Iain B McInnes

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study
    Hilary A Capell
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
    Ann Rheum Dis 66:235-41. 2007
  2. ncbi request reprint New cytokine targets in inflammatory rheumatic diseases
    Laura Connell
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Best Pract Res Clin Rheumatol 20:865-78. 2006
  3. ncbi request reprint Psoriatic arthritis: current topics
    David McCarey
    Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow, Scotland, G31 2ER, UK
    Curr Rheumatol Rep 9:442-8. 2007
  4. pmc Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?
    David W McCarey
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK
    Arthritis Res Ther 7:55-61. 2005
  5. pmc Synovial tissue response to treatment in psoriatic arthritis
    Veronica Codullo
    University of Glasgow, UK
    Open Rheumatol J 5:133-7. 2011
  6. ncbi request reprint A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62
    Iain B McInnes
    Department of Immunology and Center for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom
    J Immunol 171:2127-33. 2003
  7. pmc Leukotrienes, mast cells, and T cells
    Iain B McInnes
    Centre for Rheumatic Diseases, University of Glasgow, Scotland, UK
    Arthritis Res Ther 5:288-9. 2003
  8. ncbi request reprint Rheumatoid arthritis. From bench to bedside
    I B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Rheum Dis Clin North Am 27:373-87. 2001
  9. ncbi request reprint Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland
    Curr Rheumatol Rep 6:336-42. 2004
  10. pmc Interleukin-18: a therapeutic target in rheumatoid arthritis?
    Iain B McInnes
    Division of Immunology, Infection and Inflammation, University of Glasgow, UK
    Arthritis Res Ther 7:38-41. 2005

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. pmc Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study
    Hilary A Capell
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
    Ann Rheum Dis 66:235-41. 2007
    ..Aim: To establish whether a combination of SASP and MTX is superior to either drug alone in patients with rheumatoid arthritis with a suboptimal response to 6 months of SASP...
  2. ncbi request reprint New cytokine targets in inflammatory rheumatic diseases
    Laura Connell
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Best Pract Res Clin Rheumatol 20:865-78. 2006
    ..Since we wish to reflect the current predominant research effort, we will focus primarily on rheumatoid arthritis (RA) based studies...
  3. ncbi request reprint Psoriatic arthritis: current topics
    David McCarey
    Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow, Scotland, G31 2ER, UK
    Curr Rheumatol Rep 9:442-8. 2007
    ..Finally, new insights into the disorder's genetic antecedents are emerging as more cohorts of patients undergo advanced genetic screening methods...
  4. pmc Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?
    David W McCarey
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK
    Arthritis Res Ther 7:55-61. 2005
    ..Together with their known vasculoprotective effects, this growing body of evidence provides compelling support for longer-term trials of statin therapy in human disease such as rheumatoid arthritis...
  5. pmc Synovial tissue response to treatment in psoriatic arthritis
    Veronica Codullo
    University of Glasgow, UK
    Open Rheumatol J 5:133-7. 2011
    ..The availability of less invasive and reproducible analysis techniques to obtain and evaluate synovial biopsies will further enhance the utility of this approach in due course...
  6. ncbi request reprint A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62
    Iain B McInnes
    Department of Immunology and Center for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom
    J Immunol 171:2127-33. 2003
    ..ES-62 represents one such mechanism. We now provide proof of concept that parasite-derived immunomodulatory strategies offer a novel therapeutic opportunity in inflammatory arthritis...
  7. pmc Leukotrienes, mast cells, and T cells
    Iain B McInnes
    Centre for Rheumatic Diseases, University of Glasgow, Scotland, UK
    Arthritis Res Ther 5:288-9. 2003
  8. ncbi request reprint Rheumatoid arthritis. From bench to bedside
    I B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Rheum Dis Clin North Am 27:373-87. 2001
    ..Through this rapid evolution, close communication between physician and scientist is essential...
  9. ncbi request reprint Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland
    Curr Rheumatol Rep 6:336-42. 2004
    ..The possibility that some may be useful in partial responders to tumor necrosis factor blocking agents or in synergy with the latter is discussed...
  10. pmc Interleukin-18: a therapeutic target in rheumatoid arthritis?
