Donald C McMillan

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Systemic inflammatory response predicts survival following curative resection of colorectal cancer
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Surg 90:215-9. 2003
  2. pmc Evaluation of a cumulative prognostic score based on the systemic inflammatory response in patients undergoing potentially curative surgery for colorectal cancer
    K Canna
    University Department of Surgery, Glasgow Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1707-9. 2004
  3. pmc The relationship between interleukin-6 and C-reactive protein in patients with benign and malignant prostate disease
    P A McArdle
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Br J Cancer 91:1755-7. 2004
  4. pmc The relationship between quality of life (EORTC QLQ-C30) and survival in patients with gastro-oesophageal cancer
    M McKernan
    University Department of Surgery, Royal Infirmary, and Department of Surgery, Southern General Hospital, Glasgow G31 2ER, UK
    Br J Cancer 98:888-93. 2008
  5. pmc The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer
    E Bromwich
    University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
    Br J Cancer 91:1236-8. 2004
  6. pmc The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer
    P A McArdle
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:541-3. 2004
  7. pmc The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases
    R Al-Shaiba
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:205-7. 2004
  8. pmc Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1704-6. 2004
  9. pmc The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer
    A M Al Murri
    University Department of Surgery, University of Glasgow Faculty of Medicine, Royal and Western Infirmaries, Glasgow G31 2ER, UK
    Br J Cancer 99:1013-9. 2008
  10. pmc Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer
    L H Moyes
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow, UK
    Br J Cancer 100:1236-9. 2009

Detail Information

Publications135 found, 100 shown here

  1. ncbi request reprint Systemic inflammatory response predicts survival following curative resection of colorectal cancer
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Surg 90:215-9. 2003
    ..The aim of this study was to examine the relationship between the inflammatory response and overall and cancer-specific survival in patients undergoing potentially curative resection for colorectal cancer...
  2. pmc Evaluation of a cumulative prognostic score based on the systemic inflammatory response in patients undergoing potentially curative surgery for colorectal cancer
    K Canna
    University Department of Surgery, Glasgow Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1707-9. 2004
    ..The cancer-specific survival rates at 3 years for patients with a cumulative prognostic score of 0, 1 and 2 were 100, 77 and 40%, respectively (HR 4.76, 2.78-8.15, P<0.001)...
  3. pmc The relationship between interleukin-6 and C-reactive protein in patients with benign and malignant prostate disease
    P A McArdle
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Br J Cancer 91:1755-7. 2004
    ..632, P<0.001 and rs=0.663, P<0.001, respectively. These results indicate that the relationship between interleukin-6 and C-reactive protein is similar in patients with benign and malignant prostate disease...
  4. pmc The relationship between quality of life (EORTC QLQ-C30) and survival in patients with gastro-oesophageal cancer
    M McKernan
    University Department of Surgery, Royal Infirmary, and Department of Surgery, Southern General Hospital, Glasgow G31 2ER, UK
    Br J Cancer 98:888-93. 2008
    ..0001) were significant independent predictors of cancer-specific survival. The present study highlights the importance of quality of life (EORTC QLQ-C30) measures, in particular appetite loss, as a prognostic factor in these patients...
  5. pmc The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer
    E Bromwich
    University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
    Br J Cancer 91:1236-8. 2004
    ..In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates, only C-reactive protein was a significant independent predictor of survival (HR 2.03, 95% CI 1.09-3.80, P=0.026)...
  6. pmc The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer
    P A McArdle
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:541-3. 2004
    ..29, 95% CI 1.25-4.22, P=0.008) had independent significance. Increased CD4+ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer...
  7. pmc The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases
    R Al-Shaiba
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:205-7. 2004
    ..001) but not percentage hepatic replacement (P=0.34). These results show that hypoalbuminaemia is associated with the presence of a systemic inflammatory response rather than tumour volume in patients with colorectal liver metastases...
  8. pmc Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1704-6. 2004
    ..On multivariate analysis with ECOG, white cell count and the GPS entered as covariates, only the GPS was a significant independent predictor of survival (HR 1.88, 95% CI 1.25-2.84, P=0.002)...
