Research Topics
Species | Carmel M McEnierySummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Central pressure: variability and impact of cardiovascular risk factors: the Anglo-Cardiff Collaborative Trial IICarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital Box 110, Cambridge CB2 2QQ, United Kingdom
Hypertension 51:1476-82. 2008..However, assessment of central pressure may improve the identification and management of patients with elevated cardiovascular risk...
Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humansCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Hypertension 48:602-8. 2006..001), which remained independent after adjusting for confounding factors. In healthy individuals, a decline in endothelial function is associated with increased large artery stiffness, wave reflections, and central pulse pressure...- An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective studyCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 0QQ, UK
Hypertension 56:36-43. 2010..Adequate control of pulse pressure and heart rate, as well as reducing inflammation, may, in the long-term, retard aortic stiffening, although this remains to be tested directly... - Antihypertensive drugs and central blood pressureCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital Box 110, Cambridge CB20QQ, United Kingdom
Curr Hypertens Rep 11:253-9. 2009..This may help to explain the results of recent large outcome studies using atenolol. Further research is required to clarify whether other antihypertensive agents lower central pressure beyond the effects observed on brachial pressure... - Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT)Carmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
J Am Coll Cardiol 46:1753-60. 2005.... - The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III)Carmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Hills Rd, Cambridge CB2 0QQ, UK
Hypertension 56:591-7. 2010..Additional studies are required to assess the impact of these arterial measures on cardiovascular outcome within a single population... - Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adultsCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Hypertension 46:221-6. 2005..Long-term follow-up of these individuals is now required to determine whether they are at increased risk compared with age-matched normotensive individuals... - Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individualsCarmel M McEniery
Clinical Pharmacology Unit, Box 100, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
Hypertension 53:524-31. 2009..These data suggest that calcification may be important in the process of aortic stiffening and the development of ISH. Calcification may underlie treatment resistance in ISH, and anticalcification strategies may present a novel therapy... - Age, hypertension and arterial functionCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Clin Exp Pharmacol Physiol 34:665-71. 2007..In addition, inhibitors or breakers of advanced glycation end-product cross-links between proteins, such as collagen and elastin, hold substantial promise... 
Novel therapeutic strategies for reducing arterial stiffnessCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ
Br J Pharmacol 148:881-3. 2006- Endogenous endothelin-1 limits exercise-induced vasodilation in hypertensive humansCarmel M McEniery
Clinical Pharmacology Unit and Research Centre, University of Endinburgh, Western General Hospital, United Kingdom
Hypertension 40:202-6. 2002..Treatment with endothelin receptor antagonists may, therefore, increase exercise capacity in essential hypertension... - Cardiovascular consequences of extreme prematurity: the EPICure studyCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, UK
J Hypertens 29:1367-73. 2011..The aim of the current study was to examine the cardiovascular consequences of extreme prematurity in 11-year-olds born at or before 25 completed weeks of gestation... - Endothelin-1 regulates arterial pulse wave velocity in vivoCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
J Am Coll Cardiol 42:1975-81. 2003..The aim of this study was to investigate whether endothelin-1, acting locally, regulates arterial distensibility, assessed by measuring pulse-wave velocity in vivo... - Nebivolol increases arterial distensibility in vivoCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Hypertension 44:305-10. 2004..This effect of nebivolol is mediated through the release of NO via a beta2 adrenoceptor-dependent mechanism. Thus, nebivolol may be of benefit in conditions of increased large artery stiffness, such as isolated systolic hypertension... - Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness- Yasmin
Clinical Pharmacology Unit, University of Cambridge Addenbrooke s Hospital Cambridge, United Kingdom
Arterioscler Thromb Vasc Biol 25:372. 2005..We hypothesized that elastase activity would be related to arterial stiffness and tested this using isolated systolic hypertension (ISH) as a model of stiffening and separately in a large cohort of healthy individuals... - Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritisKaisa M Maki-Petaja
Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom
J Am Coll Cardiol 50:852-8. 2007..The aim of this study was to investigate the effect of simvastatin and ezetimibe on inflammation, disease activity, endothelial dysfunction, and arterial stiffness in a cohort of rheumatoid arthritis (RA) patients... - Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertensionIsla S Mackenzie
