Jane Mellor

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The dynamics of chromatin remodeling at promoters
    Jane Mellor
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, UK
    Mol Cell 19:147-57. 2005
  2. pmc A pre-initiation complex at the 3'-end of genes drives antisense transcription independent of divergent sense transcription
    Struan C Murray
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Nucleic Acids Res 40:2432-44. 2012
  3. pmc Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae
    Esther R Loney
    Institute of Genetics, University of Nottingham, Nottingham, UK
    Epigenetics Chromatin 2:18. 2009
  4. pmc Transcription: from regulatory ncRNA to incongruent redundancy
    Jane Mellor
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Genes Dev 24:1449-55. 2010
  5. doi request reprint Linking the cell cycle to histone modifications: Dot1, G1/S, and cycling K79me2
    Jane Mellor
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Cell 35:729-30. 2009
  6. doi request reprint A glimpse into the epigenetic landscape of gene regulation
    Jane Mellor
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Curr Opin Genet Dev 18:116-22. 2008
  7. ncbi request reprint It takes a PHD to read the histone code
    Jane Mellor
    Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK
    Cell 126:22-4. 2006
  8. ncbi request reprint Dynamic nucleosomes and gene transcription
    Jane Mellor
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Trends Genet 22:320-9. 2006
  9. ncbi request reprint ISWI complexes in Saccharomyces cerevisiae
    Jane Mellor
    Department of Biochemistry, Microbiology Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Biochim Biophys Acta 1677:100-12. 2004
  10. ncbi request reprint Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II
    Antonin Morillon
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Cell 115:425-35. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint The dynamics of chromatin remodeling at promoters
    Jane Mellor
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, UK
    Mol Cell 19:147-57. 2005
    ..Recent advances have allowed nucleosome dynamics on promoters to be studied in real time, dramatically changing how we think about gene regulation on chromatin templates...
  2. pmc A pre-initiation complex at the 3'-end of genes drives antisense transcription independent of divergent sense transcription
    Struan C Murray
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Nucleic Acids Res 40:2432-44. 2012
    ....
  3. pmc Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae
    Esther R Loney
    Institute of Genetics, University of Nottingham, Nottingham, UK
    Epigenetics Chromatin 2:18. 2009
    ..CONCLUSION: Our data identifies chromatin features that correlate with the silencing state and indicate that an array of phased nucleosomes is not sufficient for full repression...
  4. pmc Transcription: from regulatory ncRNA to incongruent redundancy
    Jane Mellor
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Genes Dev 24:1449-55. 2010
    ....
  5. doi request reprint Linking the cell cycle to histone modifications: Dot1, G1/S, and cycling K79me2
    Jane Mellor
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Cell 35:729-30. 2009
    ..2009) described distinct distributions and regulation of Dot1-dependent methylation states at lysine 79 on histone H3 and showed cell-cycle regulation of K79 dimethylation on genes expressed during the G1/S phase...
  6. doi request reprint A glimpse into the epigenetic landscape of gene regulation
    Jane Mellor
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Curr Opin Genet Dev 18:116-22. 2008
    ..Many genes in stem cells are poised for expression with initiated RNA polymerase II at the promoter. This state is maintained by an epigenetic mark through multiple lineages until the gene is expressed...
  7. ncbi request reprint It takes a PHD to read the histone code
    Jane Mellor
    Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK
    Cell 126:22-4. 2006
    ..The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes...
  8. ncbi request reprint Dynamic nucleosomes and gene transcription
    Jane Mellor
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Trends Genet 22:320-9. 2006
    ..Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored...
  9. ncbi request reprint ISWI complexes in Saccharomyces cerevisiae
    Jane Mellor
    Department of Biochemistry, Microbiology Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Biochim Biophys Acta 1677:100-12. 2004
    ....
  10. ncbi request reprint Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II
    Antonin Morillon
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Cell 115:425-35. 2003
    ..Overall these studies establish the central role played by Isw1p in the coordination of transcription...
