Helen M McGettrick

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Analysis of the effects of stromal cells on the migration of lymphocytes into and through inflamed tissue using 3-D culture models
    Hannah C Jeffery
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Immunol Methods 400:45-57. 2013
  2. doi request reprint Tissue stroma as a regulator of leukocyte recruitment in inflammation
    Helen M McGettrick
    College of Medical and Dental Sciences, Medical School, The University of Birmingham, Birmingham, UK
    J Leukoc Biol 91:385-400. 2012
  3. pmc Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium
    Helen M McGettrick
    Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, Medical School, The University of Birmingham, Birmingham, UK
    Immunology 131:357-70. 2010
  4. pmc Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells
    Helen M McGettrick
    Centre for Cardiovascular Sciences, The Medical School, The University of Birmingham, Birmingham, UK
    Eur J Immunol 39:113-25. 2009
  5. doi request reprint Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress
    Nick M Matharu
    Division of Medical Sciences, The Medical School, University of Birmingham, UK
    J Cell Physiol 216:732-41. 2008
  6. pmc Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration
    Helen M McGettrick
    The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    J Leukoc Biol 85:98-107. 2009
  7. pmc Influence of stromal cells on lymphocyte adhesion and migration on endothelial cells
    Helen M McGettrick
    Centre for Cardiovascular Sciences and Centre for Immune Regulation, The Medical School, University of Birmingham, Birmingham, UK
    Methods Mol Biol 616:49-68. 2010
  8. doi request reprint Adhesion of tumor cells to matrices and endothelium
    Clara M Yates
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Methods Mol Biol 1070:57-75. 2014
  9. pmc Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture
    Victoria J Burton
    Centre for Cardiovascular Sciences and MRC Centre for Immune Regulation, College of Medical and Dental Sciences, The University of Birmingham, Birmingham B15 2TT, UK
    Exp Cell Res 317:276-92. 2011
  10. pmc Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium
    Emily Smith
    Department of Physiology, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Arthritis Rheum 58:1968-73. 2008

Collaborators

Detail Information

Publications18

  1. pmc Analysis of the effects of stromal cells on the migration of lymphocytes into and through inflamed tissue using 3-D culture models
    Hannah C Jeffery
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Immunol Methods 400:45-57. 2013
    ....
  2. doi request reprint Tissue stroma as a regulator of leukocyte recruitment in inflammation
    Helen M McGettrick
    College of Medical and Dental Sciences, Medical School, The University of Birmingham, Birmingham, UK
    J Leukoc Biol 91:385-400. 2012
    ....
  3. pmc Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium
    Helen M McGettrick
    Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, Medical School, The University of Birmingham, Birmingham, UK
    Immunology 131:357-70. 2010
    ....
  4. pmc Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells
    Helen M McGettrick
    Centre for Cardiovascular Sciences, The Medical School, The University of Birmingham, Birmingham, UK
    Eur J Immunol 39:113-25. 2009
    ..Actions of IL-6 might be pro-inflammatory or anti-inflammatory, depending on the local milieu...
  5. doi request reprint Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress
    Nick M Matharu
    Division of Medical Sciences, The Medical School, University of Birmingham, UK
    J Cell Physiol 216:732-41. 2008
    ..Prolonged cessation of flow may increase the sensitivity of EC to inflammatory stimuli, but this effect may be suppressed by residual flow...
  6. pmc Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration
    Helen M McGettrick
    The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    J Leukoc Biol 85:98-107. 2009
    ..These observations suggest a novel model for lymphoid migration in which EC support migration but retain lymphocytes (as opposed to neutrophils), and additional signal(s) are required for onward migration...
  7. pmc Influence of stromal cells on lymphocyte adhesion and migration on endothelial cells
    Helen M McGettrick
    Centre for Cardiovascular Sciences and Centre for Immune Regulation, The Medical School, University of Birmingham, Birmingham, UK
    Methods Mol Biol 616:49-68. 2010
    ..In general, static assays have the higher throughput and greatest ease of use, while the flow-based assays are more physiologically relevant and allow detailed recording of cell behaviour in real time...
  8. doi request reprint Adhesion of tumor cells to matrices and endothelium
    Clara M Yates
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Methods Mol Biol 1070:57-75. 2014
    ..In addition, there is a section detailing the use of endothelial cell cultures on three-dimensional collagen gels which are useful when studying adhesion to endothelial cells and onward invasion through a protein matrix. ..
  9. pmc Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture
    Victoria J Burton
    Centre for Cardiovascular Sciences and MRC Centre for Immune Regulation, College of Medical and Dental Sciences, The University of Birmingham, Birmingham B15 2TT, UK
    Exp Cell Res 317:276-92. 2011
    ..The lesser effect of BM on lymphocytes and monocytes supports the concept that crossing the BM is a separate, leukocyte-specific, regulated step in migration...
  10. pmc Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium
    Emily Smith
    Department of Physiology, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Arthritis Rheum 58:1968-73. 2008
    ..The aim of this study was to investigate the role of CXCL5 and DARC in regulating neutrophil recruitment, using an in vitro model of RA synovium...
  11. ncbi request reprint An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31
    Srabasti J Chakravorty
    Centre for Cardiovascular Sciences, The Medical School, The University of Birmingham, Birmingham, UK
    Biorheology 43:71-82. 2006
    ....
  12. pmc Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium
    Helen M McGettrick
    Centre for Cardiovascular Sciences, The Medical School, The University of Birmingham, Birmingham, B15 2TT, UK
    J Leukoc Biol 79:779-88. 2006
    ..Thus, a complex interplay between migration- and activation-dependent signals and adhesive interaction in tissue may combine to effectively prolong the survival of neutrophils recruited during inflammation...
  13. doi request reprint Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium
    S Rumel Ahmed
    School of Clinical and Experimental Medicine, Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 187:1432-9. 2011
    ..Thus, chemokines may not regulate all stages of lymphocyte migration during inflammation, and paradigms describing their trafficking may need to account for the role of PGD(2)...
  14. ncbi request reprint Analysis of leukocyte migration through monolayers of cultured endothelial cells
    Helen M McGettrick
    Division of Medical Sciences, Department of Physiology, The Medical School, The University of Birmingham, Birmingham, UK
    Methods Mol Biol 370:37-54. 2007
    ..In general, the filter-based assay has the highest throughput and greatest ease of use but yields less detailed information, whereas the flow-based assay is most difficult to set up but is most physiologically relevant...
  15. doi request reprint Static and dynamic assays of cell adhesion relevant to the vasculature
    Lynn M Butler
    Department of Physiology, The Medical School, The University of Birmingham, UK
    Methods Mol Biol 467:211-28. 2009
    ....
  16. doi request reprint The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue
    Ester Hidalgo
    University of Birmingham, Birmingham, UK
    Arthritis Rheum 63:3284-93. 2011
    ..This study was undertaken to assess the expression and regulation of CD126 and CD130 and determine how these affect the response of CD4+ T cells to IL-6 in the joints of patients with rheumatoid arthritis (RA)...
  17. doi request reprint Crosstalk between mesenchymal stem cells and endothelial cells leads to downregulation of cytokine-induced leukocyte recruitment
    N Thin Luu
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom
    Stem Cells 31:2690-702. 2013
    ..These studies establish a novel mechanism by which MSC might have protective effects against inflammatory pathology and cardiovascular disease...
  18. ncbi request reprint Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration
    Christopher D Buckley
    The Medical School, The University of Birmingham, UK
    J Leukoc Biol 79:303-11. 2006
    ....