Dennis McGonagle

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Diagnosis and treatment of enthesitis
    Dennis McGonagle
    Academic Department of Rheumatology, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, West Yorkshire, UK
    Rheum Dis Clin North Am 29:549-60. 2003
  2. ncbi Enthesitis in psoriatic disease
    Dennis G McGonagle
    Department of Investigative Rheumatology, University of Leeds, Leeds, UK
    Dermatology 225:100-9. 2012
  3. ncbi Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
  4. ncbi Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis
    Kristel B Van Landuyt
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, B3000, Belgium
    Arthritis Res Ther 12:R15. 2010
  5. ncbi The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self
    Dennis McGonagle
    The Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, The University of Leeds, Leeds, UK
    Semin Immunopathol 29:303-13. 2007
  6. ncbi Heberden's nodes and what Heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond
    D McGonagle
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 47:1278-85. 2008
  7. ncbi MRI for the assessment and monitoring of RA--what can it tell us?
    Dennis McGonagle
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Academic Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Nat Rev Rheumatol 7:185-9. 2011
  8. ncbi Nailing down the genetic and immunological basis for psoriatic disease
    Dennis McGonagle
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Dermatology 221:15-22. 2010
  9. ncbi The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond
    Dennis McGonagle
    Academic Unit of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Arthritis Rheum 56:2482-91. 2007
  10. ncbi Imaging the joint and enthesis: insights into pathogenesis of psoriatic arthritis
    D McGonagle
    Academic Unit Musculoskeletal Diseases, University of Leeds, Calderdale Royal Hospital, Salterhebble, Halifax HX3 0PW, UK
    Ann Rheum Dis 64:ii58-60. 2005

Detail Information

Publications115 found, 100 shown here

  1. ncbi Diagnosis and treatment of enthesitis
    Dennis McGonagle
    Academic Department of Rheumatology, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, West Yorkshire, UK
    Rheum Dis Clin North Am 29:549-60. 2003
    ..Now that clinicians better understand enthesitis-related disease mechanisms and have the ability to image them in early disease and monitor them, there is an urgent need to assess optimal conventional drug therapy in these conditions...
  2. ncbi Enthesitis in psoriatic disease
    Dennis G McGonagle
    Department of Investigative Rheumatology, University of Leeds, Leeds, UK
    Dermatology 225:100-9. 2012
    ..In this article, we review methods for detecting and assessing enthesitis, current thinking regarding the role of enthesitis in the pathogenesis of PsA, and trial evidence for the treatment of PsA and, therefore, enthesitis...
  3. ncbi Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
    ..This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts...
  4. ncbi Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis
    Kristel B Van Landuyt
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, B3000, Belgium
    Arthritis Res Ther 12:R15. 2010
    ..The aim of this study was to develop flow cytometry for the quantitative analysis of synovial cell populations pre and post culture and to characterize mesenchymal cell populations residing in the inflammatory synovium...
  5. ncbi The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self
    Dennis McGonagle
    The Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, The University of Leeds, Leeds, UK
    Semin Immunopathol 29:303-13. 2007
    ....
  6. ncbi Heberden's nodes and what Heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond
    D McGonagle
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 47:1278-85. 2008
    ....
  7. ncbi MRI for the assessment and monitoring of RA--what can it tell us?
    Dennis McGonagle
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Academic Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Nat Rev Rheumatol 7:185-9. 2011
    ..Given the ever-increasing sophistication of MRI, we anticipate that it will continue to be a key research tool in the coming years...
  8. ncbi Nailing down the genetic and immunological basis for psoriatic disease
    Dennis McGonagle
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Dermatology 221:15-22. 2010
    ....
  9. ncbi The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond
    Dennis McGonagle
    Academic Unit of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Arthritis Rheum 56:2482-91. 2007
  10. ncbi Imaging the joint and enthesis: insights into pathogenesis of psoriatic arthritis
    D McGonagle
    Academic Unit Musculoskeletal Diseases, University of Leeds, Calderdale Royal Hospital, Salterhebble, Halifax HX3 0PW, UK
    Ann Rheum Dis 64:ii58-60. 2005
    ..These findings suggest a reason for the localisation of disease to skeletal sites that are subject to repeated mechanical stressing...
  11. ncbi Successful treatment of resistant pseudogout with anakinra
    Dennis McGonagle
    Calderdale Royal Hospital, Halifax, UK
    Arthritis Rheum 58:631-3. 2008
    ..The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers...
