Research Topics
Species | R C MaySummaryAffiliation: University of Birmingham Country: UK Publications
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Publications
The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophagesNicola J Cumley
School of Biosciences, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Infect Immun 80:1650-61. 2012..Moreover, we show that the GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome...
Caenorhabditis elegans, a model organism for investigating immunityElizabeth K Marsh
School of Biosciences, University of Birmingham, Birmingham, West Midlands, UK
Appl Environ Microbiol 78:2075-81. 2012..In this review, we consider the application of C. elegans to human infectious disease research, as well as consider the nematode response to these natural pathogens...
Direct cell-to-cell spread of a pathogenic yeastHansong Ma
Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
BMC Immunol 8:15. 2007..This intracellular phase is thought to underlie the ability of the pathogen to remain latent for long periods of time within infected individuals...
Gender, immunity and the regulation of longevityRobin C May
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
Bioessays 29:795-802. 2007..Finally, I expand on the recent suggestion of a key role for the insulin/IGF-1 signalling pathway in regulating sex-dependent differences in lifespan and I highlight a number of areas for future investigation...
The Arp2/3 complex: a central regulator of the actin cytoskeletonR C May
School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
Cell Mol Life Sci 58:1607-26. 2001..Furthermore, several pathogenic microorganisms have evolved strategies to 'hijack' the Arp2/3 complex to their own advantage. Finally, I discuss some of the questions which remain unanswered about this fascinating complex...
Plagiarism and pathogenesis: common themes in actin remodelingR C May
School of Biosciences, University of Birmingham, Egbaston, United Kingdom
Dev Cell 1:317-8. 2001..The involvement of Nck in pedestal formation by EPEC highlights the similar strategies adopted by this bacterium and the Vaccinia virus to hijack the host cell's cytoskeleton...
Phagocytosis and the actin cytoskeletonR C May
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
J Cell Sci 114:1061-77. 2001..Similarly, a wide diversity of 'effector molecules' are now implicated in actin-remodelling downstream of these receptors...
The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenesR C May
Department of Biochemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Curr Biol 9:759-62. 1999..We conclude that the Arp2/3 complex is a host-cell factor essential for the actin-based motility of L. monocytogenes, suggesting that it plays a pivotal role in regulating the actin cytoskeleton...
Sex-dependent resistance to the pathogenic fungus Cryptococcus neoformansMaaike C W van den Berg
Department of Molecular Pathobiology, University of Birmingham, UK
Genetics 173:677-83. 2006..Our results hint at an overlap between the pathways controlling immunity and longevity and raise the possibility that differential regulation of these pathways may contribute to sex-dependent and species-dependent variation...
Younger for longer: insulin signalling, immunity and ageingFrancis R G Amrit
School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Curr Aging Sci 3:166-76. 2010..We also reflect on the impact and significance of the evolutionary diversification of this pathway and propose a model for how such differences could explain both inter and intra-species differences in ageing...