  9. pmc The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer
    A M Al Murri
    University Department of Surgery, University of Glasgow Faculty of Medicine, Royal and Western Infirmaries, Glasgow G31 2ER, UK
    Br J Cancer 99:1013-9. 2008
    ..05) was independently associated with poorer cancer-specific survival. The host inflammatory responses are closely associated with poor tumour differentiation, proliferation and malignant disease progression in breast cancer...
  10. pmc Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer
    L H Moyes
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow, UK
    Br J Cancer 100:1236-9. 2009
    ..Preoperative elevated mGPS predicts increased postoperative infectious complications in patients undergoing potentially curative resection for colorectal cancer...
  11. pmc The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
    M D Barber
    University Department of Surgery, Royal Infirmary, Edinburgh EH3 9YW, UK
    Br J Cancer 90:1129-32. 2004
    ..05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer...
  12. pmc Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer
    E F Leitch
    1University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 97:1266-70. 2007
    ..An acute-phase protein-based prognostic score, the mGPS, appears to be a superior predictor of survival compared with the cellular components of the systemic inflammatory response...
  13. pmc The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer
    D J McKeown
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:1993-5. 2004
    ..616, P<0.001). Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer...
  14. pmc Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer
    A M Al Murri
    University Department of Surgery, Royal and Western Infirmaries, Glasgow, UK
    Br J Cancer 94:227-30. 2006
    ..The presence of a systemic inflammatory response (the GPS) appears to be a useful indicator of poor outcome independent of treatment in patients with metastatic breast cancer...
  15. pmc An evaluation of the impact of a multidisciplinary team, in a single centre, on treatment and survival in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 93:977-8. 2005
    ..However, in 2001, 23% of patients received chemotherapy treatment compared with 7% in 1997 (P<0.001). Median survival in 2001 was 6.6 months compared with 3.2 months in 1997 (P<0.001)...
  16. pmc Evaluation of an inflammation-based prognostic score in patients with inoperable gastro-oesophageal cancer
    A B C Crumley
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 94:637-41. 2006
    ..Moreover, the GPS may be used in combination with conventional staging techniques to improve the prediction of survival in patients with inoperable gastro-oesophageal cancer...
  17. pmc The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer
    G W A Lamb
    Department of Urology, Gartnavel General Hospital, Glasgow G12 0YN, UK
    Br J Cancer 94:781-4. 2006
    ..The presence of a preoperative systemic inflammatory response predicts poor cancer-specific survival in patients who have undergone potentially curative resection for renal clear cell cancer...
  18. pmc Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 89:1028-30. 2003
    ..001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised...
  19. pmc The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer
    K Canna
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 92:651-4. 2005
    ..The results of the present study show that low tumour CD4+ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and both predict poor cancer-specific survival...
  20. pmc An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer
    A B C Crumley
    1University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 94:1568-71. 2006
    ....
  21. pmc Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer
    A M Al Murri
    Royal Infirmary, University Department of Surgery, Glasgow, UK
    Br J Cancer 96:891-5. 2007
    ....
  22. pmc Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas
    N B Jamieson
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 92:21-3. 2005
    ..001). The results of the present study indicate that, in patients who have undergone potentially curative resection for ductal adenocarcinoma of the head of pancreas, the presence of a systemic inflammatory response predicts poor outcome...
  23. pmc The relationship between deprivation, tumour stage and the systemic inflammatory response in patients with primary operable breast cancer
    A M Al Murri
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:1063-5. 2004
    ..01) in patients with primary operable breast cancer (n=314). Deprivation was not associated with age, tumour size, tumour type, grade, and the proportion of patients with involved lymph nodes and oestrogen receptor status...
  24. pmc A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 92:1834-6. 2005
    ..This study confirms the prognostic value of the GPS, at diagnosis, in patients with inoperable NSCLC. However, the role of the GPS and ECOG-ps during follow-up has not been established...
  25. pmc The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer
    H R Scott
    Department of Respiratory Medicine, Wishaw General Hospital, Lanarkshire ML 0DP, UK
    Br J Cancer 87:264-7. 2002
    ..Furthermore, an increase in the magnitude of the systemic inflammatory response resulted in greater weight loss, poorer performance status, more fatigue and poorer survival...