  12. ncbi The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all?
    Dennis McGonagle
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Leeds, UK
    Curr Opin Rheumatol 21:340-7. 2009
    ....
  13. ncbi Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease
    D McGonagle
    NIHR, Leeds Biomedical Research Unit, Leeds Institute of Molecular Medicine LIMM, Wellcome Trust Brenner Building, St James University Hospital, Leeds, LS9 7TF, UK
    J Eur Acad Dermatol Venereol 23:9-13. 2009
    ....
  14. ncbi The anatomical basis for a novel classification of osteoarthritis and allied disorders
    Dennis McGonagle
    The NIHR Leeds Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Leeds, UK
    J Anat 216:279-91. 2010
    ..This has implications for therapeutic strategies including regenerative medicine therapy development...
  15. ncbi Lessons from musculoskeletal stem cell research: the key to successful regenerative medicine development
    Dennis McGonagle
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Arthritis Rheum 56:714-21. 2007
  16. ncbi A proposed classification of the immunological diseases
    Dennis McGonagle
    Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom
    PLoS Med 3:e297. 2006
  17. ncbi Report on the Second international Enthesitis Workshop
    Dennis McGonagle
    University of Leeds, UK
    Arthritis Rheum 48:896-905. 2003
  18. ncbi The early phase of psoriatic arthritis
    Dennis McGonagle
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Leeds LS74SA, UK
    Ann Rheum Dis 70:i71-6. 2011
    ..The way in which this model explains the clinical disconnect between skin and joint disease and the emerging human data that support it are demonstrated...
  19. ncbi Microanatomic studies to define predictive factors for the topography of periarticular erosion formation in inflammatory arthritis
    Dennis McGonagle
    University of Leeds, and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 60:1042-51. 2009
    ..The purpose of this study was to test the hypothesis that erosion-prone sites are associated with microdamage in macroscopically normal joints...
  20. ncbi Rituximab use in everyday clinical practice as a first-line biologic therapy for the treatment of DMARD-resistant rheumatoid arthritis
    D McGonagle
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 47:865-7. 2008
    ..This study assessed the utility of rituximab for the therapy of RA in a non-academic environment in a group of cases where anti-TNF was either not available or relatively contraindicated...
  21. ncbi The role of biomechanical factors and HLA-B27 in magnetic resonance imaging-determined bone changes in plantar fascia enthesopathy
    Dennis McGonagle
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Arthritis Rheum 46:489-93. 2002
    ..To study the role of biomechanical factors and HLA-B27 in plantar fasciitis...
  22. ncbi The importance of 'Mechnikov's thorn' for an improved understanding of 21st century medicine and immunology: a view from the eye
    D McGonagle
    The Leeds Institute of Molecular Medicine, St James s University Hospital, University of Leeds, UK
    Scand J Immunol 68:129-39. 2008
    ..We propose that this integrated view of medicine and immunology is crucial for understanding immunology from a translational angle and has implications far beyond ocular disease...
  23. ncbi Histological assessment of the early enthesitis lesion in spondyloarthropathy
    D McGonagle
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Ann Rheum Dis 61:534-7. 2002
    ..To describe the histological changes in acute enthesopathy in early spondyloarthropathies (SpA)...
  24. ncbi Distinct topography of erosion and new bone formation in achilles tendon enthesitis: implications for understanding the link between inflammation and bone formation in spondylarthritis
    Dennis McGonagle
    University of Leeds and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 58:2694-9. 2008
    ....
  25. ncbi Advances in the understanding of entheseal inflammation
    Dennis McGonagle
    Rheumatology and Rehabilitation Research Unit, The University of Leeds and Halifax General Hospital, 36 Clarendon Road, Halifax HX3 0PW, UK
    Curr Rheumatol Rep 4:500-6. 2002
    ..Unraveling the pathogenic basis of enthesitis will have important implications for understanding and defining therapies in SpA...
  26. ncbi Enthesitis in spondyloarthropathy
    D McGonagle
    Department of Rheumatology, University of Leeds, UK
    Curr Opin Rheumatol 11:244-50. 1999
    ....
  27. ncbi The nail as a musculoskeletal appendage--implications for an improved understanding of the link between psoriasis and arthritis
    Dennis McGonagle
    Academic Unit of Musculoskeletal Disease, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Dermatology 218:97-102. 2009
    ..This virtual continuum of connective tissue structures merges with a thick periosteum on the distal phalanx and with the numerous cutaneous ligaments that anchor the fatty pads of the finger pulp to the skin...
