J E McCarthy

Summary

Affiliation: University of Manchester Institute of Science and Technology
Country: UK

Publications

  1. pmc Posttranscriptional control of gene expression in yeast
    J E McCarthy
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, Manchester M60 1QD, United Kingdom
    Microbiol Mol Biol Rev 62:1492-553. 1998
  2. ncbi request reprint Translation initiation: insect virus RNAs rewrite the rule book
    J E McCarthy
    Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, UK
    Curr Biol 10:R715-7. 2000
  3. pmc Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability
    C Vilela
    Post transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    EMBO J 18:3139-52. 1999
  4. ncbi request reprint Translational repression by human 4E-BP1 in yeast specifically requires human eIF4E as target
    J M Hughes
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P O Box 88, Manchester M60 1QD, United Kingdom
    J Biol Chem 274:3261-4. 1999
  5. pmc A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties
    M Ptushkina
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Nucleic Acids Res 29:4561-9. 2001
  6. pmc The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability
    C Vilela
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    Nucleic Acids Res 26:1150-9. 1998
  7. pmc The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex
    C Vilela
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology PO Box 88, Manchester M60 1QD, UK
    EMBO J 19:4372-82. 2000
  8. pmc Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20
    M Ptushkina
    Posttranscriptional Control Group, Department of Biomolecular Sciences, UMIST, P O Box 88, Manchester M60 1QD, UK
    EMBO J 17:4798-808. 1998
  9. ncbi request reprint A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1
    M M Karim
    Posttranscriptional Control Group, Department of Biomolecular Sciences, UMIST, P. O. Box 88, Manchester M60 1QD, United Kingdom
    J Biol Chem 276:20750-7. 2001

Collaborators

  • J Warwicker
  • J M Hughes
  • G C Scheper
  • C Vilela
  • M Ptushkina
  • M M Karim
  • T von der Haar
  • B Linz
  • C Rodrigues Pousada
  • K Berthelot
  • L Geffers
  • C G Proud
  • C Velasco
  • C V Ramirez
  • S Vasilescu
  • R Birkenhäger
  • R Frank

Detail Information

Publications9

  1. pmc Posttranscriptional control of gene expression in yeast
    J E McCarthy
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, Manchester M60 1QD, United Kingdom
    Microbiol Mol Biol Rev 62:1492-553. 1998
    ....
  2. ncbi request reprint Translation initiation: insect virus RNAs rewrite the rule book
    J E McCarthy
    Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, UK
    Curr Biol 10:R715-7. 2000
    ..This seems to involve a special type of mRNA pseudoknot structure which allows bypassing of the usual P-site-dependent mechanism...
  3. pmc Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability
    C Vilela
    Post transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    EMBO J 18:3139-52. 1999
    ..Our data explain the destabilizing properties of YAP2-type uORFs and also support a more general model for the mode of action of other known uORFs, such as those in the GCN4 mRNA...
  4. ncbi request reprint Translational repression by human 4E-BP1 in yeast specifically requires human eIF4E as target
    J M Hughes
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P O Box 88, Manchester M60 1QD, United Kingdom
    J Biol Chem 274:3261-4. 1999
    ..Thus yeast eIF4E lacks structural features required for binding to human 4E-BP1. These results therefore demonstrate that the features of eIF4E required for binding to 4E-BP1 are distinct from those required for cap-complex assembly...
  5. pmc A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties
    M Ptushkina
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Nucleic Acids Res 29:4561-9. 2001
    ..Moreover, they provide insight into the molecular characteristics required for tight binding to eIF4G...
  6. pmc The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability
    C Vilela
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    Nucleic Acids Res 26:1150-9. 1998
    ..This route of control of non-aberrant mRNA decay influences the stress response in yeast. It is also potentially relevant to expression of the sizable number of eukaryotic mRNAs that are now recognized to contain uORFs...
  7. pmc The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex
    C Vilela
    Posttranscriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology PO Box 88, Manchester M60 1QD, UK
    EMBO J 19:4372-82. 2000
    ..These data on interactions at the interface between translation and mRNA decay suggest how events at the 5' cap and 3' poly(A) tail might be coupled...
  8. pmc Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20
    M Ptushkina
    Posttranscriptional Control Group, Department of Biomolecular Sciences, UMIST, P O Box 88, Manchester M60 1QD, UK
    EMBO J 17:4798-808. 1998
    ..The results presented provide a basis for understanding how cycling of eIF4E and eIF4G occurs in yeast translation and explains how p20 can act as a fine, but not as a coarse, regulator of protein synthesis...
  9. ncbi request reprint A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1
    M M Karim
    Posttranscriptional Control Group, Department of Biomolecular Sciences, UMIST, P. O. Box 88, Manchester M60 1QD, United Kingdom
    J Biol Chem 276:20750-7. 2001
    ..These results establish a quantitative framework that should contribute to understanding of the molecular interactions underlying 4E-BP1-mediated translational regulation...