  26. pmc The effect of deprivation and the systemic inflammatory response on outcome following curative resection for colorectal cancer
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 ZER, UK
    Br J Cancer 89:612-4. 2003
    ..87, P<0.05), independent of Dukes stage, in patients who had undergone apparently curative surgery for colorectal cancer (n=158). Deprivation predicted overall survival (HR 1.26, 95% CI 1.04-1.51, P<0.05) independent of Dukes stage...
  27. ncbi request reprint Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Nutrition 16:425-8. 2000
    ..These results support the concept that the magnitude of inflammation plays an important role in the regulation of circulating concentrations of vitamin antioxidants and trace elements in patients with gastrointestinal cancer...
  28. ncbi request reprint Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Nutr Cancer 41:64-9. 2001
    ..0001). The results of the present study indicate that in advanced cancer patients the presence of a systemic inflammatory response and the magnitude of that response predict the duration of cancer-specific and non-cancer survival...
  29. ncbi request reprint Performance status of male and female advanced cancer patients is independently predicted by mid-upper arm circumference measurement
    Donald C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Nutr Cancer 42:191-3. 2002
    ..286, P = 0.024). The results of the present study indicate that mid-upper arm circumference is a major factor that influences performance status in male and female patients with advanced gastrointestinal cancer...
  30. pmc A clinical risk score to predict 3-, 5- and 10-year survival in patients undergoing surgery for Dukes B colorectal cancer
    D C McMillan
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 103:970-4. 2010
    ..The aim of this study was to devise a clinical risk score to predict 3-, 5- and 10-year survival in patients undergoing surgery for Dukes stage B colorectal cancer...
  31. ncbi request reprint Male gender adversely affects survival following surgery for colorectal cancer
    C S McArdle
    University Department of Surgery, Royal Infirmary, University of Glasgow, Glasgow, UK
    Br J Surg 90:711-5. 2003
    ..The aim of the present study was to establish whether there were gender differences in survival following surgery for colorectal cancer after adjusting for case-mix...
  32. ncbi request reprint Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Nutr Cancer 39:210-3. 2001
    ....
  33. ncbi request reprint Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer
    Donald C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Int J Colorectal Dis 22:881-6. 2007
    ..The aim of the study was to examine the value of the combination of an elevated C-reactive protein and hypoalbuminaemia (GPS) in predicting cancer-specific survival after resection for colon and rectal cancer...
  34. pmc The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer
    E J Bromwich
    Department of Urology, Gartnavel General Hospital, Glasgow G12 0YN, UK
    Br J Cancer 89:1906-8. 2003
    ..Intratumoural CD4+ T-lymphocyte infiltrate was associated with poor cancer-specific survival, independent of grade, in this cohort...
  35. pmc The impact of young age on cancer-specific and non-cancer-related survival after surgery for colorectal cancer: 10-year follow-up
    D C McMillan
    University Department of Surgery, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 101:557-60. 2009
    ..The aim of this study was to compare cancer-specific and non-cancer-related survival at 10 years in a young age cohort and a middle age cohort in patients undergoing surgery for colorectal cancer...
  36. pmc The impact of old age on cancer-specific and non-cancer-related survival following elective potentially curative surgery for Dukes A/B colorectal cancer
    D C McMillan
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK
    Br J Cancer 99:1046-9. 2008
    ..These results suggest that cancer-specific and non-cancer-related mortality should be considered separately in survival analysis of these cancer patients...
  37. ncbi request reprint Longitudinal study of body cell mass depletion and the inflammatory response in cancer patients
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Nutr Cancer 31:101-5. 1998
    ..806, p < 0.001) change in total body potassium over the follow-up period. This study demonstrates the association of a chronic inflammatory response with the rate of loss of body cell mass observed in cancer patients...
  38. doi request reprint Systemic inflammation, nutritional status and survival in patients with cancer
    Donald C McMillan
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow, UK
    Curr Opin Clin Nutr Metab Care 12:223-6. 2009
    ..This review examines the role of recent simple objective systemic inflammation-based scores in predicting reduction of nutritional status and survival...
  39. ncbi request reprint Relation between pyridoxal and pyridoxal phosphate concentrations in plasma, red cells, and white cells in patients with critical illness
    Aikaterini T Vasilaki
    University Department of Surgery, Royal Infirmary, Glasgow, United Kingdom
    Am J Clin Nutr 88:140-6. 2008
    ..Evidence suggests that the relation between plasma and red cell vitamin B-6 concentrations is perturbed as part of the systemic inflammatory response in critically ill patients...
