Paul M Matthews

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Noninvasive brain imaging for experimental medicine in drug discovery
    Paul M Matthews
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Expert Opin Drug Discov 1:111-21. 2006
  2. ncbi request reprint Towards understanding language organisation in the brain using fMRI
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom
    Hum Brain Mapp 18:239-47. 2003
  3. ncbi request reprint Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis
    A Parry
    Centre for Functional Magnetic Resonance Imaging of the Brain, The John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    J Neurol 250:171-8. 2003
  4. ncbi request reprint Functional magnetic resonance imaging: clinical applications and potential
    P M Matthews
    Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headington, UK
    J Inherit Metab Dis 22:337-52. 1999
  5. ncbi request reprint An update on neuroimaging of multiple sclerosis
    Paul M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Curr Opin Neurol 17:453-8. 2004
  6. ncbi request reprint Non-invasive mapping of brain functions and brain recovery: applying lessons from cognitive neuroscience to neurorehabilitation
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, UK
    Restor Neurol Neurosci 22:245-60. 2004
  7. ncbi request reprint Novel approaches to imaging brain tumors
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Hematol Oncol Clin North Am 15:609-30. 2001
  8. pmc Functional magnetic resonance imaging
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 75:6-12. 2004
  9. pmc Structural and functional bases for individual differences in motor learning
    Valentina Tomassini
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, United Kingdom
    Hum Brain Mapp 32:494-508. 2011
  10. pmc Relating brain damage to brain plasticity in patients with multiple sclerosis
    Valentina Tomassini
    Oxford Centre for Functional MRI of the Brain FMRIB, University of Oxford, Oxford, UK
    Neurorehabil Neural Repair 26:581-93. 2012

Detail Information

Publications84

  1. doi request reprint Noninvasive brain imaging for experimental medicine in drug discovery
    Paul M Matthews
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Expert Opin Drug Discov 1:111-21. 2006
    ..Imaging methods offer the ultimate promise for the development of clinically predictive surrogate markers of disease responses to new drugs...
  2. ncbi request reprint Towards understanding language organisation in the brain using fMRI
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom
    Hum Brain Mapp 18:239-47. 2003
    ..We describe how TMS combined with fMRI has confirmed a role for the left inferior frontal cortex in semantic processing...
  3. ncbi request reprint Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis
    A Parry
    Centre for Functional Magnetic Resonance Imaging of the Brain, The John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    J Neurol 250:171-8. 2003
    ..The consequences of reduced inflammation on pathological progression relevant to disability therefore may be present, but substantially delayed. Alternatively, distinct mechanisms may contribute to the two processes...
  4. ncbi request reprint Functional magnetic resonance imaging: clinical applications and potential
    P M Matthews
    Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headington, UK
    J Inherit Metab Dis 22:337-52. 1999
    ....
  5. ncbi request reprint An update on neuroimaging of multiple sclerosis
    Paul M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Curr Opin Neurol 17:453-8. 2004
    ..Continued developments of imaging methods and their use for diagnosis, monitoring pathology and understanding disease progression are reviewed here...
  6. ncbi request reprint Non-invasive mapping of brain functions and brain recovery: applying lessons from cognitive neuroscience to neurorehabilitation
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, UK
    Restor Neurol Neurosci 22:245-60. 2004
    ..The combination of strategies based on a strong biological rational with monitoring their effects using highly informative functional brain imaging methods heralds a new era of scientifically-founded neurorehabilitation...
  7. ncbi request reprint Novel approaches to imaging brain tumors
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Hematol Oncol Clin North Am 15:609-30. 2001
    ..An important focus for technical development is in the robust integration of complementary information to allow optimization of the sensitivity and specificity of multimodal examinations...
  8. pmc Functional magnetic resonance imaging
    P M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 75:6-12. 2004
    ..In conjunction with MRI methods for characterising pathological load, fMRI promises a refined understanding of when disease processes begin and how they can be modified by new treatments...
  9. pmc Structural and functional bases for individual differences in motor learning
    Valentina Tomassini
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, United Kingdom
    Hum Brain Mapp 32:494-508. 2011
    ....
  10. pmc Relating brain damage to brain plasticity in patients with multiple sclerosis
    Valentina Tomassini
    Oxford Centre for Functional MRI of the Brain FMRIB, University of Oxford, Oxford, UK
    Neurorehabil Neural Repair 26:581-93. 2012
    ..However, functional impairments can be reduced with practice, suggesting that brain plasticity is preserved even in patients with substantial damage...
