Research Topics
| G A McVeanSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
What drives recombination hotspots to repeat DNA in humans?Gil McVean
Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK
Philos Trans R Soc Lond B Biol Sci 365:1213-8. 2010..I suggest that rapid evolution of hotspot motifs may, surprisingly, tend to favour sequences present in repeat DNA and outline the data required to differentiate between hypotheses...- High recombination rates and hotspots in a Plasmodium falciparum genetic crossHongying Jiang
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Genome Biol 12:R33. 2011..A better understanding of these mechanisms may provide important information for studying parasite evolution, immune evasion and drug resistance... - A genealogical interpretation of principal components analysisGil McVean
Department of Statistics, University of Oxford, Oxford, United Kingdom
PLoS Genet 5:e1000686. 2009..Using examples from human genetics, I discuss the application of these results to empirical data and the implications for inference... - The structure of linkage disequilibrium around a selective sweepGil McVean
Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
Genetics 175:1395-406. 2007..In particular, I demonstrate that while selective sweeps can eliminate LD, they generate patterns of genetic variation very different from those expected from recombination hotspots... 
Scanning the human genome for signals of selectionGil McVean
Department of Statistics, Oxford University, 1 South Parks Road, Oxford, OX1 3TG, UK
Curr Opin Genet Dev 16:624-9. 2006..Nevertheless, recent work has shown that genome scans can be used to identify both functional polymorphisms underlying selected traits and entire classes of genes enriched for signals of adaptation...- Perspectives on human genetic variation from the HapMap ProjectGil McVean
Department of Statistics, University of Oxford, Oxford, United Kingdom
PLoS Genet 1:e54. 2005..In this review we focus on what the HapMap Project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it... - Approximating the coalescent with recombinationGilean A T McVean
Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1 3TG, UK
Philos Trans R Soc Lond B Biol Sci 360:1387-93. 2005.... - The fine-scale structure of recombination rate variation in the human genomeGilean A T McVean
Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
Science 304:581-4. 2004..We demonstrate that recombination hotspots are a ubiquitous feature of the human genome, occurring on average every 200 kilobases or less, but recombination occurs preferentially outside genes... - A coalescent-based method for detecting and estimating recombination from gene sequencesGil McVean
Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
Genetics 160:1231-41. 2002..The extremely high level of recombination detected in both HIV1 and HIV2 sequences demonstrates that recombination cannot be ignored in the analysis of viral population genetic data... - A genealogical interpretation of linkage disequilibriumGilean A T McVean
Department of Statistics, University of Oxford, United Kingdom
Genetics 162:987-91. 2002..I show that the effects of population growth, population bottlenecks, and population structure on linkage disequilibrium can be described through their effects on the covariance in coalescence times... - What do patterns of genetic variability reveal about mitochondrial recombination?G A McVean
Department of Statistics, 1 South Parks Road, Oxford OX1 3TG, UK
Heredity (Edinb) 87:613-20. 2001..I discuss whether plausible mutational and selective processes can give rise to such a pattern... - Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ lineAnne Goriely
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
Science 301:643-6. 2003..We propose that these FGFR2 mutations, although harmful to embryonic development, are paradoxically enriched because they confer a selective advantage to the spermatogonial cells in which they arise... - Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogoniaAnne Goriely
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
Proc Natl Acad Sci U S A 102:6051-6. 2005..Among FGFR2 mutations, those causing Apert syndrome may be especially prevalent because they enhance signaling by FGF ligands specific for each of the major expressed isoforms... - Comparison of fine-scale recombination rates in humans and chimpanzeesWendy Winckler
Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA
Science 308:107-11. 2005..Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence... - Recombination hotspots and population structure in Plasmodium falciparumJianbing Mu
Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, Maryland, USA
PLoS Biol 3:e335. 2005..This study supports the feasibility of genome-wide association studies in some parasite populations... - Estimating recombination rates from population-genetic dataMichael P H Stumpf
Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK
Nat Rev Genet 4:959-68. 2003..Such knowledge will become increasingly important owing to the growing use of population-genetic methods in biomedical research... - Evidence for widespread cryptic sexual generations in apparently purely asexual Andricus gallwaspsGraham N Stone
Institute of Evolutionary Biology, School of Biology, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Mol Ecol 17:652-65. 2008..We confirm cryptic sexual generations in a total of 11 Andricus species, suggesting that secondary loss of sex is rare in Andricus... - Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genomeJianbing Mu
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 39:126-30. 2007..In addition, we report new antigens, providing urgently needed vaccine candidates for disease control... - Use of population genetic data to infer oviposition behaviour: species-specific patterns in four oak gallwasps (Hymenoptera: Cynipidae)Rachel J Atkinson
Department of Biology, University of Stirling, Stirling FK9 4LA, UK
Proc Biol Sci 269:383-90. 2002..coriarius and A. panteli over half of the galls sampled were multiple founded. We suggest that variation in levels of multiple founding may be due to consistent ecological differences between the four species...