David K Menon

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
  2. pmc Quantification of lean and fat tissue repletion following critical illness: a case report
    Clare L Reid
    Division of Anaesthesia, University of Cambridge, Box 93, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Crit Care 12:R79. 2008
  3. pmc BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil
    Anthony R Absalom
    University Division of Anaesthesia, Addenbrookes Hospital, Cambridge CB2 2QQ, UK
    Crit Care 13:137. 2009
  4. doi request reprint Position statement: definition of traumatic brain injury
    David K Menon
    University of Cambridge, United Kingdom
    Arch Phys Med Rehabil 91:1637-40. 2010
  5. ncbi request reprint Diffusion limited oxygen delivery following head injury
    David K Menon
    Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1384-90. 2004
  6. doi request reprint Unique challenges in clinical trials in traumatic brain injury
    David K Menon
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Crit Care Med 37:S129-35. 2009
  7. ncbi request reprint Integrated approaches to academic anaesthesia - the Cambridge experience
    D K Menon
    University Department of Anaesthesia, University of Cambridge, Box 93, Addenbrooke s Hospital, CB2 2QQ, UK
    Anaesthesia 59:785-92. 2004
  8. ncbi request reprint Brain ischaemia after traumatic brain injury: lessons from 15O2 positron emission tomography
    David K Menon
    Division of Anaesthesia, University of Cambridge, Honorary Consultant, Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Crit Care 12:85-9. 2006
  9. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
  10. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004

Detail Information

Publications147 found, 100 shown here

  1. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
    ..Previous experience with cooling also appears to be important if complications, which may outweigh the benefits of hypothermia, are to be avoided...
  2. pmc Quantification of lean and fat tissue repletion following critical illness: a case report
    Clare L Reid
    Division of Anaesthesia, University of Cambridge, Box 93, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Crit Care 12:R79. 2008
    ....
  3. pmc BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil
    Anthony R Absalom
    University Division of Anaesthesia, Addenbrookes Hospital, Cambridge CB2 2QQ, UK
    Crit Care 13:137. 2009
    ..BIS and entropy values should be interpreted in combination with clinical findings in patients sedated with these agents...
  4. doi request reprint Position statement: definition of traumatic brain injury
    David K Menon
    University of Cambridge, United Kingdom
    Arch Phys Med Rehabil 91:1637-40. 2010
    ..Technologic advances in magnetic resonance imaging and the development of biomarkers offer potential for improving diagnostic accuracy in these situations...
  5. ncbi request reprint Diffusion limited oxygen delivery following head injury
    David K Menon
    Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1384-90. 2004
    ..To use a range of techniques to explore diffusion limitation as a mechanism of cellular hypoxia in the setting of head injury...
  6. doi request reprint Unique challenges in clinical trials in traumatic brain injury
    David K Menon
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Crit Care Med 37:S129-35. 2009
    ..Novel approaches to trial design, such as sliding dichotomy, coupled with robust outcome prediction models, can increase statistical power and improve trial design...
  7. ncbi request reprint Integrated approaches to academic anaesthesia - the Cambridge experience
    D K Menon
    University Department of Anaesthesia, University of Cambridge, Box 93, Addenbrooke s Hospital, CB2 2QQ, UK
    Anaesthesia 59:785-92. 2004
    ..We believe that these are important steps in safeguarding research and teaching in anaesthesia, critical care and peri-operative medicine...
  8. ncbi request reprint Brain ischaemia after traumatic brain injury: lessons from 15O2 positron emission tomography
    David K Menon
    Division of Anaesthesia, University of Cambridge, Honorary Consultant, Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Crit Care 12:85-9. 2006
    ..There is a need for a technique that can provide a comprehensive and quantitative description of cerebral physiology in this setting...
  9. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
    ..Whether treatment-related improvement in biochemistry translates into better outcome remains to be established...
  10. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
    ..To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury...
  11. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  12. ncbi request reprint Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?
    Jonathan P Coles
    Division of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Brain 127:2479-90. 2004
    ..It also remains unclear whether CPP values below 65 mmHg can be safely used in this population. Clarification of the significance of a reduction in CMRO2 and neuronal electrical function will require further study...