  40. doi request reprint The relationship between tumor inflammatory cell infiltrate and outcome in patients with pancreatic ductal adenocarcinoma
    Nigel B Jamieson
    West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom
    Ann Surg Oncol 19:3581-90. 2012
    ..However, the prognostic value of the tumor inflammatory cell infiltrate has not been established in pancreatic ductal adenocarcinoma (PDAC) nor has its relationship with the systemic inflammatory response...
  41. doi request reprint Comparison of pre-treatment clinical prognostic factors in patients with gastro-oesophageal cancer and proposal of a new staging system
    Andrew B C Crumley
    University Department of Surgery, University of Glasgow Faculty of Medicine, Royal Infirmary, Glasgow G31 2ER, UK
    J Gastrointest Surg 14:781-7. 2010
    ..Despite recent advances in clinical staging, overall survival remains poor. The aim of the present study was to examine the relationship between pre-treatment clinical prognostic factors and cancer-specific survival...
  42. doi request reprint Deprivation and colorectal cancer surgery: longer-term survival inequalities are due to differential postoperative mortality between socioeconomic groups
    Raymond Oliphant
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Ann Surg Oncol 20:2132-9. 2013
    ..Deprivation is associated with poorer survival after surgery for colorectal cancer, but determinants of this socioeconomic inequality are poorly understood...
  43. doi request reprint Optimization of the systemic inflammation-based Glasgow prognostic score: a Glasgow Inflammation Outcome Study
    Michael J Proctor
    Academic Unit of Surgery, University of Glasgow School of Medicine, Royal Infirmary, Glasgow, UK
    Cancer 119:2325-32. 2013
    ..The objective of the current study was to establish whether the addition of a differential leukocyte count and a high-sensitivity C-reactive protein measurement enhanced the prognostic value of the mGPS...
  44. doi request reprint Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer
    Sumanta Dutta
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Am J Surg 204:294-9. 2012
    ..The aim of the present study was to compare the prognostic value of selected markers of the systemic inflammatory response in patients undergoing resection of gastric cancer...
  45. doi request reprint Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative resection of oesophageal cancer
    Sumanta Dutta
    Academic Unit of Surgery, School of Medicine, University of Glasgow, Wolfson Medical School Bldg, University Ave, Glasgow, G12 8QQ, Scotland, UK
    World J Surg 35:1861-6. 2011
    ..The aim of the present study was to compare the predictive value of selected markers of systemic inflammation in patients who undergo surgical resection of oesophageal cancer...
  46. ncbi request reprint The relationship between plasma and red cell B-vitamin concentrations in critically-ill patients
    Tara Quasim
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK University Department of Anaesthesia, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Nutr 24:956-60. 2005
    ..Using direct methods for assessing vitamin status, we examined the effect of B-complex vitamin supplementation by measuring plasma and red blood cell B1, B2 and B6-vitamin concentrations in critically-ill patients...
  47. doi request reprint Interrelationships between tumor proliferative activity, leucocyte and macrophage infiltration, systemic inflammatory response, and survival in patients selected for potentially curative resection for gastroesophageal cancer
    Andrew B C Crumley
    University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK
    Ann Surg Oncol 18:2604-12. 2011
    ..We examined the interrelationships between standard clinicopathological factors, systemic and local inflammatory responses, tumor proliferative activity, and survival...
  48. ncbi request reprint Systemic inflammatory response and survival in patients with localised prostate cancer: 10-year follow-up
    Peter A McArdle
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK peters doctors org uk
    Urol Int 84:430-5. 2010
    ..To examine the prognostic value of circulating C-reactive protein concentrations at diagnosis in patients with organ-confined prostate cancer...
  49. ncbi request reprint The relationship between the acute changes in the systemic inflammatory response, lipid soluble antioxidant vitamins and lipid peroxidation following elective knee arthroplasty
    Andrew Gray
    Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Nutr 24:746-50. 2005
    ....
  50. doi request reprint The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer
    Elaine Y L Leung
    University Department of Surgery and Micronutrient Unit Biochemistry, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Nutr Cancer 64:515-20. 2012
    ..The presence of a SIR was associated with lower concentrations of plasma PLP but not red cell PLP concentrations in patients with colorectal cancer. Neither FAD and PLP were associated with the tumor inflammatory cell infiltrate...