Clinical Pharmacology Unit, Addenbrooke s Hospital Box 110, Cambridge, CB2 0QQ United Kingdom
Hypertension 54:409-13. 2009..Because central PP and increased wave reflections are considered important risk factors in patients with isolated systolic hypertension, the choice of therapy may be influenced by these findings in the future... - Nitric oxide regulates local arterial distensibility in vivoIan B Wilkinson
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Circulation 105:213-7. 2002..We hypothesized that nitric oxide (NO) acting locally regulates arterial stiffness in vivo, and the aim of this experiment was to test this hypothesis in an ovine hind-limb preparation... - A comparison of atenolol and nebivolol in isolated systolic hypertensionZahid Dhakam
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
J Hypertens 26:351-6. 2008..The aim of the present study was to test this in a double-blind, randomized, cross-over study, in a cohort of subjects with isolated systolic hypertension... - Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals- Yasmin
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 2QQ, UK
Arterioscler Thromb Vasc Biol 26:1799-805. 2006..Therefore, we investigated the influence of known MMP-9 (-1562C>T, R279Q) polymorphisms on arterial stiffness in a large cohort of healthy individuals (n=865)... - Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial functionIan B Wilkinson
Clinical Pharmacology Units, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
Arterioscler Thromb Vasc Biol 22:147-52. 2002..This methodology provides a simple, repeatable, noninvasive means of assessing endothelial function in vivo... - Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunctionSharon M L Wallace
Clinical Pharmacology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Hypertension 50:228-33. 2007..Our results suggest that endothelial function contributes significantly to increased arterial stiffness in patients with isolated systolic hypertension and with age... - The impact of birth weight on blood pressure and arterial stiffness in later life: the Enigma StudyKaren L Miles
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Hypertens 29:2324-31. 2011..However, the relationship between birth weight, blood pressure, arterial stiffness and wave reflections as putative mechanisms is controversial... - The effects of urotensin II and urantide on forearm blood flow and systemic haemodynamics in humansJoseph Cheriyan
Clinical Pharmacology Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
Br J Clin Pharmacol 68:518-23. 2009.... - The relationship of age with regional aortic stiffness and diameterStacey S Hickson
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
JACC Cardiovasc Imaging 3:1247-55. 2010..The purpose of this study was to determine the impact of age on regional aortic pulse wave velocity (aPWV)... - Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocityZahid Dhakam
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, England
Am J Hypertens 19:214-9. 2006..This provides one potential explanation for the failure of atenolol to improve outcome in older patients with essential hypertension... - Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humansIsla S Mackenzie
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Arterioscler Thromb Vasc Biol 25:1891-5. 2005..We investigated the role of ALDH2 in the vascular effects of nitroglycerin (NTG) in humans in vivo... - Inducible nitric oxide synthase activity is increased in patients with rheumatoid arthritis and contributes to endothelial dysfunctionKaisa M Maki-Petaja
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge, UK
Int J Cardiol 129:399-405. 2008..The aim of the study was to establish the contribution of iNOS to endothelial function... - Validity and repeatability of the Vicorder apparatus: a comparison with the SphygmoCor deviceStacey S Hickson
University of Cambridge, Addenbrooke s Hospital, UK
Hypertens Res 32:1079-85. 2009..This difference in transit time and inherent bias was reduced when adjustment for the additional femoral artery segment measured by the Vicorder device was made... - Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunctionSharon M L Wallace
University of Cambridge, UK
Br J Clin Pharmacol 70:799-806. 2010..The aim of this study was to determine whether simvastatin would protect against inflammation-induced aortic stiffening and endothelial dysfunction... - Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: the ENIGMA studyStacey S Hickson
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Hypertens 29:1155-9. 2011..The aim of this study was to determine the relationship between use of the OCP and aortic stiffness and wave reflections in a young, healthy cohort of women... - Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapyKaisa M Maki-Petaja
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 2QQ, United Kingdom
Circulation 114:1185-92. 2006..In addition, we tested the hypothesis that aortic stiffness could be reduced with anti-tumor necrosis factor-alpha (TNF-alpha) therapy... - C-reactive protein is associated with arterial stiffness in apparently healthy individualsCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
Arterioscler Thromb Vasc Biol 24:969-74. 2004..Anti-inflammatory strategies may, therefore, be of benefit in reducing arterial stiffness and thus cardiovascular risk, especially in patients with premature arterial stiffening... - Genetic variation in fibrillin-1 gene is not associated with arterial stiffness in apparently healthy individuals- Yasmin
