Helene McNulty

Summary

Affiliation: University of Ulster
Country: UK

Publications

  1. doi request reprint Nutrition throughout life: folate
    Helene McNulty
    University of Ulster, Coleraine, UK
    Int J Vitam Nutr Res 82:348-54. 2012
  2. doi request reprint C(1) metabolism and CVD outcomes in older adults
    Helene McNulty
    Northern Ireland Centre for Food and Health, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    Proc Nutr Soc 71:213-21. 2012
  3. ncbi request reprint Folate bioavailability
    Helene McNulty
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 63:529-36. 2004
  4. ncbi request reprint Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
    Helene McNulty
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Circulation 113:74-80. 2006
  5. doi request reprint Homocysteine, B-vitamins and CVD
    Helene McNulty
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 67:232-7. 2008
  6. doi request reprint Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status
    Helene McNulty
    The Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Br J Nutr 99:S48-54. 2008
  7. ncbi request reprint Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults
    Leane Hoey
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 86:1405-13. 2007
  8. ncbi request reprint The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 84:167-73. 2006
  9. ncbi request reprint Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women
    Julie M W Wallace
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, County Londonderry, UK
    Br J Nutr 108:1264-71. 2012
  10. doi request reprint Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial
    Carol P Wilson
    Northern Ireland Centre for Food and Health, University of Ulster, Cromore Rd, Coleraine, BT52 1SA, Northern Ireland
    Hypertension 61:1302-8. 2013

