D McAlpine

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Neural responses in the inferior colliculus to binaural masking level differences created by inverting the noise in one ear
    A R Palmer
    Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Neurophysiol 84:844-52. 2000
  2. ncbi request reprint GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences
    Neil J Ingham
    The Ear Institute and Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:6187-98. 2005
  3. pmc Creating a sense of auditory space
    David McAlpine
    Department of Physiology and The Ear Institute, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 566:21-8. 2005
  4. ncbi request reprint Optimal neural population coding of an auditory spatial cue
    Nicol S Harper
    Department of Physiology and UCL Ear Institute, University College London, London WC1E 6BT, UK
    Nature 430:682-6. 2004
  5. ncbi request reprint Neural sensitivity to periodicity in the inferior colliculus: evidence for the role of cochlear distortions
    David McAlpine
    Dept of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Neurophysiol 92:1295-311. 2004
  6. pmc Evaluation of the acoustic coordinated reset (CR ®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial
    Derek J Hoare
    National Institute for Health Research NIHR Nottingham Hearing Biomedical Research Unit, University of Nottingham, Ropewalk House, 113 The Ropewalk, Nottingham NG1 5DU, UK
    Trials 14:207. 2013
  7. ncbi request reprint A neural code for low-frequency sound localization in mammals
    D McAlpine
    MRC Institute of Hearing Research, Science Road, University of Nottingham, Nottingham NG7 2RD, UK
    Nat Neurosci 4:396-401. 2001
  8. ncbi request reprint Blocking GABAergic inhibition increases sensitivity to sound motion cues in the inferior colliculus
    David McAlpine
    Department of Physiology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 22:1443-53. 2002
  9. ncbi request reprint Sound localization and delay lines--do mammals fit the model?
    David McAlpine
    Department of Physiology, University College London, London WC1E 6BT, UK
    Trends Neurosci 26:347-50. 2003
  10. ncbi request reprint Spike-frequency adaptation in the inferior colliculus
    Neil J Ingham
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurophysiol 91:632-45. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Neural responses in the inferior colliculus to binaural masking level differences created by inverting the noise in one ear
    A R Palmer
    Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Neurophysiol 84:844-52. 2000
    ..6 dB (NoSo vs. NpiSo) compared with 6.6 dB for the NoSo versus NoSpi BMLD we had previously reported. This lower magnitude is consistent with the hierarchy of human psychophysical BMLDs...
  2. ncbi request reprint GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences
    Neil J Ingham
    The Ear Institute and Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:6187-98. 2005
    ..This gain control appears to arise from a combination of additive and multiplicative processes, and may involve mechanisms such as shunting inhibition or changes in the efficacy of inhibitory and excitatory inputs...
  3. pmc Creating a sense of auditory space
    David McAlpine
    Department of Physiology and The Ear Institute, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 566:21-8. 2005
    ....
  4. ncbi request reprint Optimal neural population coding of an auditory spatial cue
    Nicol S Harper
    Department of Physiology and UCL Ear Institute, University College London, London WC1E 6BT, UK
    Nature 430:682-6. 2004
    ..For humans, the optimal strategy to code ITDs from an acoustically measured distribution depends on frequency; above 400 Hz a homogeneous distribution is optimal, and below 400 Hz distinct sub-populations are optimal...
  5. ncbi request reprint Neural sensitivity to periodicity in the inferior colliculus: evidence for the role of cochlear distortions
    David McAlpine
    Dept of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Neurophysiol 92:1295-311. 2004
    ..The auditory midbrain appears to show a robust representation of cochlear distortions generated by amplitude-modulated sounds...
  6. pmc Evaluation of the acoustic coordinated reset (CR ®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial
    Derek J Hoare
    National Institute for Health Research NIHR Nottingham Hearing Biomedical Research Unit, University of Nottingham, Ropewalk House, 113 The Ropewalk, Nottingham NG1 5DU, UK
    Trials 14:207. 2013
    ..The most effective stimulation paradigm is now in clinical use as a sound therapy device, the acoustic coordinated reset (CR®) neuromodulation (Adaptive Neuromodulation GmbH (ANM), Köln, Germany)...
