A M McIntosh

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Declarative memory in unaffected adult relatives of patients with schizophrenia: a systematic review and meta-analysis
    Marie Claire Whyte
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Schizophr Res 78:13-26. 2005
  2. ncbi request reprint Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 61:1127-34. 2007
  3. doi request reprint Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
    Benjamin J Baig
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, United Kingdom
    Psychiatry Res 183:195-201. 2010
  4. pmc Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression
    Andrew M McIntosh
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Front Genet 3:116. 2012
  5. doi request reprint Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, UK
    Psychol Med 43:1197-206. 2013
  6. doi request reprint Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 73:938-43. 2013
  7. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
  8. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
  9. pmc Low birthweight and preterm birth in young people with special educational needs: a magnetic resonance imaging analysis
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    BMC Med 6:1. 2008
  10. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006

Detail Information

Publications63

  1. ncbi request reprint Declarative memory in unaffected adult relatives of patients with schizophrenia: a systematic review and meta-analysis
    Marie Claire Whyte
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Schizophr Res 78:13-26. 2005
    ..Investigation of sub-groups within these cohorts (e.g. age groups within or beyond the maximum age of risk) is recommended in order to identify deficits specific to the disease process...
  2. ncbi request reprint Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 61:1127-34. 2007
    ....
  3. doi request reprint Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
    Benjamin J Baig
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, United Kingdom
    Psychiatry Res 183:195-201. 2010
    ....
  4. pmc Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression
    Andrew M McIntosh
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Front Genet 3:116. 2012
    ..The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population...
  5. doi request reprint Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, UK
    Psychol Med 43:1197-206. 2013
    ..We tested whether depressive symptoms were related to reduced white-matter tract fractional anisotropy (FA), a measure of integrity, and then examined whether high neuroticism or low extraversion mediated this relationship...
  6. doi request reprint Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 73:938-43. 2013
    ..No study has determined whether cognitive impairments can be attributed to schizophrenia's polygenic architecture using data from GWAS...
  7. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
    ....
  8. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
    ..The CaliBrain project was designed to provide for an assessment of scanner differences at three centres in Scotland, and to assess the practicality of pooling scans from multiple-centres...
  9. pmc Low birthweight and preterm birth in young people with special educational needs: a magnetic resonance imaging analysis
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    BMC Med 6:1. 2008
    ..Our aim was to address these issues in a sample of young people receiving additional learning support...
  10. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
    ....
  11. doi request reprint Prefrontal gyral folding and its cognitive correlates in bipolar disorder and schizophrenia
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH105HF, UK
    Acta Psychiatr Scand 119:192-8. 2009
    ..We sought to address whether dorsal or ventral prefrontal gyrification is abnormal in bipolar disorder and to determine its diagnostic specificity and cognitive associations...
  12. doi request reprint Prefrontal function and activation in bipolar disorder and schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK
    Am J Psychiatry 165:378-84. 2008
    ..The authors sought to determine whether there are differences in language-associated prefrontal activation that discriminate bipolar disorder and schizophrenia...
  13. ncbi request reprint The effects of a neuregulin 1 variant on white matter density and integrity
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Mol Psychiatry 13:1054-9. 2008
    ..This finding is discussed in the context of NRG1 effects on neuronal migration, axon guidance and myelination...
  14. ncbi request reprint Maternal recall bias, obstetric history and schizophrenia
    A M McIntosh
    Royal Edinburgh Hospital, UK
    Br J Psychiatry 181:520-5. 2002
    ..This study sought to clarify the role of obstetric complications (OCs) and maternal recall bias for patients with first episodes of schizophrenia and those at increased risk of the disorder...
  15. doi request reprint Longitudinal volume reductions in people at high genetic risk of schizophrenia as they develop psychosis
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 69:953-8. 2011
    ..In the Edinburgh High Risk Study, we have followed up 162 individuals at high genetic risk of schizophrenia and 36 healthy control subjects over 10 years...
