D Melzer

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Framingham Stroke Risk Profile and poor cognitive function: a population-based study
    David J Llewellyn
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 8:12. 2008
  2. ncbi request reprint Local population differences and the needs of people with cognitive impairment
    D Melzer
    Institute of Public Health, University of Cambridge, UK
    Int J Geriatr Psychiatry 12:883-7. 1997
  3. ncbi request reprint Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey
    David Melzer
    Epidemiology for Policy Group, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Soc Psychiatry Psychiatr Epidemiol 39:33-8. 2004
  4. ncbi request reprint The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Age Ageing 32:619-25. 2003
  5. ncbi request reprint Variation in thresholds for reporting mobility disability between national population subgroups and studies
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK
    J Gerontol A Biol Sci Med Sci 59:1295-303. 2004
  6. ncbi request reprint Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life
    David Melzer
    Demography and Biometry Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:60-6. 2003
  7. ncbi request reprint Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain
    David Melzer
    Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Soc Psychiatry Psychiatr Epidemiol 38:238-43. 2003
  8. ncbi request reprint Educational differences in the prevalence of mobility disability in old age: the dynamics of incidence, mortality, and recovery
    D Melzer
    Epidemiology, Demography, and Biometry Office, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 56:S294-301. 2001
  9. pmc Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey
    Elizabeth A Gardener
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Forvie Site, Cambridge, UK
    J Gen Intern Med 21:1091-6. 2006
  10. ncbi request reprint The role of waist circumference in predicting disability in periretirement age adults
    S B Angleman
    Department of Public Health and Primary Care, Cambridge, UK
    Int J Obes (Lond) 30:364-73. 2006

Research Grants

  1. Disability of elders: US and England comparisons
    David Melzer; Fiscal Year: 2005
  2. Aging pathways polymorphisms in older persons
    David Melzer; Fiscal Year: 2007

