Ian McKeith

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
  2. ncbi request reprint Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?
    Fiona E Matthews
    Medical Resarch Council Biostatistics Unit, Institute of Public Health, Cambridge, United Kindom
    J Am Geriatr Soc 56:1424-33. 2008
  3. ncbi request reprint The clinical trial protocol of the Metrifonate in Alzheimer's Trial (MALT)
    I G McKeith
    Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 9:2-7. 1998
  4. ncbi request reprint Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop
    Ian G McKeith
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Alzheimers Dis 9:417-23. 2006
  5. ncbi request reprint Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide
    I McKeith
    Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Pract Neurol 7:374-82. 2007
  6. ncbi request reprint Galantamine for vascular dementia
    Ian McKeith
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE46BE, UK
    Lancet Neurol 1:210. 2002
  7. ncbi request reprint Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 18:94-100. 2004
  8. ncbi request reprint Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
    Ian McKeith
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Neurol 6:305-13. 2007
  9. ncbi request reprint Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
  10. ncbi request reprint Behavioural changes and psychological symptoms in dementia disorders
    Ian McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 4:735-42. 2005

Detail Information

Publications82

  1. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  2. ncbi request reprint Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?
    Fiona E Matthews
    Medical Resarch Council Biostatistics Unit, Institute of Public Health, Cambridge, United Kindom
    J Am Geriatr Soc 56:1424-33. 2008
    ..To determine the 2-year outcome from 16 different current classifications of mild cognitive impairment (MCI) in a population-based sample...
  3. ncbi request reprint The clinical trial protocol of the Metrifonate in Alzheimer's Trial (MALT)
    I G McKeith
    Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 9:2-7. 1998
    ..The protocol of MALT is discussed here. Full results of the study will be available in a separate publication...
  4. ncbi request reprint Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop
    Ian G McKeith
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Alzheimers Dis 9:417-23. 2006
    ..Virtu-ally unrecognised 20 years ago, DLB could within this decade be one of the best characterised and potentially treatable neurodegenerative disorders of late life...
  5. ncbi request reprint Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide
    I McKeith
    Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Pract Neurol 7:374-82. 2007
    ..Precise use of terminology and a clear understanding of the biological substrates underlying symptom formation are particularly helpful to both clinicians and patients...
  6. ncbi request reprint Galantamine for vascular dementia
    Ian McKeith
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE46BE, UK
    Lancet Neurol 1:210. 2002
  7. ncbi request reprint Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 18:94-100. 2004
    ..This may reflect the greater cholinergic deficits in areas of the brain responsible for visual hallucinations, offering greater potential for attentional improvement...
  8. ncbi request reprint Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
    Ian McKeith
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Neurol 6:305-13. 2007
    ..Diagnostic accuracy, positive and negative predictive values, and inter-reader agreement were the secondary endpoints and a subgroup of possible DLB patients was also included...
  9. ncbi request reprint Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
    ....
  10. ncbi request reprint Behavioural changes and psychological symptoms in dementia disorders
    Ian McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 4:735-42. 2005
    ..Progress in understanding the pathophysiological mechanisms underpinning behavioural and psychological symptoms in dementia will assist in developing more effective treatment approaches...
  11. ncbi request reprint Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia
    I G McKeith
    Department of Old Age Psychiatry, Institute for the Health of the Elderly, Wolfson Research Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Neurol Clin 18:865-902. 2000
    ..The relationship between dementia in PD and DLB has not been fully resolved but may be considered useful in terms of neuropathologic substrate, clinical features, and response to treatment...
  12. ncbi request reprint Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study
    I McKeith
    Institute for the Health of the Elderly, University of Newcastle upon Tyne, UK
    Lancet 356:2031-6. 2000
    ..Rivastigmine, a cholinesterase inhibitor, was tested in a group of clinically characterised patients with Lewy-body dementia...
