T M Mayhew

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Quantitative immunoelectron microscopy: alternative ways of assessing subcellular patterns of gold labeling
    Terry M Mayhew
    Centre for Integrated System Biology and Medicine, School of Biomedical Sciences and Institute of Clinical Research, University of Nottingham, UK
    Methods Mol Biol 369:309-29. 2007
  2. doi request reprint Estimating oxygen diffusive conductances of gas-exchange systems: A stereological approach illustrated with the human placenta
    Terry M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom Electronic address
    Ann Anat 196:34-40. 2014
  3. doi request reprint Turnover of human villous trophoblast in normal pregnancy: What do we know and what do we need to know?
    T M Mayhew
    School of Life Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK Electronic address
    Placenta 35:229-40. 2014
  4. pmc Cross-sectional data on soft tissue morphometry of the growing hand and fingers of dextral individuals 5-65 years old
    T M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Anat 221:373-81. 2012
  5. pmc Effects of estradiol and FSH on maturation of the testis in the hypogonadal (hpg) mouse
    Helen Baines
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Reprod Biol Endocrinol 6:4. 2008
  6. pmc Allometric studies on growth and development of the human placenta: growth of tissue compartments and diffusive conductances in relation to placental volume and fetal mass
    Terry M Mayhew
    School of Biomedical Sciences and Institute of Clinical Research, Queen s Medical Centre, University of Nottingham, UK
    J Anat 208:785-94. 2006
  7. ncbi request reprint The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 28:233-8. 2007
  8. ncbi request reprint Stereology and the placenta: where's the point? -- a review
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Floor E, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 27:S17-25. 2006
  9. ncbi request reprint Morphometric evidence that villous development and fetoplacental angiogenesis are compromised by intrauterine growth restriction but not by pre-eclampsia
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 25:829-33. 2004
  10. ncbi request reprint Applications of an efficient method for comparing immunogold labelling patterns in the same sets of compartments in different groups of cells
    Terry M Mayhew
    Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research and School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, NG7 2UH, Nottingham, UK
    Histochem Cell Biol 122:171-7. 2004

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Quantitative immunoelectron microscopy: alternative ways of assessing subcellular patterns of gold labeling
    Terry M Mayhew
    Centre for Integrated System Biology and Medicine, School of Biomedical Sciences and Institute of Clinical Research, University of Nottingham, UK
    Methods Mol Biol 369:309-29. 2007
    ..This chapter reviews these new methods and illustrates their application with a consistent dataset...
  2. doi request reprint Estimating oxygen diffusive conductances of gas-exchange systems: A stereological approach illustrated with the human placenta
    Terry M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom Electronic address
    Ann Anat 196:34-40. 2014
    ..The underlying principles were formulated in pioneering studies on the pulmonary lung but are illustrated here by taking the human placenta as the gas exchanger...
  3. doi request reprint Turnover of human villous trophoblast in normal pregnancy: What do we know and what do we need to know?
    T M Mayhew
    School of Life Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK Electronic address
    Placenta 35:229-40. 2014
    ..This would also provide a surer foundation for interpreting results from different research groups and changes in normal and complicated pregnancies. ..
  4. pmc Cross-sectional data on soft tissue morphometry of the growing hand and fingers of dextral individuals 5-65 years old
    T M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Anat 221:373-81. 2012
    ..It is tempting to speculate that these are manifestations of the antero-posterior gradients established by signalling events that control digit development and patterning in utero...
  5. pmc Effects of estradiol and FSH on maturation of the testis in the hypogonadal (hpg) mouse
    Helen Baines
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Reprod Biol Endocrinol 6:4. 2008
    ..The aim of the current studies was to investigate whether these effects of estradiol are direct effects in the testis, or indirect actions via paradoxical stimulation of FSH secretion from the pituitary gland...
