Peter McGlynn

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Rep provides a second motor at the replisome to promote duplication of protein-bound DNA
    Colin P Guy
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
    Mol Cell 36:654-66. 2009
  2. pmc Interaction of Rep and DnaB on DNA
    John Atkinson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 39:1351-9. 2011
  3. pmc Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication
    John Atkinson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 39:949-57. 2011
  4. pmc Replication fork blockage by transcription factor-DNA complexes in Escherichia coli
    Bryony T I Payne
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 34:5194-202. 2006
  5. doi The conflict between DNA replication and transcription
    Peter McGlynn
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Mol Microbiol 85:12-20. 2012
  6. doi Helicases that underpin replication of protein-bound DNA in Escherichia coli
    Peter McGlynn
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Biochem Soc Trans 39:606-10. 2011
  7. ncbi Links between DNA replication and recombination in prokaryotes
    Peter McGlynn
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Opin Genet Dev 14:107-12. 2004
  8. doi Replication forks blocked by protein-DNA complexes have limited stability in vitro
    Peter McGlynn
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Mol Biol 381:249-55. 2008
  9. pmc Protein-DNA complexes are the primary sources of replication fork pausing in Escherichia coli
    Milind K Gupta
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Proc Natl Acad Sci U S A 110:7252-7. 2013
  10. ncbi PriB stimulates PriA helicase via an interaction with single-stranded DNA
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 280:39693-700. 2005

Collaborators

  • Robert G Lloyd
  • Christian J Rudolph
  • Mark S Dillingham
  • Nigel J Savery
  • David J Sherratt
  • STEVEN MATSON
  • N Goosen
  • John Atkinson
  • Milind K Gupta
  • Chris J Cadman
  • Colin P Guy
  • Hazel Bell
  • Gary J Sharples
  • Josephine Wardle
  • Ingeborg C van Knippenberg
  • Peter B Moon
  • Bryony T I Payne
  • Timothy Moore
  • Amanda V Gregg
  • Joseph T P Yeeles
  • Kenneth J Marians
  • Emma J Gwynn
  • Akeel A Mahdi
  • Geri F Moolenaar
  • Bernard A Connolly
  • Peter M J Burgers
  • Erik Johansson
  • Isaac K O Cann
  • Li Jung Lin
  • Kate Darley
  • Jonathan Sanvoisin
  • Carrie M Stith
  • Pauline Heslop
  • Sergio R Filipe
  • Matthew Lopper
  • James L Keck
  • Edward L Bolt
  • Fiona A Curtis
  • Hien Ping Ngo
  • Razieh P Jaktaji