  11. pmc Motor practice promotes increased activity in brain regions structurally disconnected after subcortical stroke
    Rosemary A Bosnell
    Nuffield Department of Clinical Neurosciences, Centre for Functional MRI of the Brain FMRIB, University of Oxford, Oxford, UK
    Neurorehabil Neural Repair 25:607-16. 2011
    ..Imaging studies in healthy individuals show that dynamic brain activation changes with practice. Defining patterns of functional brain plasticity associated with motor practice following stroke could guide rehabilitation...
  12. doi request reprint Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimer's disease
    Mojtaba Zarei
    FMRIB Centre, John Radcliffe Hospital, Oxford, UK
    Neuroimage 49:1-8. 2010
    ..This combined shape and connectivity analysis provides MRI evidence of regional thalamic degeneration in AD...
  13. ncbi request reprint Model-free characterization of brain functional networks for motor sequence learning using fMRI
    Zsigmond Tamás Kincses
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Neuroimage 39:1950-8. 2008
    ..Particular value for multi-variant, model-free methods such as TICA lies in the potential for generating hypotheses regarding functional anatomical networks underlying specific behaviors...
  14. doi request reprint Regional white matter integrity differentiates between vascular dementia and Alzheimer disease
    Mojtaba Zarei
    FMRIB Centre, University Oxford, Oxford, UK
    Stroke 40:773-9. 2009
    ..This study aimed to identify regional FA changes to identify a biomarker that could be used to differentiate VaD from AD...
  15. ncbi request reprint Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects
    Zubin Bhagwagar
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 61:806-12. 2007
    ..The aim of this study was to use MRS to determine whether changes in GABA and Glu levels were present in patients with mood disorders who had recovered and were no longer taking medication...
  16. doi request reprint Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease
    Gwenaelle Douaud
    Functional MRI of the Brain FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 33:2147-55. 2013
    ....
  17. pmc Preservation of motor skill learning in patients with multiple sclerosis
    Valentina Tomassini
    Oxford Centre for Functional MRI of the Brain FMRIB, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Mult Scler 17:103-15. 2011
    ..Several studies have demonstrated benefits of rehabilitation in multiple sclerosis (MS). However, the neuroscientific foundations for rehabilitation in MS are poorly established...
  18. pmc The role of the posterior fusiform gyrus in reading
    Joseph T Devlin
    University of Oxford, UK
    J Cogn Neurosci 18:911-22. 2006
    ..More importantly, this function is not specific to reading but is also engaged when processing any meaningful visual stimulus...
  19. doi request reprint DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease
    Gwenaelle Douaud
    FMRIB Centre, University of Oxford, UK
    Neuroimage 55:880-90. 2011
    ....
  20. ncbi request reprint Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia
    Gwenaelle Douaud
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 130:2375-86. 2007
    ..Together, our observations suggest that the neuropathology of adolescent-onset schizophrenia involves larger and widespread changes than in the adult form, consistent with the greater clinical severity...
  21. doi request reprint The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis
    Rose Gelineau-Morel
    Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
    Hum Brain Mapp 33:2802-14. 2012
    ..Volumetric or morphometric imaging studies, where lesion amount and characteristics may vary between groups of patients or change over time, may especially benefit from this correction...
  22. ncbi request reprint Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: cross-validation of BSI, SIENA and SIENAX
    Stephen M Smith
    Oxford University Centre for Functional MRI of the Brain FMRIB, Oxford, UK
    Neuroimage 36:1200-6. 2007
    ..We also compare the SIENA longitudinal measure with atrophy state estimated by SIENAX using just the earliest scan taken from each subject. We show strong correspondence and similar sensitivity to atrophy between all 3 measures...
  23. pmc Diffuse cortical atrophy in a marmoset model of multiple sclerosis
    Ian M Pomeroy
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neurosci Lett 437:121-4. 2008
    ..Marmoset EAE is an invaluable tool which can be used to further investigate the cause and the substrate of cortical loss in demyelinating diseases...
  24. ncbi request reprint Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data
    Stephen M Smith
    Oxford University Centre for Functional MRI of the Brain FMRIB, Dept Clinical Neurology, University of Oxford, UK
    Neuroimage 31:1487-505. 2006
    ..TBSS aims to improve the sensitivity, objectivity and interpretability of analysis of multi-subject diffusion imaging studies. We describe TBSS in detail and present example TBSS results from several diffusion imaging studies...
