Peter McGlynn

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Proc Natl Acad Sci U S A 98:8235-40. 2001
  2. ncbi Recombinational repair and restart of damaged replication forks
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Nat Rev Mol Cell Biol 3:859-70. 2002
  3. ncbi Genome stability and the processing of damaged replication forks by RecG
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Trends Genet 18:413-9. 2002
  4. ncbi Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities
    Amanda V Gregg
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, United Kingdom
    Mol Cell 9:241-51. 2002
  5. ncbi The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA
    Timothy Moore
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:735-45. 2003
  6. ncbi DNA binding and helicase domains of the Escherichia coli recombination protein RecG
    A A Mahdi
    Department of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Nucleic Acids Res 25:3875-80. 1997
  7. ncbi Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, United Kingdom
    Cell 101:35-45. 2000
  8. ncbi Replicating past lesions in DNA
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen's Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Mol Cell 10:700-1. 2002
  9. ncbi The DNA replication protein PriA and the recombination protein RecG bind D-loops
    P McGlynn
    Department of Genetics, University of Nottingham, Queens Medical Centre, United Kingdom
    J Mol Biol 270:212-21. 1997
  10. ncbi Action of RuvAB at replication fork structures
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Center, Nottingham, NG7 2UH, United Kingdom
    J Biol Chem 276:41938-44. 2001

Collaborators

  • Gary J Sharples
  • KENNETH MARIANS
  • Jing Liu
  • D Sherratt
  • STEVEN MATSON
  • Chris J Cadman
  • Josephine Wardle
  • Bryony T I Payne
  • Timothy Moore
  • Robert G Lloyd
  • Amanda V Gregg
  • Isaac K O Cann
  • Erik Johansson
  • Bernard A Connolly
  • Jonathan Sanvoisin
  • Kate Darley
  • Pauline Heslop
  • Li-Jung Lin
  • Peter M J Burgers
  • Li Jung Lin
  • Carrie M Stith
  • Ingeborg C van Knippenberg
  • Sergio R Filipe
  • Hazel Bell
  • James L Keck
  • Matthew Lopper
  • Peter B Moon
  • A A Mahdi
  • Hien-Ping Ngo
  • Hien Ping Ngo
  • Razieh P Jaktaji
  • S D Levett
  • R G Lloyd

Detail Information

Publications20

  1. ncbi Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Proc Natl Acad Sci U S A 98:8235-40. 2001
    ....
  2. ncbi Recombinational repair and restart of damaged replication forks
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Nat Rev Mol Cell Biol 3:859-70. 2002
    ....
  3. ncbi Genome stability and the processing of damaged replication forks by RecG
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Trends Genet 18:413-9. 2002
    ..Such direct rescue of stalled forks might help safeguard genome integrity in all organisms...
  4. ncbi Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities
    Amanda V Gregg
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, United Kingdom
    Mol Cell 9:241-51. 2002
    ..The combined action of PriA and RecG helicase activities may thus avoid the potential dangers of rescue pathways involving fork breakage and recombination...
  5. ncbi The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA
    Timothy Moore
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    EMBO J 22:735-45. 2003
    ..Mutations in RNA polymerase also reduce the toxic effect of RecFOR, providing a further link between DNA replication, transcription and repair...
  6. ncbi DNA binding and helicase domains of the Escherichia coli recombination protein RecG
    A A Mahdi
    Department of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Nucleic Acids Res 25:3875-80. 1997
    ..These data suggest that the C-terminus does contain the helicase active site whereas the N-terminus confers junction DNA specificity...
  7. ncbi Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, United Kingdom
    Cell 101:35-45. 2000
    ....
  8. ncbi Replicating past lesions in DNA
    Peter McGlynn
    Institute of Genetics, University of Nottingham, Queen's Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Mol Cell 10:700-1. 2002
    ..How Escherichia coli employs these different mechanisms to effect efficient, accurate replication of a damaged template is revealed in this issue of Molecular Cell...
  9. ncbi The DNA replication protein PriA and the recombination protein RecG bind D-loops
    P McGlynn
    Department of Genetics, University of Nottingham, Queens Medical Centre, United Kingdom
    J Mol Biol 270:212-21. 1997
    ..RecG, like PriA, binds D-loops and unwinds the DNA. However, it prefers branched structures with at least two duplex components. The possibility that it competes with PriA for binding recombination intermediates is discussed...
  10. ncbi Action of RuvAB at replication fork structures
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen s Medical Center, Nottingham, NG7 2UH, United Kingdom
    J Biol Chem 276:41938-44. 2001
    ..These data argue against RuvAB acting directly at damaged replication forks and imply that other mechanisms must operate in vivo to catalyze Holliday junction formation...
  11. ncbi Rescue of stalled replication forks by RecG: simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation
    P McGlynn
    Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom
    Proc Natl Acad Sci U S A 98:8227-34. 2001
    ....
  12. ncbi DNA structure specificity of Rap endonuclease
    G J Sharples
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Nucleic Acids Res 27:4121-7. 1999
    ..Almost no binding or cleavage was detected with duplex, partial duplex and single-stranded DNA. Thus Rap endonuclease shows a bias for structures that resemble D-loop and Holliday junction recombination intermediates...
  13. ncbi Replication fork blockage by transcription factor-DNA complexes in Escherichia coli
    Bryony T I Payne
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 34:5194-202. 2006
    ....
  14. ncbi PriB stimulates PriA helicase via an interaction with single-stranded DNA
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 280:39693-700. 2005
    ..However, stimulation of PriA by PriB is not DNA structure-specific, demonstrating that targeting of stalled forks and recombination intermediates during replication restart likely resides with PriA alone...
  15. ncbi PriA helicase and SSB interact physically and functionally
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucleic Acids Res 32:6378-87. 2004
    ..Taken together with previous data, these findings indicate that protein-protein interactions involving SSB may coordinate replication fork reloading from start to finish...
  16. ncbi Links between DNA replication and recombination in prokaryotes
    Peter McGlynn
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Opin Genet Dev 14:107-12. 2004
    ..Indeed, an emerging theme is that a single recombination enzyme or complex can perform highly varied tasks, depending on the context of the recombination reaction...
  17. ncbi Replication forks blocked by protein-DNA complexes have limited stability in vitro
    Peter McGlynn
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Mol Biol 381:249-55. 2008
    ....
  18. ncbi Holliday junction binding and resolution by the Rap structure-specific endonuclease of phage lambda
    Gary J Sharples
    Centre for Infectious Diseases, Wolfson Research Institute, University of Durham, Queen s Campus, Stockton on Tees TS17 6BH, UK
    J Mol Biol 340:739-51. 2004
    ..The results demonstrate that Rap can function as a Holliday junction resolvase in addition to eliminating other branched structures that may arise during phage recombination...
  19. ncbi Unwinding of forked DNA structures by UvrD
    Chris J Cadman
    School of Medical Sciences, Institute of Medical Sciences University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Mol Biol 362:18-25. 2006
    ..This reaction is reminiscent of the PriC-Rep pathway of replication restart, suggesting that UvrD and Rep may have at least partially redundant functions...
  20. ncbi Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya
    Josephine Wardle
    Institute for Cell and Molecular Biosciences ICaMB, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 36:705-11. 2008
    ..The confinement of uracil recognition to polymerases of the archaeal domain is discussed in terms of the DNA repair pathways necessary for the elimination of uracil...