    Iain B McInnes
    Division of Immunology, Infection and Inflammation, University of Glasgow, UK
    Arthritis Res Ther 7:38-41. 2005
    ..The aim of this article is to briefly review the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to the relative merits of IL-18 as an alternative to existing targets...
  11. pmc New strategies to control inflammatory synovitis: interleukin 15 and beyond
    I B McInnes
    Centre for Rheumatic Diseases, Division of Immunology, Infection and Inflammation, Department of Medicine, University of Glasgow, UK
    Ann Rheum Dis 62:ii51-4. 2003
  12. pmc Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells
    I B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, University of Glasgow, Glasgow, UK
    Arthritis Res 2:374-8. 2000
    ..Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets...
  13. ncbi request reprint Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland
    Curr Pain Headache Rep 9:405-11. 2005
    ..The possibility that some may be useful in partial responders to tumor necrosis factor blocking agents or in synergy with the latter is discussed...
  14. ncbi request reprint Cytokine networks--towards new therapies for rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, University of Glasgow, UK
    Nat Clin Pract Rheumatol 1:31-9. 2005
    ..As therapeutic goals move from disease control towards remission induction, development of the capacity for cytokine targeting to modify the underlying immune dysregulation remains a major priority...
  15. ncbi request reprint Cytokines in the pathogenesis of rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 7:429-42. 2007
    ..Here, we discuss the crucial effector function of cytokines in the immunological processes that are central to the pathogenesis of rheumatoid arthritis...
  16. ncbi request reprint Interleukin-15: a new cytokine target for the treatment of inflammatory diseases
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Curr Opin Pharmacol 4:392-7. 2004
    ..These data hold promise for therapeutic targeting in ongoing human studies and those in the near future...
  17. doi request reprint Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, GBRC, University of Glasgow, Glasgow, United Kingdom
    Circ Res 107:650-8. 2010
    ..The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear...
  18. doi request reprint IL-33 induces skin inflammation with mast cell and neutrophil activation
    Axel J Hueber
    Glasgow Biomedical Research Centre, University of Glasgow, UK
    Eur J Immunol 41:2229-37. 2011
    ..These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis...
  19. doi request reprint IL-33 exacerbates autoantibody-induced arthritis
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    J Immunol 184:2620-6. 2010
    ....
  20. doi request reprint Identifying the cells breaching self-tolerance in autoimmunity
    Robert A Benson
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:6378-85. 2010
    ..We further demonstrate the importance of this finding by clinically relevant, therapeutic manipulation of conventional DC function, resulting in decreased autoimmune phenotype and disease severity...
  21. doi request reprint IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
    Mariola Kurowska-Stolarska
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 183:6469-77. 2009
    ..Taken together, we demonstrate here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation...
  22. ncbi request reprint Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells
    Andrew M Platt
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 185:1558-67. 2010
    ..Thus, we provide a novel mode of action for abatacept with profound implications for its potential usefulness in early inflammatory arthropathies associated with autoantibody expression...
  23. doi request reprint Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein E-deficient mice
    Neil Macritchie
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom
    Arterioscler Thromb Vasc Biol 32:2569-79. 2012
    ..Results from animal models are controversial, with pDCs seen to inhibit or promote lesion development depending on the experimental settings. Here, we investigated the role of pDCs in atherosclerosis in apolipoprotein E-deficient mice...
  24. pmc IL-33 exacerbates antigen-induced arthritis by activating mast cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 105:10913-8. 2008
    ..Thus, this IL-1 superfamily member represents a therapeutic target for RA...
  25. doi request reprint Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis
    Darren L Asquith
    Glasgow Biomedical Research Center, Division of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow, UK
    Arthritis Rheum 60:2655-65. 2009
    ..This study was therefore undertaken to explore the biologic mechanisms of LXRs in vivo and in vitro in an experimental inflammatory arthritis model...
  26. pmc IL-33 reduces the development of atherosclerosis
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, UK
    J Exp Med 205:339-46. 2008
    ..In conclusion, IL-33 may play a protective role in the development of atherosclerosis via the induction of IL-5 and ox-LDL antibodies...
  27. ncbi request reprint A novel anti-inflammatory role for simvastatin in inflammatory arthritis
    Bernard P Leung
    Department of Immunology, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Immunol 170:1524-30. 2003
    ..These data clearly illustrate the therapeutic potential of statin-sensitive pathways in inflammatory arthritis...