  13. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
    ..Cerebrovascular autoregulation is frequently measured in head-injured patients. We attempted to validate 4 bedside methods used for assessment of autoregulation...
  14. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
    ..To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury...
  15. ncbi request reprint Intersubject variability and reproducibility of 15O PET studies
    Jonathan P Coles
    The Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 26:48-57. 2006
    ..While ideally each centre should develop its own bank of such data, the figures provided will allow initial generic approximations of sample size for such studies...
  16. doi request reprint A combined microdialysis and FDG-PET study of glucose metabolism in head injury
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Acta Neurochir (Wien) 151:51-61; discussion 61. 2009
    ..In particular, we aimed to determine the fate of glucose in terms of differential metabolism to pyruvate and lactate...
  17. ncbi request reprint Incidence and mechanisms of cerebral ischemia in early clinical head injury
    Jonathan P Coles
    The Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:202-11. 2004
    ..The ischemic burden represented by this "traumatic penumbra" is poorly detected by bedside clinical monitors and has significant associations with outcome...
  18. doi request reprint Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    J Neurotrauma 27:1951-8. 2010
    ..THx may be of diagnostic value to optimize therapy oriented toward restoration and continuity of cerebrovascular reactivity, especially in patients for whom direct ICP monitoring is not feasible...
  19. doi request reprint Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity
    M Giulia Abate
    The Division of Anaesthesia, Addenbrooke s Hospital, University of Cambridge, Box 93, Cambridge, CB2 2QQ, UK
    Neurocrit Care 9:319-25. 2008
    ..Conclusive evidence of cerebral ischemia following head injury has been elusive. We aimed to use (15)O and (18)Fluorodeoxyglucose positron emission tomography (PET) to investigate pathophysiological derangements following head injury...
  20. pmc Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury
    Virginia F J Newcombe
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 2QQ, UK
    Brain 134:759-68. 2011
    ..The ability to detect such damage in vivo may have important implications for patient management, patient selection for trials, and to help understand complex neurocognitive pathways...
  21. ncbi request reprint Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 35:568-78. 2007
    ..To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury...
  22. pmc Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location
    Ivan Timofeev
    Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 28:849-60. 2011
    ..Decreases in perfusion and oxygenation were associated with deteriorating neurochemistry and these effects were more pronounced in perilesional tissue and when cerebrovascular reactivity was impaired...
  23. ncbi request reprint Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings
    Jurgens Nortje
    University Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 36:273-81. 2008
    ..To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury...
  24. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
    ..Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation...
  25. pmc Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury
    Emmanuel Carrera
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurotrauma 28:889-96. 2011
    ..Further studies are needed to determine whether monitoring of arterial and CSF compartment compliances may detect and prevent an adverse ischemic event during hyperventilation...
  26. ncbi request reprint Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology
    Jonathan P Coles
    The Division of Anesthesia, and The Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:191-201. 2004
    ..We conclude that this technique is a valid and useful tool for quantifying ischemic burden after traumatic brain injury...
  27. ncbi request reprint Nitric oxide in acute brain injury: a pilot study of NO(x) concentrations in human brain microdialysates and their relationship with energy metabolism
    Keri L H Carpenter
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Acta Neurochir Suppl 102:207-13. 2008
    ....
  28. doi request reprint The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
    Clare N Gallagher
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Brain 132:2839-49. 2009
    ..This is the first direct demonstration of brain utilization of lactate as an energy source in humans...
  29. doi request reprint Outcome following evacuation of acute subdural haematomas: a comparison of craniotomy with decompressive craniectomy
    Lucia M Li
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital and University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
    Acta Neurochir (Wien) 154:1555-61. 2012
    ....
  30. ncbi request reprint The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesth Analg 97:572-6, table of contents. 2003
    ..We propose that large doses of propofol should be used cautiously in head-injured patients, because there is the potential to increase the injured brain's vulnerability to secondary insults...
  31. doi request reprint Early metabolic characteristics of lesion and nonlesion tissue after head injury
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 29:965-75. 2009
    ..Such pathophysiological derangements may result in selective neuronal loss and impact on functional outcome...