Collaborators

Detail Information

Publications42

  1. pmc Framingham Stroke Risk Profile and poor cognitive function: a population-based study
    David J Llewellyn
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 8:12. 2008
    ..The objective of this study was to examine the relationship between 10-year risk for incident stroke and cognitive function in a large population-based sample...
  2. ncbi request reprint Local population differences and the needs of people with cognitive impairment
    D Melzer
    Institute of Public Health, University of Cambridge, UK
    Int J Geriatr Psychiatry 12:883-7. 1997
    ..As moderate and severe cognitive impairment is a major cause of need for long-term care, population-based estimates of the numbers and characteristics of this group were calculated, to explore the effects of local differences...
  3. ncbi request reprint Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey
    David Melzer
    Epidemiology for Policy Group, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Soc Psychiatry Psychiatr Epidemiol 39:33-8. 2004
    ..Adverse occupational conditions and involuntary exit from work are linked to high rates of common mental disorders, but voluntary retirement is associated with improved mental health...
  4. ncbi request reprint The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Age Ageing 32:619-25. 2003
    ..Evidence of the MOBLI 's responsiveness over time has been presented. Evidence of the predictive validity of the index is needed...
  5. ncbi request reprint Variation in thresholds for reporting mobility disability between national population subgroups and studies
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK
    J Gerontol A Biol Sci Med Sci 59:1295-303. 2004
    ..We also aimed to compare reported and tested performance across two national population studies...
  6. ncbi request reprint Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life
    David Melzer
    Demography and Biometry Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:60-6. 2003
    ..in people aged 65 and over who died in the US in 1993, and to measure mobility outcomes during their last year of life...
  7. ncbi request reprint Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain
    David Melzer
    Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Soc Psychiatry Psychiatr Epidemiol 38:238-43. 2003
    ..This project aimed to estimate effect sizes and independence of social position markers as risk factors for common mental disorders. Disorders with disability were examined to identify groups with high clinical and policy priority...
  8. ncbi request reprint Educational differences in the prevalence of mobility disability in old age: the dynamics of incidence, mortality, and recovery
    D Melzer
    Epidemiology, Demography, and Biometry Office, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 56:S294-301. 2001
    ..This study aimed to establish the relative contributions of incidence, recovery rates, and death to prevalence differences in mobility disability associated with educational status...
  9. pmc Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey
    Elizabeth A Gardener
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Forvie Site, Cambridge, UK
    J Gen Intern Med 21:1091-6. 2006
    ..Lower limb mobility disabilities are well understood in older people, but the causes in middle age have attracted little attention...
  10. ncbi request reprint The role of waist circumference in predicting disability in periretirement age adults
    S B Angleman
    Department of Public Health and Primary Care, Cambridge, UK
    Int J Obes (Lond) 30:364-73. 2006
    ..To measure the risk of periretirement age disability associated with five different anthropometric measures of body mass and shape, and to compare the measures in this group, the peak age group of obesity prevalence...
  11. ncbi request reprint The mental health of early retirees-- national interview survey in Britain
    Julian W Buxton
    Epidemiology for Policy Group, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Soc Psychiatry Psychiatr Epidemiol 40:99-105. 2005
    ..There is intense political interest in retaining older workers in the workforce, to fund lengthening retirements. While health is important in early exit from work, the health of early retirees has been little studied...
  12. ncbi request reprint Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Age Ageing 33:253-9. 2004
    ..Brazil is characterised by gross socio-economic inequalities, but there have been no previous national data on disability prevalence...
  13. ncbi request reprint Responsiveness of the index of mobility limitation: comparison with gait speed alone in the longitudinal aging study amsterdam
    Tzuo Yun Lan
    Department of Public Health and Primary Care, University of Cambridge, UK
    J Gerontol A Biol Sci Med Sci 58:721-7. 2003
    ..In this article, we examine whether the index is responsive to changes in self-reported mobility disability...
  14. ncbi request reprint Performance tests and disability: developing an objective index of mobility-related limitation in older populations
    Tzuo Yun Lan
    Department of Public Health and Primary Care, University of Cambridge, United Kingdom
    J Gerontol A Biol Sci Med Sci 57:M294-301. 2002
    ..This study aimed to identify an index of mobility-related limitations composed of physiological measures that are most closely associated with reported mobility disability in elders...
  15. ncbi request reprint Common mental disorder symptom counts in populations: are there distinct case groups above epidemiological cut-offs?
    D Melzer
    Department of Public Health and Primary Care, University of Cambridge
    Psychol Med 32:1195-201. 2002
    ..This study aimed to establish whether such a subpopulation exists in distributions of common mental disorder and depression symptom scores, above epidemiological 'case' cut-offs...
  16. ncbi request reprint Low prevalence of depression and anxiety is linked to statutory retirement ages rather than personal work exit: a national survey
    Elena Villamil
    Epidemiology for Policy Group, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Psychol Med 36:999-1009. 2006
    ..The aim of this study was to establish whether work status, age or other known risk factors account for the reduced prevalence of depressive episode and anxiety disorder around retirement ages for men and for women...
  17. ncbi request reprint Pharmacogenetics: policy needs for personal prescribing
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK
    J Health Serv Res Policy 10:40-4. 2005
    ....
  18. pmc The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, UK
    J Gerontol A Biol Sci Med Sci 60:1319-23. 2005
    ....
  19. pmc Neighbourhood deprivation and incident mobility disability in older adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter EX2 5DW, UK
    Age Ageing 37:403-10. 2008
    ..to assess whether incident mobility disability and neighbourhood deprivation in older people are associated independent of the effects of individual socio-economic status, health behaviours and health status...
