R C May
Affiliation: University of Birmingham
- The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophagesNicola J Cumley
School of Biosciences, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Infect Immun 80:1650-61. 2012..Moreover, we show that the GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome...
- Caenorhabditis elegans, a model organism for investigating immunityElizabeth K Marsh
School of Biosciences, University of Birmingham, Birmingham, West Midlands, UK
Appl Environ Microbiol 78:2075-81. 2012..In this review, we consider the application of C. elegans to human infectious disease research, as well as consider the nematode response to these natural pathogens...
- Direct cell-to-cell spread of a pathogenic yeastHansong Ma
Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
BMC Immunol 8:15. 2007..This intracellular phase is thought to underlie the ability of the pathogen to remain latent for long periods of time within infected individuals...
- Gender, immunity and the regulation of longevityRobin C May
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
Bioessays 29:795-802. 2007..Finally, I expand on the recent suggestion of a key role for the insulin/IGF-1 signalling pathway in regulating sex-dependent differences in lifespan and I highlight a number of areas for future investigation...
- The Arp2/3 complex: a central regulator of the actin cytoskeletonR C May
School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
Cell Mol Life Sci 58:1607-26. 2001..Furthermore, several pathogenic microorganisms have evolved strategies to 'hijack' the Arp2/3 complex to their own advantage. Finally, I discuss some of the questions which remain unanswered about this fascinating complex...
- Plagiarism and pathogenesis: common themes in actin remodelingR C May
School of Biosciences, University of Birmingham, Egbaston, United Kingdom
Dev Cell 1:317-8. 2001..The involvement of Nck in pedestal formation by EPEC highlights the similar strategies adopted by this bacterium and the Vaccinia virus to hijack the host cell's cytoskeleton...
- Phagocytosis and the actin cytoskeletonR C May
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
J Cell Sci 114:1061-77. 2001..Similarly, a wide diversity of 'effector molecules' are now implicated in actin-remodelling downstream of these receptors...
- The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenesR C May
Department of Biochemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Curr Biol 9:759-62. 1999..We conclude that the Arp2/3 complex is a host-cell factor essential for the actin-based motility of L. monocytogenes, suggesting that it plays a pivotal role in regulating the actin cytoskeleton...
- Sex-dependent resistance to the pathogenic fungus Cryptococcus neoformansMaaike C W van den Berg
Department of Molecular Pathobiology, University of Birmingham, UK
Genetics 173:677-83. 2006..Our results hint at an overlap between the pathways controlling immunity and longevity and raise the possibility that differential regulation of these pathways may contribute to sex-dependent and species-dependent variation...
- Younger for longer: insulin signalling, immunity and ageingFrancis R G Amrit
School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Curr Aging Sci 3:166-76. 2010..We also reflect on the impact and significance of the evolutionary diversification of this pathway and propose a model for how such differences could explain both inter and intra-species differences in ageing...