Roberto Mayor

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Contact inhibition of locomotion in vivo controls neural crest directional migration
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nature 456:957-61. 2008
  2. doi request reprint The neural crest
    Roberto Mayor
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 140:2247-51. 2013
  3. pmc Keeping in touch with contact inhibition of locomotion
    Roberto Mayor
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Cell Biol 20:319-28. 2010
  4. pmc Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction
    Ben Steventon
    Department of Cell and Developmental Biology, University College London, London, UK
    Development 136:771-9. 2009
  5. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
  6. pmc Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion
    Rachel Moore
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 140:4763-75. 2013
  7. pmc Complement fragment C3a controls mutual cell attraction during collective cell migration
    Carlos Carmona-Fontaine
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Cell 21:1026-37. 2011
  8. doi request reprint Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
    Helen K Matthews
    Department of Anatomy and Development Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 135:1771-80. 2008
  9. doi request reprint Chase-and-run between adjacent cell populations promotes directional collective migration
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Nat Cell Biol 15:763-72. 2013
  10. doi request reprint Cadherins in collective cell migration of mesenchymal cells
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 24:677-84. 2012

Collaborators

Detail Information

Publications28

  1. pmc Contact inhibition of locomotion in vivo controls neural crest directional migration
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nature 456:957-61. 2008
    ..These results provide the first example of contact inhibition of locomotion in vivo, provide an explanation for coherent directional migration of groups of cells and establish a previously unknown role for non-canonical Wnt signalling...
  2. doi request reprint The neural crest
    Roberto Mayor
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 140:2247-51. 2013
    ..Here, we provide an overview of NC formation, differentiation and migration, highlighting the molecular mechanisms governing NC migration...
  3. pmc Keeping in touch with contact inhibition of locomotion
    Roberto Mayor
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Cell Biol 20:319-28. 2010
    ..Finally, we propose possible cell surface proteins that could be involved in the initial contact that regulates Rho GTPases during CIL...
  4. pmc Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction
    Ben Steventon
    Department of Cell and Developmental Biology, University College London, London, UK
    Development 136:771-9. 2009
    ..Finally, our results emphasise the importance of considering the order of exposure to signals during an inductive event...
  5. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
    ....
  6. pmc Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion
    Rachel Moore
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 140:4763-75. 2013
    ..Our results demonstrate a novel role of Par3 during neural crest migration, which is likely to be conserved in other processes that involve CIL such as cancer invasion or cell dispersion...
  7. pmc Complement fragment C3a controls mutual cell attraction during collective cell migration
    Carlos Carmona-Fontaine
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Cell 21:1026-37. 2011
    ..We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents...
  8. doi request reprint Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
    Helen K Matthews
    Department of Anatomy and Development Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 135:1771-80. 2008
    ..In addition, we show that RhoA inhibits Rac in NC cells. We present a model in which Syn4 and PCP control directional NC migration by, at least in part, regulating membrane protrusions through the regulation of small GTPase activities...
  9. doi request reprint Chase-and-run between adjacent cell populations promotes directional collective migration
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Nat Cell Biol 15:763-72. 2013
    ..The cell interactions described here are essential for correct NC migration and for segregation of placodes in vivo and are likely to represent a general mechanism of coordinated migration. ..
  10. doi request reprint Cadherins in collective cell migration of mesenchymal cells
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 24:677-84. 2012
    ..Here we will explore the idea that Cadherins play an essential role during collective migration of mesenchymal cells...
  11. pmc The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition
    Elias H Barriga
    Department of Cell and Developmental Biology, University College London, London, England, UK
    J Cell Biol 201:759-76. 2013
    ..Our results point to Hif-1α as a novel and key regulator that integrates EMT and chemotaxis during migration of neural crest cells...
  12. pmc The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction
    Bo Li