  28. ncbi What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis--the first 50 years
    Dennis McGonagle
    Academic Unit of Musculoskeletal Disease, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK
    Arthritis Res Ther 10:222. 2008
    ..As the power of MRI increases, there is a need to define normality since apparently normal joints occasionally exhibit MRI evidence of synovitis in the absence of symptoms...
  29. ncbi Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort
    Ann W Morgan
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Arthritis Res Ther 12:R57. 2010
    ..This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort...
  30. ncbi Transcriptional profile of native CD271+ multipotential stromal cells: evidence for multiple fates, with prominent osteogenic and Wnt pathway signaling activity
    Sarah M Churchman
    NIHR Leeds Musculoskeletal Biomedical Research Unit and University of Leeds, Leeds, UK
    Arthritis Rheum 64:2632-43. 2012
    ..The aim of this study was to clarify the nature of candidate BM-MSCs by profiling transcripts that reflect different aspects of their putative functions in vivo...
  31. ncbi Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease
    James I Robinson
    NIHR Leeds Musculoskeletal Biomedical Research Unit, St James s University Hospital, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Ann Rheum Dis 69:1054-7. 2010
    ..This study aimed to replicate previous candidate gene studies that had identified a significant association between the FCGR3A-158V allele and RA and then sought to estimate specific subgroup effects...
  32. ncbi Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis
    Elena A Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 50:817-27. 2004
    ..These findings could determine the role of MPCs in the pathogenesis of inflammatory arthritis, together with their role in attempted joint regeneration in degenerative arthritis, which has yet to be established...
  33. ncbi Efficacy of infliximab on MRI-determined bone oedema in psoriatic arthritis
    Helena Marzo-Ortega
    Consultant Rheumatologist, Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 66:778-81. 2007
    ..On MRI, areas of active clinical involvement are represented by bone oedema and synovitis. Aim: To assess the impact of infliximab on bone oedema in PsA as shown by MRI...
  34. ncbi Reduced-dose rituximab in rheumatoid arthritis: efficacy depends on degree of B cell depletion
    Edward M Vital
    National Institute for Health Research Leeds Musculoskeletal Biomedical Research Unit and University of Leeds, Leeds, UK
    Arthritis Rheum 63:603-8. 2011
    ..Using the same techniques, we undertook the present study to test the hypothesis that the level of B cell depletion, rather than the rituximab dose, determines clinical response...
  35. ncbi Ten-year follow-up of SpA-related oligoarthritis involving the knee: the presence of psoriasis but not HLA-B27 or baseline MRI bone oedema predicts outcome
    Alexander N Bennett
    Academic Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 51:1099-106. 2012
    ..The aim of this study was to investigate the influence of HLA-B27, MRI BMO and psoriasis on long-term outcomes in early SpA-related knee joint oligoarthritis...
  36. ncbi Optimization of a flow cytometry-based protocol for detection and phenotypic characterization of multipotent mesenchymal stromal cells from human bone marrow
    Elena A Jones
    Academic Unit of Musculoskeletal Disease, Leeds Institute for Molecular Medicine, University of Leeds, Leeds, United Kingdom
    Cytometry B Clin Cytom 70:391-9. 2006
    ..The purpose of this work was to verify the phenotype of BM MSCs in vivo and to develop flow cytometry-based methods for their evaluation...
  37. ncbi Persistently moderate DAS-28 is not benign: loss of function occurs in early RA despite step-up DMARD therapy
    Philip G Conaghan
    Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds, UK
    Rheumatology (Oxford) 49:1894-9. 2010
    ..The aim of this study was to examine the effect on patient-reported function of persistently moderate DAS-28 despite modern step-up DMARD therapy in an early arthritis cohort...
  38. ncbi Evidence for a different anatomic basis for joint disease localization in polymyalgia rheumatica in comparison with rheumatoid arthritis
    Helena Marzo Ortega
    University of Leeds, and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 56:3496-501. 2007
    ..This study used contrast-enhanced and fat suppression magnetic resonance imaging (MRI) to evaluate the relationship between synovial and extracapsular inflammation in PMR and early rheumatoid arthritis (RA)...
  39. ncbi Discrepancies in categorizing rheumatoid arthritis patients by DAS-28(ESR) and DAS-28(CRP): can they be reduced?