  13. ncbi request reprint Clinical Lewy body syndromes
    I G McKeith
    Department of Old Age Psychiatry, Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Ann N Y Acad Sci 920:1-8. 2000
    ..LB disease should be considered in the differential diagnosis of a wide range of clinical presentations including episodic disturbances of consciousness, syncope, sleep disorders, and unexplained delirium...
  14. ncbi request reprint More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction
    Ian G McKeith
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:582-8. 2006
    ..The objective of this study was to compare functional impairments in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) and their relationship with motor and neuropsychiatric symptoms...
  15. ncbi request reprint Dementia in Parkinson's disease: common and treatable
    Ian McKeith
    Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 3:456. 2004
  16. ncbi request reprint Dementia with Lewy bodies and Parkinson's disease
    I G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Parkinsonism Relat Disord 10:S15-8. 2004
    ..Distinguishing them as separate disorders may be useful in clinical practice, but may be of limited value in terms of investigating and treating the underlying neurobiology...
  17. ncbi request reprint Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Psychopharmacol 25:997-1019. 2011
    ..Although results of pivotal studies are awaited, results to date have been equivocal and no disease-modifying agents are either licensed or can be currently recommended for clinical use...
  18. ncbi request reprint Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease
    David Burn
    Regional Neuroscience Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1899-907. 2006
    ..Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD...
  19. ncbi request reprint Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatum
    Melissa Ray
    Institute for Ageing and Health, University of Newcastle upon Tyne, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 372:220-5. 2004
    ....
  20. doi request reprint Determining the minimum clinically important differences for outcomes in the DOMINO trial
    Robert Howard
    King s College London, Institute of Psychiatry, Department of Old Age Psychiatry, London, UK
    Int J Geriatr Psychiatry 26:812-7. 2011
    ..Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these...
  21. ncbi request reprint Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis
    Mani Bhasin
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 22:890-5. 2007
    ..To compare efficacy of different cholinesterase inhibitors (ChEIs) for treating patients with dementia with Lewy bodies (DLB)...
  22. ncbi request reprint Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 40:1056-63. 2008
    ....
  23. ncbi request reprint Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging
    Emma J Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:842-9. 2006
    ..The objective of this study was to investigate cross-sectional and longitudinal white matter hyperintensity (WMH) changes in older subjects with clinically diagnosed dementia...
  24. ncbi request reprint Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies
    Elise Rowan
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:161-7. 2007
    ..We examined attention-enhancing effects of the cholinesterase inhibitor donepezil in Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) by means of open label study...
  25. ncbi request reprint Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 18:884-9. 2003
    ..Neurodegeneration within the cholinergic system is likely to mediate many of these motor problems, as well as playing a significant role in determining the neuropsychiatric symptomatology of both PDD and DLB...
  26. doi request reprint Examining carer stress in dementia: the role of subtype diagnosis and neuropsychiatric symptoms
    David R Lee
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 28:135-41. 2013
    ..What remains less clear is the impact of neuropsychiatric symptoms and subtype of dementia on carer stress and this study aimed to examine these...
  27. ncbi request reprint Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies
    Elaine Perry
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Neurology 60:1852-3. 2003
    ..The authors report a highly significant association between temporal cortex butyrylcholinesterase activity and the rate of cognitive decline in a prospectively studied, autopsy-confirmed dementia with Lewy bodies series...
  28. ncbi request reprint Levodopa use and sleep in patients with dementia with Lewy bodies
    Sophie Molloy
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Mov Disord 24:609-12. 2009
    ..Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. The use of levodopa does not appear to adversely affect subjective sleep measures or increase EDS in DLB patients...
  29. ncbi request reprint Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies
    Thanasak Teaktong
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE, UK
    Behav Brain Res 161:299-305. 2005
    ..Upregulation of M2 and M4 muscarinic receptors in cingulate and adjacent cortex may thus contribute to the development of psychosis in DLB, with potential implications for treatments with drugs acting on these receptors...