  16. doi request reprint White matter tractography in bipolar disorder and schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh United Kingdom
    Biol Psychiatry 64:1088-92. 2008
    ....
  17. ncbi request reprint White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK
    Biol Psychiatry 58:254-7. 2005
    ..This study sought to assess white matter density in patients and relatives with histories of bipolar disorder and/or schizophrenia...
  18. ncbi request reprint Compliance therapy for schizophrenia
    A M McIntosh
    University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK EH10 5HF
    Cochrane Database Syst Rev 3:CD003442. 2006
    ..Schizophrenia is a severe mental illness characterised by delusions and hallucinations. Antipsychotic drugs does reduce these symptoms, but at least half of people given these drugs do not comply with the treatment regimen prescribed...
  19. ncbi request reprint Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 186:378-85. 2005
    ..Neuropsychological abnormalities in schizophrenia are well replicated and are present in unaffected relatives. Cognitive findings in bipolar disorder are less clearly established...
  20. ncbi request reprint Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 56:544-52. 2004
    ..This study sought to examine these issues and clarify the associations of phenotypic expression and genetic liability...
  21. ncbi request reprint Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH 10 5HF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:76-83. 2006
    ..Genes for bipolar illness might have subtle effects on brain structure, which may need particularly large samples to detect...
  22. ncbi request reprint Set shifting and reversal learning in patients with bipolar disorder or schizophrenia
    J McKirdy
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 39:1289-93. 2009
    ..Deficits in reversal learning (RL) have also been shown in schizophrenia but not in bipolar disorder. This study sought to assess the specificity of these findings in a direct comparison of clinically stable patients with each disorder...
  23. doi request reprint Hippocampal function in schizophrenia and bipolar disorder
    J Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 40:761-70. 2010
    ..However, no previous studies have compared hippocampal activation in schizophrenia and bipolar disorder directly...
  24. doi request reprint A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia
    S Muñoz Maniega
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Schizophr Res 106:132-9. 2008
    ..We also found reduced FA in the ALIC of both patients and subjects at high risk of schizophrenia when compared to controls. This may be a possible indicator of the higher vulnerability of relatives to develop the disorder...
  25. doi request reprint fMRI changes over time and reproducibility in unmedicated subjects at high genetic risk of schizophrenia
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Psychol Med 39:1189-99. 2009
    ..e. state effects)...
  26. doi request reprint Anterior cingulate morphology in people at genetic high-risk of schizophrenia
    S M Meredith
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, United Kingdom
    Eur Psychiatry 27:377-85. 2012
    ..We also investigated the association of the cingulate sulcus (CS) and paracingulate sulcus (PCS) variants with intelligence quotient (IQ)...
  27. pmc The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Transl Psychiatry 2:e130. 2012
    ..The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD...
  28. ncbi request reprint A common neural system mediating two different forms of social judgement
    J Hall
    Division of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK
    Psychol Med 40:1183-92. 2010
    ..We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders...
  29. doi request reprint Orbitofrontal morphology in people at high risk of developing schizophrenia
    G Chakirova
    Imaging lab, Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Kennedy Tower, EH10 5HF, Edinburgh, Scotland, UK
    Eur Psychiatry 25:366-72. 2010
    ..Abnormalities of orbitofrontal cortex (OFC) sulcogyral patterns have been reported in schizophrenia, but it is not known if these predate psychosis...
  30. doi request reprint Tensor-based morphometry of cannabis use on brain structure in individuals at elevated genetic risk of schizophrenia
    K A Welch
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, UK
    Psychol Med 43:2087-96. 2013
    ..We used automated image analysis to compare brain structural changes over time in people at elevated risk of schizophrenia for familial reasons who did and did not use cannabis...
  31. doi request reprint Specific cognitive deficits in a group at genetic high risk of schizophrenia
    M O'CONNOR
    University of Edinburgh, UK
    Psychol Med 39:1649-55. 2009
    ....