    Elizabeth M A Hensor
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, UK
    Rheumatology (Oxford) 49:1521-9. 2010
    ..The 28-joint disease activity score (DAS-28) guides the use of biologics in RA. The aims of this study were to investigate agreement between the ESR- and CRP-based DAS-28 definitions, and to examine how this agreement may be improved...
  40. ncbi Regional variation and differential response to therapy for knee synovitis adjacent to the cartilage-pannus junction and suprapatellar pouch in inflammatory arthritis: implications for pathogenesis and treatment
    Laura A Rhodes
    University of Leeds, and Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 50:2428-32. 2004
    ....
  41. ncbi High abundance of CD271(+) multipotential stromal cells (MSCs) in intramedullary cavities of long bones
    George Cox
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Bone 50:510-7. 2012
    ....
  42. ncbi Role of metacarpophalangeal joint anatomic factors in the distribution of synovitis and bone erosion in early rheumatoid arthritis
    Ai Lyn Tan
    Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 48:1214-22. 2003
    ..These findings have implications regarding the pathogenesis of joint damage in RA...
  43. ncbi NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man
    Ippokratis Pountos
    LIMM, Section Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Cell Mol Med 15:525-34. 2011
    ..These findings suggest that NSAIDs may inhibit bone formation via blockage of MSC chondrogenic differentiation which is an important intermediate phase in normal endochondral bone formation...
  44. ncbi Effect of the early use of the anti-tumor necrosis factor adalimumab on the prevention of job loss in patients with early rheumatoid arthritis
    Victoria Bejarano
    University of Leeds, Leeds, UK
    Arthritis Rheum 59:1467-74. 2008
    ..To compare work disability and job loss in early rheumatoid arthritis (RA) patients receiving adalimumab plus methotrexate (adalimumab + MTX) versus MTX alone...
  45. ncbi Single-platform quality control assay to quantify multipotential stromal cells in bone marrow aspirates prior to bulk manufacture or direct therapeutic use
    Richard Cuthbert
    Academic Unit of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, UK
    Cytotherapy 14:431-40. 2012
    ..The aim of this study was to develop a rapid single-platform assay to quantify MSC in BM aspirates...
  46. ncbi The evidence for whole-spine MRI in the assessment of axial spondyloarthropathy
    Alexander N Bennett
    Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 49:426-32. 2010
    ....
  47. ncbi Synovial fluid mesenchymal stem cells in health and early osteoarthritis: detection and functional evaluation at the single-cell level
    Elena A Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 58:1731-40. 2008
    ..This study used the bovine model to explore SF MSCs in health and enumerated them at the earliest stages of human osteoarthritis (OA) in radiographically normal joints...
  48. ncbi Ligament and bone pathologic abnormalities more frequent in neuropathic joint disease in comparison with degenerative arthritis of the foot and ankle: implications for understanding rapidly progressive joint degeneration
    Jill Halstead
    University of Leeds, Leeds, UK
    Arthritis Rheum 62:2353-8. 2010
    ....
  49. ncbi Effects of antithrombotic drugs fondaparinux and tinzaparin on in vitro proliferation and osteogenic and chondrogenic differentiation of bone-derived mesenchymal stem cells
    Argiris Papathanasopoulos
    LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
    J Orthop Res 29:1327-35. 2011
    ..Whilst MSC proliferation, but not differentiation, is negatively affected by TZP, there was no evidence for adverse effects of FDP in this in vitro model system which argues well for its use in the orthopedic setting...
  50. ncbi The synovio-entheseal complex and its role in tendon and capsular associated inflammation
    Dennis McGonagle
    Leeds Institute of Molecular Medicine and UK National Institute for Health Research Musculoskeletal Biomedical Research Unit, University of Leeds and Leeds Teaching Hospitals National Health ServiceTrust, Leeds, UK
    J Rheumatol Suppl 89:11-4. 2012
    ..Therefore SEC are likely to represent key orchestrators that contribute to joint inflammation by mechanisms that have been hitherto poorly appreciated...
  51. ncbi Clinical and imaging efficacy of infliximab in HLA-B27-Positive patients with magnetic resonance imaging-determined early sacroiliitis
    Nick Barkham
    University of Leeds, Leeds, UK
    Arthritis Rheum 60:946-54. 2009
    ..To evaluate the efficacy of infliximab in HLA-B27-positive patients with magnetic resonance imaging (MRI)-determined early sacroiliitis, using both clinical and MRI assessments...