  51. doi request reprint Is perioperative systemic inflammation the result of insufficient cortisol production in patients with colorectal cancer?
    Michelle L Ramanathan
    Academic Unit of Surgery, School of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Ann Surg Oncol 20:2172-9. 2013
    ..The aim of the present study was to examine the relationship between the perioperative systemic inflammatory response and endogenous cortisol production...
  52. ncbi request reprint Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer
    Ahmed S K Almushatat
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Int J Cancer 118:1051-3. 2006
    ..269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer...
  53. ncbi request reprint Score based on hypoalbuminemia and elevated C-reactive protein predicts survival in patients with advanced gastrointestinal cancer
    Maqsood M Elahi
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Nutr Cancer 48:171-3. 2004
    ..It has the advantage that it is based on routinely available well-standardized measurements and is simple to use...
  54. doi request reprint A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
    Michael J Proctor
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Eur J Cancer 47:2633-41. 2011
    ..The aim of the present study was to compare the prognostic value of these scores...
  55. ncbi request reprint The longitudinal relationship between the systemic inflammatory response, circulating T-lymphocytes, interleukin-6 and -10 in patients undergoing immunotherapy for metastatic renal cancer
    Sara Ramsey
    Department of Urology, Gartnavel General Hospital, Glasgow, Scotland, UK
    BJU Int 102:125-9. 2008
    ....
  56. ncbi request reprint Towards a simple objective framework for the investigation and treatment of cancer cachexia: the Glasgow Prognostic Score
    Euan Douglas
    Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, United Kingdom Electronic address
    Cancer Treat Rev 40:685-91. 2014
    ..Furthermore, to put forward the case for the Glasgow Prognostic Score to act a simple objective framework for the investigation and treatment of cancer cachexia. ..
  57. doi request reprint The relationship between the local and systemic inflammatory responses and survival in patients undergoing curative surgery for colon and rectal cancers
    Campbell S D Roxburgh
    University Department of Surgery, Faculty of Medicine, University of Glasgow Royal Infirmary, Glasgow, UK
    J Gastrointest Surg 13:2011-8; discussion 2018-9. 2009
    ..The present study assesses the prognostic value of local and systemic inflammation in colon and rectal cancers and defines 3-year survival according to inflammation-based criteria for stage II/III disease...
  58. ncbi request reprint The clinical utility of the combination of T stage and venous invasion to predict survival in patients undergoing surgery for colorectal cancer
    Campbell S D Roxburgh
    University Department of Surgery, Glasgow Royal Infirmary University Department of Pathology, Southern General Hospital, Glasgow, United Kingdom
    Ann Surg 259:1156-65. 2014
    ..To examine the clinical utility of improved detection of venous invasion (VI) in patients undergoing potentially curative resection of colorectal cancer...
  59. ncbi request reprint The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty
    Andrew Gray
    Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Nutr 23:1080-3. 2004
    ..The aim of the study was to examine the relationship between plasma and intra-cellular B-vitamins following the systemic inflammatory response of surgery...
  60. ncbi request reprint A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients
    Roma Maguire
    University Department of Surgery, Royal Infirmary, Glasgow, Scotland, UK
    Cytokine 20:174-7. 2002
    ..Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed...
  61. doi request reprint C-reactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer
    Jonathan J Platt
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Ann Surg Oncol 19:4168-77. 2012
    ..However, their relative predictive value is unclear. The aim of the present study was to examine the diagnostic accuracy of serial postoperative WCC, albumin and CRP in detecting infective complications...
  62. ncbi request reprint Adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer
    Nigel B Jamieson
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Cytokine 27:90-2. 2004
    ..These results suggest that adipokine production is normal and is unlikely to play a major role in the abnormal fat metabolism in weight-losing cancer patients...
  63. doi request reprint The revised ACPGBI model is a simple and accurate predictor of operative mortality after potentially curative resection of colorectal cancer
    Colin H Richards
    Glasgow University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Ann Surg Oncol 18:3680-5. 2011
    ..The aim of the present study was to compare the performance of the revised ACPGBI model, the original ACPGBI model, P-POSSUM, and CR-POSSUM, in the prediction of operative mortality after resection of colorectal cancer...