  32. ncbi request reprint Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma
    Virginia F J Newcombe
    University Division of Anaesthesia, Cambridge University, Box 93, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Acta Neurochir Suppl 102:247-51. 2008
    ..Cerebral edema is a common sequelum post traumatic brain injury (TBI). Quantification of the apparent diffusion coefficient (ADC) using diffusion tensor imaging (DTI) may help to characterize the pathophysiology of brain swelling...
  33. pmc The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production
    Adel Helmy
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 31:658-70. 2011
    ..No clear arterio-jugular venous gradients were apparent. These data provide evidence for the cerebral production of these cytokines and show a stereotyped temporal pattern after TBI...
  34. doi request reprint Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications
    Virginia F J Newcombe
    University Division of Anaesthesia, University of Cambridge, Box 93, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 81:552-61. 2010
    ..The authors have used diffusion tensor imaging (DTI) to characterise the extent and location of white matter loss in VS secondary to traumatic brain injury (TBI) and ischaemic-hypoxic injury...
  35. ncbi request reprint The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurosurgery 71:652-60; discussion 660-1. 2012
    ..From a practical point of view, PRx can be monitored continuously, whereas Mx can only be monitored in short periods when transcranial Doppler probes can be applied...
  36. ncbi request reprint Hyperglycemia and brain tissue pH after traumatic brain injury
    David A Zygun
    Neuroscience Critical Care Unit and Department of Anaesthesia, University of Cambridge, Cambridge, England
    Neurosurgery 55:877-81; discussion 882. 2004
    ..We tested the hypothesis that blood glucose levels are associated with brain tissue pH (pH(b)) and that the correction of hyperglycemia would result in an improvement in pH(b)...
  37. ncbi request reprint Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study
    Peter J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 22:735-45. 2002
    ..9 kPa resulted in a significant elevation of the OEF, in association with a reduction in glucose, but no significant elevation in the L/P ratio or glutamate...
  38. doi request reprint Hierarchical log linear analysis of admission blood parameters and clinical outcome following traumatic brain injury
    Adel Helmy
    Division of Neurosurgery, University of Cambridge, Cambridge, UK
    Acta Neurochir (Wien) 152:953-7. 2010
    ..Hierarchical log linear analysis can be utilised to present the complex interactions between these variables and outcome visually...
  39. doi request reprint Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury
    Marcel J H Aries
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, and Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 40:2456-63. 2012
    ..We then validated the CPPopt algorithm by determining the association between outcome and the deviation of actual CPP from CPPopt...
  40. doi request reprint Fixed, dilated pupils following traumatic brain injury: historical perspectives, causes and ophthalmological sequelae
    Adel Helmy
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 114:295-9. 2012
    ..A FDP is a grave prognostic sign following TBI commonly resulting in long term ophthalmological sequelae; however, a favourable outcome is still attainable...
  41. doi request reprint Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury
    Thomas Geeraerts
    University Division of Anaesthesia, University of Cambridge, Cambridge, UK
    Ann Nucl Med 25:396-405. 2011
    ..The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a group of patients with head injury...
  42. ncbi request reprint Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 30:1950-9. 2002
    ..To investigate the effect of hyperventilation on cerebral blood flow in traumatic brain injury...
  43. doi request reprint Traumatic brain injury alters the functional brain network mediating working memory
    Maki Kasahara
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, UK
    Brain Inj 25:1170-87. 2011
    ..Investigation of the impact of traumatic brain injury (TBI) on the functional brain network that mediates working memory function...
  44. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  45. ncbi request reprint Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra
    Peter J Hutchinson
    Academic Unit of Neurosurgery, Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, and Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 24:1545-57. 2007
    ..It remains to be seen whether exogenous IL-1ra or other agents can be used to manipulate cytokine levels in the brain, for potential therapeutic effect...
  46. ncbi request reprint Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors
    Claire H Salmond
    Wolfson Brain Imaging Centre, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Int Neuropsychol Soc 12:697-706. 2006
    ..These complex deficits may contribute to difficulties in daily living resulting from apathy, poor judgment, or inhibition in SAH survivors...
  47. ncbi request reprint Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy
    I Timofeev
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:11-6. 2006
    ..Formal prospective randomized studies of decompressive craniectomy are now indicated...