  25. ncbi request reprint Blood oxygenation level dependent contrast resting state networks are relevant to functional activity in the neocortical sensorimotor system
    Marilena De Luca
    John Radcliffe Hospital, Functional Magnetic Resonance Imaging Centre of the Brain FMRIB, Department of Clinical Neurology, University of Oxford, Headley Way, Headington, Oxford, UK OX3 9DU, UK
    Exp Brain Res 167:587-94. 2005
    ..74, p<0.001). The RSN thus define anatomically relevant regions of motor cortex and change with functionally relevant variations in hemispheric lateralisation of sensorimotor cortical interactions with hand movement...
  26. ncbi request reprint Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease
    Ricarda A Menke
    FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Neuroimage 52:1175-80. 2010
    ..This pilot study showed that automated DTI-based parcellation of SN subregions may provide a useful tool for in-vivo identification of SNc and SNr and might therefore assist to detect changes that occur in patients with PD...
  27. doi request reprint Functional and structural changes in the memory network associated with left temporal lobe epilepsy
    Natalie L Voets
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Hum Brain Mapp 30:4070-81. 2009
    ..Relative to standard model-based methods, novel objective functional connectivity analyses may offer improved sensitivity to subtle changes in the distribution of memory functions relevant for surgical planning in TLE...
  28. doi request reprint Structural brain and neuropsychometric changes associated with pediatric bipolar disorder with psychosis
    Anthony James
    Highfield Family and Adolescent Unit, Warneford Hospital Oxford Centre for Functional MRI of the Brain FMRIB, John Radcliffe Hospital, Oxford GSK Clinical Imaging Centre, Imperial College London, London, UK
    Bipolar Disord 13:16-27. 2011
    ..To identify neuropsychological and structural brain changes using a combination of high-resolution structural and diffusion tensor imaging in pediatric bipolar disorder (PBD) with psychosis (presence of delusions and or hallucinations)...
  29. ncbi request reprint Variability in fMRI: a re-examination of inter-session differences
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Hum Brain Mapp 24:248-57. 2005
    ..Finally, we show that the use of different first-level preprocessing, time-series statistics, and registration analysis methodologies can give significantly different inter-session analysis results...
  30. ncbi request reprint Loss of interhemispheric inhibition in patients with multiple sclerosis is related to corpus callosum atrophy
    Stephanie C Manson
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, UK
    Exp Brain Res 174:728-33. 2006
    ..This work suggests one way in which FMRI monitoring of the transcallosal interactions in motor cortex could become a tool for evaluation of therapies that may enhance function in reversibly impaired pathways...
  31. ncbi request reprint Effects of elevated plasma tryptophan on brain activation associated with the Stroop task
    Rhian M Morgan
    Cellular Nutrition Research Group, Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Psychopharmacology (Berl) 190:383-9. 2007
    ..Previous studies identified functional changes in subcortical regions in patients who experience central fatigue but did not address neural correlates of the subjective experience of fatigue...
  32. ncbi request reprint Two-dimensional population map of cortical connections in the human internal capsule
    Mojtaba Zarei
    Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Magn Reson Imaging 25:48-54. 2007
    ..To exploit diffusion imaging tractography to produce a two-dimensional (xy) probabilistic population map of the cortical connections within the human internal capsule (IC)...
  33. doi request reprint Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia
    Richard G Wise
    Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Magn Reson Imaging 28:1129-34. 2010
    ..5 ± 0.2 (mean ± S.D.) for cortical gray matter to white matter and 1.0 ± 0.3 for cortical gray matter to deep gray matter...
  34. ncbi request reprint The role of microembolisation in cerebral injury as defined by functional magnetic resonance imaging
    Yasir Abu-Omar
    Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Eur J Cardiothorac Surg 26:586-91. 2004
    ....
  35. ncbi request reprint Diffusion-weighted imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations
    Valentina Tomassini
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 27:10259-69. 2007
    ....
  36. ncbi request reprint Color of scents: chromatic stimuli modulate odor responses in the human brain
    Robert A Osterbauer
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Neurophysiol 93:3434-41. 2005
    ..These findings demonstrate the neuronal correlates of olfactory response modulation by color cues in brain areas previously identified as encoding the hedonic value of smells...
  37. ncbi request reprint Reduced brain functional reserve and altered functional connectivity in patients with multiple sclerosis
    Sarah Cader
    Centre for Functional Magnetic Resonance Imaging of the Brain, The John Radcliffe Hospital, Headington, Oxford, UK
    Brain 129:527-37. 2006
    ....