  52. ncbi Optical coherence tomography: a new tool to assess nail disease in psoriasis?
    Sibel Zehra Aydin
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, UK
    Dermatology 222:311-3. 2011
    ..Nail disease is a characteristic manifestation of the psoriatic disease spectrum but is poorly understood...
  53. ncbi Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis
    Philip G Conaghan
    University of Leeds and Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 48:64-71. 2003
    ..In the treatment of patients with RA, outcome measures and therapies should focus on synovitis...
  54. ncbi Imaging of the musculoskeletal system: magnetic resonance imaging, ultrasonography and computed tomography
    Ai Lyn Tan
    Academic Unit of Musculoskeletal Disease, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Best Pract Res Clin Rheumatol 17:513-28. 2003
    ..This chapter reviews recent imaging studies relevant to rheumatic diseases...
  55. ncbi Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis
    Shouvik Dass
    University of Leeds, and Leeds Teaching Hospitals National Health Service Trust, Leeds, UK
    Arthritis Rheum 58:2993-9. 2008
    ..A highly sensitive assay was used to test the hypothesis that B cell depletion is variable, and that incomplete depletion leads to a poorer outcome...
  56. ncbi Infliximab in combination with methotrexate in active ankylosing spondylitis: a clinical and imaging study
    H Marzo-Ortega
    Academic Unit of Musculoskeletal Disease, Department of Rheumatology, 1st Floor, Old Nurses Home, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 64:1568-75. 2005
    ..However, disease flares were reported 8 weeks after the last infusion, indicating that addition of methotrexate failed to extend the infliximab dosing interval...
  57. ncbi High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: short-term efficacy correlates with reduction of macroscopic and histologic synovitis
    Sarah Bingham
    University of Leeds, Leeds, UK
    Arthritis Rheum 46:837-9. 2002
  58. ncbi Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia
    Frederique Ponchel
    Molecular Medicine Unit, University of Leeds, Leeds, UK
    Arthritis Res Ther 7:R80-92. 2005
    ....
  59. ncbi Magnetic resonance imaging in spondyloarthritis
    Helena Marzo-Ortega
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Curr Opin Rheumatol 22:381-7. 2010
    ..This review synthesises the most recently published data and offers a critical appraisal of findings...
  60. ncbi A high-resolution magnetic resonance imaging study of distal interphalangeal joint arthropathy in psoriatic arthritis and osteoarthritis: are they the same?
    Ai Lyn Tan
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, and University of Leeds, UK
    Arthritis Rheum 54:1328-33. 2006
    ..This study used high-resolution magnetic resonance imaging (MRI) to investigate the basis for hand disease localization in both conditions...
  61. ncbi Efficacy of etanercept in the treatment of the entheseal pathology in resistant spondylarthropathy: a clinical and magnetic resonance imaging study
    H Marzo-Ortega
    The University of Leeds, UK
    Arthritis Rheum 44:2112-7. 2001
    ..This is associated with marked improvement of enthesitis and associated osteitis pathology as determined by MRI...
  62. ncbi Quantitative magnetization transfer ultrashort echo time imaging of the Achilles tendon
    Richard J Hodgson
    Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom
    Magn Reson Med 65:1372-6. 2011
    ..1 ± 0.3 μsec in the healthy volunteers and 6.0 μsec in the patient. This technique appears clinically feasible and may be useful for assessing the collagen and water changes which occur in Achilles tendinopathy...
  63. ncbi Bone regeneration: current concepts and future directions
    Rozalia Dimitriou
    Department of Trauma and Orthopaedics, Academic Unit, Clarendon Wing, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    BMC Med 9:66. 2011
    ....
  64. ncbi Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor alpha blockade
    Maya H Buch
    University of Leeds, Leeds, UK
    Arthritis Rheum 50:725-8. 2004
    ..These data do not provide evidence of a dominant role for IL-1 in patients who do not respond to TNF alpha blockade, but they do not exclude a role for other proinflammatory mediators...
  65. ncbi Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis
    Cosimo De Bari
    Department of Rheumatology, King s College London School of Medicine, Thomas Guy House, Guy s Hospital, London, UK
    Arthritis Rheum 54:1209-21. 2006
    ..To investigate whether periosteal cells from adult humans have features of multipotent mesenchymal stem cells (MSCs) at the single-cell level...