Collaborators

Detail Information

Publications49

  1. doi request reprint Nutrition throughout life: folate
    Helene McNulty
    University of Ulster, Coleraine, UK
    Int J Vitam Nutr Res 82:348-54. 2012
    ..This review considers the established and emerging roles for folate throughout the lifecycle, and some public health issues related to optimising folate status. ..
  2. doi request reprint C(1) metabolism and CVD outcomes in older adults
    Helene McNulty
    Northern Ireland Centre for Food and Health, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    Proc Nutr Soc 71:213-21. 2012
    ..This novel gene-nutrient interaction may provide insights as to the mechanism that links C(1) metabolism with CVD outcomes...
  3. ncbi request reprint Folate bioavailability
    Helene McNulty
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 63:529-36. 2004
    ..A recent workshop convened by the Food Standards Agency concluded that gaining a better understanding of folate bioavailability in representative human diets is a high priority for future research...
  4. ncbi request reprint Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
    Helene McNulty
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Circulation 113:74-80. 2006
    ....
  5. doi request reprint Homocysteine, B-vitamins and CVD
    Helene McNulty
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 67:232-7. 2008
    ..About 10% of the UK and Irish populations have the TT genotype. In the present paper the potential role of folate and related B-vitamins in the primary prevention of CVD and the implications for nutrition policy are explored...
  6. doi request reprint Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status
    Helene McNulty
    The Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Br J Nutr 99:S48-54. 2008
    ..Finally, there is evidence that riboflavin status is generally low in the UK population, and particularly so in younger women; this warrants further investigation...
  7. ncbi request reprint Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults
    Leane Hoey
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 86:1405-13. 2007
    ..Thus, it is virtually nonexistent in Europe, albeit many countries allow food fortification on a voluntary basis...
  8. ncbi request reprint The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 84:167-73. 2006
    ..Evidence is conflicting as to whether the bioavailability of food folates is influenced by the extent of their conjugation...
  9. ncbi request reprint Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women
    Julie M W Wallace
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, County Londonderry, UK
    Br J Nutr 108:1264-71. 2012
    ....
  10. doi request reprint Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial
    Carol P Wilson
    Northern Ireland Centre for Food and Health, University of Ulster, Cromore Rd, Coleraine, BT52 1SA, Northern Ireland
    Hypertension 61:1302-8. 2013
    ..Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: ISRCTN23620802...
  11. doi request reprint Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up
    Carol P Wilson
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Am J Clin Nutr 95:766-72. 2012
    ....
  12. doi request reprint Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum
    Angela P McGlynn
    Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
    J Nutr 143:27-33. 2013
    ..Folate supplementation trials aimed at colon cancer prevention should target individuals with suboptimal folate status...
  13. doi request reprint Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters
    Breige McNulty
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 98:92-8. 2013
    ..Supplementation with folic acid (FA) is recommended worldwide before and during early pregnancy because of its proven effect in preventing neural tube defects, but the role of FA after the 12th gestational week (GW) is much less clear...
  14. ncbi request reprint Determining bioavailability of food folates in a controlled intervention study
    Mary P Hannon-Fletcher
    Northern Ireland Centre for Food and Health and the School of Hotel, Leisure, and Tourism, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 80:911-8. 2004
    ..However, many published reports on folate bioavailability are problematic because of several confounding factors...
  15. ncbi request reprint The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men
    Kristina Pentieva
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
    J Nutr 134:580-5. 2004
    ..Supplementation with the natural folate derivative could have all the beneficial effects associated with FA, but without the potential disadvantage of masking the anemia of vitamin B-12 deficiency...
  16. doi request reprint A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy
    Paula Tighe
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland and Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Am J Clin Nutr 93:11-8. 2011
    ..The lowest dose of folic acid required to achieve effective reductions in homocysteine is controversial but important for food fortification policy given recent concerns about the potential adverse effects of overexposure to this vitamin...
  17. doi request reprint Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR
    Geraldine Horigan
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, Ireland
    J Hypertens 28:478-86. 2010
    ..The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) for the common 677C-->T polymorphism in MTHFR...
  18. ncbi request reprint Folate status and mood: is there a relationship?
    Emma Williams
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Public Health Nutr 11:118-23. 2008
    ..To explore the relationship between subjective mood, folate status and homocysteine in healthy individuals...
  19. doi request reprint B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension
    Mary Ward
    Nothern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Int J Vitam Nutr Res 81:240-4. 2011
    ....
  20. doi request reprint Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later life
    Maeve A Kerr
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Pediatrics 123:627-35. 2009
    ....
  21. doi request reprint Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials
    Leane Hoey
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Am J Clin Nutr 89:1981S-1996S. 2009
    ..Furthermore, different biomarkers of vitamin B-12 status have not been systematically reviewed...
  22. ncbi request reprint Protocol for the production of concentrated extracts of food folate for use in human bioavailability studies
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
    J Agric Food Chem 51:4382-8. 2003
    ..Neither the mono- to polyglutamate ratio nor the distribution of the main folate derivatives was altered during processing, making these extracts suitable for use in human bioavailability studies...
  23. doi request reprint Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery
    William Dickey
    Department of Gastroenterology, Altnagelvin Hospital, Londonderry, Northern Ireland, UK
    Scand J Gastroenterol 43:682-8. 2008
    ..The objective of this study was to compare plasma homocysteine levels and biomarker status of metabolically related B vitamins (folate, vitamin B(12), B(6) and riboflavin) in treated and untreated CD patients and healthy controls...
  24. doi request reprint Studies of biomarker responses to intervention with riboflavin: a systematic review
    Leane Hoey
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Am J Clin Nutr 89:1960S-1980S. 2009
    ..In addition, the effectiveness of different biomarkers of riboflavin status has not been critically evaluated...
  25. doi request reprint Women's compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects
    Breige McNulty
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
    Hum Reprod 26:1530-6. 2011