  6. pmc Allometric studies on growth and development of the human placenta: growth of tissue compartments and diffusive conductances in relation to placental volume and fetal mass
    Terry M Mayhew
    School of Biomedical Sciences and Institute of Clinical Research, Queen s Medical Centre, University of Nottingham, UK
    J Anat 208:785-94. 2006
    ..Allometric analysis of results from recent studies on the murine placenta suggest further that diffusive conductances may also be matched to fetal mass during gestation and to fetal mass at term across species...
  7. ncbi request reprint The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 28:233-8. 2007
    ..The decline in total conductances is indicative of perturbations operating at the levels of villous trophoblast and fetal vasculature and these may contribute to fetal hypoxic stress...
  8. ncbi request reprint Stereology and the placenta: where's the point? -- a review
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Floor E, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 27:S17-25. 2006
    ..Examples include diffusive transport, villous growth, fetoplacental angiogenesis, trophoblast turnover, arterial vascular remodelling and high-resolution immuno-localization studies...
  9. ncbi request reprint Morphometric evidence that villous development and fetoplacental angiogenesis are compromised by intrauterine growth restriction but not by pre-eclampsia
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 25:829-33. 2004
    ..The latter is due to production of fewer and/or shorter capillary segments (rather than a decrease in capillary calibre), does not affect villous capillarization and is not accompanied by luminal remodelling...
  10. ncbi request reprint Applications of an efficient method for comparing immunogold labelling patterns in the same sets of compartments in different groups of cells
    Terry M Mayhew
    Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research and School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, NG7 2UH, Nottingham, UK
    Histochem Cell Biol 122:171-7. 2004
    ..Its application is illustrated using datasets from immunolabelling studies designed to localise the KDEL receptor, phosphatidyl-inositol 4,5-bisphosphate, GLUT4 and rab4 at the electron microscopic level...
  11. ncbi request reprint A simple method for comparing immunogold distributions in two or more experimental groups illustrated using GLUT1 labelling of isolated trophoblast cells
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 25:580-4. 2004
    ..The method is illustrated using datasets from immunolabelling studies on the localization of GLUT1 glucose transporters in cultured human trophoblast cells exposed to different treatments...
  12. ncbi request reprint Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 25:127-39. 2004
    ..A more integrated approach involving also parallel analysis of the effects of erythropoietin and other potential vasoactive factors on the behaviour and morphology of fetal vessels would be beneficial...
  13. ncbi request reprint Taking tissue samples from the placenta: an illustration of principles and strategies
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 29:1-14. 2008
    ..It is hoped that this review will inform future study designs, encourage greater transparency and facilitate sampling improvements...
  14. pmc Human 2D (index) and 4D (ring) digit lengths: their variation and relationships during the menstrual cycle
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine and Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Anat 211:630-8. 2007
    ..We conclude that finger lengths are cycle-dependent and that account should be taken of this, and of oral contraceptive usage, in future studies on female digit lengths and their ratios...
  15. doi request reprint Quantifying immunogold labelling patterns of cellular compartments when they comprise mixtures of membranes (surface-occupying) and organelles (volume-occupying)
    Terry M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    Histochem Cell Biol 129:367-78. 2008
    ..LDs of the chosen compartments are used to calculate RLI and chi-squared values and these serve to identify those compartments in which there is preferential labelling. The methods are illustrated by synthetic and real data...
  16. pmc Developments in cell biology for quantitative immunoelectron microscopy based on thin sections: a review
    Terry M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, Nottingham, NG7 2UH, UK
    Histochem Cell Biol 130:299-313. 2008
    ..Finally, we discuss labelling efficiency (the number of gold particles per target molecule) and describe how it can be estimated for volume- or surface-occupiers by combining stereological data with biochemical determinations...
  17. doi request reprint A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs
    Terry M Mayhew
    School of Biomedical Sciences, Centre for Integrated Systems Biology and Medicine, Queen s Medical Centre, E Floor, University of Nottingham, Nottingham NG7 2UH, UK
    Ann Anat 191:153-70. 2009
    ..g. total volumes, surfaces and numbers of structures per cell. Here, the utility, limitations and recent applications of these methods are reviewed...
