Emma J McGhie

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Salmonella takes control: effector-driven manipulation of the host
    Emma J McGhie
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Curr Opin Microbiol 12:117-24. 2009
  2. ncbi request reprint The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology
    Peter J Hume
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK
    Mol Microbiol 49:425-39. 2003
  3. ncbi request reprint A Salmonella SipB-derived polypeptide blocks the 'trigger' mechanism of bacterial entry into eukaryotic cells
    Richard D Hayward
    University of Cambridge, Department of Pathology, UK
    Mol Microbiol 45:1715-27. 2002
  4. ncbi request reprint Control of actin turnover by a salmonella invasion protein
    Emma J McGhie
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Mol Cell 13:497-510. 2004
  5. ncbi request reprint Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells
    Richard D Hayward
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Microbiol 56:590-603. 2005
  6. pmc WAVE regulatory complex activation by cooperating GTPases Arf and Rac1
    Vassilis Koronakis
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QP, United Kingdom
    Proc Natl Acad Sci U S A 108:14449-54. 2011
  7. ncbi request reprint Topology of the Salmonella invasion protein SipB in a model bilayer
    Emma J McGhie
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Microbiol 44:1309-21. 2002

Detail Information

Publications7

  1. pmc Salmonella takes control: effector-driven manipulation of the host
    Emma J McGhie
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Curr Opin Microbiol 12:117-24. 2009
    ..This review focuses on the actions of the effectors on their host cell targets during each stage of Salmonella infection...
  2. ncbi request reprint The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology
    Peter J Hume
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK
    Mol Microbiol 49:425-39. 2003
    ....
  3. ncbi request reprint A Salmonella SipB-derived polypeptide blocks the 'trigger' mechanism of bacterial entry into eukaryotic cells
    Richard D Hayward
    University of Cambridge, Department of Pathology, UK
    Mol Microbiol 45:1715-27. 2002
    ..These findings reveal a potential strategy to identify inhibitors of the 'trigger' mechanism underlying cell entry by these major invasive pathogens...
  4. ncbi request reprint Control of actin turnover by a salmonella invasion protein
    Emma J McGhie
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Mol Cell 13:497-510. 2004
    ..These data suggest that SipA focuses host cytoskeletal reorganization by locally inhibiting both ADF/cofilin- and gelsolin-directed actin disassembly, while simultaneously stimulating pathogen-induced actin polymerization...
  5. ncbi request reprint Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells
    Richard D Hayward
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Microbiol 56:590-603. 2005
    ..The data reveal that cholesterol-dependent association of the bacterial TTSS translocon with the target cell plasma membrane is essential for translocon activation and effector delivery into mammalian cells...
  6. pmc WAVE regulatory complex activation by cooperating GTPases Arf and Rac1
    Vassilis Koronakis
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QP, United Kingdom
    Proc Natl Acad Sci U S A 108:14449-54. 2011
    ..This cooperativity between the two GTPases was sufficient to induce WAVE-dependent bead motility in cell extracts. Our findings suggest that Arf GTPases may be central components in WAVE signalling, acting directly, alongside Rac1...
  7. ncbi request reprint Topology of the Salmonella invasion protein SipB in a model bilayer
    Emma J McGhie
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Microbiol 44:1309-21. 2002
    ..The combined data suggest a topological model for membrane-inserted SipB...