    ..We investigated compliance of pregnant women with current folic acid recommendations (400 µg/day from preconception to 12 weeks) in relation to achieving a folate status associated with lowest risk of NTDs...
  26. ncbi request reprint Effect of folic acid supplementation on mood and serotonin response in healthy males
    Emma Williams
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Br J Nutr 94:602-8. 2005
    ..Further research is needed to address the effect of folic acid supplementation or of longer duration or increased dose, particularly in the face of sub-optimal folate status...
  27. doi request reprint Vitamin B12 and ageing: current issues and interaction with folate
    Catherine F Hughes
    The Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Ann Clin Biochem 50:315-29. 2013
    ..The aim of this review is to examine the known and emerging issues related to vitamin B12 in ageing, its assessment and inter-relationship with folate. ..
  28. ncbi request reprint Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements
    Helene McNulty
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 76:436-41. 2002
    ..A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy)...
  29. pmc Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study
    Julie Mw Wallace
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 87:391-7. 2008
    ..Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns...
  30. ncbi request reprint The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet
    Derek J McKillop
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
    Br J Nutr 88:681-8. 2002
    ..Thus, public health efforts to increase folate intake in order to improve folate status should incorporate practical advice on cooking...
  31. ncbi request reprint Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation
    Valerie A Holmes
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Clin Chem 51:629-34. 2005
    ..Low folate status is associated with an increased concentration of plasma total homocysteine (tHcy), a risk factor associated with pregnancy complications such as preeclampsia...
  32. doi request reprint Laying hens can convert high doses of folic acid added to the feed into natural folates in eggs providing a novel source of food folate
    Leane Hoey
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Br J Nutr 101:206-12. 2009
    ..Such foods may be particularly relevant to European populations without access to FA fortification and therefore dependent on natural food folate sources for the primary prevention of folate-related disease...
  33. doi request reprint Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adults
    Ruth K Price
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
    J Nutr 140:2153-7. 2010
    ..Although this supports a role for betaine in the protective effects of whole grains, concomitant decreases in LDL suggest more than one component or mechanism may be responsible...
  34. doi request reprint Biomarker responses to folic acid intervention in healthy adults: a meta-analysis of randomized controlled trials
    Maresa E Duffy
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland MED, L Hoey, CFH, JJS, AR, and HM the Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, Netherlands OWS and CD and Norwich Medical School, University of East Anglia, Norfolk, United Kingdom RC and L Hooper
    Am J Clin Nutr 99:96-106. 2014
    ..The task of revising dietary folate recommendations for optimal health is complicated by a lack of data quantifying the biomarker response that reliably reflects a given folate intake...
  35. doi request reprint EURRECA-Estimating folate requirements for deriving dietary reference values
    Leane Hoey
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Crit Rev Food Sci Nutr 53:1041-50. 2013
    ..This review summarizes the available evidence and the issues to consider in the setting of dietary reference values for folate...
  36. ncbi request reprint Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation
    Gillian R Wasson
    Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
    J Nutr 136:2748-53. 2006
    ..This study also introduces 2 novel functional biomarkers of DNA hypomethylation and demonstrates their suitability to detect folate depletion-induced molecular changes...
  37. pmc Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)
    I Maeve Rea
    Department of Geriatric Medicine, The Queen s University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK
    Age (Dordr) 31:261-7. 2009
    ..36/kg), skin-fold-thickness (OR = 1.33/mm) and serum sodium (OR = 1.37 mmol/l). In BELFAST participants over 80 years old, blood pressure ≥140/90 mmHg is associated with BMI, in apparently similar ways to younger groups...
  38. ncbi request reprint Association between the NAT1 1095C > A polymorphism and homocysteine concentration
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Am J Med Genet A 140:2374-7. 2006
  39. ncbi request reprint Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
    Steinar Hustad
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Clin Chem 48:1571-7. 2002
    ..We investigated the relationships of EGRAC and plasma and erythrocyte concentrations of riboflavin, FMN, and FAD in elderly volunteers and their responses to riboflavin administration...
  40. ncbi request reprint The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs
    Terje Apeland
    Department of Internal Medicine, Rogaland Central Hospital, 4011 Stavanger, Norway
    Epilepsy Res 51:237-47. 2002
    ..Furthermore, B-vitamin supplementation influenced endothelial activation, although the clinical implication is uncertain...
  41. doi request reprint An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA, 19104 6084, USA
    Hum Genet 123:289-95. 2008
    ....
  42. ncbi request reprint Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
    Leo A J Kluijtmans
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 101:2483-8. 2003
    ..These data underscore the potential benefits that may be gained by improving the dietary status of young adults, and provide support for the implementation of folate/B-vitamin food fortification programs...
  43. doi request reprint Evidence for sex differences in the determinants of homocysteine concentrations
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Genet Metab 93:355-62. 2008
    ..Among females, smokers (regardless of MTHFR genotype) appear to be at the highest risk, and to be the most vulnerable to a single factor (i.e. RBC folate) that is associated with homocysteine raising effects...
  44. ncbi request reprint Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Arterioscler Thromb Vasc Biol 23:1014-20. 2003
    ..Nitric oxide may also modulate plasma homocysteine (tHcy) concentrations, either by direct inhibition of methionine synthase or via an indirect effect on folate catabolism...
  45. ncbi request reprint Folate bioavailability: UK Food Standards Agency workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, Aviation House, 125 Kingsway, London WC2 6NH, UK
    Br J Nutr 90:473-9. 2003
    ....
  46. ncbi request reprint The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 114:182-5. 2004
    ..Our findings indicate that the TYMS 3R3R genotype is not a determinant of homocysteine in this sample of healthy young Caucasian adults from Northern Ireland...
  47. ncbi request reprint Fasting and post-methionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugs
    Terje Apeland
    Department of Internal Medicine, Rogaland Central Hospital, Armauer Hansens vei 20, 4011 Stavanger, Norway
    Clin Chem 49:1005-8. 2003
  48. ncbi request reprint A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
    Carmel Kealey
    Department of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 116:347-53. 2005
    ....
  49. ncbi request reprint The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 174:315-22. 2004
    ..We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low...