  18. pmc A stereological perspective on placental morphology in normal and complicated pregnancies
    Terry M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    J Anat 215:77-90. 2009
    ..Finally, quantitative immunoelectron microscopy now permits more rigorous analysis of the spatial distributions of interesting molecules between subcellular compartments or shifts in distributions following experimental manipulation...
  19. doi request reprint Quantifying immunogold localization patterns on electron microscopic thin sections of placenta: recent developments
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 30:565-70. 2009
    ..The methods are illustrated using data taken from studies aimed at localising protein antigens (caveolin-1 and GLUT1) in specimens of term human placenta...
  20. doi request reprint Multiple-labelling immunoEM using different sizes of colloidal gold: alternative approaches to test for differential distribution and colocalization in subcellular structures
    Terry M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, E Floor, Nottingham, NG7 2UH, UK
    Histochem Cell Biol 135:317-26. 2011
    ..These simple and efficient approaches should be of more immediate utility to those interested in codistribution and colocalization in multiple immunogold labelling investigations...
  21. doi request reprint Quantifying immunogold localization on electron microscopic thin sections: a compendium of new approaches for plant cell biologists
    Terry M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Exp Bot 62:4101-13. 2011
    ..The various methods are illustrated with worked examples based on empirical and synthetic data and will be of practical benefit to those applying single or multiple immunogold labelling in their research...
  22. ncbi request reprint Maternal diabetes mellitus is associated with altered deposition of fibrin-type fibrinoid at the villous surface in term placentae
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    Placenta 24:524-31. 2003
    ....
  23. ncbi request reprint Fibrin-type fibrinoid in placentae from pregnancies associated with maternal smoking: association with villous trophoblast and impact on intervillous porosity
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Placenta 24:501-9. 2003
    ..This activity seems to reside in thin regions of syncytium...
  24. ncbi request reprint Numbers of nuclei in different tissue compartments of fetal ventricular myocardium from 16 to 35 weeks of gestation
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, UK
    Virchows Arch 433:167-72. 1998
    ..7 million nuclei per hour) and that for endothelial cell nuclei was 5.1 x 10(7) per week (0.3 million nuclei per hour). Predictions are made about the postnatal ages at which adult ratios of different nuclear types might be attained...
  25. ncbi request reprint Relative labelling index: a novel stereological approach to test for non-random immunogold labelling of organelles and membranes on transmission electron microscopy thin sections
    T M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, Nottingham NG7 2UH, UK
    J Microsc 205:153-64. 2002
    ..Contingency table analysis allows labelling distributions in different groups of cells to be compared. Protocols are described and illustrated using worked specimen examples and real data...
  26. ncbi request reprint Villous trophoblast of human placenta: a coherent view of its turnover, repair and contributions to villous development and maturation
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, United Kingdom
    Histol Histopathol 16:1213-24. 2001
    ..Adaptive re-settings of the epithelial steady state may also occur in abnormal pregnancies...
  27. ncbi request reprint Thinning of the intervascular tissue layers of the human placenta is an adaptive response to passive diffusion in vivo and may help to predict the origins of fetal hypoxia
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, UK
    Eur J Obstet Gynecol Reprod Biol 81:101-9. 1998
    ..To test the hypothesis that thinning of the placental intervascular layers, and greater variability in thickness, are positive adaptations to facilitate passive diffusion and may help to resolve different categories of fetal hypoxia...
  28. pmc Stereological comparison of 3D spatial relationships involving villi and intervillous pores in human placentas from control and diabetic pregnancies
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, UK
    J Anat 197:263-74. 2000
    ..Therefore, it is likely that fetal hypoxia associated with maternal diabetes mellitus is due to metabolic disturbances rather than abnormalities in the quantities or arrangements of maternal vascular spaces...
  29. ncbi request reprint A stereological method for testing whether or not there is random deposition of perivillous fibrin-type fibrinoid at the villous surface: description and pilot applications to term placentae
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Placenta 21:684-92. 2000
    ..The nascent detachment site is immediately covered by FTF prior to repair by re-epithelialization...
  30. ncbi request reprint Second-order stereology and ultrastructural examination of the spatial arrangements of tissue compartments within glomeruli of normal and diabetic kidneys
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, U K
    J Microsc 195:87-95. 1999
    ..These studies re-emphasize the relative invariance of biological organization and the value and limitations of covariance analysis for quantifying different levels of organization in different tissues and experimental groups...
  31. ncbi request reprint Proliferation, differentiation and apoptosis in villous trophoblast at 13-41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes)
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Placenta 20:407-22. 1999
    ..We propose further that clustered nuclei (pre-apoptotic and apoptotic) in syncytial knots probably represent the extrusion component of normal continuous epithelial turnover...
  32. pmc Quantitative description of the spatial arrangement of organelles in a polarised secretory epithelial cell: the salivary gland acinar cell
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, UK
    J Anat 194:279-85. 1999
    ..These findings provide quantitative confirmation of the polarised arrangement of zymogen granules within acinar cells and further support for the relative invariance of biological organisation between subjects...
  33. ncbi request reprint Epithelial integrity, cell death and cell loss in mammalian small intestine
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, United Kingdom
    Histol Histopathol 14:257-67. 1999
    ....
  34. ncbi request reprint Hypobaric hypoxia and villous trophoblast: evidence that human pregnancy at high altitude (3600 m) perturbs epithelial turnover and coagulation-fibrinolysis in the intervillous space
    T M Mayhew
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Placenta 23:154-62. 2002
    ..The findings are partly consistent with results from in vitro studies which indicate that hypoxia stimulates proliferation of cytotrophoblast but impairs fusion into syncytium...
  35. ncbi request reprint Enhanced fetoplacental angiogenesis in pre-gestational diabetes mellitus: the extra growth is exclusively longitudinal and not accompanied by microvascular remodelling
    T M Mayhew
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Diabetologia 45:1434-9. 2002
    ..Here, placentas from control subjects and patients with pre-gestational Type I (insulin-dependent) diabetes mellitus were used to test for differences in measures of angiogenesis and vascular remodelling...
  36. ncbi request reprint A simpler way of comparing the labelling densities of cellular compartments illustrated using data from VPARP and LAMP-1 immunogold labelling experiments
    Terry Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, Nottingham, NG7 2UH, UK
    Histochem Cell Biol 119:333-41. 2003
    ..This approach provides a simple and efficient way of comparing LDs in different compartments. Its utility is illustrated using data from VPARP and LAMP-1 labelling experiments...
  37. ncbi request reprint Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction
    T M Mayhew
    School of Human Development, University of Nottingham, City Hospital, UK
    Placenta 24:219-26. 2003
    ..These changes are likely to reduce placental oxygen diffusive conductances and contribute to fetal hypoxic stress...
  38. ncbi request reprint Recent applications of the new stereology have thrown fresh light on how the human placenta grows and develops its form
    T M Mayhew
    Department of Human Anatomy and Cell Biology, University of Nottingham, Queen s Medical Centre, U K
    J Microsc 186:153-63. 1997
    ..Elaboration of finer terminal branches on villous trees leads to a decline in the star volumes of villi and intervillous pores. Some of the functional implications of these findings are discussed...
  39. ncbi request reprint Changes in fetal capillaries during preplacental hypoxia: growth, shape remodelling and villous capillarization in placentae from high-altitude pregnancies
    Terry M Mayhew
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, UK
    Placenta 24:191-8. 2003
    ..The importance of controlling for various potential confounders is also emphasized...
  40. ncbi request reprint The 'reference trap' revisited: examples of the dangers in using ratios to describe fetoplacental angiogenesis and trophoblast turnover
    T M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    Placenta 24:1-7. 2003
    ..Sometimes (e.g. when relying on biopsy samples), the size of the reference cannot be determined. In such cases, ratio data must be interpreted with due caution...
  41. ncbi request reprint Quantitative studies on the villi, trophoblast and intervillous pores of placentae from women with well-controlled diabetes mellitus
    T M Mayhew
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, UK
    Placenta 19:371-7. 1998
    ..It is concluded that normal values are preserved by good glycaemic control regardless of diabetic grouping...
