Harvey T McMahon

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Clathrin interacts specifically with amphiphysin and is displaced by dynamin
    H T McMahon
    Neurobiology Division, MRC LMB, Cambridge, UK
    FEBS Lett 413:319-22. 1997
  2. doi request reprint Molecular mechanism and physiological functions of clathrin-mediated endocytosis
    Harvey T McMahon
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Rev Mol Cell Biol 12:517-33. 2011
  3. doi request reprint Membrane curvature in synaptic vesicle fusion and beyond
    Harvey T McMahon
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB0 2QH, UK
    Cell 140:601-5. 2010
  4. ncbi request reprint COP and clathrin-coated vesicle budding: different pathways, common approaches
    Harvey T McMahon
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Cell Biol 16:379-91. 2004
  5. pmc FCHo proteins are nucleators of clathrin-mediated endocytosis
    William Mike Henne
    Medical Research Council, Laboratory of Molecular Biology MRC LMB, Hills Road, Cambridge CB2 0QH, UK
    Science 328:1281-4. 2010
  6. pmc Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly
    Eva M Schmid
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    PLoS Biol 4:e262. 2006
  7. ncbi request reprint Solitary and repetitive binding motifs for the AP2 complex alpha-appendage in amphiphysin and other accessory proteins
    Lene E Olesen
    Laboratory of Molecular Biology, Medical Research Council, Neurobiology Division, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 283:5099-109. 2008
  8. ncbi request reprint BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
    Brian J Peter
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 303:495-9. 2004
  9. pmc Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis
    Gerrit J K Praefcke
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 23:4371-83. 2004
  10. pmc EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking
    Ian G Mills
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    J Cell Biol 160:213-22. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Clathrin interacts specifically with amphiphysin and is displaced by dynamin
    H T McMahon
    Neurobiology Division, MRC LMB, Cambridge, UK
    FEBS Lett 413:319-22. 1997
    ..Dynamin, which interacts with the SH3 domain of Amph2, displaces clathrin from the N-terminus. We propose a model that may explain how clathrin and dynamin are recruited to non-overlapping sites of the coated pit...
  2. doi request reprint Molecular mechanism and physiological functions of clathrin-mediated endocytosis
    Harvey T McMahon
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Rev Mol Cell Biol 12:517-33. 2011
    ..Some modules can be used in other pathways, and additions or substitutions confer cell specificity and adaptability...
  3. doi request reprint Membrane curvature in synaptic vesicle fusion and beyond
    Harvey T McMahon
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB0 2QH, UK
    Cell 140:601-5. 2010
    ..We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events...
  4. ncbi request reprint COP and clathrin-coated vesicle budding: different pathways, common approaches
    Harvey T McMahon
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Cell Biol 16:379-91. 2004
    ..These themes point to the way in which evolutionarily conserved features underpin these diverse pathways...
  5. pmc FCHo proteins are nucleators of clathrin-mediated endocytosis
    William Mike Henne
    Medical Research Council, Laboratory of Molecular Biology MRC LMB, Hills Road, Cambridge CB2 0QH, UK
    Science 328:1281-4. 2010
    ..The FCHo F-BAR membrane-bending activity was required, leading to the proposal that FCHo1/2 sculpt the initial bud site and recruit the clathrin machinery for CCV formation...
  6. pmc Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly
    Eva M Schmid
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    PLoS Biol 4:e262. 2006
    ..However, proteins such as beta-arrestin (non-visual arrestin) and autosomal recessive hypercholesterolemia protein, which have direct clathrin interactions, will remain in the coated pits with their interacting receptors...
  7. ncbi request reprint Solitary and repetitive binding motifs for the AP2 complex alpha-appendage in amphiphysin and other accessory proteins
    Lene E Olesen
    Laboratory of Molecular Biology, Medical Research Council, Neurobiology Division, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 283:5099-109. 2008
    ..We describe the optimal sequence of the FXDXF motif using thermodynamic and structural data and show how sequence variation controls the affinities of these motifs for the alpha-appendage...
  8. ncbi request reprint BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
    Brian J Peter
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 303:495-9. 2004
    ..From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module...
  9. pmc Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis
    Gerrit J K Praefcke
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 23:4371-83. 2004
    ..In the final coated vesicle, most appendage binding partners are absent and thus the functional status of the appendage domain as an interaction hub is temporal and transitory giving directionality to vesicle assembly...
  10. pmc EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking
    Ian G Mills
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    J Cell Biol 160:213-22. 2003
    ....
  11. ncbi request reprint Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission
    Jennifer L Gallop
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 438:675-8. 2005
    ..The proposed locus of activity in endophilins includes the BAR domain, which has no catalytic site but instead senses positive membrane curvature. These data will prompt a re-evaluation of the molecular details of membrane budding...
