R Hamish McAllister-Williams

..This demonstrates a serotonergic-nicotinic interaction in the generation of hypothermia in mice and is consistent with corticosterone selectively attenuating somatodendritic 5-HT1A receptor function...

..Local Implementation Teams would be well advised to take note of the recently published British Association for Psychopharmacology guidelines for the management of BD...

..However, following treatment with cortisol, the effect of buspirone was significantly attenuated. This is consistent with corticosteroids having a similar effect on somatodendritic 5-HT(1A) autoreceptors in man as seen in rodents...

..All other treatment options currently have an extremely limited evidence base and do not feature consistently in the published guidelines...

..Animal research suggests that pindolol is an agonist at these receptors but an antagonist at postsynaptic 5-HT(1A) receptors...

..The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown...

..Neuropsychological impairments in depressive illness may be secondary to proposed serotonergic abnormalities. Acute tryptophan depletion (ATD) in healthy subjects impairs episodic memory, but the mechanism of this is unclear...

..Neuropsychological impairments in depressive illness may be secondary to hypercortisolaemia. Cortisol administration to healthy subjects impairs episodic memory, though how this is mediated is unknown...

..The results support the hypothesis of causal effects of cortisol on the laterality of cortical activity occurring during an episodic memory task...

..These unique findings demonstrate that while the laterality of the neural correlates of episodic memory is sensitive to cortisol, it is not altered by the non-specific laterality effects seen in depression...

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..These findings are distinctive, being the first to show such beneficial effects of DHEA on memory in healthy young men...

..The effects of motivational factors should not be overlooked when interpreting absolute levels of performance in neuropsychological processes...

..2;R(2) 0.04). It is crucial that future studies are aware of these issues and are cognizant of the effects of the method of collection when examining steroid levels in saliva...

..This study also demonstrates the utility of ERPs for investigating the effect of neuroendocrine manipulations on the neural correlates of neuropsychological function...

..Despite the numerous treatment approaches, poor response combined with the burden of residual symptoms negatively affects the overall outcome. Novel pharmacological approaches could help to address this issue...

..In addition, the degree of attenuation depends on CORT concentrations at the time of testing. These findings may have implications regarding mechanisms of adaptation to stress...

..Low-dose acute tryptophan depletion (LD-ATD), while having no effect on mood, has been shown to reduce specificity of autobiographical memory in patients who have recovered from a depressive episode...

..However, outcomes are often far from ideal with patients left with residual symptoms of depression. These are associated with poor social functioning and an increased risk of relapse...

..Both of these uses of the EEG are illustrated in reference to the study of mood disorders and in particular depression and its treatment with antidepressants...

..However, there has been recent concern over cardiotoxicity and sudden death associated with some antipsychotic medication and droperidol has now been withdrawn...

..No significant effect of tryptophan depletion was found on ASF-slope. These negative findings cast further doubt on the hypothesis that the ASF-slope is an indicator of central 5-HT function...

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