L Matthews

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Geographic determinants of reported human Campylobacter infections in Scotland
    Paul R Bessell
    Boyd Orr Centre for Population and Ecosystem Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    BMC Public Health 10:423. 2010
  2. pmc Temporal and spatial patterns of bovine Escherichia coli O157 prevalence and comparison of temporal changes in the patterns of phage types associated with bovine shedding and human E. coli O157 cases in Scotland between 1998-2000 and 2002-2004
    Michael C Pearce
    8 Stour Court, Sandwich, Kent, CT13 9FY, UK
    BMC Microbiol 9:276. 2009
  3. pmc Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies
    Suzanne G St Rose
    Centre for Infectious Diseases, University of Edinburgh, King s Buildings, Edinburgh EH9 3JF, UK
    BMC Infect Dis 6:5. 2006
  4. pmc Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon
    Karim Gharbi
    Institute of Comparative Medicine, University of Glasgow, Glasgow, UK
    BMC Genet 10:20. 2009
  5. doi request reprint Exploiting strain diversity to expose transmission heterogeneities and predict the impact of targeting supershedding
    L Matthews
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Epidemics 1:221-9. 2009
  6. pmc Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control
    L Matthews
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, United Kingdom
    Proc Natl Acad Sci U S A 103:547-52. 2006
  7. pmc Modelling the epidemiology and transmission of Verocytotoxin-producing Escherichia coli serogroups O26 and O103 in two different calf cohorts
    W C Liu
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Midlothian, UK
    Epidemiol Infect 135:1316-23. 2007
  8. pmc Associations between the presence of virulence determinants and the epidemiology and ecology of zoonotic Escherichia coli
    K M O'Reilly
    Boyd Orr Centre for Population and Ecosystem Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom
    Appl Environ Microbiol 76:8110-6. 2010
  9. doi request reprint Quantifying the sources of variability in equine faecal egg counts: implications for improving the utility of the method
    M J Denwood
    Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK
    Vet Parasitol 188:120-6. 2012
  10. pmc Modelling the epidemiology of Verocytotoxin-producing Escherichia coli serogroups in young calves
    W C Liu
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland, EH25 9RG, UK
    Epidemiol Infect 133:449-58. 2005

