Roderick C McKenzie

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Selenium, ultraviolet radiation and the skin
    R C McKenzie
    Division of Dermatology, Department of Medical and Radiological Sciences, University of Edinburgh, Scotland, UK
    Clin Exp Dermatol 25:631-6. 2000
  2. ncbi request reprint Cutaneous leukemia inhibitory factor and its potential role in the development of skin tumors
    Roddie C McKenzie
    Epidermal Inflammation and Protection Group, Laboratory for Clinical and Molecular Virology, Royal Dick Veterinary College, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Dermatol Surg 30:279-90. 2004
  3. ncbi request reprint Selenium and the regulation of cell signaling, growth, and survival: molecular and mechanistic aspects
    Roderick C McKenzie
    Department of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, EH3 9YW, Scotland, UK
    Antioxid Redox Signal 4:339-51. 2002
  4. ncbi request reprint Mechanisms of selenium-mediated protection from photocarcinogenesis and cell death are not solely p53-dependent
    Roddie C McKenzie
    Epidermal Infection and Protection Group, Laboratory for Clinical and Molecular Virology, Royal Dick Veterinary School, Summerhall, University of Edinburgh, Edinburgh EH9 1QH, UK
    J Photochem Photobiol B 71:99-101. 2003
  5. ncbi request reprint Defective cyclic guanosine monophosphate-gated calcium channels and the pathogenesis of psoriasis
    Roddie C McKenzie
    Epidermal Inflammation and Protection Group, Department of Dermatology, University of Edinburgh, Edinburgh, Scotland, UK
    Acta Derm Venereol 83:414-8. 2003
  6. ncbi request reprint Aberrant signalling and transcription factor activation as an explanation for the defective growth control and differentiation of keratinocytes in psoriasis: a hypothesis
    R C McKenzie
    Epidermal Inflammation and Protection Group, Department of Dermatology, University of Edinburgh, Edinburgh, Scotland, UK
    Exp Dermatol 12:337-45. 2003
  7. doi request reprint Differential effects of doses and forms of dietary selenium on immune cell numbers in the skin of ultraviolet-irradiated and unirradiated mice
    Roderick C McKenzie
    The Epidermal Infection and Protection Group, Laboratory for Clinical and Molecular Virology, University of Edinburgh, Edinburgh, Scotland
    Biol Trace Elem Res 125:255-67. 2008
  8. ncbi request reprint Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Edinburgh EH3 9YW, UK
    Br J Dermatol 148:1001-9. 2003
  9. ncbi request reprint Selenium protects primary human keratinocytes from apoptosis induced by exposure to ultraviolet radiation
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Scotland
    Clin Exp Dermatol 28:294-300. 2003
  10. pmc Differential expression of selenoproteins by human skin cells and protection by selenium from UVB-radiation-induced cell death
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Biochem J 332:231-6. 1998

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Selenium, ultraviolet radiation and the skin
    R C McKenzie
    Division of Dermatology, Department of Medical and Radiological Sciences, University of Edinburgh, Scotland, UK
    Clin Exp Dermatol 25:631-6. 2000
    ..Although little is known about whether selenium can protect human skin from UV-induced damage, clinical studies are underway and the anti-oxidant may offer considerable benefits...
  2. ncbi request reprint Cutaneous leukemia inhibitory factor and its potential role in the development of skin tumors
    Roddie C McKenzie
    Epidermal Inflammation and Protection Group, Laboratory for Clinical and Molecular Virology, Royal Dick Veterinary College, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Dermatol Surg 30:279-90. 2004
    ..Accordingly, LIF may be a useful target for anticancer therapy and as a growth factor for normal skin during reconstructive surgery...
  3. ncbi request reprint Selenium and the regulation of cell signaling, growth, and survival: molecular and mechanistic aspects
    Roderick C McKenzie
    Department of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, EH3 9YW, Scotland, UK
    Antioxid Redox Signal 4:339-51. 2002
    ..We consider some aspects of the molecular mechanisms by which Se modulates cell growth, intracellular signaling, and gene transcription...