  11. pmc The Isw2 chromatin-remodeling ATPase cooperates with the Fkh2 transcription factor to repress transcription of the B-type cyclin gene CLB2
    Julia A Sherriff
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Mol Cell Biol 27:2848-60. 2007
    ..We propose that chromatin-mediated repression by Isw1 and Isw2 may serve to limit activation of CLB2 expression by the Clb2/Cdk1 kinase during G(2)/M and to fully repress expression during G(1)...
  12. pmc Nucleosome remodeling and transcriptional repression are distinct functions of Isw1 in Saccharomyces cerevisiae
    Marina Pinskaya
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, United Kingdom
    Mol Cell Biol 29:2419-30. 2009
    ..Thus, chromatin remodeling and transcriptional repression are distinct activities of Isw1...
  13. pmc Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36
    Michael L Youdell
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Mol Cell Biol 28:4915-26. 2008
    ..We suggest that the C-terminal region of Set2, in conjunction with the phosphorylated CTD of RNAPII, influences the KMTase activity to promote H3K36me3 during transcription elongation...
  14. ncbi request reprint Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription
    Antonin Morillon
    Department of Biochemistry, Division of Molecular Genetics, Oxford, United Kingdom
    Mol Cell 18:723-34. 2005
    ..This releases RNAPII from Isw1 control and promotes controlled transcription elongation and termination. We propose that newly initiated RNAPII is under epigenetic control...
  15. ncbi request reprint Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1
    Carlos Martinez-Campa
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Mol Cell 15:69-81. 2004
    ..We propose that nucleosome positioning at the nucleotide level provides a subtle, but highly effective, mechanism for gene regulation...
  16. pmc 14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation
    Wendy Walter
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3 QU, United Kingdom
    Mol Cell Biol 28:2840-9. 2008
    ..The importance of acetylation in this interaction is also seen in vivo, where K14 acetylation is required for optimal Bmh1 recruitment to the GAL1 promoter during transcriptional activation...
  17. ncbi request reprint Gene loops juxtapose promoters and terminators in yeast
    Justin M O'Sullivan
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Nat Genet 36:1014-8. 2004
    ..They also predict a previously unknown structural dimension to gene regulation, in which both ends of the transcription unit are defined before and during the transcription cycle...
  18. ncbi request reprint Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast
    Antonin Morillon
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Science 300:492-5. 2003
    ..Our results suggest that, in addition to their documented promoter function, Fkh1p and Fkh2p coordinate early transcription elongation and pre-mRNA processing. This may reflect a general feature of gene regulation in eukaryotes...
  19. ncbi request reprint Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast
    Nicholas A Kent
    Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:27116-23. 2004
    ..Cbf1p has been shown to interact with the chromatin-remodeling ATPase Isw1p. Here we show that recruitment of Isw1p by Cbf1p is likely to be general but that Isw1p is only partially required for Cbf1p-dependent chromatin structures...
  20. ncbi request reprint Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin
    Helena Santos-Rosa
    Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Mol Cell 12:1325-32. 2003
    ..These results indicate that K4 H3 methylation and Isw1p ATPase activity are intimately linked in regulating transcription of certain genes in yeast...
  21. ncbi request reprint Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex
    Jean Luc Moreau
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, United Kingdom
    Mol Cell 11:1609-20. 2003
    ..The results point to a promoter-specific Isw1p-dependent mechanism for targeted regulation of basal transcription by displacement of TBP from a promoter...
  22. ncbi request reprint Transcription, nucleosome positioning and protein binding modulate nucleotide excision repair of the Saccharomyces cerevisiae MET17 promoter
    Neville G Powell
    School of Biological Sciences, University of Wales Swansea, Singleton Park, UK
    DNA Repair (Amst) 2:375-86. 2003
    ..This effect overrode the influences of nucleosome positioning and protein binding...
  23. ncbi request reprint Active genes are tri-methylated at K4 of histone H3
    Helena Santos-Rosa
    Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nature 419:407-11. 2002
    ..These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications...