Research Topics
Species | Helene McNultySummaryAffiliation: University of Ulster Country: UK Publications
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Detail Information
Publications
C(1) metabolism and CVD outcomes in older adultsHelene McNulty
Northern Ireland Centre for Food and Health, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
Proc Nutr Soc 71:213-21. 2012..This novel gene-nutrient interaction may provide insights as to the mechanism that links C(1) metabolism with CVD outcomes...
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphismHelene McNulty
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
Circulation 113:74-80. 2006....- Folate bioavailabilityHelene McNulty
Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
Proc Nutr Soc 63:529-36. 2004..A recent workshop convened by the Food Standards Agency concluded that gaining a better understanding of folate bioavailability in representative human diets is a high priority for future research... - Homocysteine, B-vitamins and CVDHelene McNulty
Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
Proc Nutr Soc 67:232-7. 2008..About 10% of the UK and Irish populations have the TT genotype. In the present paper the potential role of folate and related B-vitamins in the primary prevention of CVD and the implications for nutrition policy are explored... - Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal statusHelene McNulty
The Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland
Br J Nutr 99:S48-54. 2008..Finally, there is evidence that riboflavin status is generally low in the UK population, and particularly so in younger women; this warrants further investigation... - The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugationDerek J McKillop
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
Am J Clin Nutr 84:167-73. 2006..CONCLUSION: These results suggest that the ratio of monoglutamate to polyglutamate in natural folates is not a factor that limits the extent of intestinal absorption of food folate... - Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adultsLeane Hoey
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
Am J Clin Nutr 86:1405-13. 2007..Thus, it is virtually nonexistent in Europe, albeit many countries allow food fortification on a voluntary basis... - Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal womenJulie M W Wallace
Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, County Londonderry, UK
Br J Nutr 108:1264-71. 2012.... - Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-upCarol P Wilson
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United Kingdom
Am J Clin Nutr 95:766-72. 2012.... - Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectumAngela P McGlynn
Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
J Nutr 143:27-33. 2013..Folate supplementation trials aimed at colon cancer prevention should target individuals with suboptimal folate status... - Determining bioavailability of food folates in a controlled intervention studyMary P Hannon-Fletcher
Northern Ireland Centre for Food and Health and the School of Hotel, Leisure, and Tourism, University of Ulster, Coleraine, United Kingdom
Am J Clin Nutr 80:911-8. 2004..However, many published reports on folate bioavailability are problematic because of several confounding factors... - The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in menKristina Pentieva
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
J Nutr 134:580-5. 2004..Supplementation with the natural folate derivative could have all the beneficial effects associated with FA, but without the potential disadvantage of masking the anemia of vitamin B-12 deficiency... - A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policyPaula Tighe
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland and Biochemistry and Immunology, Trinity College, Dublin, Ireland
Am J Clin Nutr 93:11-8. 2011..The lowest dose of folic acid required to achieve effective reductions in homocysteine is controversial but important for food fortification policy given recent concerns about the potential adverse effects of overexposure to this vitamin... - Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFRGeraldine Horigan
Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, Ireland
J Hypertens 28:478-86. 2010..The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) for the common 677C-->T polymorphism in MTHFR... - Folate status and mood: is there a relationship?Emma Williams
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland
Public Health Nutr 11:118-23. 2008..To explore the relationship between subjective mood, folate status and homocysteine in healthy individuals... - B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertensionMary Ward
Nothern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
Int J Vitam Nutr Res 81:240-4. 2011.... - Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trialsLeane Hoey
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
Am J Clin Nutr 89:1981S-1996S. 2009..Furthermore, different biomarkers of vitamin B-12 status have not been systematically reviewed... - Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later lifeMaeve A Kerr
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland
Pediatrics 123:627-35. 2009.... - Women's compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defectsBreige McNulty
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
Hum Reprod 26:1530-6. 2011..We investigated compliance of pregnant women with current folic acid recommendations (400 µg/day from preconception to 12 weeks) in relation to achieving a folate status associated with lowest risk of NTDs... - Studies of biomarker responses to intervention with riboflavin: a systematic reviewLeane Hoey
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
Am J Clin Nutr 89:1960S-1980S. 2009..In addition, the effectiveness of different biomarkers of riboflavin status has not been critically evaluated... - Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recoveryWilliam Dickey
Department of Gastroenterology, Altnagelvin Hospital, Londonderry, Northern Ireland, UK
Scand J Gastroenterol 43:682-8. 2008..The objective of this study was to compare plasma homocysteine levels and biomarker status of metabolically related B vitamins (folate, vitamin B(12), B(6) and riboflavin) in treated and untreated CD patients and healthy controls... - Effect of folic acid supplementation on mood and serotonin response in healthy malesEmma Williams
Northern Ireland Centre for Food and Health (NICHE, University of Ulster, Coleraine BT52 1SA, Northern Ireland
Br J Nutr 94:602-8. 2005..Further research is needed to address the effect of folic acid supplementation or of longer duration or increased dose, particularly in the face of sub-optimal folate status... - Protocol for the production of concentrated extracts of food folate for use in human bioavailability studiesDerek J McKillop
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
J Agric Food Chem 51:4382-8. 2003..Neither the mono- to polyglutamate ratio nor the distribution of the main folate derivatives was altered during processing, making these extracts suitable for use in human bioavailability studies... - Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirementsHelene McNulty
Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom
Am J Clin Nutr 76:436-41. 2002..A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy)... 