  64. doi request reprint A prospective comparison of the prognostic value of tumor- and patient-related factors in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma
    Nigel B Jamieson
    Department of Surgery, Glasgow University, Glasgow, Scotland, UK
    Ann Surg Oncol 18:2318-28. 2011
    ....
  65. doi request reprint A comparison of POSSUM and GPS models in the prediction of post-operative outcome in patients undergoing oesophago-gastric cancer resection
    Sumanta Dutta
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Ann Surg Oncol 18:2808-17. 2011
    ....
  66. doi request reprint The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer
    Gavin W A Lamb
    Department of Urology, Gartnavel General Hospital, Glasgow, UK
    BJU Int 102:756-61. 2008
    ....
  67. doi request reprint Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer
    Elaine Y L Leung
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Int J Cancer 123:2460-4. 2008
    ..Of the antioxidant vitamins measured, only retinol was independently associated with cancer-specific survival...
  68. doi request reprint Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer
    Joseph E M Crozier
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Am J Surg 197:544-9. 2009
    ..The present study examined the hypothesis that an enhanced systemic inflammatory response, prior to surgery, might explain the impact of emergency presentation on survival...
  69. doi request reprint Relation between riboflavin, flavin mononucleotide and flavin adenine dinucleotide concentrations in plasma and red cells in patients with critical illness
    Aikaterini T Vasilaki
    University Department of Surgery, University of Glasgow Faculty of Medicine, Royal Infirmary, Glasgow G312ER, Scotland, United Kingdom
    Clin Chim Acta 411:1750-5. 2010
    ..The aim of the present study was to examine the longitudinal interrelationships between riboflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) in plasma and red cells in patients with critical illness...
  70. ncbi request reprint Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation
    Dinesh Talwar
    Department of Biochemistry, Royal Infirmary, Glasgow G31 2ER, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 792:333-43. 2003
    ..There was a strong positive correlation (r(2)=0.81) between plasma and red cell PLP levels in the reference population. The HPLC method described was found to be suitable for the routine measurement of PLP in both plasma and red cells...
  71. doi request reprint The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer
    Claire L Meek
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, UK
    Clin Nutr 29:206-9. 2010
    ..The aim of the present study was to examine the relationship between IGF-1 and IGFBP-3, performance status, mGPS and survival in patients with inoperable NSCLC...
  72. ncbi request reprint Evaluation of an inflammation-based prognostic score in patients with metastatic renal cancer
    Sara Ramsey
    Department of Urology, Gartnavel General Hospital, Glasgow, United Kingdom
    Cancer 109:205-12. 2007
    ..The objective of the current study was to examine the value of the GPS compared with established scoring systems in predicting cancer-specific survival in patients with metastatic renal cancer...
  73. doi request reprint Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer
    Campbell S D Roxburgh
    Department of Surgery, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom
    Ann Surg 249:788-93. 2009
    ....
  74. doi request reprint Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements
    Andrew Duncan
    Scottish Trace Elements and Micronutrient Reference Laboratory, Department of Clinical Biochemistry, Faculty of Medicine, University of Glasgow, Royal Infirmary, United Kingdom
    Am J Clin Nutr 95:64-71. 2012
    ..Plasma concentrations of several trace elements and vitamins decrease because of the systemic inflammatory response. Thus, low values do not necessarily indicate deficiency...
  75. ncbi request reprint The relationship between reduced vitamin antioxidant concentrations and the systemic inflammatory response in patients with common solid tumours
    Donald C McMillan
    University Department of Surgery, Glasgow, UK
    Clin Nutr 21:161-4. 2002
    ..In order to determine whether this relationship was independent of tumour type patients other common solid tumours were studied...
  76. doi request reprint Elastica staining for venous invasion results in superior prediction of cancer-specific survival in colorectal cancer
    Campbell S D Roxburgh
    Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Ann Surg 252:989-97. 2010
    ..To examine the prognostic implications of routine elastica staining for venous invasion on prediction of cancer-specific survival in colorectal cancer...