  4. ncbi request reprint Mechanisms of selenium-mediated protection from photocarcinogenesis and cell death are not solely p53-dependent
    Roddie C McKenzie
    Epidermal Infection and Protection Group, Laboratory for Clinical and Molecular Virology, Royal Dick Veterinary School, Summerhall, University of Edinburgh, Edinburgh EH9 1QH, UK
    J Photochem Photobiol B 71:99-101. 2003
    ..Moreover the non-physiologically high levels of selenium used in some studies leads us to question the relevance of such effects for selenium-induced photoprotection...
  5. ncbi request reprint Defective cyclic guanosine monophosphate-gated calcium channels and the pathogenesis of psoriasis
    Roddie C McKenzie
    Epidermal Inflammation and Protection Group, Department of Dermatology, University of Edinburgh, Edinburgh, Scotland, UK
    Acta Derm Venereol 83:414-8. 2003
    ....
  6. ncbi request reprint Aberrant signalling and transcription factor activation as an explanation for the defective growth control and differentiation of keratinocytes in psoriasis: a hypothesis
    R C McKenzie
    Epidermal Inflammation and Protection Group, Department of Dermatology, University of Edinburgh, Edinburgh, Scotland, UK
    Exp Dermatol 12:337-45. 2003
    ..The role of these systems in the development of the psoriatic phenotype and tests of these hypotheses are proposed...
  7. doi request reprint Differential effects of doses and forms of dietary selenium on immune cell numbers in the skin of ultraviolet-irradiated and unirradiated mice
    Roderick C McKenzie
    The Epidermal Infection and Protection Group, Laboratory for Clinical and Molecular Virology, University of Edinburgh, Edinburgh, Scotland
    Biol Trace Elem Res 125:255-67. 2008
    ..However, this conclusion may only apply to the experimental conditions chosen, and additional studies at different Se dosages and reduced intensities of chronic UVB exposure are required to confirm the results...
  8. ncbi request reprint Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Edinburgh EH3 9YW, UK
    Br J Dermatol 148:1001-9. 2003
    ..Preincubation with 200 nmol L-1 selenomethionine was similarly protective. Conclusions Selenite and selenomethionine protect keratinocytes from UVR-induced oxidative damage, but not from formation of UVR-induced excision repair sites...
  9. ncbi request reprint Selenium protects primary human keratinocytes from apoptosis induced by exposure to ultraviolet radiation
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Scotland
    Clin Exp Dermatol 28:294-300. 2003
    ..Collectively, this data suggests that selenium prevents UVR-induced cell death by inhibiting p53-independent cell death pathways...
  10. pmc Differential expression of selenoproteins by human skin cells and protection by selenium from UVB-radiation-induced cell death
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Biochem J 332:231-6. 1998
    ..5% to about 50% with both compounds. In all of the experiments sodium selenite was more potent than selenomethionine at providing protection from UVB radiation...
  11. ncbi request reprint Inhibition of ultraviolet B radiation-induced interleukin 10 expression in murine keratinocytes by selenium compounds
    T S Rafferty
    Department of Dermatology, University of Edinburgh, Royal Infirmary of Edinburgh, Lauriston Building, Edinburgh EH3 9YW, UK
    Br J Dermatol 146:485-9. 2002
    ..One possible mechanism of protection is that selenium can prevent oxidative stress-induced release of cytokines such as interleukin (IL)-10, which could suppress cell-mediated immunity...
  12. ncbi request reprint Selenium in the immune system
    John R Arthur
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    J Nutr 133:1457S-9S. 2003
    ..When the functions of all selenoproteins are described, only then will it be possible to fully understand their role in maintaining optimal immune function...
  13. pmc The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes
    Scott R Macfarlane
    Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, 27 Taylor Street, Glasgow G4 0NR, Scotland
    Br J Pharmacol 145:535-44. 2005
    ..7 These results suggest a predominant role for the InsP3/Ca2+ axis in the regulation of IKK signalling and NFkappaB transcriptional activation...