  38. ncbi request reprint Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study
    Sean P David
    Cancer Research United Kingdom General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, UK
    Biol Psychiatry 58:488-94. 2005
    ..Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity...
  39. pmc Functional anatomy of interhemispheric cortical connections in the human brain
    Mojtaba Zarei
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Anat 209:311-20. 2006
    ..Our map showed high consistency across individuals. We propose that this map might be useful in the study of the effects of damage to human CC in neurodegenerative and cognitive disorders...
  40. doi request reprint Evidence for abnormalities of cortical development in adolescent-onset schizophrenia
    Natalie L Voets
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, UK
    Neuroimage 43:665-75. 2008
    ..Evidence for changes in local surface area (as opposed to simply cortical thinning) is consistent with a neurodevelopmental contribution to the underlying neuropathology of the disease...
  41. doi request reprint Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation
    Charlotte J Stagg
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Neurosci 29:5202-6. 2009
    ....
  42. doi request reprint Schizophrenia delays and alters maturation of the brain in adolescence
    Gwenaelle Douaud
    Department of Clinical Neurology, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 132:2437-48. 2009
    ..Taken together, these results suggest common aetiological mechanisms for adolescent- and adult-onset schizophrenia with an altered neurodevelopmental time course in the schizophrenic patients that is particularly salient in adolescence...
  43. ncbi request reprint Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine
    Allyson M M Parry
    Centre for Functional Magnetic Resonance Imaging of the Brain, The John Radcliffe Hospital, Headington, Oxford, UK
    Brain 126:2750-60. 2003
    ..This functional plasticity is modulated by cholinergic agonism and must arise from potentially highly dynamic mechanisms such as the 'unmasking' of latent pathways...
  44. ncbi request reprint Short-term changes in cerebral activity in on-pump and off-pump cardiac surgery defined by functional magnetic resonance imaging and their relationship to microembolization
    Yasir Abu-Omar
    Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, UK
    J Thorac Cardiovasc Surg 132:1119-25. 2006
    ....
  45. pmc Morphology and the internal structure of words
    Joseph T Devlin
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK
    Proc Natl Acad Sci U S A 101:14984-8. 2004
    ..As neural regions sensitive to morphological structure overlapped almost entirely with regions sensitive to orthographic and semantic relatedness, our results suggest that morphology emerges from the convergence of form and meaning...
  46. ncbi request reprint Rapid modulation of GABA concentration in human sensorimotor cortex during motor learning
    Anna Floyer-Lea
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Neurophysiol 95:1639-44. 2006
    ..Although apparently confined to the contralateral hemisphere, the magnitude of changes seen within a large spectroscopic voxel suggests that these changes occur over a wide local neocortical field...
  47. pmc Category-related activation for written words in the posterior fusiform is task specific
    Joseph T Devlin
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK
    Neuropsychologia 43:69-74. 2005
    ..The results suggest that category-related activation in the posterior fusiform gyri can be driven either "bottom-up" by visual processing of images or "top-down" by word processing...
  48. pmc Left inferior prefrontal cortex activity reflects inhibitory rather than facilitatory priming
    Eileen R Cardillo
    Department of Experimental Psychology, University of Oxford, OX1 3UD, UK
    J Cogn Neurosci 16:1552-61. 2004
    ..Our results suggest that the left inferior prefrontal cortex inhibits interference from prepotent representations in order to select a task-appropriate target, and is consistent with its broader role in behavioral inhibition...
  49. pmc Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele
    Nicola Filippini
    University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7209-14. 2009
    ..The APOE epsilon4 allele modulates brain function decades before any clinical or neurophysiological expression of neurodegenerative processes...
  50. ncbi request reprint New approaches for exploring anatomical and functional connectivity in the human brain
    Narender Ramnani
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Headley Way, Oxford OX3 9DU, United Kingdom
    Biol Psychiatry 56:613-9. 2004
    ..We also highlight recent thinking on the ways in which functional imaging can be used to characterize information transmission across networks in the human brain (functional and effective connectivity)...
  51. ncbi request reprint Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus
    Heidi Johansen-Berg
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Cereb Cortex 15:31-9. 2005
    ..This provides a tool for specific localization of functional activations or lesions to putative thalamic nuclei...
  52. doi request reprint Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
    ..Regional variations with allele load may be related to different mechanisms for effects of APOE epsilon4 load on susceptibility and disease progression...
