, Jackson, WY 83001, USA
    Chemosphere 90:835-9. 2013
    ..This is the first report of these neurotoxic amino acids in birds. We discuss the origin and significance of DAB, alongside other cyanotoxins of dietary origin, in the feathers of the Lesser Flamingo...
  20. ncbi request reprint An international intercomparison exercise for the determination of purified microcystin-LR and microcystins in cyanobacterial field material
    Jutta Fastner
    Technical University Berlin, Franklinstr 29, 10587 Berlin, Germany
    Anal Bioanal Chem 374:437-44. 2002
    ....
  21. pmc Effects of light on the microcystin content of Microcystis strain PCC 7806
    Claudia Wiedner
    Institute for Biodiversity and Ecosystem Dynamics, Aquatic Microbiology, University of Amsterdam, 1018 VW Amsterdam, The Netherlands
    Appl Environ Microbiol 69:1475-81. 2003
    ....
  22. ncbi request reprint Oxidative elimination of cyanotoxins: comparison of ozone, chlorine, chlorine dioxide and permanganate
    Eva Rodriguez
    Departamento de Ingeniería Química y Química Física, Faculdad de Ciencias, Universidad de Extremadura, Avda Elvas s n, 06071 Badajoz, Spain
    Water Res 41:3381-93. 2007
    ..The formation of trihalomethanes (THMs) in the treated water may be a restriction to the application of sufficiently high-chlorine doses...
  23. pmc Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid
    Paul Alan Cox
    Institute for Ethnomedicine, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 102:5074-8. 2005
    ..The ubiquity of cyanobacteria in terrestrial, as well as freshwater, brackish, and marine environments, suggests a potential for wide-spread human exposure...
  24. ncbi request reprint Accumulation and depuration of the cyanobacterial toxin cylindrospermopsin in the freshwater mussel Anodonta cygnea
    Martin L Saker
    Centro Interdisciplinar de Investigacao Marinha e Ambiental, Rua dos Bragas, Portugal
    Toxicon 43:185-94. 2004
    ....
  25. ncbi request reprint Interlaboratory comparison trial on cylindrospermopsin measurement
    Andrea Torokne
    Department of Hygienic Water Biology, National Institute of Environmental Health, P O Box 26, Budapest H 1450, Hungary
    Anal Biochem 332:280-4. 2004
    ..1% (v/v) trifluoroacetic acid as the mobile phase...
  26. ncbi request reprint Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland
    Tomoharu Sano
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Phytochemistry 66:543-8. 2005
    ..Both strongly inhibited the activity of leucine aminopeptidase M with IC50 values of 40 and 12 ng/ml, respectively...
  27. ncbi request reprint Analysis of nodularin-R in eider (Somateria mollissima), roach (Rutilus rutilus L.), and flounder (Platichthys flesus L.) liver and muscle samples from the western Gulf of Finland, northern Baltic Sea
    Vesa O Sipiä
    Finnish Institute of Marine Research, Erik Palménin aukio 1, FI 00561 Helsinki, Finland
    Environ Toxicol Chem 25:2834-9. 2006
    ....
  28. ncbi request reprint Kinetics of the oxidation of cylindrospermopsin and anatoxin-a with chlorine, monochloramine and permanganate
    Eva Rodriguez
    Departamento de Ingenieria Quimica y Energetica, Universidad de Extremadura, 06071 Badajoz, Spain
    Water Res 41:2048-56. 2007
    ..Therefore, chlorination is a feasible option for CYN degradation during oxidation and disinfection processes but not for ANTX removal. The permanganate dose required for CYN oxidation is very high and not applicable in waterworks...
  29. ncbi request reprint Necrotic enteritis in mute swans associated with cyanobacterial toxins
    Tom Pennycott
    Vet Rec 154:575-6. 2004
  30. ncbi request reprint Microcystin analysis in single filaments of Planktothrix spp. in laboratory cultures and environmental blooms
    Reyhan Akcaalan
    Istanbul University, Fisheries Faculty, Ordu Cad No 200 34470 Laleli, Istanbul, Turkey
    Water Res 40:1583-90. 2006
    ..rubescens from environmental samples. Under culture conditions, P. rubescens showed a good relationship between filament biovolume and toxin content...
  31. ncbi request reprint First observation of cylindrospermopsin in Anabaena lapponica isolated from the boreal environment (Finland)
    Lisa Spoof
    Department of Biochemistry and Pharmacy, Abo Akademi University, Tykistokatu 6A, FI 20520 Turku, Finland
    Environ Toxicol 21:552-60. 2006
    ..Cylindrospermopsin was confirmed by all three techniques in a culture sample of Anabaena lapponica at a concentration of 242 microg cylindrospermopsin per g freeze-dried cyanobacterial material...