  77. ncbi request reprint Circulating concentrations of "free" leptin in relation to fat mass and appetite in gastrointestinal cancer patients
    A Michael Wallace
    University Department of Pathological Biochemistry, Royal Infirmary, Glasgow G4 0SF, UK
    Nutr Cancer 44:157-60. 2002
    ..Furthermore, the increase in circulating leptin concentrations after megestrol acetate treatment is not associated with any alteration in leptin binding...
  78. doi request reprint Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer?
    Andrew B C Crumley
    University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
    World J Surg 34:2393-8. 2010
    ..The aim of the study was to assess the relation between hypoalbuminemia, the systemic inflammatory response, and survival in patients with gastric cancer...
  79. ncbi request reprint An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer
    Donald C McMillan
    University Dept of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Proc Nutr Soc 67:257-62. 2008
    ..The role of GPS in clinical decision making will be discussed...
  80. ncbi request reprint The systemic inflammatory response predicts overall and cancer specific survival in patients with malignant lymphoma
    Maqsood M Elahi
    University Department of Surgery, Royal Infirmary, Glasgow, United Kingdom
    Med Sci Monit 11:CR75-8. 2005
    ..The value of C-reactive protein concentrations in the assessment of prognosis in patients with advanced lymphoma has not been clearly defined...
  81. doi request reprint The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up
    Arfon G M T Powell
    Unit of Experimental Therapeutics, Institute of Cancer Science, University of Glasgow, McGregor Building, Western Infirmary Glasgow, Glasgow, G11 6NT, UK
    J Cancer Res Clin Oncol 139:2013-20. 2013
    ..This study aims to identify which clinicopathological factors and genetic profiling markers predict outcome in node-negative disease...
  82. doi request reprint Comparison of visual and automated assessment of microvessel density and their impact on outcome in primary operable invasive ductal breast cancer
    Zahra M A Mohammed
    Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences, University of Glasgow, Royal Infirmary, Glasgow, G31 2ER, UK
    Hum Pathol 44:1688-95. 2013
    ..01). Although automated assessment of microvessel density (CD34(+)) is in reasonable agreement, it poorly predicts outcome in patients with operable invasive ductal breast cancer. ..
  83. ncbi request reprint Tumoral C-reactive protein and nuclear factor kappa-B expression are associated with clinical outcome in patients with prostate cancer
    Pamela McCall
    Unit of Experimental Therapeutics, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Cancer Biomark 10:91-9. 2011
    ..Tumoral CRP is a significant independent predictor of cancer specific survival. The relationship between tumour CRP and signalling pathways warrants further investigation in a larger cohort...
  84. ncbi request reprint Systemic inflammatory response, prostate-specific antigen and survival in patients with metastatic prostate cancer
    Peter A McArdle
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Urol Int 77:127-9. 2006
    ....
  85. ncbi request reprint The relationship between leptin concentrations, the systemic inflammatory response and illness severity in surgical patients admitted to ITU
    Tara Quasim
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Clin Nutr 23:233-8. 2004
    ..The aim of the present study was to examine these relationships in critically ill surgical patients admitted to the intensive therapy unit (ITU)...
  86. doi request reprint A systematic review of POSSUM and its related models as predictors of post-operative mortality and morbidity in patients undergoing surgery for colorectal cancer
    Colin Hewitt Richards
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow G4 0SF, UK
    J Gastrointest Surg 14:1511-20. 2010
    ..This aim of this systematic review was to assess the predictive value of the POSSUM models in colorectal cancer surgery...
  87. ncbi request reprint Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer
    Paul Glen
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Pancreatology 6:450-3. 2006
    ..The present study assesses the value of an inflammation-based score (Glasgow Prognostic Score, GPS) in patients with inoperable pancreatic cancer...
  88. ncbi request reprint Biological variation of vitamins in blood of healthy individuals
    Dinesh K Talwar
    Scottish Trace Element and Micronutrient Reference Laboratory, Department of Clinical Biochemistry, Royal Infirmary, Glasgow, UK
    Clin Chem 51:2145-50. 2005
    ....
  89. doi request reprint The role of the tumour inflammatory cell infiltrate in predicting recurrence and survival in patients with primary operable breast cancer
    Zahra M A Mohammed
    Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Cancer Treat Rev 38:943-55. 2012
    ....
  90. ncbi request reprint Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer
    Campbell S D Roxburgh
    University Department of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Eur J Cancer 45:2138-45. 2009
    ..The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer...
