David W Meek

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi MAGE-A antigens as targets in tumour therapy
    David W Meek
    Division of Cancer Research, Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Cancer Lett 324:126-32. 2012
  2. ncbi Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcom
    Sharon I King
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Breast Cancer Res 14:R40. 2012
  3. ncbi Induction and activation of the p53 pathway: a role for the protein kinase CK2?
    David W Meek
    Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Mol Cell Biochem 356:133-8. 2011
  4. ncbi Tumour suppression by p53: a role for the DNA damage response?
    David W Meek
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Nat Rev Cancer 9:714-23. 2009
  5. ncbi The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours?
    David W Meek
    Biomedical Research Institute, The University of Dundee, Ninewells Hospital, Biomedical Research Institute, Dundee, United Kingdom
    Semin Cancer Biol 20:19-28. 2010
  6. ncbi Posttranslational modification of p53: cooperative integrators of function
    David W Meek
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Cold Spring Harb Perspect Biol 1:a000950. 2009
  7. ncbi p53-dependent repression of polo-like kinase-1 (PLK1)
    Lynsey McKenzie
    Biomedical Research Institute, University of Dundee, Dundee, UK
    Cell Cycle 9:4200-12. 2010
  8. ncbi Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
    Sylvia S Dias
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    FEBS Lett 583:3543-8. 2009
  9. ncbi Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli
    Miranda L Cox
    Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Cell Signal 22:564-71. 2010
  10. ncbi Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin
    Lynnette Marcar
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    Cancer Res 70:10362-70. 2010

Collaborators

  • Anna Maria Ochocka
  • Nicola J MacLaine
  • Uwe Knippschild
  • C Mackintosh
  • Lynnette Marcar
  • Sylvia S Dias
  • Sharon I King
  • Miranda L Cox
  • Lynsey McKenzie
  • Nicola T Wood
  • Alastair M Thompson
  • Philip R Quinlan
  • Colin A Purdie
  • Lee B Jordan
  • Susan E Bray
  • Sharon King
  • Neil Perkins
  • Katie Schumm
  • Pamela Robertson
  • Frances Fuller-Pace
  • Ted R Hupp
  • Sam Nicol
  • Jean Christophe Bourdon
  • Carol Hogan

Detail Information

Publications14

  1. ncbi MAGE-A antigens as targets in tumour therapy
    David W Meek
    Division of Cancer Research, Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Cancer Lett 324:126-32. 2012
    ..Here we review recent progress in this area and consider how these interactions might be exploited, especially for the treatment of malignant cancers for which available treatments are inadequate...
  2. ncbi Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcom
    Sharon I King
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Breast Cancer Res 14:R40. 2012
    ..Consistent with this model, cultured cells lacking p53 fail to repress PLK1 expression. This study examined PLK1 expression, p53 mutation and clinical outcome in breast cancer...
  3. ncbi Induction and activation of the p53 pathway: a role for the protein kinase CK2?
    David W Meek
    Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Mol Cell Biochem 356:133-8. 2011
    ....
  4. ncbi Tumour suppression by p53: a role for the DNA damage response?
    David W Meek
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Nat Rev Cancer 9:714-23. 2009
    ..The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed...
  5. ncbi The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours?
    David W Meek
    Biomedical Research Institute, The University of Dundee, Ninewells Hospital, Biomedical Research Institute, Dundee, United Kingdom
    Semin Cancer Biol 20:19-28. 2010
    ..This analysis also provides an opportunity to consider the signalling pathways regulating MDM2 as potential targets for non-genotoxic therapies aimed at restoring p53 function in tumour cells...
  6. ncbi Posttranslational modification of p53: cooperative integrators of function
    David W Meek
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Cold Spring Harb Perspect Biol 1:a000950. 2009
    ..The present article focuses on recent, exciting progress and develops the idea that the impact of modification on p53 function is achieved through collective and integrated events...
  7. ncbi p53-dependent repression of polo-like kinase-1 (PLK1)
    Lynsey McKenzie
    Biomedical Research Institute, University of Dundee, Dundee, UK
    Cell Cycle 9:4200-12. 2010
    ..These data establish PLK1 as a direct transcriptional target of p53, independently of p21, that is required for efficient G₂/M arrest...
  8. ncbi Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
    Sylvia S Dias
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    FEBS Lett 583:3543-8. 2009
    ..These data are consistent with the idea that deregulation of PLK1 during tumourigenesis may help suppress p53 function...
  9. ncbi Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli
    Miranda L Cox
    Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Cell Signal 22:564-71. 2010
    ..These data suggest that, physiologically, Ser392 may be phosphorylated by an, as yet, unidentified protein kinase...
  10. ncbi Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin
    Lynnette Marcar
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    Cancer Res 70:10362-70. 2010
    ..These data reveal a novel mechanism by which Mage-A proteins may suppress the p53 transcriptional program during tumor development and highlight the p53/Mage-A interaction as a prospective therapeutic target...
  11. ncbi The p53 response to DNA damage
    David W Meek
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    DNA Repair (Amst) 3:1049-56. 2004
    ....
  12. ncbi 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)
    Nicola T Wood
    MRC Protein Phosphorylation Unit, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 583:615-20. 2009
    ..The implications of these findings for regulation of the p53 pathway, oncogenesis and drug discovery are discussed...
  13. ncbi Posttranslational modification of MDM2
    David W Meek
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cancer Res 1:1017-26. 2003
    ..In this review, we summarize our current knowledge of the role of posttranslational modifications of MDM2 and their functional relevance...
  14. ncbi p53 Induction: phosphorylation sites cooperate in regulating
    David W Meek
    Biomedical Research Centre, Biomedical Research Center, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Cancer Biol Ther 1:284-6. 2002