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development StudyJulie Mw Wallace
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom
Am J Clin Nutr 87:391-7. 2008..Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns...- The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK dietDerek J McKillop
Northern Ireland Centre for Food and Health (NICHE, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
Br J Nutr 88:681-8. 2002..Thus, public health efforts to increase folate intake in order to improve folate status should incorporate practical advice on cooking... - Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementationValerie A Holmes
Northern Ireland Centre for Food and Health (NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, UK
Clin Chem 51:629-34. 2005..These results indicate a potential role for continued folic acid supplementation in reducing pregnancy complications associated with hyperhomocysteinemia... - Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adultsRuth K Price
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
J Nutr 140:2153-7. 2010..Although this supports a role for betaine in the protective effects of whole grains, concomitant decreases in LDL suggest more than one component or mechanism may be responsible... - Laying hens can convert high doses of folic acid added to the feed into natural folates in eggs providing a novel source of food folateLeane Hoey
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
Br J Nutr 101:206-12. 2009..Such foods may be particularly relevant to European populations without access to FA fortification and therefore dependent on natural food folate sources for the primary prevention of folate-related disease... - Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementationGillian R Wasson
Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
J Nutr 136:2748-53. 2006..This study also introduces 2 novel functional biomarkers of DNA hypomethylation and demonstrates their suitability to detect folate depletion-induced molecular changes... - Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)I Maeve Rea
Department of Geriatric Medicine, The Queen s University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK
Age (Dordr) 31:261-7. 2009..36/kg), skin-fold-thickness (OR = 1.33/mm) and serum sodium (OR = 1.37 mmol/l). In BELFAST participants over 80 years old, blood pressure ≥140/90 mmHg is associated with BMI, in apparently similar ways to younger groups... - Genetic and nutritional factors contributing to hyperhomocysteinemia in young adultsLeo A J Kluijtmans
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Blood 101:2483-8. 2003..These data underscore the potential benefits that may be gained by improving the dietary status of young adults, and provide support for the implementation of folate/B-vitamin food fortification programs... - Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementationSteinar Hustad
LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
Clin Chem 48:1571-7. 2002..We investigated the relationships of EGRAC and plasma and erythrocyte concentrations of riboflavin, FMN, and FAD in elderly volunteers and their responses to riboflavin administration... - Fasting and post-methionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugsTerje Apeland
Department of Internal Medicine, Rogaland Central Hospital, Armauer Hansens vei 20, 4011 Stavanger, Norway
Clin Chem 49:1005-8. 2003 - The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugsTerje Apeland
Department of Internal Medicine, Rogaland Central Hospital, 4011 Stavanger, Norway
Epilepsy Res 51:237-47. 2002..Furthermore, B-vitamin supplementation influenced endothelial activation, although the clinical implication is uncertain... - Folate bioavailability: UK Food Standards Agency workshop reportPeter Sanderson
Nutrition Division, Food Standards Agency, Aviation House, 125 Kingsway, London WC2 6NH, UK
Br J Nutr 90:473-9. 2003.... - The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjectsKaren S Brown
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Hum Genet 114:182-5. 2004..Our findings indicate that the TYMS 3R3R genotype is not a determinant of homocysteine in this sample of healthy young Caucasian adults from Northern Ireland... - Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemiaKaren S Brown
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Arterioscler Thromb Vasc Biol 23:1014-20. 2003..Nitric oxide may also modulate plasma homocysteine (tHcy) concentrations, either by direct inhibition of methionine synthase or via an indirect effect on folate catabolism... - An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in womenAnna Stanisławska-Sachadyn
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA, 19104 6084, USA
Hum Genet 123:289-95. 2008.... - Evidence for sex differences in the determinants of homocysteine concentrationsAnna Stanisławska-Sachadyn
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Mol Genet Metab 93:355-62. 2008..Among females, smokers (regardless of MTHFR genotype) appear to be at the highest risk, and to be the most vulnerable to a single factor (i.e. RBC folate) that is associated with homocysteine raising effects... - The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteineKaren S Brown
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Atherosclerosis 174:315-22. 2004..We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low... - Association between the NAT1 1095C > A polymorphism and homocysteine concentrationAnna Stanisławska-Sachadyn
Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
Am J Med Genet A 140:2374-7. 2006 - A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrationsCarmel Kealey
Department of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Hum Genet 116:347-53. 2005....