  20. ncbi request reprint Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence
    Iain Lang
    Epidemiology and Public Health Group, Peninsula Medical School, RD and E Wonford Site, Exeter, UK
    Age Ageing 36:256-61. 2007
    ....
  21. ncbi request reprint Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK
    Age Ageing 36:638-43. 2007
    ..Transitions such as retirement may represent points at which changes in health behaviour occur...
  22. doi request reprint Obesity, physical function, and mortality in older adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 56:1474-8. 2008
    ..To estimate the effects of excess body weight on objective and subjective physical function and mortality risks in noninstitutionalized older adults...
  23. ncbi request reprint Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 55:1836-41. 2007
    ..To assess the association between physical activity and subsequent physical functioning in middle-aged adults across a range of body mass index (BMI) categories...
  24. pmc Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 56:191-8. 2008
    ..To assess the relationship between cognitive function, socioeconomic status, and neighborhood deprivation (lack of local resources of all types, financial and otherwise)...
  25. doi request reprint Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing
    Kara N Stevens
    Peninsula Medical School, Epidemiology and Public Health Group, UK
    Age Ageing 37:300-5. 2008
    ..to identify socio-economic, behavioural and disease status risks for impaired balance or self-reported dizziness in older people from a large population-based study...
  26. ncbi request reprint Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS)
    Carol Jagger
    Leicester Nuffield Research Unit, Department of Health Sciences, University of Leicester, Leicester, UK
    Int J Epidemiol 36:358-65. 2007
    ....
  27. ncbi request reprint What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts
    Iain Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK
    J Am Geriatr Soc 55:49-57. 2007
    ..To estimate disability plus mortality risks in older people according to level of alcohol intake...
  28. ncbi request reprint [Disability among elderly women in Brazil]
    Maria Isabel Parahyba
    Universidade Aberta da Terceira Idade, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
    Rev Saude Publica 39:383-90. 2005
    ..To estimate disability rates and explore associations, identifying the most significant socioeconomic markers associated with the prevalence of mobility disability among elderly women...
  29. ncbi request reprint Social inequalities and the common mental disorders: a systematic review of the evidence
    Tom Fryers
    Department of Psychiatry, University of Leicester, Leicester, UK
    Soc Psychiatry Psychiatr Epidemiol 38:229-37. 2003
    ..This study reviews the published evidence on the links between conventional markers of social position and the common mental disorders in developed countries...
  30. ncbi request reprint Mental health and the timing of men's retirement
    Sarah C Gill
    Centre for Mental Health Research, Bldg 63, Eggleston Rd, The Australian National University, Canberra, ACT, Australia, 0200
    Soc Psychiatry Psychiatr Epidemiol 41:515-22. 2006
    ..The aim of this analysis was to investigate this pattern of results in a national sample of Australian men, and the mediating role of socio-demographic factors...
  31. ncbi request reprint Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing
    David Melzer
    Department of Epidemiology and Public Health, Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Age Ageing 34:594-602. 2005
    ..Whether mobility disability has different causes in the middle-aged has received limited attention...
  32. ncbi request reprint Retirement and mental health: analysis of the Australian national survey of mental health and well-being
    Peter Butterworth
    Centre for Mental Health Research, The Australian National University, Canberra, ACT Australia
    Soc Sci Med 62:1179-91. 2006
    ..Given current policy changes in many countries to curtail early retirement, these findings highlight the need to consider mental health, and its influencing factors, when encouraging continued employment amongst older adults...
  33. ncbi request reprint Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity
    Traolach Brugha
    University of Leicester, Department of Health Sciences, Brandon Mental Health Unit, Leicester General Hospital, Gwendolen Rd, Leicester LE5 4PW, UK
    Am J Psychiatry 162:774-80. 2005
    ..The authors compared two samples of subjects 16-64 years of age: those from the general population of residents in Great Britain and prisoners in England and Wales...
  34. doi request reprint Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
    ..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...
  35. pmc Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England
    Nicholas Steel
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 337:a957. 2008
    ..To assess the receipt of effective healthcare interventions in England by adults aged 50 or more with serious health conditions...
  36. ncbi request reprint Trends in service use and treatment for mental disorders in adults throughout Great Britain
    Traolach S Brugha
    Brandon Mental Health Unit, Department of Health Sciences, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Psychiatry 185:378-84. 2004
    ..Trends in health treatments and outcomes in the general population may be used to monitor achievement of health targets...
  37. pmc A common variant of the p16(INK4a) genetic region is associated with physical function in older people
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Mech Ageing Dev 128:370-7. 2007
    ..The mechanism involved may be via greater cellular restorative activity and reduced stem cell senescence...
  38. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
    ..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...
  39. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  40. pmc The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    BMC Med Genet 7:51. 2006
    ..We performed a large case-control and family-based study to test the hypothesis that KL-VS is associated with type 2 diabetes in a UK Caucasian population...
  41. pmc An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people
    Timothy M Frayling
    Peninsula Medical School, Exeter, United Kingdom
    J Gerontol A Biol Sci Med Sci 62:73-8. 2007
    ..The role of common variation in the IL-18 gene on serum concentrations and functioning in old age is unknown...
  42. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    ..The specific associations with ALP levels may point to genes for bone or intestinal diseases...

Research Grants5

  1. Disability of elders: US and England comparisons
    David Melzer; Fiscal Year: 2005
    ....
  2. Aging pathways polymorphisms in older persons
    David Melzer; Fiscal Year: 2007
    ..It also builds in replication of findings in independent populations. The proposed study could therefore make a major contribution to 'gene to behavior' science in aging. ..