Research Topics

Genomes and Genes


Helene McNulty


Affiliation: University of Ulster
Country: UK


  1. Hughes C, Ward M, Tracey F, Hoey L, Molloy A, Pentieva K, et al. B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study. Nutrients. 2017;9: pubmed publisher
    ..Vitamin B6 may be an important protective factor in helping maintain cognitive health in ageing. ..
  2. Moore K, Hughes C, Hoey L, Ward M, Cunningham C, Molloy A, et al. B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study. J Am Med Dir Assoc. 2019;: pubmed publisher
    ..If confirmed by a randomized trial, these results may have implications for nutrition and mental health policy, and thus quality of life, in older people. ..
  3. Whitfield K, da Silva L, Feldman F, Singh S, McCann A, McAnena L, et al. Adequate vitamin B12 and riboflavin status from menus alone in residential care facilities in the Lower Mainland, British Columbia. Appl Physiol Nutr Metab. 2018;: pubmed publisher
    ..However, 26% were riboflavin deficient (EGRac ?1.4), which may warrant further investigation. ..
  4. Gaál S, Kerr M, Ward M, McNulty H, Livingstone M. Breakfast Consumption in the UK: Patterns, Nutrient Intake and Diet Quality. A Study from the International Breakfast Research Initiative Group. Nutrients. 2018;10: pubmed publisher
    ..These findings could help to inform the development of nutrient-based recommendations for a balanced breakfast for the first time in the UK. ..
  5. McMahon A, McNulty H, Hughes C, Strain J, Ward M. Novel Approaches to Investigate One-Carbon Metabolism and Related B-Vitamins in Blood Pressure. Nutrients. 2016;8: pubmed
    ..The role of ABPM in B-vitamin research and in nutrition research generally will also be reviewed. ..
  6. Porter K, Hoey L, Hughes C, Ward M, McNulty H. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients. 2016;8: pubmed
    ..This review will examine the evidence linking folate and related B-vitamins with health and disease in ageing, associated mechanisms and public health implications. ..
  7. Altic L, McNulty H, Hoey L, McAnena L, Pentieva K. Validation of Folate-Enriched Eggs as a Functional Food for Improving Folate Intake in Consumers. Nutrients. 2016;8: pubmed
    ..Further studies will confirm their effectiveness in optimizing the biomarker folate status of consumers. ..
  8. request reprint
    McNulty H, Dowey L, Strain J, Dunne A, Ward M, Molloy A, et al. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. Circulation. 2006;113:74-80 pubmed
    ..Our findings might explain why this common polymorphism carries an increased risk of coronary heart disease in Europe but not in North America, where riboflavin fortification has existed for >50 years. ..
  9. McNulty H, Strain J, Hughes C, Ward M. Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension. Mol Aspects Med. 2017;53:2-9 pubmed publisher
    ..Further investigations of this novel gene-nutrient interaction in relation to blood pressure, hypertension and hypertension in pregnancy are required. ..

More Information


  1. Laird E, Thurston S, van Wijngaarden E, Shamlaye C, Myers G, Davidson P, et al. Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study. Nutrients. 2017;9: pubmed publisher
    ..Larger studies with greater variability in vitamin D status are needed to further explore optimal cut-offs or non-linear associations (including for maternal health) that might exist among populations with sub-optimal exposure. ..