  48. pmc Inter subject variability and reproducibility of diffusion tensor imaging within and between different imaging sessions
    Tonny V Veenith
    Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 8:e65941. 2013
    ..These data can be utilised in interventional studies to quantify change within a single imaging session, or to assess the significance of change in longitudinal studies of brain injury and disease. ..
  49. ncbi request reprint Integrated image analysis solutions for PET datasets in damaged brain
    Peter Smielewski
    Wolfson Brain Imaging Centre, Department of Neurosurgery, University of Cambridge, UK
    J Clin Monit Comput 17:427-40. 2002
    ..To present an integrated imaging solution for analysis of such datasets and report on its use in practice...
  50. ncbi request reprint Formal characterization and extension of the linearized diffusion tensor model
    Raymond Salvador
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hum Brain Mapp 24:144-55. 2005
    ..The combination of diffusivity and its error may provide added value in diagnostic DTI of acute pathologic expansion of the extracellular fluid compartment in brain parenchymal tissue...
  51. pmc Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging
    Virginia F J Newcombe
    Division of Anaesthesia, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 33:855-62. 2013
    ..This rim of hypointensity may characterize a region of microvascular failure resulting in cytotoxic edema, and may represent a 'traumatic penumbra' which may be rescued by effective therapy...
  52. pmc Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure
    Thomas Geeraerts
    University Division of Anaesthesia and Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Crit Care 12:R114. 2008
    ..The objective of this study was to assess the relationship between optic nerve sheath diameter (ONSD), as measured using MRI, and ICP...
  53. ncbi request reprint Cognitive reserve as a resilience factor against depression after moderate/severe head injury
    Claire H Salmond
    Wolfson Brain Imaging Centre, University Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 23:1049-58. 2006
    ..No significant anatomical differences were found between depressed and non-depressed survivors. These results suggest that premorbid intelligence may provide a resilience factor against depression in head injury survivors...
  54. doi request reprint The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury
    David A Zygun
    Department of Anaesthesia, University of Cambridge, Cambridge, United Kingdom
    Crit Care Med 37:1074-8. 2009
    ..To understand the acute effect of packed red blood cell transfusion on cerebral oxygenation and metabolism in patients with sTBI...
  55. ncbi request reprint Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage
    Pawan S Minhas
    Wolfson Brain Imaging Centre and Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 52:1017-22; discussion 1022-4. 2003
    ..We studied cerebral perfusion patterns and associated TCD indices for 25 patients who developed clinical signs of delayed neurological deficits...
  56. ncbi request reprint Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome
    Richard J Mannion
    Wolfson Brain Injury Unit, Addenbrooke s Hospital NHS Foundation Trust, Hills Road, Cambridge, United Kingdom
    J Neurotrauma 24:128-35. 2007
    ..Understanding the anatomy and extent of brainstem injury, as well as its relationship to supratentorial abnormalities, will facilitate a more accurate use of early MRI as a prognostic tool and assist in the counseling of families...
  57. doi request reprint Quantitative BOLD: the effect of diffusion
    John D Dickson
    Department of Physics, Cavendish Laboratory, Cambridge University, Cambridge, UK
    J Magn Reson Imaging 32:953-61. 2010
    ..To make the quantitative blood oxygenation level-dependent (qBOLD) method more suitable for clinical application by accounting for proton diffusion and reducing acquisition times...
  58. ncbi request reprint Specialist neurocritical care and outcome from head injury
    Hiren C Patel
    Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Intensive Care Med 28:547-53. 2002
    ..To document the effect of neurocritical care, delivered by specialist staff and based on protocol-driven therapy aimed at intracranial pressure (ICP) and cerebral perfusion pressure (CPP) targets, on outcome in acute head injury...
  59. ncbi request reprint Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study
    Masashi Takasawa
    Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 27:679-89. 2007
    ..These findings strongly support the validity of 18F-FMISO as a marker of viable hypoxic tissue/penumbra after stroke...
  60. ncbi request reprint Effect of methylene blue on middle cerebral artery flow velocity in a patient with severe sepsis following clipping of a cerebral aneurysm
    David A Zygun
    Department of Anaesthesia, University of Cambridge, Cambridge, UK
    Neurocrit Care 2:39-42. 2005
    ..The use of methylene blue, an inhibitor of guanylate cyclase, has been described in patients with septic shock who are unresponsive to inotropic agents. However, the effects of methylene blue on the human cerebral circulation are not known...