  30. ncbi request reprint The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life
    Louise Allan
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 22:230-7. 2006
    ....
  31. ncbi request reprint A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects
    John T O'Brien
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, U K
    Am J Psychiatry 161:2081-90. 2004
    ..This study determined whether cognitive impairments and structural brain changes in older depressed subjects, especially in the hippocampus, are related to hypercortisolemia...
  32. ncbi request reprint What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia
    Thais S C Minett
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 18:988-93. 2003
    ....
  33. ncbi request reprint A comparison of the efficacy of donepezil in Parkinson's disease with dementia and dementia with Lewy bodies
    Alan J Thomas
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:938-44. 2005
    ..Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) overlap in phenomenology and neurochemical deficits. We hypothesised they would not differ in their response to the cholinesterase inhibitor donepezil...
  34. ncbi request reprint Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Psychiatry Res 139:79-88. 2005
    ..We have identified important neural correlates of key clinical features in Lewy body dementia and postulate that the associations can be understood through the influence of the cholinergic system on attention...
  35. ncbi request reprint Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
    ..Dementia developing late in the course of PD shares many of the same clinical and pathological characteristics...
  36. ncbi request reprint A comparison of computerized and pencil-and-paper tasks in assessing cognitive function in community-dwelling older people in the Newcastle 85+ Pilot Study
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    J Am Geriatr Soc 55:1630-5. 2007
    ..To compare the acceptability and feasibility of computerized and pencil-and-paper tests of cognitive function in 85-year-old people...
  37. ncbi request reprint Why people see things that are not there: a novel Perception and Attention Deficit model for recurrent complex visual hallucinations
    Daniel Collerton
    South of Tyne and Wearside Mental Health NHS Trust, Bensham Hospital, Gateshead NE8 4YL, United Kingdom
    Behav Brain Sci 28:737-57; discussion 757-94. 2005
    ..Several tests of the model are indicated, together with a number of treatment options that it generates...
  38. ncbi request reprint Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia
    Daniel Collerton
    Bensham Hospital, Gateshead, UK
    Dement Geriatr Cogn Disord 16:229-37. 2003
    ..These findings need to be confirmed in prospective, longitudinal, clinicopathological studies...
  39. ncbi request reprint In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
    ..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects...
  40. ncbi request reprint Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 14:153-60. 2006
    ..Recurrent visual hallucinations (RVH) are common in both disorders. The authors have compared details of hallucination characteristics and associated neuropsychiatric features in DLB and PDD...
  41. ncbi request reprint Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 18:86-90. 2010
    ....
  42. doi request reprint Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Geriatr Psychiatry Neurol 23:54-62. 2010
    ..Principal component analysis captures additional sources of variance and if perfusion SPECT is the only scan available, this procedure may offer extra information...
  43. pmc Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies
    John Paul Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 78:1069-71. 2007
    ..As ChEi are frequently used in people with dementia, it is important to determine whether their use affects 123I-FP-CIT uptake in the striatum...
  44. ncbi request reprint The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 23:956-66. 2004
    ....
  45. ncbi request reprint Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease
    Frauke Boddy
    Institute for Ageing and Health, University of Newcastle, UK
    Int J Geriatr Psychiatry 22:529-35. 2007
    ..We investigated whether sleep dysfunction and EDS associate with motor phenotype in PD, PDD and DLB...
  46. ncbi request reprint A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 20:1124-40. 2008
    ....
  47. ncbi request reprint Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
    Margaret A Piggott
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Synapse 61:903-11. 2007
    ..That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB...
  48. ncbi request reprint Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 194:34-9. 2009
    ..123)I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease...
  49. ncbi request reprint Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia
    Margaret A Piggott
    IAH Research Laboratories, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:231-44. 2007
    ..D2 receptor binding did not vary with cognitive decline (MMSE) or visual hallucinations, but was significantly higher with increased extrapyramidal symptoms...