  91. ncbi request reprint The effect of gender on postoperative mortality after emergency abdominal surgery
    Johann Harten
    Department of Anaesthesia, University of Glasgow, Glasgow, Scotland
    Gend Med 2:35-40. 2005
    ..The factors contributing to the high mortality after emergency abdominal surgery are unclear. Recent studies have revealed gender differences in immune function after trauma and in the presence of sepsis...
  92. doi request reprint Chronic inflammation and pancreatic cancer
    Colin J McKay
    Lister Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Best Pract Res Clin Gastroenterol 22:65-73. 2008
    ..Further understanding of the details of the relationship between inflammation, carcinogenesis and cancer prognosis may lead to new therapeutic possibilities as part of multi-modality management of this difficult disease...
  93. doi request reprint Persistent elevation of C-reactive protein following esophagogastric cancer resection as a predictor of postoperative surgical site infectious complications
    Sumanta Dutta
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    World J Surg 35:1017-25. 2011
    ..The aim of the present study was to examine serial postoperative WCC, albumin, and CRP and their diagnostic accuracy in case of infectious complications...
  94. doi request reprint The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty
    David Reid
    Department of Anaesthesia, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom
    Am J Clin Nutr 93:1006-11. 2011
    ..However, other lipid-soluble vitamins decrease during the systemic inflammatory response, and this response may confound the interpretation of plasma 25(OH)D...
  95. doi request reprint Prospective study of the relationship between the systemic inflammatory response, prognostic scoring systems and relapse-free and cancer-specific survival in patients undergoing potentially curative resection for renal cancer
    Sara Ramsey
    Department of Urology, Gartnavel General Hospital, Glasgow, UK
    BJU Int 101:959-63. 2008
    ....
  96. doi request reprint Assessment of vitamin E status in patients with systemic inflammatory response syndrome: plasma, plasma corrected for lipids or red blood cell measurements?
    Aikaterini T Vasilaki
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Clin Chim Acta 409:41-5. 2009
    ..The aim of the present study was to examine the longitudinal inter-relationships between plasma and red blood cell vitamin alpha-tocopherol in patients with systemic inflammatory response syndrome...
  97. ncbi request reprint Longitudinal study of resting energy expenditure, body cell mass and the inflammatory response in male patients with non-small cell lung cancer
    H R Scott
    Department of Respiratory Medicine, Stobhill NHS Trust, G21 3UW, Glasgow, UK
    Lung Cancer 32:307-12. 2001
    ..These results highlight the impact of the inflammatory response on the increase in the resting energy expenditure which precedes the onset of weight loss in patients with NSCLC...
  98. doi request reprint Clinical utility of the pretreatment glasgow prognostic score in patients with advanced inoperable non-small cell lung cancer
    Elaine Y L Leung
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow, United Kingdom
    J Thorac Oncol 7:655-62. 2012
    ..The aim of this study was to examine the clinical application of the pretreatment GPS in a mature cohort of patients with inoperable NSCLC...
  99. doi request reprint Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the pathogenesis of colorectal cancer
    Fraser Maxwell
    Department of Surgery, Institute of Cancer Sciences, University of Glasgow, Western Infirmary, Scotland, UK
    Clin Cancer Res 17:5573-81. 2011
    ..An understanding of the biology of aging and factors which regulate it may provide insight into cancer pathogenesis. The role of telomere biology in both the cancer and aging process could prove useful in this regard...
  100. doi request reprint POSSUM and its related models as predictors of postoperative mortality and morbidity in patients undergoing surgery for gastro-oesophageal cancer: a systematic review
    Sumanta Dutta
    University Department of Surgery, Faculty of Medicine, University of Glasgow, 4th Floor Walton Building, Glasgow Royal Infirmary, Castle Street, Glasgow G4 0SF, UK
    World J Surg 34:2076-82. 2010
    ..The aim was to undertake the first systematic review of the use of these models in gastro-oesophageal surgery patients...
  101. doi request reprint The impact of perioperative risk, tumor pathology and surgical complications on disease recurrence following potentially curative resection of colorectal cancer
    Colin H Richards
    University Department of Surgery, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom
    Ann Surg 254:83-9. 2011
    ..The objective of the study was to identify determinants of disease recurrence after potentially curative resection of colorectal cancer...