  66. ncbi Validation of ultrasound imaging for Achilles entheseal fibrocartilage in bovines and description of changes in humans with spondyloarthritis
    Sibel Zehra Aydin
    Section of Musculoskeletal Diseases, The Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Leeds, UK
    Ann Rheum Dis 69:2165-8. 2010
    ..This work aimed to demonstrate face and content validity of ultrasound for EF visualisation both by bovine histological evaluation and EF imaging in spondyloarthritis...
  67. ncbi Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis
    L A Rhodes
    Academic Unit of Medical Physics, University of Leeds, Wellcome Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 64:1347-9. 2005
    ..IRE and ME measures were greater at the CPJ than the SPP. CONCLUSIONS: The magnitude of synovitis at the CPJ is not disease-specific and applies across the spectrum of degenerative disease as well as inflammatory diseases...
  68. ncbi MRI and clinical findings in patients with ankylosing spondylitis eligible for anti-tumour necrosis factor therapy after a short course of etoricoxib
    S J Jarrett
    University of Leeds, Leeds, UK
    Ann Rheum Dis 68:1466-9. 2009
    ..To describe and assess the response to short-term etoricoxib as shown by MRI and clinical variables in patients with ankylosing spondylitis (AS) selected for eligibility for anti-tumour necrosis factor therapy...
  69. ncbi Treatment of psoriatic arthritis and rheumatoid arthritis with disease modifying drugs -- comparison of drugs and adverse reactions
    Philip S Helliwell
    Academic Unit of Musculoskeletal and Rehabilitation Medicine, University of Leeds, Leeds, UK
    J Rheumatol 35:472-6. 2008
    ..Although it seems likely that these conditions have a different pathogenesis, the drugs used to treat them are the same. Our study used a cross-sectional clinical database to compare drug use and side-effect profile in these 2 diseases...
  70. ncbi The role of mesenchymal stem cells in maintenance and repair of bone
    Robert Bielby
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Injury 38:S26-32. 2007
    ..The purpose of this article is to review bone and fracture biology from the perspective of recent advances in our understanding of MSCs and to highlight the major deficiencies in our current knowledge...
  71. ncbi Combining variational and model-based techniques to register PET and MR images in hand osteoarthritis
    Derek Magee
    School of Computing, University of Leeds, Leeds, UK
    Phys Med Biol 55:4755-69. 2010
    ..The method outperforms some established non-rigid registration techniques and results in a mean registration error that is less than approximately 1.5 mm in the vicinity of the finger joints...
  72. ncbi Magnetic resonance imaging as a predictor of progressive joint destruction in neuropathic joint disease
    Adam S Greenstein
    University of Leeds, Leeds, UK
    Arthritis Rheum 46:2814-5. 2002
  73. ncbi Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population
    Ann W Morgan
    Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St James University Hospital, Leeds, UK
    Arthritis Rheum 60:2565-76. 2009
    ..To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA)...
  74. ncbi Severity of baseline magnetic resonance imaging-evident sacroiliitis and HLA-B27 status in early inflammatory back pain predict radiographically evident ankylosing spondylitis at eight years
    A N Bennett
    Leeds Institute of Molecular Medicine, and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 58:3413-8. 2008
    ..This study was undertaken to investigate what proportion of patients with MRI-evident sacroiliitis develop ankylosing spondylitis (AS) in the long term and whether there are predictors of outcome...
  75. ncbi Efficacy of etanercept for treatment of Crohn's related spondyloarthritis but not colitis
    H Marzo-Ortega
    Rheumatology Research Unit, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Ann Rheum Dis 62:74-6. 2003
    ..These findings suggest that the effect of TNFalpha blockade in SpA differs between the joint and the bowel...
  76. ncbi Bone loss in very early inflammatory back pain in undifferentiated spondyloarthropathy: a 1-year observational study
    G Haugeberg
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 69:1364-6. 2010
    ..The aim of this study was to examine changes in bone mineral density (BMD) at the hip, lumbar spine and hand in patients with early IBP and to look for possible biomarkers associated with this change...
  77. ncbi Large-scale extraction and characterization of CD271+ multipotential stromal cells from trabecular bone in health and osteoarthritis: implications for bone regeneration strategies based on uncultured or minimally cultured multipotential stromal cells
    E Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 62:1944-54. 2010
    ..To test the hypothesis that CD45(low)CD271+ bone marrow multipotential stromal cells (MSCs) are abundant in the trabecular bone niche and to explore their functional "fitness" in health and osteoarthritis (OA)...