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Hypertens 24:499-502. 2006..The aim of this study was to investigate the possible influence of the common FBN-1 genotypes on arterial stiffness in a large cohort of healthy individuals... - The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveformStacey S Hickson
University of Cambridge, Addenbrooke s Hospital, UK
J Hypertens 27:1784-8. 2009..We also compared pSBP(2) with the true cSBP measured by cardiac catheterization [invasively measured cSBP (cSBPi)]... - Does arterial stiffness predict atherosclerotic coronary events?Carmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Adv Cardiol 44:160-72. 2007.... - Atenolol and cardiovascular risk: an issue close to the heartIan B Wilkinson
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
Lancet 367:627-9. 2006 - Age-related changes of regional pulse wave velocity in the descending aorta using Fourier velocity encoded M-modeValentina Taviani
Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Magn Reson Med 65:261-8. 2011..There was a preferential stiffening of the thoracic aorta with age, which may be due to progressive fragmentation of elastin fibers in this region... - Arterial stiffness, endothelial function and novel pharmacological approachesIan B Wilkinson
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Clin Exp Pharmacol Physiol 31:795-9. 2004..Furthermore, differences in the effect of existing drugs on larger artery stiffness may explain, in part, why some drugs produce better clinical outcomes than others... - Endothelin antagonism: physiology or pharmacology?Carmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, UK
Clin Sci (Lond) 102:667-8. 2002 - Evaluation of the Vicorder, a novel cuff-based device for the noninvasive estimation of central blood pressureGiacomo Pucci
aClinical Pharmacology Unit, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK bUnit of Internal Medicine, University of Perugia at Terni and S Maria Hospital, Terni, Italy cDepartment of Cardiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Giacomo Pucci and Joseph Cheriyan contributed equally to the writing of this article
J Hypertens 31:77-85. 2013..The Vicorder is a new brachial cuff-based device that estimates central blood pressure (cBP) using a brachial-to-aortic transfer function. The aim of this study was to evaluate cBP estimated by the Vicorder... - Maternal cardiovascular changes from pre-pregnancy to very early pregnancyAmita A Mahendru
Fetal Medicine Department, Rosie Hospital, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK
J Hypertens 30:2168-72. 2012..Our aim was to assess changes in maternal cardiovascular haemodynamics, including central blood pressure (BP), wave reflections and aortic stiffness, from pre-pregnancy to very early pregnancy... - Systolic hypertension in young adults: spurious definition of a genuine conditionCarmel M McEniery
J Hypertens 24:2316-7; author reply 2317-9. 2006 - Effects of arterial stiffness, pulse wave velocity, and wave reflections on the central aortic pressure waveformWilmer W Nichols
Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Clin Hypertens (Greenwich) 10:295-303. 2008..The decrease in systolic BP brought about by this mechanism is grossly underestimated when systolic BP is measured in the brachial artery... - Pseudo hypertension of youth: too much of a good thing?John R Cockcroft
Am J Hypertens 16:262-4. 2003 - Maternal wave reflections and arterial stiffness in normal pregnancy as assessed by applanation tonometryMaria L Macedo
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 8RS, UK
Hypertension 51:1047-51. 2008..2 for carotid-radial, P=0.5 for carotid-femoral). In summary, we found that normal pregnancy is associated with a reduction in central BP and wave reflection... - Pulse waveform analysis and arterial stiffness: realism can replace evangelism and scepticismIan B Wilkinson
J Hypertens 23:213; author reply 213-4. 2005 - Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemiaJames E Sharman
The University of Queensland, Department of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
J Hypertens 25:1249-54. 2007..This study aimed to assess the central and peripheral BP response to exercise with aging and hypercholesterolemia... - Arterial stiffness and osteoporosis in chronic obstructive pulmonary diseaseRamsey Sabit
Department of Respiratory Medicine, Cardiff University, Academic Centre, Llandough Hospital, Penlan Road, Penarth, Vale of Glamorgan CF64 2XX, UK
Am J Respir Crit Care Med 175:1259-65. 2007..Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of cardiovascular events and osteoporosis. Increased arterial stiffness is an independent predictor of cardiovascular disease... - Basal NO locally modulates human iliac artery function in vivoMatthias Schmitt
Department of Cardiology, Wales Heart Research Institute, College of Medicine, University Hospital of Wales, Cardiff, UK
Hypertension 46:227-31. 2005..These data indicate that under resting conditions, local NO production modulates human iliac artery distensibility and that exogenous NO increases arterial distensibility... - Nitric oxide does not significantly contribute to changes in pulse pressure amplification during light aerobic exerciseJames E Sharman
Department of Medicine, University of Queensland, Brisbane, Australia
Hypertension 51:856-61. 2008....