  12. pmc Mechanism of endophilin N-BAR domain-mediated membrane curvature
    Jennifer L Gallop
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 25:2898-910. 2006
    ..Its presence defines an endophilin/nadrin subclass of BAR domains. We propose that N-BAR domains function as low-affinity dimers regulating binding partner recruitment to areas of high membrane curvature...
  13. ncbi request reprint Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature
    William Mike Henne
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB1 0QH, United Kingdom
    Structure 15:839-52. 2007
    ..This structure shows a distant relationship to curvature-sensing BAR modules, and suggests how similar coiled-coil architectures in the BAR superfamily have evolved to expand the repertoire of membrane-sculpting possibilities...
  14. pmc The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading
    Gary J Doherty
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Mol Biol Cell 22:4380-9. 2011
    ..We propose that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes...
  15. ncbi request reprint Curvature of clathrin-coated pits driven by epsin
    Marijn G J Ford
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 419:361-6. 2002
    ..We propose that this helix is inserted into one leaflet of the lipid bilayer, inducing curvature. On lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations...
  16. pmc Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis
    María José Sánchez-Barrena
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    PLoS ONE 7:e52401. 2012
    ..Further understanding of this protein may be key to understand the behaviour of leucocytes under physiological and pathological conditions...
  17. pmc The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate
    Rohit Mittal
    Medical Research Council MRC, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Biol Chem 285:19927-34. 2010
    ....
  18. pmc Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains
    Emmanuel Boucrot
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Cell 149:124-36. 2012
    ..This fission mechanism gives a new framework for understanding membrane scission in the absence of mechanoenzymes such as dynamin and suggests how Arf and Sar proteins work in vesicle scission...
  19. pmc Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission
    Michael Meinecke
    Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 0QH, United Kingdom
    J Biol Chem 288:6651-61. 2013
    ..Furthermore, GTP-dependent membrane scission by dynamin was dramatically elevated by BAR domain proteins. Thus, BAR domain proteins and dynamin act in synergy in membrane recruitment and GTP-dependent vesicle scission...
  20. doi request reprint Mechanisms of membrane fusion: disparate players and common principles
    Sascha Martens
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Nat Rev Mol Cell Biol 9:543-56. 2008
    ..We also highlight common principles that can be derived from the analysis of the role of these proteins...
  21. pmc Arf family GTP loading is activated by, and generates, positive membrane curvature
    Richard Lundmark
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Biochem J 414:189-94. 2008
    ..Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix...
  22. pmc The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway
    Richard Lundmark
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Curr Biol 18:1802-8. 2008
    ....
  23. ncbi request reprint The dynamin superfamily: universal membrane tubulation and fission molecules?
    Gerrit J K Praefcke
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Mol Cell Biol 5:133-47. 2004
    ..Here, we review the superfamily of dynamins and their related proteins, and propose that a common mechanism leading to membrane tubulation and/or fission could encompass their many varied functions...
  24. ncbi request reprint How synaptotagmin promotes membrane fusion
    Sascha Martens
    Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 0QH Cambridge, UK
    Science 316:1205-8. 2007
    ..Thus, synaptotagmin-1 triggers the fusion of docked vesicles by local Ca2+-dependent buckling of the plasma membrane together with the zippering of SNAREs. This mechanism may be widely used in membrane fusion...
  25. ncbi request reprint Integrating molecular and network biology to decode endocytosis
    Eva M Schmid
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 448:883-8. 2007
    ..This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation...
  26. doi request reprint Mediation, modulation, and consequences of membrane-cytoskeleton interactions
    Gary J Doherty
    MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom
    Annu Rev Biophys 37:65-95. 2008
    ....
  27. doi request reprint Mechanisms of endocytosis
    Gary J Doherty
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Annu Rev Biochem 78:857-902. 2009
    ..We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes...
  28. pmc Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling
    Rohit Mittal
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 103:18574-9. 2006
    ....
  29. ncbi request reprint Membrane curvature and mechanisms of dynamic cell membrane remodelling
    Harvey T McMahon
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 438:590-6. 2005
    ..This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement...
  30. ncbi request reprint Snap-shots of clathrin-mediated endocytosis
    Matthew K Higgins
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Trends Biochem Sci 27:257-63. 2002
    ..In this article, these techniques and the insights gained are reviewed, and their role in providing snap-shots of the stages of endocytosis in atomic detail is discussed...
  31. ncbi request reprint Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin
    Helen M Kent
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Structure 10:1139-48. 2002
    ..This observation explains the demonstrated brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi complex...