  78. ncbi The relationship between limited MRI section analyses and volumetric assessment of synovitis in knee osteoarthritis
    L A Rhodes
    Academic Unit of Medical Physics, University of Leeds and Leeds General Infirmary, UK
    Clin Radiol 60:1295-9. 2005
    ..To assess whether simple, limited section analysis can replace detailed volumetric assessment of synovitis in patients with osteoarthritis (OA) of the knee using contrast-enhanced magnetic resonance imaging (MRI)...
  79. ncbi Etanercept treatment in resistant spondyloarthropathy: imaging, duration of effect and efficacy on reintroduction
    H Marzo-Ortega
    Rheumatology and Rehabilitation Research Unit, University of Leeds, UK
    Clin Exp Rheumatol 20:S175-7. 2002
    ..Whilst limited follow up data have been reported in the case of infliximab there are no data on how patients on etanercept fare after a years' treatment...
  80. ncbi Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level
    E Jones
    Leeds Institute of Molecular Medicine, UK
    Ann Rheum Dis 69:450-7. 2010
    ..However, the inflammatory milieu in the RA synovium could adversely affect endogenous MSC function. To test this hypothesis, the frequency and multipotency of RA synovial MSCs was evaluated in relation to existing synovial inflammation...
  81. ncbi MR imaging of erosions in interphalangeal joint osteoarthritis: is all osteoarthritis erosive?
    A J Grainger
    Department of Radiology, Leeds Teaching Hospitals, Leeds, UK
    Skeletal Radiol 36:737-45. 2007
    ..The aim of this study was to compare routine CR and MRI to investigate erosion numbers and morphology to determine whether hand OA in general is a more erosive disease than previously recognised...
  82. ncbi Magnetic resonance imaging in the assessment of metacarpophalangeal joint disease in early psoriatic and rheumatoid arthritis
    H Marzo-Ortega
    Academic Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Leeds LS74SA, UK
    Scand J Rheumatol 38:79-83. 2009
    ....
  83. ncbi Baseline and 1-year magnetic resonance imaging of the sacroiliac joint and lumbar spine in very early inflammatory back pain. Relationship between symptoms, HLA-B27 and disease extent and persistence
    H Marzo-Ortega
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Leeds LS7 4SA, UK
    Ann Rheum Dis 68:1721-7. 2009
    ..The precise anatomical location of pathology associated with inflammatory back pain (IBP) in early spondyloarthropathy (SpA) remains unclear...
  84. ncbi Psoriatic arthritis: correlation between imaging and pathology
    Ai Lyn Tan
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, United Kingdom
    Joint Bone Spine 77:206-11. 2010
    ....
  85. ncbi Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells
    Elena A Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 46:3349-60. 2002
    ..CONCLUSION: This study shows the distinct phenotype, morphology, and method of isolation of BM MPCs. The findings may have implications for defining the physiologic roles of MPCs in arthritis, bone diseases, and joint regeneration...
  86. ncbi An integrated classification of pediatric inflammatory diseases, based on the concepts of autoinflammation and the immunological disease continuum
    Dennis McGonagle
    NIHR Leeds Molecular Biology Research Unit NIHR LMBRU, University of Leeds, Leeds LS9 7TF, United Kingdom
    Pediatr Res 65:38R-45R. 2009
    ..Furthermore, the etiopathogenesis of poorly defined "autoimmune" diseases, such as juvenile idiopathic arthritis, may be inferred to have substantial innate immune involvement, based on response to IL-1 antagonism...
  87. ncbi Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis
    A L Tan
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 65:1267-72. 2006
    ..CONCLUSIONS: Small-joint collateral ligaments and tendons have a central role in the early stages of hand osteoarthritis, and determine the early expression of both the soft tissue and bony changes in disease...
  88. ncbi A comparative assessment of cartilage and joint fat pad as a potential source of cells for autologous therapy development in knee osteoarthritis
    A English
    The Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Rheumatology (Oxford) 46:1676-83. 2007
    ..The aim of this work was to assess OA Hoffa's fat pad as an alternative source of autologous chondroprogenitor cells and to compare it with OA chondrocytes derived from different areas of cartilage...
  89. ncbi Acute neuropathic joint disease: a medical emergency?