Detail Information

Publications22

  1. pmc Rep provides a second motor at the replisome to promote duplication of protein-bound DNA
    Colin P Guy
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
    Mol Cell 36:654-66. 2009
    ..Rep and UvrD therefore provide two contrasting solutions as to how organisms may promote replication of protein-bound DNA...
  2. pmc Interaction of Rep and DnaB on DNA
    John Atkinson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 39:1351-9. 2011
    ....
  3. pmc Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication
    John Atkinson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 39:949-57. 2011
    ....
  4. pmc Replication fork blockage by transcription factor-DNA complexes in Escherichia coli
    Bryony T I Payne
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 34:5194-202. 2006
    ....
  5. doi The conflict between DNA replication and transcription
    Peter McGlynn
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Mol Microbiol 85:12-20. 2012
    ....
  6. doi Helicases that underpin replication of protein-bound DNA in Escherichia coli
    Peter McGlynn
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Biochem Soc Trans 39:606-10. 2011
    ....
  7. ncbi Links between DNA replication and recombination in prokaryotes
    Peter McGlynn
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Opin Genet Dev 14:107-12. 2004
    ..Indeed, an emerging theme is that a single recombination enzyme or complex can perform highly varied tasks, depending on the context of the recombination reaction...
  8. doi Replication forks blocked by protein-DNA complexes have limited stability in vitro
    Peter McGlynn
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Mol Biol 381:249-55. 2008
    ....
  9. pmc Protein-DNA complexes are the primary sources of replication fork pausing in Escherichia coli
    Milind K Gupta
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Proc Natl Acad Sci U S A 110:7252-7. 2013
    ..They also demonstrate that efficient chromosome duplication requires mechanisms that aid resumption of replication by paused replisomes, especially those halted by protein-DNA barriers such as transcription complexes...
  10. ncbi PriB stimulates PriA helicase via an interaction with single-stranded DNA
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 280:39693-700. 2005
    ..However, stimulation of PriA by PriB is not DNA structure-specific, demonstrating that targeting of stalled forks and recombination intermediates during replication restart likely resides with PriA alone...
  11. pmc Stimulation of UvrD helicase by UvrAB
    John Atkinson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 284:9612-23. 2009
    ..More generally, these data support the idea that helicase activity is regulated in vivo, with helicases acting as part of multisubunit complexes rather than in isolation...
  12. pmc DNA structure specificity conferred on a replicative helicase by its loader
    Milind K Gupta
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    J Biol Chem 285:979-87. 2010
    ..The ability of other replicative helicases to translocate along single-stranded and double-stranded DNA raises the possibility that analogous regulatory mechanisms exist in other organisms...
  13. pmc Replication fork reversal and the maintenance of genome stability
    John Atkinson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 37:3475-92. 2009
    ..Here, we discuss the contexts in which fork regression might occur, the factors that may promote such a reaction and the possible roles of replication fork unwinding in normal DNA metabolism...
  14. ncbi Unwinding of forked DNA structures by UvrD
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Mol Biol 362:18-25. 2006
    ..This reaction is reminiscent of the PriC-Rep pathway of replication restart, suggesting that UvrD and Rep may have at least partially redundant functions...
  15. pmc PriA helicase and SSB interact physically and functionally
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 32:6378-87. 2004
    ..Taken together with previous data, these findings indicate that protein-protein interactions involving SSB may coordinate replication fork reloading from start to finish...
  16. pmc Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya
    Josephine Wardle
    Institute for Cell and Molecular Biosciences ICaMB, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 36:705-11. 2008
    ..The confinement of uracil recognition to polymerases of the archaeal domain is discussed in terms of the DNA repair pathways necessary for the elimination of uracil...
  17. pmc The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA
    Timothy Moore
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:735-45. 2003
    ..Mutations in RNA polymerase also reduce the toxic effect of RecFOR, providing a further link between DNA replication, transcription and repair...
  18. ncbi Replicating past lesions in DNA
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Mol Cell 10:700-1. 2002
    ..How Escherichia coli employs these different mechanisms to effect efficient, accurate replication of a damaged template is revealed in this issue of Molecular Cell...
  19. ncbi Recombinational repair and restart of damaged replication forks
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Nat Rev Mol Cell Biol 3:859-70. 2002
    ....
  20. ncbi Genome stability and the processing of damaged replication forks by RecG
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Trends Genet 18:413-9. 2002
    ..Such direct rescue of stalled forks might help safeguard genome integrity in all organisms...
  21. ncbi Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities
    Amanda V Gregg
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, United Kingdom
    Mol Cell 9:241-51. 2002
    ..The combined action of PriA and RecG helicase activities may thus avoid the potential dangers of rescue pathways involving fork breakage and recombination...
  22. ncbi Holliday junction binding and resolution by the Rap structure-specific endonuclease of phage lambda
    Gary J Sharples
    Centre for Infectious Diseases, Wolfson Research Institute, University of Durham, Queen s Campus, Stockton on Tees TS17 6BH, UK
    J Mol Biol 340:739-51. 2004
    ..The results demonstrate that Rap can function as a Holliday junction resolvase in addition to eliminating other branched structures that may arise during phage recombination...