Collaborators

Detail Information

Publications25

  1. pmc Geographic determinants of reported human Campylobacter infections in Scotland
    Paul R Bessell
    Boyd Orr Centre for Population and Ecosystem Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    BMC Public Health 10:423. 2010
    ..This relationship is further complicated by differences in the presentation of cases, their investigation, identification, and reporting; thus, the actual differences in risk must be considered alongside the artefactual differences...
  2. pmc Temporal and spatial patterns of bovine Escherichia coli O157 prevalence and comparison of temporal changes in the patterns of phage types associated with bovine shedding and human E. coli O157 cases in Scotland between 1998-2000 and 2002-2004
    Michael C Pearce
    8 Stour Court, Sandwich, Kent, CT13 9FY, UK
    BMC Microbiol 9:276. 2009
    ..Cattle are considered the main reservoir for E. coli O157. Significant associations between livestock related exposures and human infection have been identified in a number of studies...
  3. pmc Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies
    Suzanne G St Rose
    Centre for Infectious Diseases, University of Edinburgh, King s Buildings, Edinburgh EH9 3JF, UK
    BMC Infect Dis 6:5. 2006
    ....
  4. pmc Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon
    Karim Gharbi
    Institute of Comparative Medicine, University of Glasgow, Glasgow, UK
    BMC Genet 10:20. 2009
    ..In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively...
  5. doi request reprint Exploiting strain diversity to expose transmission heterogeneities and predict the impact of targeting supershedding
    L Matthews
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Epidemics 1:221-9. 2009
    ..This analysis demonstrates the critical importance of disentangling the effects of multiple sources of heterogeneity when designing targeted interventions...
  6. pmc Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control
    L Matthews
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, United Kingdom
    Proc Natl Acad Sci U S A 103:547-52. 2006
    ..We conclude that a greater understanding of the cause of the heterogeneity in bacterial carriage could lead to highly efficient control measures to reduce the prevalence of E. coli O157...
  7. pmc Modelling the epidemiology and transmission of Verocytotoxin-producing Escherichia coli serogroups O26 and O103 in two different calf cohorts
    W C Liu
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Midlothian, UK
    Epidemiol Infect 135:1316-23. 2007
    ..For serogroup O26 but not O103, there is evidence for unequal environmental exposure to infection with different PFGE types...
  8. pmc Associations between the presence of virulence determinants and the epidemiology and ecology of zoonotic Escherichia coli
    K M O'Reilly
    Boyd Orr Centre for Population and Ecosystem Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom
    Appl Environ Microbiol 76:8110-6. 2010
    ..coli serogroup. Our results suggest that the capacity of E. coli strains to derive fitness benefits from virulence determinants influences the prevalence in the cattle population and the ecology and epidemiology of the host organism...
  9. doi request reprint Quantifying the sources of variability in equine faecal egg counts: implications for improving the utility of the method
    M J Denwood
    Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK
    Vet Parasitol 188:120-6. 2012
    ....
  10. pmc Modelling the epidemiology of Verocytotoxin-producing Escherichia coli serogroups in young calves
    W C Liu
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland, EH25 9RG, UK
    Epidemiol Infect 133:449-58. 2005
    ..We suggest that future field studies may wish to adopt a tighter sampling frame in order to detect all circulating VTEC serogroups in similar animal populations...
  11. pmc Epidemiological implications of the contact network structure for cattle farms and the 20-80 rule
    M E J Woolhouse
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Biol Lett 1:350-2. 2005
    ..Despite this, it is still the case that just 20% of holdings contribute at least 80% of the value of R0...
  12. pmc The basic reproduction number for scrapie
    L Matthews
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Midlothian, UK
    Proc Biol Sci 266:1085-90. 1999
    ..Using this formulation, R0 is calculated for an outbreak of scrapie in a flock of Cheviot sheep...
  13. ncbi request reprint A centuries-long epidemic of scrapie in British sheep?
    M E Woolhouse
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, Midlothian, UK
    Trends Microbiol 9:67-70. 2001
    ..This interpretation implies that scrapie should eventually disappear from the sheep population...
  14. pmc From phenotype to genotype: a Bayesian solution
    M J Denwood
    Boyd Orr Centre for Population and Ecosystem Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK
    Proc Biol Sci 278:1434-40. 2011
    ..The methods presented could be applied to other types of phenotypic data, and represent a useful and generic mechanism of inferring the genetic population structure of organisms...
  15. pmc Super-shedding cattle and the transmission dynamics of Escherichia coli O157
    L Matthews
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, UK
    Epidemiol Infect 134:131-42. 2006
    ..The pattern of prevalence displayed in the second dataset also strongly supports the super-shedder hypothesis...
  16. doi request reprint Comparison of three alternative methods for analysis of equine Faecal Egg Count Reduction Test data
    M J Denwood
    Boyd Orr Centre for Population and Ecosystem Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    Prev Vet Med 93:316-23. 2010
    ....
  17. doi request reprint A mechanistic model of developing immunity to Teladorsagia circumcincta infection in lambs
    D R Singleton
    Faculty of Veterinary Medicine, The Boyd Orr Centre for Population and Ecosystem Health, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland
    Parasitology 138:322-32. 2011
    ..This feedback in the immune priming suggests that nematode infections may be difficult to eliminate...
  18. ncbi request reprint Population dynamics of a scrapie outbreak
    L Matthews
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Roslin, Midlothian, UK
    Arch Virol 146:1173-86. 2001
    ....
  19. doi request reprint The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated
    M J Denwood
    Comparative Epidemiology and Informatics, Institute for Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Parasitology 135:1225-35. 2008
    ..battus counts were indeed zero-inflated. Estimating the extent of zero-inflation is important for effective statistical analysis and for the accurate identification of genetically resistant animals...
  20. ncbi request reprint Low-coverage vaccination strategies for the conservation of endangered species
    D T Haydon
    Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Nature 443:692-5. 2006
    ....
  21. doi request reprint Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle
    G F Codner
    Institute for Animal Health, Compton, Berks, UK
    Anim Genet 43:239-49. 2012
    ..The decrease in a common haplotype, the reduced number of homozygous bulls and the associations with disease and production traits together indicate that MHC diversity in dairy cattle is maintained by heterozygote advantage...
  22. ncbi request reprint An evolutionary perspective on gastrointestinal nematodes of sheep
    M J Stear
    Boyd Orr Centre for Population and Ecosystem Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, G61 1QH, UK
    J Helminthol 85:113-20. 2011
    ..This increase benefits host and parasite and appears to be a consequence of coevolution. In conclusion, an evolutionary perspective can shed light on many aspects of the host-parasite relationship in domestic animals. ..
  23. pmc Neighbourhood control policies and the spread of infectious diseases
    L Matthews
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin EH25 9RG, UK
    Proc Biol Sci 270:1659-66. 2003
    ..The total loss to the population is relatively insensitive to the level of control as it increases beyond the optimal level, suggesting that over-control is a safer policy than under-control...
  24. pmc Comparative epidemiology of scrapie outbreaks in individual sheep flocks
    C A Redman
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Roslin, Midlothian, UK
    Epidemiol Infect 128:513-21. 2002
    ..Scrapie incidence was higher in ewes than rams and at certain times of years, though these effects were not consistent between flocks. There was no evidence for high levels of vertical transmission...
  25. ncbi request reprint Associations among body condition score, body weight, somatic cell count, and clinical mastitis in seasonally calving dairy cattle
    D P Berry
    Teagasc, Moorepark Dairy Production Research Centre, Fermoy, Co Cork, Ireland
    J Dairy Sci 90:637-48. 2007
    ..Results are important in assuring the public that modern dairy systems, where cows are subjected to substantial amounts of BCS mobilization in early lactation, do not unduly compromise cow udder health...