Samantha L McLean
Affiliation: University of Bradford
- Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contextsSamantha L McLean
School of Pharmacy, University of Bradford, Richmond Road, Bradford, UK
J Pain Palliat Care Pharmacother 27:132-5. 2013..There remains insufficient direct evidence to definitively support the use of haloperidol for the management of nausea and vomiting in palliative care. However, generalizing evidence from other clinical contexts may have some validity...
- D(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophreniaSamantha L McLean
Bradford School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD71DP, UK
Eur Neuropsychopharmacol 19:440-50. 2009..0 mg/kg) improved this PCP-induced deficit, an effect antagonised by SCH-23390 (P<0.05). These results suggest a role for D(1)-like receptors in improvement of cognitive function in paradigms of relevance to schizophrenia...
- PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female ratsSamantha L McLean
Bradford School of Pharmacy, University of Bradford, Bradford, UK
J Psychopharmacol 26:1265-70. 2012..001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors...
- Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: implications for therapy of cognitive dysfunction in schizophreniaSamantha L McLean
Bradford School of Pharmacy, The University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
Eur Neuropsychopharmacol 21:333-43. 2011..Nicotinic α7 acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia...
- Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the ratSamantha L McLean
The School of Pharmacy, University of Bradford, Bradford, BD7 1DP West Yorkshire, UK
Behav Brain Res 214:240-7. 2010..We evaluated the effects of asenapine, risperidone, and olanzapine on acute and subchronic psychotomimetic-induced disruption of cued reversal learning in rats...
- Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonismJoanna C Neill
The School of Pharmacy, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
Pharmacol Ther 128:419-32. 2010..This will facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of cognitive deficits and negative symptoms in schizophrenia...
- Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the ratSamantha L McLean
Bradford School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
Psychopharmacology (Berl) 206:403-14. 2009..5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia...
- A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female ratsSamantha L McLean
Bradford School of Pharmacy, The University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
Behav Brain Res 189:152-8. 2008..A loss in executive function and the ability to shift attention between stimulus dimensions is impaired in schizophrenia; this can be assessed in rodents by the perceptual attentional set-shifting task...