  61. doi request reprint Juguloarterial endothelin-1 gradients after severe traumatic brain injury
    Doris A Chatfield
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 14:55-60. 2011
    ..Both CSF and plasma concentrations have been shown to be increased after TBI, but there is little evidence to confirm an intracranial site of production...
  62. ncbi request reprint Do vegetative patients retain aspects of language comprehension? Evidence from fMRI
    Martin R Coleman
    Impaired Consciousness Study Group, Wolfson Brain Imaging Centre, University of Cambridge, UK
    Brain 130:2494-507. 2007
    ..These results provide further evidence that a subset of patients fulfilling the behavioural criteria for the vegetative state retain islands of preserved cognitive function...
  63. ncbi request reprint Modelling the impact of an influenza pandemic on critical care services in England
    D K Menon
    University of Cambridge, Box 93, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Anaesthesia 60:952-4. 2005
    ..Current critical care bed capacity in England would be unable to cope with the increased demand provided by an influenza pandemic. Appropriate contingency planning is essential...
  64. ncbi request reprint Predicting the response of intracranial pressure to moderate hyperventilation
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Acta Neurochir (Wien) 147:477-83; discussion 483. 2005
    ..We investigated the ability of pre-hyperventilation ICP and cerebrospinal compensatory reserve to predict the reduction in ICP achievable with moderate hyperventilation in head injured patients...
  65. doi request reprint Room air dilution of heliox given by facemask
    Thomas D A Standley
    Addenbrooke s Hospital, Division of Anaesthesia, University of Cambridge, CB2 2QQ, Cambridge, UK
    Intensive Care Med 34:1469-76. 2008
    ..Substantial dilution of heliox by room air under these circumstances might alter its physical properties sufficiently to negate any potential clinical benefit in obstructive respiratory failure...
  66. ncbi request reprint Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method
    Arun K Gupta
    Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:263-8. 2002
    ..The goal of this study was to validate the use of a new multiparameter sensor that measures brain tissue oxygenation and metabolism (Neurotrend) by comparing it with positron emission tomography (PET) scanning...
  67. ncbi request reprint Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients
    Andrew J Johnston
    University of Cambridge Department of Anaesthetics, Addenbrooke s Hospital, Box 93, Cambridge, CB2 2QQ, United Kingdom
    Intensive Care Med 30:45-50. 2004
    ..To explore the pharmacokinetics and pharmacodynamics of dopamine and norepinephrine...
  68. ncbi request reprint Non-neurological organ dysfunction in neurocritical care
    David A Zygun
    Neuroscience Critical Care Unit, Addengrooke s Hospital, Cambridge, UK
    J Crit Care 18:238-44. 2003
    ..To determine the incidence of non-neurological organ dysfunction in patients with severe neurological injury...
  69. pmc Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent
    P J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Clin Pharmacol 53:275-83. 2002
    ....
  70. ncbi request reprint Changes over time in cognitive and structural profiles of head injury survivors
    C H Salmond
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Neuropsychologia 44:1995-8. 2006
    ..These findings suggest that cholinergic enhancers may be an effective treatment for cognitive deficits post-head injury in survivors up to three years post-injury...
  71. pmc Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: an FMRI study
    R A E Honey
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1203-14. 2004
    ..Furthermore, we have shown that ketamine's effects may be elucidated by fMRI even when overt behavioral measures show no evidence of impairment...
  72. ncbi request reprint Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury
    A K Gupta
    Department of Anesthesia, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 88:549-53. 1999
    ..Thus, monitoring of PbO2 is a useful addition to multimodal monitoring of patients with traumatic head injury...
  73. ncbi request reprint Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:17-20. 2005
    ..Our data suggest that the response of pressure reactivity to hyperventilation is heterogeneous. This could be due to hyperventilation-induced changes in cerebral metabolism, or the change in CPP...
  74. ncbi request reprint Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury
    A S Cunningham
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK
    Brain 128:1931-42. 2005
    ..At a voxel-based level, however (and in common with ischaemic stroke), the extent of irreversible tissue damage cannot be accurately predicted by early abnormalities of any single physiological variable...