  50. ncbi request reprint Pathophysiology of synuclein aggregation in Lewy body disease
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, University of Newcastle, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 127:188-202. 2006
    ..Understanding the mechanisms leading to intraneuronal alpha-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease...
  51. ncbi request reprint Current treatment of dementia with Lewy bodies and dementia associated with Parkinson's disease
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, United Kingdom
    Mov Disord 18:S72-9. 2003
    ..Early identification of PD patients at greatest risk of developing dementia would permit early use of disease modifying treatments which represent the "golden fleece" management approach to these groups...
  52. ncbi request reprint Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls
    Emma J Burton
    The Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle, UK
    Brain 127:791-800. 2004
    ..This provides important information about the pattern of cerebral atrophy in Parkinson's disease and PDD...
  53. ncbi request reprint Advances in the diagnosis and treatment of dementia with Lewy bodies. Introduction
    Ian G McKeith
    Department of Old Age Psychiatry, Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 17:1-2. 2004
  54. ncbi request reprint Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies
    Clive G Ballard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Am J Psychiatry 161:843-9. 2004
    ..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies...
  55. ncbi request reprint Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 61:919-25. 2004
    ..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced...
  56. ncbi request reprint Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Brain 128:1267-76. 2005
    ..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease...
  57. ncbi request reprint Lewy body disease: thalamic cholinergic activity related to dementia and parkinsonism
    Iryna Ziabreva
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 27:433-8. 2006
    ..These findings show that significant thalamic presynaptic cholinergic deficits occur only in cases of combined cortical and subcortical neurodegeneration in which dementia developed after prolonged parkinsonism...
  58. ncbi request reprint Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies
    Michael J Firbank
    The Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:776-82. 2005
    ..Whilst perfusion studies have shown parieto-occipital hypoperfusion in DLB and PDD relative to controls, there have not been any longitudinal studies of perfusion changes in PDD and DLB...
  59. ncbi request reprint Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging
    Emma J Burton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Mov Disord 20:1571-6. 2005
    ..Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis...
  60. ncbi request reprint Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT
    Sean J Colloby
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 32:1176-85. 2005
    ....
  61. ncbi request reprint The dementia cognitive fluctuation scale, a new psychometric test for clinicians to identify cognitive fluctuations in people with dementia
    David R Lee
    Biomedical Research Building, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 22:926-35. 2014
    ....
  62. ncbi request reprint A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping
    Sean J Colloby
    Wolfson Research Centre, The Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 29:615-22. 2002
    ..In conclusion, we found evidence of frontal and parietal hypoperfusion in both AD and DLB, while temporal perfusion deficits were observed exclusively in AD and parieto-occipital deficits in DLB...
  63. ncbi request reprint Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT
    Sanjeet Pakrasi
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:907-13. 2007
    ..One of the most characteristic changes in Alzheimer's disease (AD) is a deficit in cortical cholinergic neurotransmission and associated receptor changes...
  64. ncbi request reprint Dementia with Lewy bodies
    Ian G McKeith
    Department of Old Age Psychiatry, Institute for the Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Br J Psychiatry 180:144-7. 2002
    ..Dementia with Lewy bodies (DLB) is a common dementia subtype that has only been recognised in the past decade and that remains widely underdiagnosed...
  65. ncbi request reprint Effects of hypertension on attention, memory, and executive function in older adults
    Brian K Saxby
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Health Psychol 22:587-91. 2003
    ..Using composite scores simplified data interpretation and suggested differential effects of hypertension on cognitive performance not clearly evident in individual test results...
  66. ncbi request reprint Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
    ..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...
  67. ncbi request reprint Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex
    Clive G Ballard
    Centre Development in Clinical Brain Aging, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, London, UK
    Conscious Cogn 11:461-74. 2002
    ....
