Jill A McKay
Affiliation: University of Newcastle
Wakeling L, Ions L, Escolme S, Cockell S, Su T, Dey M, et al
. SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing. Hum Genomics. 2015;9:14 pubmed publisher
..Although the mechanism through which SIRT1 has these effects is yet to be uncovered, this action is likely to contribute to extended healthspan, for example under conditions of dietary restriction. ..
McKay J, Xie L, Adriaens M, Evelo C, Ford D, Mathers J. Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion. Nutrients. 2016;8: pubmed
..Only 25 differentially expressed genes were common between organs. Maternal folate intake during pregnancy influences fetal gene expression in a highly organ specific manner which may reflect organ-specific functions. ..
McKay J, Wong Y, Relton C, Ford D, Mathers J. Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut. Mol Nutr Food Res. 2011;55:1717-23 pubmed publisher
..We reported low folate supply in utero was associated with reduced global DNA methylation in the murine small intestine of adult offspring. We hypothesised that aberrant methylation would be observed during early development...
McKay J, Groom A, Potter C, Coneyworth L, Ford D, Mathers J, et al
. Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. PLoS ONE. 2012;7:e33290 pubmed publisher
..In addition, gestational length appears to be an important determinant of infant DNA methylation patterns. ..
McKay J, Adriaens M, Evelo C, Ford D, Mathers J. Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy. Mol Nutr Food Res. 2016;60:2031-42 pubmed publisher
..In response to maternal folate depletion, altered expression at the mRNA level was not associated with altered promoter methylation of the same gene in fetal liver. ..