Frank McCaughan

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi Single-molecule genomics
    Frank McCaughan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Pathol 220:297-306. 2010
  2. pmc Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia
    Frank McCaughan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Pathol 224:153-9. 2011
  3. pmc Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer
    Frank McCaughan
    Centre for Respiratory Research, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 182:83-91. 2010
  4. pmc Cell migration leads to spatially distinct but clonally related airway cancer precursors
    Christodoulos P Pipinikas
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK
    Thorax 69:548-57. 2014
  5. pmc IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer
    Elizabeth Day
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Int J Exp Pathol 94:203-11. 2013
  6. doi Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine
    Elizabeth Day
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Methods 59:101-7. 2013
  7. pmc Single-molecule analysis of genome rearrangements in cancer
    Jessica C M Pole
    Hutchison MRC Research Centre and Department of Pathology, University of Cambridge, Hills Road, Cambridge, CB2 0XZ, UK
    Nucleic Acids Res 39:e85. 2011

Collaborators

Detail Information

Publications7

  1. doi Single-molecule genomics
    Frank McCaughan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Pathol 220:297-306. 2010
    ..Single-molecule sequencing refers to a number of different methods that are mainly still in development but have the potential to make a huge impact on personalized medicine in the future...
  2. pmc Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia
    Frank McCaughan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Pathol 224:153-9. 2011
    ..Finally, in this small cohort, the degree of 3q amplification corresponds to clinical progression...
  3. pmc Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer
    Frank McCaughan
    Centre for Respiratory Research, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 182:83-91. 2010
    ..For technical reasons, previous attempts to analyze 3q amplification in preinvasive lesions have focused on small numbers of predetermined candidate loci rather than an unbiased survey of copy-number variation...
  4. pmc Cell migration leads to spatially distinct but clonally related airway cancer precursors
    Christodoulos P Pipinikas
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK
    Thorax 69:548-57. 2014
    ..Synchronous preinvasive lesions identified at autopsy have been previously shown to be clonally related...
  5. pmc IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer
    Elizabeth Day
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Int J Exp Pathol 94:203-11. 2013
    ..Together, these data identify IRS2 as a likely driver oncogene in the prevalent 13q34 region of gain/amplification and suggest that IRS2 over-expression may provide an additional mechanism of PI3 kinase pathway activation in CRC...
  6. doi Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine
    Elizabeth Day
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Methods 59:101-7. 2013
    ..We will explore recent developments in this field including examples of how digital PCR may integrate with next generation sequencing to deliver truly personalized medicine...
  7. pmc Single-molecule analysis of genome rearrangements in cancer
    Jessica C M Pole
    Hutchison MRC Research Centre and Department of Pathology, University of Cambridge, Hills Road, Cambridge, CB2 0XZ, UK
    Nucleic Acids Res 39:e85. 2011
    ..We conclude that HAPPY mapping is a versatile tool for determining the structure of rearrangements in the human genome...