  32. ncbi request reprint Connecting the brain and new drug targets for schizophrenia
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland, UK
    Curr Pharm Des 15:2615-31. 2009
    ..We conclude that substantial work needs to be done on standardising connectivity analyses across laboratories and that disconnectivity studies should be an integral part of drug discovery programmes...
  33. ncbi request reprint Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant
    Ajay Mirakhur
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom
    Biol Psychiatry 66:293-7. 2009
    ..The present study examined longitudinal trends in prefrontal gyrification index (GI) in bipolar disorder and the effect of BDNF genotype...
  34. pmc Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential
    S M Lawrie
    Division of Psychiatry, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 153:S120-4. 2008
    ..We provide examples of how these advances in our knowledge could lead to the development of new treatments for psychosis...
  35. ncbi request reprint Progressive gray matter loss in patients with bipolar disorder
    T William J Moorhead
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 62:894-900. 2007
    ..We sought to address these uncertainties in a prospective cohort study of people with bipolar I disorder...
  36. doi request reprint Genetic risk for white matter abnormalities in bipolar disorder
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Int Rev Psychiatry 21:387-93. 2009
    ..These findings are discussed in the context of the current literature, along with possible future research directions...
  37. doi request reprint Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms
    H C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    J Affect Disord 109:99-106. 2008
    ..The current study sought to investigate the neural correlates of depression in these subjects. We hypothesised abnormal activation of dorsolateral prefrontal regions in those at high risk with depression...
  38. ncbi request reprint A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Nat Neurosci 9:1477-8. 2006
    ..We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ...
  39. doi request reprint Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1474-82. 2010
    ..BDNF may therefore be one of the heritable factors involved in the development of abnormal prefrontal function in schizophrenia. © 2010 Wiley-Liss, Inc...
  40. ncbi request reprint The 'continuum of psychosis': scientifically unproven and clinically impractical
    Stephen M Lawrie
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 197:423-5. 2010
    ..Systematic studies are needed to evaluate which of a range of plausible approaches to the classification of psychosis is most useful before change could be justified...
  41. doi request reprint Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia
    Liana Romaniuk
    University of Edinburgh, Royal Edinburgh Hospital, Scotland
    Arch Gen Psychiatry 67:1246-54. 2010
    ..Recent theories have suggested that the inappropriate activation of limbic motivational systems in response to neutral stimuli may underlie the development of delusions in schizophrenia...
  42. pmc DISC1 in schizophrenia: genetic mouse models and human genomic imaging
    Mandy Johnstone
    Department of Psychiatry, The Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF, UK
    Schizophr Bull 37:14-20. 2011
    ..Here, we focus on the growing literature relating genetic variation in the DISC1 pathway to functional and structural studies of the brain in humans and in the mouse...
  43. ncbi request reprint Brain-behaviour relationships in people at high genetic risk of schizophrenia
    G Katherine S Lymer
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 33:275-85. 2006
    ..These results suggest complex and changing patterns of structural-functional relationships in those subjects at high-risk of schizophrenia...
  44. ncbi request reprint A neuropsychological investigation into 'Theory of Mind' and enhanced risk of schizophrenia
    Dominic Marjoram
    Division of Psychiatry, Edinburgh University, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Psychiatry Res 144:29-37. 2006
    ..The observed ToM deficits measured by this battery of ToM tasks appeared to be related to state effects rather than enhanced risk of schizophrenia...
  45. ncbi request reprint A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia
    Dominic Marjoram
    University of Edinburgh, Division of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 31:1850-8. 2006
    ..This study is the first time relatives of individuals with schizophrenia have been imaged using a ToM paradigm, and the results provide evidence of both a state and state-mediated trait effect...
  46. doi request reprint Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:428-33. 2008
    ..Preliminary evidence in healthy control subjects has implicated genetic variation in the DAOA gene in the modulation of hippocampal complex and prefrontal cortex activation...
  47. doi request reprint Functional imaging of emotional memory in bipolar disorder and schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Bipolar Disord 11:840-56. 2009
    ..We also investigate associations between activation levels and symptom severity across the disorders...