  28. ncbi request reprint Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1
    Clive S McKimmie
    Division of Immunology, Grasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 181:8171-81. 2008
    ..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes...
  29. doi request reprint A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration
    Clive S McKimmie
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow, United Kingdam
    Blood 113:4224-31. 2009
    ..These data highlight a novel role for TLR ligands, such as BLP, in regulating leukocyte retention and migration away from innate immune lesions via discrete constitutive and inflammatory chemokine receptor regulation...
  30. doi request reprint Interleukin-21--a biomarker of importance in predicting myocardial function following acute infarction?
    Robin A P Weir
    Cardiology Department, Hairmyres Hospital, Lanarkshire, Scotland, UK
    Cytokine 60:220-5. 2012
    ..Interleukin-21 (IL-21) plays a key role in immunoregulation; whether IL-21 is associated with left ventricular (LV) remodelling after AMI is unknown...
  31. doi request reprint The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release
    Darren Lee Asquith
    Department of Immunology, Infection and Inflammation, College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 72:2024-31. 2013
    ..Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood...
  32. doi request reprint Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane
    Anne Crilly
    Institute of Infection, Immunity and Infl ammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 70:1130-7. 2011
    ..To date, few data have directly addressed whether synovial cytokine and chemokine production is modified by PDE4...
  33. doi request reprint Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis
    Darren L Asquith
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 62:472-7. 2010
    ..To determine whether elevated serum lipid levels resulting from feeding animals a high-fat diet can affect the inflammatory process in C57BL/6 (B6) wild-type (WT) and B6 ApoE(-/-) mouse models of collagen-induced arthritis (CIA)...
  34. ncbi request reprint Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis
    Sarah L Jongbloed
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    J Immunol 182:963-8. 2009
    ..pDC may offer a net anti-inflammatory function in the context of articular breach of tolerance. Such data will be vital in informing DC modulatory/therapeutic approaches...
  35. ncbi request reprint Chemoattraction of human T cells by IL-18
    Mousa Komai-Koma
    Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, United Kingdom
    J Immunol 170:1084-90. 2003
    ..These data therefore demonstrate for the first time lymphocyte chemoattractant properties of a member of the IL-1 cytokine family and its relevance in inflammatory diseases...
  36. ncbi request reprint IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    Wanda Niedbala
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:3021-9. 2007
    ..Thus, IL-35 is a novel anti-inflammatory cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development...
  37. ncbi request reprint Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis
    Alistair G Tindell
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Room 405, Level 4, McGregor Building, Western Infirmary, Dumbarton Road, Glasgow, Scotland, G11 6NT, UK
    Rheumatol Int 32:3077-86. 2012
    ..Secretion of this cytokine was dose-dependently inhibited by ENMD-1068, providing evidence of a functional role for PAR-2 in promoting synovitis...
  38. pmc Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice
    Lindsay M Maclellan
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 63:3897-907. 2011
    ..The aim of this study was to explore an entirely novel route of immunoglobulin-mediated regulation, involving simultaneous suppression of the inflammatory and erosive processes in the synovium...
  39. ncbi request reprint IL-33 is a chemoattractant for human Th2 cells
    Mousa Komai-Koma
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:2779-86. 2007
    ..These data therefore demonstrate that IL-33 is a selective Th2 chemoattractant associated with the pro-inflammatory property of this novel cytokine...
  40. doi request reprint Embracing novel cytokines in RA - complexity grows as does opportunity!
    Axel J Hueber
    Centre for Rheumatic Diseases, Division of Immunology, Infection and Inflammation, 120 University Place Glasgow, G12 8TA, U K
    Best Pract Res Clin Rheumatol 24:479-87. 2010
    ....
  41. doi request reprint Mast cells express IL-17A in rheumatoid arthritis synovium
    Axel J Hueber
    Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:3336-40. 2010
    ....
  42. doi request reprint Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease
    Agapitos Patakas
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Immunol Lett 138:38-46. 2011
    ....
  43. ncbi request reprint Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells
    Pasquale Maffia
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    J Immunol 173:151-6. 2004
    ..Furthermore, the ability to track these cells in vivo will make feasible studies revealing the dynamic role of T cells in arthritis...