  53. ncbi request reprint Independent anatomical and functional measures of the V1/V2 boundary in human visual cortex
    Holly Bridge
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    J Vis 5:93-102. 2005
    ..The development of very high-resolution structural MRI may permit the definition of cortical areas based on myeloarchitecture when functional definition is not possible...
  54. ncbi request reprint Advances in functional and structural MR image analysis and implementation as FSL
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Department of Clinical Neurology, John Radcliffe Hospital, Oxford University, Headington, Oxford OX3 9DU, UK
    Neuroimage 23:S208-19. 2004
    ..The majority of the research laid out in this paper has been implemented as freely available software tools within FMRIB's Software Library (FSL)...
  55. ncbi request reprint Imaging attentional modulation of pain in the periaqueductal gray in humans
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 22:2748-52. 2002
    ..This provides direct evidence supporting the notion that the periaqueductal gray is a site for higher cortical control of pain modulation in humans...
  56. ncbi request reprint Semantic processing in the left inferior prefrontal cortex: a combined functional magnetic resonance imaging and transcranial magnetic stimulation study
    Joseph T Devlin
    FMRIB Center, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headington, UK
    J Cogn Neurosci 15:71-84. 2003
    ..In addition, the findings go beyond simply establishing a correlation between semantic processing and activation in the LIPC and demonstrate that a transient disruption of processing selectively interfered with semantic processing...
  57. ncbi request reprint Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design
    Teddy Tjandra
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, England, UK
    Neuroimage 27:393-401. 2005
    ..In addition, the reduction of variance over time using CBF measurements (non-significant) suggests it could potentially provide a more useful approach when assessing longitudinal activation changes...
  58. ncbi request reprint Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis
    Ian M Pomeroy
    Department of Neuropathology, Radcliffe Infirmary, Oxford, UK
    Brain 128:2713-21. 2005
    ..We believe that this tool can be exploited in future studies to investigate the aetiology, development and clinical significance of cortical lesions in demyelinating disease...
  59. doi request reprint MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study
    Ricarda A Menke
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, Oxford, UK
    Neuroimage 47:435-41. 2009
    ..Combining DESPOT1 imaging and DTI could therefore serve as a diagnostic marker for idiopathic Parkinson's disease in the future...
  60. ncbi request reprint Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 161:368-70. 2004
    ..The authors used magnetic resonance spectroscopy (MRS) to assess the effect of acute administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on cortical levels of gamma-aminobutyric acid (GABA)...
  61. ncbi request reprint Applications of fMRI in translational medicine and clinical practice
    Paul M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Dept of Clinical Neurology, University of Oxford, UK
    Nat Rev Neurosci 7:732-44. 2006
    ..Realization of this potential will require changes in the way clinical neuroimaging services are planned and delivered...
  62. ncbi request reprint Methamphetamine activates reward circuitry in drug naïve human subjects
    Birgit A Vollm
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropsychopharmacology 29:1715-22. 2004
    ..Our data also support recent hypotheses suggesting a central role for the orbitofrontal cortex in drug reinforcement and the development of addiction...
  63. ncbi request reprint Hemispheric specialization for processing auditory nonspeech stimuli
    Helen L Jamison
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Cereb Cortex 16:1266-75. 2006
    ..These findings are consistent with the notion that the hemispheres are differentially specialized for processing auditory stimuli even in the absence of linguistic information...
  64. doi request reprint Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease
    Paul M Matthews
    Department of Medicine, Division of Brain Sciences, Imperial College, London, UK
    J Alzheimers Dis 33:S163-72. 2013
    ..Together, our studies and related work are helping to establish the exciting potential of a new range of MRI methods as neuropathological measures and as biomarkers of disease progression...
  65. ncbi request reprint Functional asymmetry for auditory processing in human primary auditory cortex
    Joseph T Devlin
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Neurosci 23:11516-22. 2003
    ....
  66. ncbi request reprint Thalamic neurodegeneration in multiple sclerosis
    Alberto Cifelli
    Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Ann Neurol 52:650-3. 2002
    ..Our results show that neuronal loss in multiple sclerosis can be substantial (30-35% reduction). We conclude that a neurodegenerative pathology may make a major contribution to the genesis of symptoms in multiple sclerosis...
  67. pmc The role of ipsilateral premotor cortex in hand movement after stroke
    Heidi Johansen-Berg
    Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 99:14518-23. 2002
    ....