  48. ncbi request reprint Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: a voxel-based study
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    Neuroimage 35:1181-91. 2007
    ....
  49. ncbi request reprint Overactivation of fear systems to neutral faces in schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:70-3. 2008
    ..We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli...
  50. pmc Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk
    Stephen M Lawrie
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Bull 34:330-40. 2008
    ..Overall, the literature supports the view that there are measurable changes in brain structure and function during the genesis of the disorder, which provide opportunities for early detection and intervention...
  51. ncbi request reprint Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies
    Andrew C Stanfield
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Eur Psychiatry 23:289-99. 2008
    ..Structural brain abnormalities have been described in autism but studies are often small and contradictory. We aimed to identify which brain regions can reliably be regarded as different in autism compared to healthy controls...
  52. doi request reprint White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
    Jessika E Sussmann
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:11-8. 2009
    ..Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders. We aim to address the diagnostic specificity of white matter abnormalities in these disorders...
  53. ncbi request reprint Obstetric complications and mild to moderate intellectual disability
    Jessika E Sussmann
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 194:224-8. 2009
    ..Mild to moderate intellectual disability affects 2.5% of the general population and is associated with an increased risk of several psychiatric disorders. Most cases are of unknown aetiology although genetic factors have an important role...
  54. doi request reprint Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion
    Prerona Mukherjee
    Division of Psychiatry, University of Edinburg, Edinburg, United Kingdom
    Psychiatry Res 191:182-8. 2011
    ..Together, these effects show significant differences in the neural substrate for fear processing with genetic variation in BDNF...
  55. ncbi request reprint Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development
    Jonathan M Harris
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 62:722-9. 2007
    ....
  56. doi request reprint Associative learning and the genetics of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Edinburgh, EH10 5HF, UK
    Trends Neurosci 32:359-65. 2009
    ..We illustrate how genetic variation in genes from these classes can contribute to the development of psychosis using data from the Edinburgh High Risk Study of schizophrenia...
  57. ncbi request reprint Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder
    Andrew C Stanfield
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:135-44. 2009
    ..We examined the presence and location of ventral prefrontal abnormalities in a large sample of individuals with bipolar disorder and their relationship to gender, psychotic symptoms, and age...
  58. doi request reprint The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia
    Goultchira Chakirova
    The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Psychiatry Res 192:20-8. 2011
    ..These findings may provide a better understanding of the neural effects of DISC1 variants and on the pathophysiology of schizophrenia and bipolar disorder...
  59. ncbi request reprint Reduced binocular depth inversion in regular cannabis users
    David M Semple
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, UK
    Pharmacol Biochem Behav 75:789-93. 2003
    ..Compared to the other neuropsychological tests used, the BDII appears to be a more sensitive tool for the detection of subtle impairments in visual information processing related to chronic cannabis use...
  60. ncbi request reprint Cannabis as a risk factor for psychosis: systematic review
    David M Semple
    Division of Psychiatry, University of Edinburgh, Edinburgh, UK
    J Psychopharmacol 19:187-94. 2005
    ..Addressing cannabis use, particularly in vulnerable populations, is likely to have beneficial effects on psychiatric morbidity...
  61. ncbi request reprint Working memory in schizophrenia: a meta-analysis
    N F Forbes
    University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 39:889-905. 2009
    ..There were, however, no clear differences across subdomains or between particular working memory tasks. There was substantial heterogeneity across results that could only be partly explained...
  62. ncbi request reprint Transcranial magnetic stimulation for auditory hallucinations in schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Kennedy Tower, Morningside Park, Edinburgh EH10 5HF, UK
    Psychiatry Res 127:9-17. 2004
    ..Previous positive studies could not be replicated with these parameters. TMS is safe if applied within the protocol used...
  63. doi request reprint Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task
    Viktoria Eleni Gountouna
    Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Neuroimage 49:552-60. 2010
    ....