  75. ncbi request reprint Cost-effective outcome for treating poor-grade subarachnoid hemorrhage
    Martin J Wilby
    Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2508-11. 2003
    ..Outcome measures were clinical outcome at 6 months, number needed to treat (NNT) for favorable outcomes, and cost analysis...
  76. ncbi request reprint The effect of drug concentration expression on epinephrine dosing errors: a randomized trial
    Daniel W Wheeler
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Intern Med 148:11-4. 2008
    ..The expression of drug concentration as a ratio may cause dosing errors...
  77. ncbi request reprint Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke
    Christopher J S Price
    Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Stroke 37:1749-53. 2006
    ..In this study we sought to establish temporal and spatial patterns of microglial activation in ischemic stroke with particular emphasis on a defined peri-infarct zone...
  78. doi request reprint Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer
    Virginia F J Newcombe
    University Division of Anaesthesia, Cambridge University, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 109:159-64. 2008
    ..That is, in the authors' system, it can be safely used with the transmit-and-receive head coil, but when using the transmit body coil the transducer wire must be coiled into concentric loops outside of the receive-only head coil...
  79. doi request reprint Assessing quality of life after traumatic brain injury: examination of the short form 36 health survey
    Mathew R Guilfoyle
    Academic Department of Neurosurgery, Addenbrooke s Hospital, Hills Road, Cambridge, United Kingdom
    J Neurotrauma 27:2173-81. 2010
    ..We conclude that individual SF-36 domain scores are valid measures of HRQoL in TBI patients, but that the physical and mental component summaries should be interpreted with caution...
  80. ncbi request reprint Traumatic brain injury: physiology, mechanisms, and outcome
    Jurgens Nortje
    Department of Anaesthesia, University of Cambridge, Cambridge CB2 2QQ, UK
    Curr Opin Neurol 17:711-8. 2004
    ..In particular, it tries to conceptualize why our greatly improved understanding of pathophysiology and neurobiology in traumatic brain injury has not translated into clear outcome improvements...
  81. pmc Dissociating speech perception and comprehension at reduced levels of awareness
    Matthew H Davis
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, United Kingdom
    Proc Natl Acad Sci U S A 104:16032-7. 2007
    ..These results have important implications for understanding the relationship between speech comprehension and awareness in the healthy brain in patients receiving sedation and in patients with disorders of consciousness...
  82. ncbi request reprint Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury
    Luzius A Steiner
    Academic Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Crit Care Med 30:733-8. 2002
    ..To test the hypothesis that patients with poor outcome were managed at a cerebral perfusion pressure (CPP) differing more from their CPPOPT than were patients with good outcome...
  83. ncbi request reprint Detecting residual cognitive function in persistent vegetative state
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neurocase 8:394-403. 2002
    ....
  84. ncbi request reprint Arteriojugular endothelin-1 gradients in aneurysmal subarachnoid haemorrhage
    David K Menon
    Department of Anaesthesia and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, University of Cambridge CB2 2QQ, U K
    Clin Sci (Lond) 103:399S-403S. 2002
    ..Larger AJ differences may predict vasospasm, but further work is needed to confirm this observation. AJ gradient measurement may provide a useful technique for investigating the role of other peptides in acute brain injury...
  85. ncbi request reprint Calculation of doses of drugs in solution: are medical students confused by different means of expressing drug concentrations?
    Daniel W Wheeler
    University Department of Anaesthesia, University of Cambridge, Cambridge, UK
    Drug Saf 27:729-34. 2004
    ..Administering the wrong volume of a drug may have serious consequences for patient safety. STUDY DESIGN AND PARTICIPANT GROUP: Web-based electronic multiple-choice examination of clinical medical students...
  86. ncbi request reprint Lack of effects of guanfacine on executive and memory functions in healthy male volunteers
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:205-13. 2005
    ..Guanfacine is an alpha2-adrenergic receptor agonist that has been shown to have beneficial effects on working memory and attentional functions in monkeys and in patients with attention deficit hyperactivity disorder...