  68. ncbi request reprint Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies
    Andrew B Singleton
    Medical Research Council University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 14:167-75. 2002
    ..This study demonstrates that DLB shares the APO epsilon4 allele with AD as a common risk factor, but that there are differences in the way the epsilon4 allele affects the phenotypic expression of disease...
  69. ncbi request reprint Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?
    Sanjeet Pakrasi
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:719-21. 2006
    ..There is little data on stopping cholinesterase inhibitors in Dementia with Lewy bodies (DLB). Equally, it is not known if increasing the dose of cholinesterase inhibitors may help neuropsychiatric symptoms in advanced DLB...
  70. pmc Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial
    Fiona E Shaw
    Department of Geriatric Medicine, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    BMJ 326:73. 2003
    ..To determine the effectiveness of multifactorial intervention after a fall in older patients with cognitive impairment and dementia attending the accident and emergency department...
  71. ncbi request reprint Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Neurobiol Dis 23:481-9. 2006
    ..05). This study demonstrates distinct combinations of subunits contributing to heteromeric nicotinic receptor binding in the human brain that are area/pathway specific and differentially affected by neurodegeneration...
  72. ncbi request reprint Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital, Rogaland, Stavanger, Norway
    J Clin Psychiatry 66:633-7. 2005
    ..Severe sensitivity to neuroleptic agents is a major clinical problem in dementia with Lewy bodies (DLB), but has not been determined in Parkinson's disease (PD) and PD with dementia (PDD)...
  73. ncbi request reprint Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force
    Bruno Dubois
    INSERM UPMC UMRS 610, Federation of Neurology, AP HP, Salpêtrière Hospital Université Paris6, Paris, France
    Mov Disord 22:2314-24. 2007
    ..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...
  74. ncbi request reprint Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effects
    Martina Ballmaier
    Laboratory of Neuroimaging, Department of Neurology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 23:325-35. 2004
    ..Further investigation of the influence of gender might provide a more comprehensive understanding of the pathophysiological differences underlying the two forms of dementia...
  75. ncbi request reprint Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies
    Dag Aarsland
    Rogaland Central Hospital, Psychiatric Clinic, PO Box 1163, Hillevaag, 4095 Stavanger, Norway
    J Geriatr Psychiatry Neurol 17:164-71. 2004
    ....
  76. ncbi request reprint Early cognitive change in the general population: how do different definitions work?
    Blossom C M Stephan
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, United Kingdom
    J Am Geriatr Soc 55:1534-40. 2007
    ..To explore the application of existing classifications of mild cognitive impairment (MCI) and associated states in a large population sample...
  77. ncbi request reprint APOA1 polymorphism influences risk for early-onset nonfamiliar AD
    Heike Vollbach
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Ann Neurol 58:436-41. 2005
    ..No influence of the +83/84bp polymorphism on the risk for AD was observed. These results suggest that variants of APOA1 might influence the onset and the risk for AD...
  78. ncbi request reprint Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions
    Nigel J Cairns
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neurosci Lett 341:177-80. 2003
    ....
  79. ncbi request reprint Dementia with Lewy bodies
    James B Leverenz
    Department of Veterans Affairs, Northwest Network Mental Illness and Parkinson s Disease Research, Education and Clinical Centers, Seattle, WA, 98108 USA
    Med Clin North Am 86:519-35. 2002
    ..Further research is needed to improve our understanding of the pathophysiology of this important dementing disorder, with the ultimate goal of improving clinical management of this disease...
  80. ncbi request reprint The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts
    Amanda J Myers
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892 3707, USA
    Neurobiol Dis 25:561-70. 2007
    ..We discuss these findings both in terms of the problems facing the dissection of the etiologies of complex traits and the pathogenesis of the tauopathies...
  81. ncbi request reprint Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 136:62-8. 2005
    ..Although our results are not universally negative, we were unable to replicate the results of previous studies and conclude that common variants or haplotypes of these variants in IDE are not major risk factors for LOAD...