R C May

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells
    Wilber Sabiiti
    Institute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e35455. 2012
  2. pmc A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans
    Elizabeth K Marsh
    School of Biosciences, University of Birmingham, Birmingham, West Midlands, United Kingdom
    PLoS ONE 6:e16839. 2011
  3. pmc Automated analysis of cryptococcal macrophage parasitism using GFP-tagged cryptococci
    Kerstin Voelz
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e15968. 2010
  4. pmc The human fungal pathogen Cryptococcus neoformans escapes macrophages by a phagosome emptying mechanism that is inhibited by Arp2/3 complex-mediated actin polymerisation
    Simon A Johnston
    School of Biosciences, College of Life and Environmental Sciences, The University of Birmingham, Birmingham, United Kingdom
    PLoS Pathog 6:e1001041. 2010
  5. pmc Phenotypic covariance of longevity, immunity and stress resistance in the caenorhabditis nematodes
    Francis R G Amrit
    School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom
    PLoS ONE 5:e9978. 2010
  6. pmc The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages
    Nicola J Cumley
    School of Biosciences, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Infect Immun 80:1650-61. 2012
  7. pmc Caenorhabditis elegans, a model organism for investigating immunity
    Elizabeth K Marsh
    School of Biosciences, University of Birmingham, Birmingham, West Midlands, UK
    Appl Environ Microbiol 78:2075-81. 2012
  8. pmc Direct cell-to-cell spread of a pathogenic yeast
    Hansong Ma
    Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Immunol 8:15. 2007
  9. ncbi request reprint Gender, immunity and the regulation of longevity
    Robin C May
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Bioessays 29:795-802. 2007
  10. ncbi request reprint The Arp2/3 complex: a central regulator of the actin cytoskeleton
    R C May
    School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
    Cell Mol Life Sci 58:1607-26. 2001

Collaborators

Detail Information

Publications15

  1. pmc Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells
    Wilber Sabiiti
    Institute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e35455. 2012
    ..Thus entry into brain microvascular endothelial cells is most likely a passive event that occurs following 'trapping' within capillary beds of the BBB...
  2. pmc A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans
    Elizabeth K Marsh
    School of Biosciences, University of Birmingham, Birmingham, West Midlands, United Kingdom
    PLoS ONE 6:e16839. 2011
    ..elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought...
  3. pmc Automated analysis of cryptococcal macrophage parasitism using GFP-tagged cryptococci
    Kerstin Voelz
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e15968. 2010
    ..In addition, we report the development of a method to effectively and rapidly investigate macrophage parasitism by flow cytometry, a technique that preserves the accuracy of current approaches but offers a four-fold improvement in speed...
  4. pmc The human fungal pathogen Cryptococcus neoformans escapes macrophages by a phagosome emptying mechanism that is inhibited by Arp2/3 complex-mediated actin polymerisation
    Simon A Johnston
    School of Biosciences, College of Life and Environmental Sciences, The University of Birmingham, Birmingham, United Kingdom
    PLoS Pathog 6:e1001041. 2010
    ....
  5. pmc Phenotypic covariance of longevity, immunity and stress resistance in the caenorhabditis nematodes
    Francis R G Amrit
    School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom
    PLoS ONE 5:e9978. 2010
    ..Here we investigate this phenotypic covariance by comparing longevity, stress resistance and immunity in four Caenorhabditis species...
  6. pmc The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages
    Nicola J Cumley
    School of Biosciences, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Infect Immun 80:1650-61. 2012
    ..Moreover, we show that the GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome...
  7. pmc Caenorhabditis elegans, a model organism for investigating immunity
    Elizabeth K Marsh
    School of Biosciences, University of Birmingham, Birmingham, West Midlands, UK
    Appl Environ Microbiol 78:2075-81. 2012
    ..In this review, we consider the application of C. elegans to human infectious disease research, as well as consider the nematode response to these natural pathogens...
  8. pmc Direct cell-to-cell spread of a pathogenic yeast
    Hansong Ma
    Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Immunol 8:15. 2007
    ..This intracellular phase is thought to underlie the ability of the pathogen to remain latent for long periods of time within infected individuals...
  9. ncbi request reprint Gender, immunity and the regulation of longevity
    Robin C May
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Bioessays 29:795-802. 2007
    ..Finally, I expand on the recent suggestion of a key role for the insulin/IGF-1 signalling pathway in regulating sex-dependent differences in lifespan and I highlight a number of areas for future investigation...
  10. ncbi request reprint The Arp2/3 complex: a central regulator of the actin cytoskeleton
    R C May
    School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
    Cell Mol Life Sci 58:1607-26. 2001
    ..Furthermore, several pathogenic microorganisms have evolved strategies to 'hijack' the Arp2/3 complex to their own advantage. Finally, I discuss some of the questions which remain unanswered about this fascinating complex...
  11. ncbi request reprint Plagiarism and pathogenesis: common themes in actin remodeling
    R C May
    School of Biosciences, University of Birmingham, Egbaston, United Kingdom
    Dev Cell 1:317-8. 2001
    ..The involvement of Nck in pedestal formation by EPEC highlights the similar strategies adopted by this bacterium and the Vaccinia virus to hijack the host cell's cytoskeleton...
  12. ncbi request reprint Phagocytosis and the actin cytoskeleton
    R C May
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    J Cell Sci 114:1061-77. 2001
    ..Similarly, a wide diversity of 'effector molecules' are now implicated in actin-remodelling downstream of these receptors...
  13. ncbi request reprint The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes
    R C May
    Department of Biochemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Curr Biol 9:759-62. 1999
    ..We conclude that the Arp2/3 complex is a host-cell factor essential for the actin-based motility of L. monocytogenes, suggesting that it plays a pivotal role in regulating the actin cytoskeleton...
  14. pmc Sex-dependent resistance to the pathogenic fungus Cryptococcus neoformans
    Maaike C W van den Berg
    Department of Molecular Pathobiology, University of Birmingham, UK
    Genetics 173:677-83. 2006
    ..Our results hint at an overlap between the pathways controlling immunity and longevity and raise the possibility that differential regulation of these pathways may contribute to sex-dependent and species-dependent variation...
  15. ncbi request reprint Younger for longer: insulin signalling, immunity and ageing
    Francis R G Amrit
    School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Curr Aging Sci 3:166-76. 2010
    ..We also reflect on the impact and significance of the evolutionary diversification of this pathway and propose a model for how such differences could explain both inter and intra-species differences in ageing...