P A Meredith

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi request reprint Comparison of the efficacy of candesartan and losartan: a meta-analysis of trials in the treatment of hypertension
    P A Meredith
    Department of Medicine and Therapeutics, Division of Cardiovascular and Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, Scotland, UK
    J Hum Hypertens 24:525-31. 2010
  2. ncbi request reprint A putative placebo comparison of the SCOPE and LIFE trials
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Scotland, UK
    J Renin Angiotensin Aldosterone Syst 5:59-63. 2004
  3. ncbi request reprint Trough: peak ratio and smoothness index for antihypertensive agents
    P A Meredith
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Blood Press Monit 4:257-62. 1999
  4. ncbi request reprint Angiotensin II receptor antagonists alone and combined with hydrochlorothiazide: potential benefits beyond the antihypertensive effect
    Peter A Meredith
    Department of Medicine and Therapeutics, Division of Cardiovascular and Medical Science, Gardiner Institute, Glasgow Western Infirmary, Glasgow, UK
    Am J Cardiovasc Drugs 5:171-83. 2005
  5. ncbi request reprint Dihydropyridine calcium channel blockers: basic pharmacological similarities but fundamental therapeutic differences
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, Scotland, UK
    J Hypertens 22:1641-8. 2004
  6. ncbi request reprint A chronotherapeutic approach to effective blood pressure management
    Peter A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, Scotland, GL 116NT United Kingdom
    J Clin Hypertens (Greenwich) 4:15-9. 2002
  7. doi request reprint Potential concerns about generic substitution: bioequivalence versus therapeutic equivalence of different amlodipine salt forms
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, Department of Medicine and Therapeutics, University of Glasgow, Glasgow, UK
    Curr Med Res Opin 25:2179-89. 2009
  8. ncbi request reprint Candesartan cilexetil--a review of effects on cardiovascular complications in hypertension and chronic heart failure
    Peter A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, UK
    Curr Med Res Opin 23:1693-705. 2007
  9. ncbi request reprint From hypertension to heart failure -- are there better primary prevention strategies?
    Peter A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland, UK
    J Renin Angiotensin Aldosterone Syst 7:64-73. 2006
  10. ncbi request reprint Benefits of nifedipine GITS in stable coronary artery disease: Further analysis of the "ACTION" database
    Peter A Meredith
    Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, UK
    Adv Ther 27:297-306. 2010