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 136:3267-78. 2009
    ..We propose a new genetic cascade that operates in the distinction between anterior placodal and NC territories...
  13. ncbi request reprint Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, UK
    Dev Biol 309:208-21. 2007
    ..These results demonstrate that anterior regions of the embryo lack NC because of a mechanism, conserved from fish to mammals, that suppresses Wnt/beta-catenin signaling via Dkk1...
  14. pmc Can mesenchymal cells undergo collective cell migration? The case of the neural crest
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London, UK
    Cell Adh Migr 5:490-8. 2011
    ....
  15. doi request reprint Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, UK
    Dev Biol 366:34-54. 2012
    ..Given the similarities between neural crest migration and cancer invasion, these cells may represent a useful model for understanding the mechanisms of metastasis...
  16. doi request reprint Collective cell migration of epithelial and mesenchymal cells
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London, UK
    Cell Mol Life Sci 70:3481-92. 2013
    ..In this review, we give an overview of the mechanisms driving collective cell migration in epithelial tissues and discuss how mesenchymal cells can cooperate to behave as a collective in the absence of bona fide cell-cell adhesions. ..
  17. pmc Molecular analysis of neural crest migration
    Sei Kuriyama
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 363:1349-62. 2008
    ..Finally, we analyse how the direction of migration is controlled by regulation of cell polarity and how the planar cell polarity or non-canonical Wnt signalling is involved in this process...
  18. pmc Early neural crest induction requires an initial inhibition of Wnt signals
    Ben Steventon
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 365:196-207. 2012
    ....
  19. doi request reprint Collective cell migration of the cephalic neural crest: the art of integrating information
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, United Kingdom
    Genesis 49:164-76. 2011
    ..Therefore, understanding how CNC cells interpret multiple inputs to achieve directional collective cell migration will shed light on pathological situations where cell migration is involved...
  20. doi request reprint Wnt11r is required for cranial neural crest migration
    Helen K Matthews
    Department of Cell and Developmental Biology, University College London, United Kingdom
    Dev Dyn 237:3404-9. 2008
    ..Finally, neural crest graft experiments show that wnt11r is required in a non-cell-autonomous manner to control neural crest migration...
  21. pmc A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways
    Sei Kuriyama
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 136:575-84. 2009
    ..These findings might account for previous reports implicating PKC in neural induction and allow us to propose a link between FGF and PKC signalling pathways during neural induction...
  22. pmc Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays
    Claudia Linker
    Department of Cell and Developmental Biology, University College London, Gower Street Anatomy Building, London WC1E 6BT, UK
    Dev Biol 327:478-86. 2009
    ..We propose that the animal cap assay in Xenopus and explant assays in the chick are unsuitable for studying instructive signals in neural induction...
  23. doi request reprint Beads on the run: beads as alternative tools for chemotaxis assays
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London, UK
    Methods Mol Biol 769:449-60. 2011
    ..They allow time-lapse study, high-resolution microscopy, and can be set up at no extra cost...
  24. pmc Directional cell migration in vivo: Wnt at the crest
    Carlos Carmona-Fontaine
    Department of Cell and Developmental Biology, University College London, London, UK
    Cell Adh Migr 2:240-2. 2008
    ..Here we discuss a model where these signals are integrated to generate directional migration in vivo...
  25. ncbi request reprint Essential role of non-canonical Wnt signalling in neural crest migration
    Jaime De Calisto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:2587-97. 2005
    ....
  26. ncbi request reprint Genetic network during neural crest induction: from cell specification to cell survival
    Ben Steventon
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Semin Cell Dev Biol 16:647-54. 2005
    ..We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step...
  27. doi request reprint The role of the non-canonical Wnt-planar cell polarity pathway in neural crest migration
    Roberto Mayor
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 457:19-26. 2014
    ..The present review summarizes the mechanisms that control neural crest migration and focuses on the role of non-canonical Wnt or PCP signalling in this process...
  28. doi request reprint Neural crest migration: interplay between chemorepellents, chemoattractants, contact inhibition, epithelial-mesenchymal transition, and collective cell migration
    Eric Theveneau
    Cell and Developmental Biology Department, University College London, London, UK
    Wiley Interdiscip Rev Dev Biol 1:435-45. 2012
    ..Consequently, several birth defects and craniofacial disorders, such as Treacher Collins syndrome, are due to improper NC cell migration...