  44. ncbi request reprint A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation
    Bernard P Leung
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, United Kingdom
    J Immunol 169:7071-7. 2002
    ..Furthermore, this disease process is mediated through both adaptive and innate effects of DCs; first, priming of autoreactive T cells and, second, induction of local inflammation via mediators such as TNF...
  45. pmc Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?
    Ashley M Miller
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e47830. 2012
    ..Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes...
  46. pmc Th17 effector cells support B cell responses outside of germinal centres
    Agapitos Patakas
    Institute of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e49715. 2012
    ..These data indicate that, Th17 cells have a more significant role earlier in the initiation/development of the germinal centre response and/or germinal centre-independent events, consistent with their early effector status...
  47. pmc A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo
    Vivienne B Gibson
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Blood 119:2545-51. 2012
    ..Thus, we provide the first demonstration of a method for repeated, noninvasive, in vivo imaging of lymphocyte behavior...
  48. ncbi request reprint A novel therapy of murine collagen-induced arthritis with soluble T1/ST2
    Bernard P Leung
    Division of Immunology, Infection, and Inflammation and Centre for Rheumatic Diseases, Royal Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    J Immunol 173:145-50. 2004
    ..Together these results demonstrate that sST2-Fc may provide a novel approach in treating chronic autoimmune conditions by inhibiting the release of proinflammatory cytokines...
  49. ncbi request reprint The role of innate mediators in inflammatory response
    Foo Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, G11 6NT, UK
    Mol Immunol 38:887-90. 2002
    ..Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis...
  50. ncbi request reprint Prior elevation of IL-18 promotes rapid early IFN-gamma production during staphylococcal infection
    Shauna Culshaw
    Department of Immunology and Bacteriology, Western Infirmary, Glasgow, UK
    Eur J Immunol 35:1438-44. 2005
    ....
  51. doi request reprint An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis
    Veronica Codullo
    Institute of Infection, Immunity and Infl ammation, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 70:1115-21. 2011
    ..The atypical chemokine receptor D6 has a critical role in this physiological balance. To explore potential deregulation of this system in SSc, inflammatory chemokine and D6 expression were compared with that in healthy controls (HC)...
  52. doi request reprint Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA
    Derek Baxter
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK
    Immunol Cell Biol 90:288-92. 2012
    ..Together, these observations open an exciting new vista of understanding and therapeutic opportunity for this difficult and common disease...
  53. doi request reprint Immunomodulatory role of proteinase-activated receptor-2
    Anne Crilly
    School of Science, University of the West of Scotland, Paisley PA1 2BE, Scotland, UK
    Ann Rheum Dis 71:1559-66. 2012
    ..Using the collagen-induced arthritis model (CIA) the authors have explored the capacity of PAR(2) to regulate adaptive immune pathways that could promote autoimmune mediated articular damage...
  54. pmc MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    Mariola Kurowska-Stolarska
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 108:11193-8. 2011
    ..Our data therefore identify a role of miR-155 in clinical and experimental arthritis and suggest that miR-155 may be an intriguing therapeutic target...
  55. doi request reprint Simultaneous activation of the liver X receptors (LXRα and LXRβ) drives murine collagen-induced arthritis disease pathology
    Darren L Asquith
    Glasgow Biomedical Research Centre, Institute of Immunity, Infection and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK
    Ann Rheum Dis 70:2225-8. 2011
    ..It has previously been shown that dual activation of the Liver X Receptors (LXRα and LXRβ) by the agonist, GW3965, enhances pathology in a murine model of collagen-induced arthritis...
  56. doi request reprint Characterization of the anticollagen antibody response in a new model of chronic polyarthritis
    Paola Conigliaro
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 63:2299-308. 2011
    ..This study was undertaken to create a new model of chronic autoimmune polyarthritis and characterize the associated CII-specific B cell response...
  57. ncbi request reprint TNF-blocking therapies: an alternative mode of action?
    Brian S W Choo-Kang
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Trends Immunol 26:518-22. 2005
    ....
  58. pmc Murine neutrophils present Class II restricted antigen
    Shauna Culshaw
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Immunol Lett 118:49-54. 2008
    ..These studies demonstrate that murine neutrophils present MHC Class II-restricted peptides and induce T cell proliferation, confirming findings in human neutrophils, and demonstrate a novel pro inflammatory effect of murine neutrophils...