Detail Information

Publications21

  1. doi request reprint Comparison of the efficacy of candesartan and losartan: a meta-analysis of trials in the treatment of hypertension
    P A Meredith
    Department of Medicine and Therapeutics, Division of Cardiovascular and Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, Scotland, UK
    J Hum Hypertens 24:525-31. 2010
    ..These findings were consistent when analyses according to dose and combination with HCTZ were carried out. Thus, it can be concluded that at currently recommended doses, candesartan is more effective than losartan in lowering BP...
  2. ncbi request reprint A putative placebo comparison of the SCOPE and LIFE trials
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Scotland, UK
    J Renin Angiotensin Aldosterone Syst 5:59-63. 2004
    ..Neither trial is sufficiently 'powered' to demonstrate a benefit in CHD outcomes, but with SCOPE there was a trend towards benefit with a point estimate compatible with the major meta-analysis...
  3. ncbi request reprint Trough: peak ratio and smoothness index for antihypertensive agents
    P A Meredith
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Blood Press Monit 4:257-62. 1999
    ..Overall, neither index has been proven to offer definitive superiority and hence it is reasonable to suggest that the two are complementary...
  4. ncbi request reprint Angiotensin II receptor antagonists alone and combined with hydrochlorothiazide: potential benefits beyond the antihypertensive effect
    Peter A Meredith
    Department of Medicine and Therapeutics, Division of Cardiovascular and Medical Science, Gardiner Institute, Glasgow Western Infirmary, Glasgow, UK
    Am J Cardiovasc Drugs 5:171-83. 2005
    ..Evidence from these studies suggests a beneficial role beyond the antihypertensive effect of these therapies in providing protection against cardiovascular, renovascular, and cerebrovascular events...
  5. ncbi request reprint Dihydropyridine calcium channel blockers: basic pharmacological similarities but fundamental therapeutic differences
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, Scotland, UK
    J Hypertens 22:1641-8. 2004
    ....
  6. ncbi request reprint A chronotherapeutic approach to effective blood pressure management
    Peter A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, Scotland, GL 116NT United Kingdom
    J Clin Hypertens (Greenwich) 4:15-9. 2002
    ..For example, unlike some other angiotensin II receptor blockers, telmisartan provides consistent reduction of blood pressure during the 24-hour period...
  7. doi request reprint Potential concerns about generic substitution: bioequivalence versus therapeutic equivalence of different amlodipine salt forms
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, Department of Medicine and Therapeutics, University of Glasgow, Glasgow, UK
    Curr Med Res Opin 25:2179-89. 2009
    ..These concerns are illustrated by using the calcium antagonist amlodipine besylate (innovator drug) versus amlodipine maleate (generic), indicated for the treatment of hypertension and angina pectoris, as an example...
  8. ncbi request reprint Candesartan cilexetil--a review of effects on cardiovascular complications in hypertension and chronic heart failure
    Peter A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, UK
    Curr Med Res Opin 23:1693-705. 2007
    ..The ARB candesartan was initially established as an effective once-daily antihypertensive treatment, providing 24-h blood pressure (BP) control with a trough:peak ratio close to 100%...
  9. ncbi request reprint From hypertension to heart failure -- are there better primary prevention strategies?
    Peter A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland, UK
    J Renin Angiotensin Aldosterone Syst 7:64-73. 2006
    ..However, there is now compelling evidence to suggest that this therapy should include an antihypertensive agent that inhibits the reninangiotensin- aldosterone system (RAAS)...
  10. ncbi request reprint Benefits of nifedipine GITS in stable coronary artery disease: Further analysis of the "ACTION" database
    Peter A Meredith
    Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, UK
    Adv Ther 27:297-306. 2010
    ....
  11. ncbi request reprint Efficacy and tolerability of long-term rilmenidine treatment in hypertensive diabetic patients. A retrospective analysis of a general practice study
    Peter A Meredith
    Division of Cardiovascular and Medical Sciences, The University of Glasgow, The Western Infirmary, Scotland, UK
    Am J Cardiovasc Drugs 4:195-200. 2004
    ..Recent studies have shown rilmenidine improves glucose tolerance and reduces micro-albuminuria in patients with diabetes mellitus...
  12. ncbi request reprint Therapy in the elderly hypertensive
    Peter A Meredith
    University Department of Medicine and Therapeutics, The Western Infirmary, Glasgow, G11 6NT, UK pam
    J Renin Angiotensin Aldosterone Syst 3:S49-56. 2002
  13. pmc Preferential benefits of nifedipine GITS in systolic hypertension and in combination with RAS blockade: further analysis of the 'ACTION' database in patients with angina
    H L Elliott
    Institute of Pharmaceutical and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    J Hum Hypertens 25:63-70. 2011
    ..7 and 3.3 mm Hg for systolic and diastolic BP, respectively. In summary, the lowest CV event rates were seen in those receiving (i) the combination of RAS blockade and nifedipine GITS and (ii) in those specifically treated for ISH...
  14. ncbi request reprint Organ protection and optimal blood pressure control
    P A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Scotland
    Am J Hypertens 8:59S-62S. 1995
    ..It is likely that this will only be achieved by the use of genuine long-acting antihypertensive drugs with a high trough:peak ratio...
  15. ncbi request reprint New FDA guidelines on the treatment of hypertension: comparison of different therapeutic classes according to trough/peak blood pressure responses
    P A Meredith
    Department of Medicine and Therapeutics, University of Glasgow, Gardiner Institute, Western Infirmary, Scotland
    Arch Mal Coeur Vaiss 87:1423-9. 1994
    ..abstract truncated at 250 words)..
  16. ncbi request reprint Calculation of trough-to-peak ratio in the research unit setting. Advantages and disadvantages
    H L Elliott
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Am J Hypertens 9:71S-75S; discussion 87S-90S. 1996
    ..Thus, using the trough-to-peak ratio not only appears valid but also permits the detailed study of individual patients and also lends itself to the incorporation of additional and confirmatory clinical pharmacological assessments...
  17. ncbi request reprint Intrinsically long-acting agents compared with long-acting chronoformulations
    P A Meredith
    Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, UK
    Blood Press Monit 5:S25-30. 2000
    ..However, in poorly compliant patients who miss doses of medication, intrinsically long-acting drugs are likely to be superior, because they sustain blood pressure control beyond the dosing interval...
  18. ncbi request reprint Is postural hypotension a real problem with antihypertensive medication?
    P A Meredith
    University of Glasgow, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Cardiology 96:19-24. 2001
    ..Thus, it is perhaps time to reassess the real significance of iatrogenic postural hypotension in the selection of antihypertensive therapy...
  19. ncbi request reprint Clinical outcomes according to baseline blood pressure in patients with a low ejection fraction in the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity) Program
    Peter A Meredith
    Faculty of Medicine, University of Glasgow, Glasgow, Scotland
    J Am Coll Cardiol 52:2000-7. 2008
    ..40) in the CHARM (Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity) program...
  20. ncbi request reprint Concentration-effect relationships and implications for trough-to-peak ratio
    P A Meredith
    University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, Scotland
    Am J Hypertens 9:66S-70S; discussion 87S-90S. 1996
    ....
  21. ncbi request reprint The relationships between initial blood pressure and the response to different antihypertensive agents
    Peter A Meredith
    J Hypertens 25:2513-4; author reply 2514. 2007