  7. ncbi request reprint A neural code for low-frequency sound localization in mammals
    D McAlpine
    MRC Institute of Hearing Research, Science Road, University of Nottingham, Nottingham NG7 2RD, UK
    Nat Neurosci 4:396-401. 2001
    ....
  8. ncbi request reprint Blocking GABAergic inhibition increases sensitivity to sound motion cues in the inferior colliculus
    David McAlpine
    Department of Physiology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 22:1443-53. 2002
    ..These results indicate that GABAergic inhibition strongly influences the context-dependent processing of low-frequency binaural signals in the IC...
  9. ncbi request reprint Sound localization and delay lines--do mammals fit the model?
    David McAlpine
    Department of Physiology, University College London, London WC1E 6BT, UK
    Trends Neurosci 26:347-50. 2003
    ....
  10. ncbi request reprint Spike-frequency adaptation in the inferior colliculus
    Neil J Ingham
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurophysiol 91:632-45. 2004
    ..We conclude that such binaurally derived measures of adaptation reflect processes that occur above the level of exclusively monaural pathways, and subsequent to the site of primary binaural interaction...
  11. ncbi request reprint Spatial receptive fields of inferior colliculus neurons to auditory apparent motion in free field
    N J Ingham
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurophysiol 85:23-33. 2001
    ..In addition, the data indicate that the sequential activation of an array of speakers to produce apparent auditory motion may not be an optimal stimulus paradigm to separate the temporal and spatial aspects of auditory motion processing...
  12. doi request reprint Adaptive coding is constrained to midline locations in a spatial listening task
    J K Maier
    UCL Ear Institute, London, United Kingdom
    J Neurophysiol 108:1856-68. 2012
    ..The data support the notion that adaptive coding in the midbrain is a key element of behaviorally efficient sound localization in dynamic acoustic environments...
  13. ncbi request reprint Modelling convergent input onto interaural-delay-sensitive inferior colliculus neurones
    T M Shackleton
    MRC Institute of Hearing Research, University of Nottingham, University Park, Nottingham, UK
    Hear Res 149:199-215. 2000
    ..Non-zero characteristic phases arise if the characteristic frequencies of the AN fibres feeding into a single superior olive cell are mismatched...
  14. ncbi request reprint Precise inhibition is essential for microsecond interaural time difference coding
    Antje Brand
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Nature 417:543-7. 2002
    ..A computer model, simulating the response of a coincidence-detector neuron with bilateral excitatory inputs and a temporally precise contralateral inhibitory input, supports this conclusion...
  15. doi request reprint Rapid neural adaptation to sound level statistics
    Isabel Dean
    University College London Ear Institute, London WC1X 8EE, United Kingdom
    J Neurosci 28:6430-8. 2008
    ..Our findings provide constraints in the search for mechanisms underlying adaptation to sound level. They also have functional implications for the role of adaptation in the representation of natural sounds...
  16. ncbi request reprint Representation of interaural time delay in the human auditory midbrain
    Sarah K Thompson
    Department of Physiology and UCL Ear Institute, University College London, 332 Gray s Inn Road, London WC1X 8EE, UK
    Nat Neurosci 9:1096-8. 2006
    ..The data require a new model for human ITD processing...
  17. ncbi request reprint Neural population coding of sound level adapts to stimulus statistics
    Isabel Dean
    Department of Physiology and University College London Ear Institute, UK
    Nat Neurosci 8:1684-9. 2005
    ..This extends the range of sound levels that can be accurately encoded, fine-tuning hearing to the local acoustic environment...
  18. ncbi request reprint Neural sensitivity to interaural envelope delays in the inferior colliculus of the guinea pig
    Sarah J Griffin
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    J Neurophysiol 93:3463-78. 2005
    ..This suggests that the neural mechanisms that mediate sensitivity to ITDs at high and low frequencies are functionally equivalent, provided that the stimuli result in appropriate temporal patterns of action potentials in ANFs...