  68. ncbi request reprint Solid and gaseous cerebral microembolization during off-pump, on-pump, and open cardiac surgery procedures
    Yasir Abu-Omar
    Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    J Thorac Cardiovasc Surg 127:1759-65. 2004
    ..Using a new generation of transcranial Doppler ultrasonography, we compared the number and nature of intraoperative microemboli in patients undergoing on-pump and off-pump cardiac surgery procedures...
  69. ncbi request reprint MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Brain 129:1481-92. 2006
    ....
  70. ncbi request reprint Testing for dual brain processing routes in reading: a direct contrast of chinese character and pinyin reading using FMRI
    YiPing Chen
    University of Oxford, Oxford, UK
    J Cogn Neurosci 14:1088-98. 2002
    ..the inferior parietal cortex for pinyin and fusiform gyrus for Chinese characters) are candidate regions for specialized processes associated with reading via predominantly assembled (pinyin) or addressed (Chinese character) procedures...
  71. ncbi request reprint Correlation between motor improvements and altered fMRI activity after rehabilitative therapy
    Heidi Johansen-Berg
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital and Rivermead Rehabilitation Centre, Oxford, UK
    Brain 125:2731-42. 2002
    ..Our results suggest that activity changes in sensorimotor regions are associated with successful motor rehabilitation...
  72. ncbi request reprint Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy
    Valerie L Stevenson
    NMR Research Unit, Institute of Neurology, London
    J Neurol 249:171-7. 2002
    ....
  73. ncbi request reprint White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007
    ..It highlights a potential relationship between anatomical changes in a frontal-temporal anatomical circuit and functional alterations in the prefrontal cortex...
  74. ncbi request reprint Perceiving identical sounds as speech or non-speech modulates activity in the left posterior superior temporal sulcus
    Riikka Möttönen
    Laboratory of Computational Engineering, Helsinki University of Technology, Finland
    Neuroimage 30:563-9. 2006
    ..Altogether, the present findings suggest that activation of the neural speech representations in the left STSp might be a pre-requisite for hearing sounds as speech...
  75. ncbi request reprint White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
    ....
  76. ncbi request reprint Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4
    Christian Enzinger
    Department of Neurology, Karl Franzens University, Graz, Austria
    Ann Neurol 55:563-9. 2004
    ..0 vs 5.7%). Accelerated brain tissue loss and a higher proportion of lesions evolving into BH therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in MS patients with APOE-epsilon4...
  77. ncbi request reprint Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy
    Andrew M Blamire
    Newcastle Magnetic Resonance Centre, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Magn Reson Med 58:880-5. 2007
    ..05). MRS demonstrated cellular damage within the cord over and above the tissue atrophy seen by MRI. Combining MRI and MRS may therefore give a more complete picture of neurodegeneration in the spinal cord...
  78. doi request reprint A neural marker of content-specific active ignoring
    Harriet A Allen
    Behavioural Brian Sciences, School of Psychology, University of Birmingham, Birmingham, UK
    J Exp Psychol Hum Percept Perform 34:286-97. 2008
    ..Activation associated with active ignoring decreased when a secondary task was imposed during the preview. The data reveal a neural marker for the process of actively ignoring the content and locations of irrelevant stimuli...
  79. doi request reprint Functional MRI correlates of lower limb function in stroke victims with gait impairment
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Stroke 39:1507-13. 2008
    ..We used ankle movement as a lower limb analog to test for similarities and differences in recovery patterns...
  80. ncbi request reprint The evolution of prefrontal inputs to the cortico-pontine system: diffusion imaging evidence from Macaque monkeys and humans
    Narender Ramnani
    Cognitive Neuroscience Laboratory, Department of Psychology, Royal Holloway University of London, UK
    Cereb Cortex 16:811-8. 2006
    ..These findings suggest the selective evolution of prefrontal inputs to the human cortico-ponto-cerebellar system...
  81. ncbi request reprint Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
    ..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
  82. ncbi request reprint Lesion probability maps of white matter hyperintensities in elderly individuals: results of the Austrian stroke prevention study
    Christian Enzinger
    Department of Neurology, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    J Neurol 253:1064-70. 2006
    ..While this increase in extension is frequently seen as evidence for a continuum of changes, histological data and clinical follow-up suggest differences in underlying pathology and their progression...
  83. ncbi request reprint Editorial comment-- finding landmarks for understanding white matter stroke
    Paul M Matthews
    Stroke 35:92-3. 2004
  84. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...