  87. ncbi request reprint Recommendations in relation to the EU clinical trials directive and medical research involving incapacitated adults
    Kathleen Liddell
    Faculty of Law, University of Cambridge and Cambridge Genetics Knowledge Park, UK
    Wien Klin Wochenschr 118:183-91. 2006
  88. ncbi request reprint The European Clinical Trials Directive revisited: the VISEAR recommendations
    Kathleen Liddell
    Faculty of Law, University of Cambridge and Cambridge Genetics Knowledge Park, UK
    Resuscitation 69:9-14. 2006
  89. ncbi request reprint Residual auditory function in persistent vegetative state: a combined PET and fMRI study
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuropsychol Rehabil 15:290-306. 2005
    ....
  90. doi request reprint Prediction of outcome in severe traumatic brain injury
    David K Menon
    Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Curr Opin Crit Care 15:437-41. 2009
    ....
  91. doi request reprint Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility
    Jennifer Landt
    Cambridge Intellectual and Developmental Disabilities Research Group, Cambridge, England
    Arch Neurol 68:890-6. 2011
    ....
  92. doi request reprint Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat
    J L Hughes
    Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, UK
    Neuroimage 49:19-31. 2010
    ..e. the penumbra threshold. This rat model may be useful in providing in vitro reference for studies aiming to validate novel imaging tracers of SNL and MA in vivo...
  93. pmc Altered functional connectivity in the motor network after traumatic brain injury
    M Kasahara
    Division of Anaesthesia, University Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Neurology 75:168-76. 2010
    ..The aim of this cross-sectional study was to establish the residual integrity of the motor network as an important proof of principle of abnormal connectivity in TBI...
  94. ncbi request reprint Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting
    L A Steiner
    University Department of Anaesthesia and Academic Neurosurgery, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Anaesthesia 58:448-54. 2003
    ..Furthermore, there was a tendency to underestimate low pressures and overestimate high pressures. In our opinion, the Colin CBM-7000 cannot be recommended for continuous blood pressure monitoring in the intensive care setting...
  95. doi request reprint Modelling the impact of pandemic influenza A(H1N1) on UK paediatric intensive care demand
    A Ercole
    Cambridge University Department of Anaesthesia, Box 93, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Arch Dis Child 94:962-4. 2009
    ..The emergence of pandemic influenza A(H1N1) has been associated with a notable predominance in children and may be expected to have a significant impact on PICU provision...
  96. ncbi request reprint Ventriculostomy for control of raised ICP in acute traumatic brain injury
    I Timofeev
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Hills Road, Cambridge CB2 0QQ, UK
    Acta Neurochir Suppl 102:99-104. 2008
    ....
  97. doi request reprint Modelling the impact of an influenza A/H1N1 pandemic on critical care demand from early pathogenicity data: the case for sentinel reporting
    A Ercole
    Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Anaesthesia 64:937-41. 2009
    ..Crucially this study highlights the need for sentinel reporting and real-time modelling to guide rational decision making...
  98. ncbi request reprint Further characterisation of a thromboembolic model of stroke in the rat
    J S Beech
    Department of Medicine, Division of Anaesthesia, University of Cambridge, Box 93, Level 4, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain Res 895:18-24. 2001
    ..21%). These data underline the relative variability of this embolic model and provide important preliminary information regarding the value of early changes in T2* in predicting eventual infarct size...
  99. ncbi request reprint Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Physiol Meas 26:423-8. 2005
    ..CMA71 microdialysis catheters can, therefore, be used for routine clinical monitoring of extracellular substances, as well as for their intended research role of larger molecular weight protein sampling...
  100. pmc Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings
    M R Coleman
    Cambridge Coma Study Group, Box 124, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 76:432-4. 2005
    ..Our preliminary results suggest patients in the vegetative state may endure an impaired coupling relation between neuronal electrical function and cerebral energy metabolism...
  101. ncbi request reprint Evaluation of infusion pump performance in a magnetic resonance environment
    P G Bradley
    Addenbrooke s Hospital, Wolfson Brain Imaging Centre, Cambridge, UK
    Eur J Anaesthesiol 21:729-33. 2004
    ..For use in a magnetic resonance (MR) scanning room infusion pumps must be MR safe and compatible. This study tested two commonly used infusion pumps (Alaris P6000 and Alaris Asena-GH) to determine if they met these criteria...