    Ai Lyn Tan
    Academic Unit of Musculoskeletal Disease, 2nd Floor, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, U K
    Diabetes Care 28:2962-4. 2005
  90. ncbi The relationship between the extensor tendon enthesis and the nail in distal interphalangeal joint disease in psoriatic arthritis--a high-resolution MRI and histological study
    A L Tan
    Academic Unit of Muscoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 46:253-6. 2007
    ..The purpose of this study was to explore the microanatomical basis for the inflammation and nail disease in PsA using a combined high-resolution magnetic resonance imaging (MRI) and histological studies...
  91. ncbi Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study
    A L Tan
    Academic Unit of Musculoskeletal Disease, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 63:1041-5. 2004
    ..CONCLUSIONS: This open label pilot study suggests that anakinra is effective in controlling the clinical manifestations of AS. The clinical response was reflected by an improvement in MRI determined spinal enthesitis/osteitis...
  92. ncbi The fatty Romanus lesion: a non-inflammatory spinal MRI lesion specific for axial spondyloarthropathy
    A N Bennett
    Academic Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Chapel Town Rd, Leeds LS7 4SA, UK
    Ann Rheum Dis 69:891-4. 2010
    ..Fatty changes at vertebral corners have been reported on MRI in ankylosing spondylitis but the distribution or specificity of these lesions to early axial spondyloarthropathy (axial-SpA) has not been determined...
  93. ncbi Comparison of extracapsular changes by magnetic resonance imaging in patients with rheumatoid arthritis and polymyalgia rheumatica
    D McGonagle
    Rheumatology Department, University of Leeds, United Kingdom
    J Rheumatol 28:1837-41. 2001
    ..This may contribute to the diffuse nature of symptoms in PMR and have implications for its pathogenesis...
  94. ncbi Autologous stem cell transplantation for rheumatoid arthritis--interim report of 6 patients
    S J Bingham
    Rheumatology and Rehabilitation Research Unit, University of Leeds, UK
    J Rheumatol Suppl 64:21-4. 2001
    ..Five patients responded to CSA when their disease had previously been refractory, suggesting an immunomodulatory effect. No serious infectious complications occurred despite prolonged reduction in CD3+CD4+ lymphocytes...
  95. ncbi Imaging the joints in early rheumatoid arthritis
    D McGonagle
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds, LS2 9NZ, UK
    Best Pract Res Clin Rheumatol 15:91-104. 2001
    ..The relationship between synovitis and bone damage is also addressed in the light of recent magnetic resonance imaging observations...
  96. ncbi Human bone marrow mesenchymal stem cells in vivo
    E Jones
    The Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Rheumatology (Oxford) 47:126-31. 2008
    ..This knowledge provides a platform for understanding MSCs in vivo leading to novel approaches for therapy development, including in situ tissue engineering...
  97. ncbi The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells
    Yasser M El-Sherbiny
    Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds, UK
    Cancer Res 67:8444-9. 2007
    ..The importance of NKp46, NKG2D, and DNAM-1 in myeloma killing mirrors the differential expression of NK cell ligands by myeloma cells, reflecting immune selection during myeloma disease progression...
  98. ncbi The relationship between pityriasis rubra pilaris and inflammatory arthritis: case report and response of the arthritis to anti-tumor necrosis factor immunotherapy
    P G Conaghan
    University of Leeds, UK
    Arthritis Rheum 42:1998-2001. 1999
    ..The arthritis, but not the skin condition, demonstrated dramatic response to anti-tumor necrosis factor immunotherapy...
  99. ncbi Magnetic resonance imaging in rheumatoid arthritis: summary of OMERACT activities, current status, and plans
    P Conaghan
    Rheumatology Research Unit, University of Leeds, UK
    J Rheumatol 28:1158-62. 2001
    ....
  100. ncbi How to diagnose axial spondyloarthropathy early
    N Barkham
    Academic Unit of Musculoskeletal Disease, University of Leeds, UK
    Ann Rheum Dis 63:471-2. 2004
  101. ncbi Imaging of seronegative spondyloarthritis
    A L Tan
    Academic Unit of Musculoskeletal Disease, University of Leeds and Chapel Allerton Hospital, Leeds, UK
    Best Pract Res Clin Rheumatol 22:1045-59. 2008
    ..MRI and US are still undergoing evaluation for the diagnosis of enthesitis of the appendicular skeleton; US, in particular, shows promise at these sites...