  59. ncbi request reprint Emerging cytokine targets in rheumatoid arthritis
    Darren L Asquith
    Glasgow Biomedical Research Centre, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Curr Opin Rheumatol 19:246-51. 2007
    ..Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive to remission induction, requires that further therapeutic targets be identified...
  60. doi request reprint Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis
    William R Ferrell
    University of Glasgow, UK
    Ann Rheum Dis 69:2051-4. 2010
    ..This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential therapeutic target in osteoarthritis...
  61. doi request reprint Animal models of rheumatoid arthritis
    Darren L Asquith
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 39:2040-4. 2009
    ..Here, we describe these animal models and discuss their advantages and limitations...
  62. ncbi request reprint Expression and alternative processing of IL-18 in human neutrophils
    Susan E Robertson
    CRD, Division of Immunology, Infection and Inflammation, Glasgow Royal Infirmary, Glasgow, UK
    Eur J Immunol 36:722-31. 2006
    ..Through cytosolic, membrane or secretory expression of such processing enzymes, together with generation of IL-18 itself, neutrophils likely play a critical role in regulating IL-18 activities during early innate immune responses...
  63. ncbi request reprint A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
    Anne McKay
    Division of Immunology, Infection, and Inflammation, Section of Respiratory Medicine, University of Glasgow, Glasgow, United Kingdom
    J Immunol 172:2903-8. 2004
    ..Simvastatin treatment did not alter serum total IgE or OVA-specific IgG1 and IgG2a levels. These data demonstrate the therapeutic potential of statin-sensitive pathways in allergic airways disease...
  64. doi request reprint Role for TNF in atherosclerosis? Lessons from autoimmune disease
    Gayle E McKellar
    Center for Rheumatic Diseases, Glasgow, Royal Infirmary, Glasgow, UK
    Nat Rev Cardiol 6:410-7. 2009
    ..Moreover, such data obtained in chronic inflammatory diseases likely have relevance to primary atherosclerosis...
  65. pmc MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice
    Ashley M Miller
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 8:e72324. 2013
    ..Together these data indicate that miR-155 plays a pivotal role regulating lipid metabolism in liver and that its deregulation may lead to hepatic steatosis in patients with diabetes. ..
  66. doi request reprint Hypoxia: a critical regulator of early human tendinopathy
    Neal L Millar
    Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK
    Ann Rheum Dis 71:302-10. 2012
    ..To seek evidence for the role of hypoxia in early human tendinopathy, and thereafter to explore mechanisms whereby tissue hypoxia may regulate apoptosis, inflammatory mediator expression and matrix regulation in human tenocytes...
  67. doi request reprint Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function
    Gao Xuzhu
    Institute of Infection, Immunity and Infl ammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 71:129-35. 2012
    ..As such, it could mediate anti-inflammatory properties of the latter and offer novel therapeutic utility in is own right...
  68. ncbi request reprint Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
    David W McCarey
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Lancet 363:2015-21. 2004
    ..We postulated that statins might reduce inflammatory factors in rheumatoid arthritis and modify surrogates for vascular risk...
  69. ncbi request reprint Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis
    Naveed Sattar
    Department of Pathological Biochemistry and Centre for Rheumatic Diseases, North Glasgow Hospitals University NHS Trust, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Circulation 108:2957-63. 2003
    ..Unraveling such complex relationships in which exaggerated inflammation-risk factor interactions are prevalent may elicit novel insights to effector mechanisms in vascular disease generally...
  70. doi request reprint Disease-associated functions of IL-33: the new kid in the IL-1 family
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 10:103-10. 2010
    ..Thus IL-33 could be a new target for therapeutic intervention across a range of diseases...
  71. doi request reprint What can the periodontal community learn from the pathophysiology of rheumatoid arthritis?
    Shauna Culshaw
    Glasgow Dental Hospital and School, University of Glasgow, Glasgow, UK
    J Clin Periodontol 38:106-13. 2011
    ..The aim of this paper is to provide a narrative review of the aetiopathogeneis and treatments of rheumatoid arthritis (RA), focusing on aspects that may share commonality with periodontitis...