  42. ncbi request reprint Fetoplacental angiogenesis during gestation is biphasic, longitudinal and occurs by proliferation and remodelling of vascular endothelial cells
    Terry M Mayhew
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, UK
    Placenta 23:742-50. 2002
    ....
  43. pmc Mapping the distributions and quantifying the labelling intensities of cell compartments by immunoelectron microscopy: progress towards a coherent set of methods
    Terry M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Anat 219:647-60. 2011
    ..Here, the current state of the art is reviewed and approaches are illustrated with virtual datasets...
  44. ncbi request reprint Vascular endothelial cadherin and beta-catenin in human fetoplacental vessels of pregnancies complicated by Type 1 diabetes: associations with angiogenesis and perturbed barrier function
    L Leach
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, UK
    Diabetologia 47:695-709. 2004
    ....
  45. pmc Human 2D (index) and 4D (ring) finger lengths and ratios: cross-sectional data on linear growth patterns, sexual dimorphism and lateral asymmetry from 4 to 60 years of age
    L Gillam
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Anat 213:325-35. 2008
    ....
  46. ncbi request reprint Villous trophoblast: morphometric perspectives on growth, differentiation, turnover and deposition of fibrin-type fibrinoid during gestation
    T M Mayhew
    School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Placenta 22:628-38. 2001
    ....
  47. ncbi request reprint Functional magnetic resonance imaging (magnetization transfer) and stereological analysis of human placentae in normal pregnancy and in pre-eclampsia and intrauterine growth restriction
    S S Ong
    Department of Obstetrics and Gynecology, School of Human Development, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Placenta 25:408-12. 2004
    ....
  48. doi request reprint Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex
    T M Mayhew
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, E Floor, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Placenta 29:366-73. 2008
    ..The findings suggest that the morphometric differences in fetoplacental vascularity are likely to be due to the effects of asthma and use of inhaled GCs rather than the effects of maternal or fetal hypoxic stress...
  49. doi request reprint Volumes and numbers of intervillous pores and villous domains in placentas associated with intrauterine growth restriction and/or pre-eclampsia
    A Rainey
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Placenta 31:602-6. 2010
    ....
  50. ncbi request reprint Induction of intrauterine growth restriction by reducing placental vascular growth with the angioinhibin TNP-470
    Catrin S Rutland
    School of Biomedical Sciences, University of Nottingham, Nottingham, NG7 2UH United Kingdom
    Biol Reprod 73:1164-73. 2005
    ..5. This study provides conclusive evidence that administration of TNP-470 interferes with placental vascular proliferation and vessel caliber and results in a reproducible model of IUGR...
  51. ncbi request reprint Remodeling of myometrial radial arteries in preeclampsia
    Stephen S Ong
    School of Human Development, University of Nottingham, City Hospital, Nottingham, United Kingdom
    Am J Obstet Gynecol 192:572-9. 2005
    ..This study was undertaken to test for structural differences between myometrial radial arteries isolated from women having normal pregnancies and pregnancies complicated by preeclampsia and intrauterine growth restriction...
  52. ncbi request reprint A rapid method for assessing the distribution of gold labeling on thin sections
    John Milton Lucocq
    School of Life Sciences, WTB MSI Complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Histochem Cytochem 52:991-1000. 2004
    ..If more precise estimates of labeling proportions over individual compartments are required (e.g., to achieve coefficients of error of 10-20%), then 100-200 particles need to be counted over each compartment of interest...
  53. ncbi request reprint A novel quantitative method for analyzing the distributions of nanoparticles between different tissue and intracellular compartments
    Christian Mühlfeld
    University of Bern, Institute of Anatomy, Division of Histology, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    J Aerosol Med 20:395-407. 2007
    ..We first describe the preconditions and the way to implement these methods, then provide three worked examples, and finally discuss the advantages, pitfalls, and limitations of this method...