  72. pmc Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis
    Sarah L Jongbloed
    Division of Immunology, Infection and Inflammation, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    Arthritis Res Ther 8:R15. 2006
    ..Maturation is incomplete in the inflamed synovial compartment. Immature DCs in SF may contribute to the perpetuation of inflammation via sampling of the inflamed synovial environment, and in situ presentation of arthritogenic antigen...
  73. ncbi request reprint Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis
    J Alastair Gracie
    Center for Rheumatic Diseases and Department of Immunology, University of Glasgow, Glasgow, UK
    Curr Opin Rheumatol 14:270-5. 2002
    ..The key recent observations in these areas, particularly in the extracellular compartment, are reviewed...
  74. ncbi request reprint Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1
    Clive S McKimmie
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 181:3353-63. 2008
    ..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes...
  75. ncbi request reprint Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: a double-blind, placebo-controlled study
    Naveed Sattar
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 56:831-9. 2007
    ....
  76. ncbi request reprint Atypical chemokine receptors in inflammatory disease
    Manish Patel
    Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, UK
    Curr Mol Med 9:86-93. 2009
    ..This review will describe the basic biology of such receptors and speculate on their potential as therapeutic agents moving forward...
  77. ncbi request reprint Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist
    Elizabeth B Kelso
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 56:765-71. 2007
    ....
  78. ncbi request reprint Cytokines as therapeutic targets to reduce cardiovascular risk in chronic inflammation
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G128TA, UK
    Curr Pharm Des 17:1-8. 2011
    ..In this review we will focus on the role of pro-inflammatory cytokines and their inhibitors in RA, and whether they may be causal in the accelerated atherosclerosis seen in these patients...
  79. doi request reprint Interleukin 27 attenuates collagen-induced arthritis
    W Niedbala
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 67:1474-9. 2008
    ....
  80. doi request reprint Inflammation is present in early human tendinopathy
    Neal L Millar
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom
    Am J Sports Med 38:2085-91. 2010
    ..The authors previously identified increased levels of inflammatory cytokines in an early human model of tendinopathy and sought to extend these studies to the cellular analysis of tissue...
  81. ncbi request reprint Ultrasound guided versus conventional joint and soft tissue fluid aspiration in rheumatology practice: a pilot study
    Peter V Balint
    Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Glasgow, Scotland
    J Rheumatol 29:2209-13. 2002
    ..To compare joint and soft tissue aspiration using a conventional technique with an ultrasound (US) guided technique...
  82. ncbi request reprint Vascular comorbidity in rheumatoid arthritis: potential mechanisms and solutions
    Naveed Sattar
    Section of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow Royal Infirmary, Scotland, UK
    Curr Opin Rheumatol 17:286-92. 2005
    ..To summarise recent evidence for elevated risk of coronary heart disease (CHD) in rheumatoid arthritis (RA) and explore explanatory mechanisms and modalities that may lessen such risk...
  83. ncbi request reprint Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage
    Rhoda Wilson
    University Department of Medicine, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Eur J Obstet Gynecol Reprod Biol 115:51-4. 2004
    ..To compare cytokine levels in serum from non-pregnant women with a history of recurrent miscarriage with those found in non-pregnant women with no such history...
  84. ncbi request reprint Immune regulation in psoriasis and psoriatic arthritis--recent developments
    Axel J Hueber
    Division of Immunology, Infection and Inflammation, 120 University Place, Glasgow G128QQ, United Kingdom
    Immunol Lett 114:59-65. 2007
    ..We also describe the pathways that are believed to link such inflammatory pathways to articular matrix dysregulation...
  85. ncbi request reprint Imaging inflammation in real time--future of nanoparticles
    Axel J Hueber
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow, G12 8TA, UK
    Autoimmunity 42:368-72. 2009
    ..Techniques, varying from MRI and fluorescence to Raman spectroscopy are being employed. In this short review, we summarise many of the recent developments in the field of NP imaging related to inflammation...
  86. ncbi request reprint Enhanced Th1 response to Staphylococcus aureus infection in human lactoferrin-transgenic mice
    Cristina Guillen
    Department of Immunology and Bacteriology, Western Infirmary, Royal Infirmary, Glasgow, United Kingdom
    J Immunol 168:3950-7. 2002
    ..These results demonstrate that human Lf can mediate both antimicrobial and immunomodulatory activities with downstream effects on the outcome of immune pathology in infectious and inflammatory disease...
  87. ncbi request reprint Interleukin-18
    J Alastair Gracie
    Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    J Leukoc Biol 73:213-24. 2003
    ..Subsequent cloning of human IL-18 cDNA revealed 65% homology with murine IL-18 [(3) ] and showed that both contain an unusual leader sequence consisting of 35 amino acids at their N terminus...
  88. pmc Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy
    P V Balint
    Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Scotland, UK
    Ann Rheum Dis 61:905-10. 2002
    ..To compare ultrasonography (US) with clinical examination in the detection of entheseal abnormality of the lower limb in patients with spondyloarthropathy (SpA)...
  89. ncbi request reprint Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    X Q Wei
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
    J Immunol 166:517-21. 2001
    ..These data directly demonstrate a pivotal role of IL-18 in the development of inflammatory arthritis and suggest that antagonists to IL-18 may have therapeutic potential in rheumatic diseases...
  90. ncbi request reprint IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
    D Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, GB
    Eur J Immunol 30:3147-56. 2000
    ..These data therefore provide a novel mechanism for Th2 cell development. Thus, IL-18, a cytokine constitutively expressed by cells of the innate response, is capable of inducing Th2 cell differentiation in the absence of IL-4...
  91. ncbi request reprint Abnormal IL-2 receptor levels in non-pregnant women with a history of recurrent miscarriage
    R Wilson
    University Departments of Medicine, Glasgow Royal Infirmary, UK
    Hum Reprod 18:1529-30. 2003
    ..This study compared interleukin-2 receptor (IL-2R) levels in non-pregnant women with a history of recurrent miscarriage with those found in serum from a non-pregnant group with no such history...
  92. pmc Role of interleukin 18 in rheumatoid arthritis
    F Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Ann Rheum Dis 62:ii48-50. 2003
  93. pmc Role of interleukin 15 and interleukin 18 in inflammatory response
    F Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, UK
    Ann Rheum Dis 61:ii100-2. 2002
    ..Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis...
  94. ncbi request reprint Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage
    Rhoda Wilson
    Department of Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Am J Reprod Immunol 51:156-9. 2004
    ..How the maternal immune system adapts to tolerate the fetus is not fully understood, but a successful pregnancy is associated with the production of Th2-type cytokines and miscarriage is associated with the production of Th1-type cytokines...
  95. pmc Do statins offer therapeutic potential in inflammatory arthritis?
    I B McInnes
    Centre for Rheumatic Diseases, Department of Vascular Biochemistry, University of Glasgow, UK
    Ann Rheum Dis 63:1535-7. 2004
  96. doi request reprint Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis
    M B Nickdel
    Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Ann Rheum Dis 68:1059-66. 2009
    ..However, the mechanisms underlying this phenomenon were unclear...
  97. ncbi request reprint A role for IL-18 in neutrophil activation
    B P Leung
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Immunol 167:2879-86. 2001
    ..Together, these data define a novel role for IL-18 in activating neutrophils and thereby promoting early innate immune responses...
  98. ncbi request reprint The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis
    M M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 67:518-23. 2008
    ..As a first step to developing ES-62-based drugs, the aim of this study was to determine whether the PC-moiety of ES-62 was responsible for its anti-inflammatory actions...
  99. ncbi request reprint Interleukin-12 to interleukin 'infinity': the rationale for future therapeutic cytokine targeting
    E J R Anderson
    Division of Immunology, Infection and Inflammation, Centre for Rheumatic Diseases, University of Glasgow, Glasgow, Scotland, UK
    Springer Semin Immunopathol 27:425-42. 2006
  100. doi request reprint State-of-the-art: rheumatoid arthritis
    Iain B McInnes
    Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, UK
    Ann Rheum Dis 69:1898-906. 2010
    ..Throughout the review, emphasis is placed on unanswered questions and challenges in this exciting field...
  101. ncbi request reprint The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
    M Orchardson
    Department of Immunology and Bacteriology and Center of Rheumatic Disease, University of Glasgow, Glasgow, United Kingdom
    J Immunol 167:277-82. 2001
    ..Thus, the Sushi domain is critical for the functional activity of sIL-15Ralpha...