Research Topics
| David R MatthewsSummaryAffiliation: University of Oxford Country: UK Publications
| Collaborators
|
Detail Information
Publications
Can we bridge the gap? Knowledge and practices related to Diabetes Mellitus among general practitioners in a developing country: A cross sectional studyPrasad Katulanda
Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
Asia Pac Fam Med 10:15. 2011..abstract:..- Banting Memorial Lecture 2010^. Type 2 diabetes as an 'infectious' disease: is this the Black Death of the 21st century?D R Matthews
Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, UK
Diabet Med 28:2-9. 2011.... - Four decades of uncertainty: landmark trials in glycaemic control and cardiovascular outcome in type 2 diabetesDavid R Matthews
Professor of Diabetes Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
Diab Vasc Dis Res 5:216-8. 2008 - Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative studyD R Matthews
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Diabetes Metab Res Rev 21:167-74. 2005..This 52-week, randomized, double-blind study compared the efficacy and safety of metformin plus pioglitazone with the established combination of metformin plus gliclazide in type 2 diabetes mellitus... - Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69David R Matthews
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, England
Arch Ophthalmol 122:1631-40. 2004..To determine the relationship between tight blood pressure (BP) control and the different aspects of diabetic retinopathy in patients with type 2 diabetes mellitus (DM)... - Recent advances in the monitoring and management of diabetic ketoacidosisT M Wallace
Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Old Road, Oxford OX3 7LJ
QJM 97:773-80. 2004..We review the management of DKA, and the emerging role of near-patient testing in diagnosing ketosis and monitoring its resolution... - Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year studyD R Matthews
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital and NIHR, Oxford Biomedical Research Centre, UK
Diabetes Obes Metab 12:780-9. 2010..To show that vildagliptin added to metformin is non-inferior to glimepiride in reducing HbA1c levels from baseline over 2 years... - The UK Diabetes Research Network--an opportunity and a challengeD R Matthews
Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Oxford, UK
Diabet Med 24:7-9. 2007..The future of trials and other important clinical research in the UK may depend on it... - 10-year follow-up of intensive glucose control in type 2 diabetesRury R Holman
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
N Engl J Med 359:1577-89. 2008..We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes... - Long-term follow-up after tight control of blood pressure in type 2 diabetesRury R Holman
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
N Engl J Med 359:1565-76. 2008.... - Additive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: a prospective observational study (UKPDS 75)I M Stratton
Diabetes Trial Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
Diabetologia 49:1761-9. 2006..Intensive treatment of both these risk factors is required to minimise the incidence of complications... - An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized studyT M Wallace
The Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Oxford, UK
Diabet Med 21:568-76. 2004..5) kg in placebo group (P = NS). CONCLUSIONS: Basal beta-cell function and insulin sensitivity improved following pioglitazone therapy. The improvement in proinsulin to insulin ratio suggests that beta-cells are under less stress... - A low-carbohydrate diet is more effective in reducing body weight than healthy eating in both diabetic and non-diabetic subjectsP A Dyson
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Diabet Med 24:1430-5. 2007..Aims To assess the impact of a low-carbohydrate diet on body weight, glycated haemoglobin (HbA(1c)), ketone and lipid levels in diabetic and non-diabetic subjects... - UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosisI M Stratton
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
Diabetologia 44:156-63. 2001..CONCLUSION/INTERPRETATION: The findings re-emphasise the need for good glycaemic control and assiduous treatment of hypertension if diabetic retinopathy is to be minimised... - Pioglitazone and metforminNathan R Hill
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Drugs Today (Barc) 43:443-54. 2007..Based on this evidence, the combination appears therapeutically efficacious and clinically safe. The side effects are not multiplicative and reflect those predictable from monotherapy with either agent... - Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetesSophie D West
Sleep Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK
Thorax 62:969-74. 2007..The effects of continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) on insulin resistance are not clear. Trials have found conflicting results and no appropriate control groups have been used... - Prevalence of overweight and obesity in Sri Lankan adultsP Katulanda
Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
Obes Rev 11:751-6. 2010..Urgent public health interventions are needed to control the problem at an early stage... - Children with type 2 diabetes: the risks of complicationsD R Matthews
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, UK
Horm Res 57:34-9. 2002..With regard to other newer agents, it seems wise to use well-established drugs with a long track record and for which the long-term safety data are available... - A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)P M Clarke
Health Economics Research Centre, Department of Public Health, University of Oxford, Headington, Oxford, UK
Diabetologia 47:1747-59. 2004.... - Glycaemic risk assessment in children and young people with Type 1 diabetes mellitusN R Hill
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Diabet Med 26:740-3. 2009..To ascertain if those with diabetes (and their carers) ascribe a similar level of risk to blood glucose control as healthcare professionals... - The diabetes epidemic in Sri Lanka - a growing problemP Katulanda
Department of Clinical Medicine, University of Colombo, Sri Lanka
Ceylon Med J 51:26-8. 2006..Further research is necessary to investigate the exact underlying mechanisms for the South Asian epidemic. Wider preventive programmes need to be urgently implemented to stem the tide... - Prevalence and projections of diabetes and pre-diabetes in adults in Sri Lanka--Sri Lanka Diabetes, Cardiovascular Study (SLDCS)P Katulanda
Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, UK
Diabet Med 25:1062-9. 2008..Projections for the year 2030 and factors associated with diabetes and pre-diabetes are also presented... - Diabetes mellitus among young adults in Sri Lanka--role of GAD antibodies in classification and treatment: the Sri Lanka Young Diabetes studyP Katulanda
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK
Diabetologia 51:1368-74. 2008..The aim of this study was to determine the prevalence and phenotypic characteristics of diabetes subtypes based on GAD65 autoantibody (GADA) status in those with young adult-onset diabetes in Sri Lanka... - Cost-utility analyses of intensive blood glucose and tight blood pressure control in type 2 diabetes (UKPDS 72)P M Clarke
Health Economics Research Centre, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK
Diabetologia 48:868-77. 2005.... - Insulin sensitivity at diagnosis of Type 2 diabetes is not associated with subsequent cardiovascular disease (UKPDS 67)A I Adler
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
Diabet Med 22:306-11. 2005..Whether insulin sensitivity measured after diagnosis of diabetes is associated with incident cardiovascular disease was evaluated in this prospective study... - The assessment of insulin resistance in manT M Wallace
The Oxford Centre for Diabetes, Endocrinology and Metabolism, The Radcliffe Infirmary, UK
Diabet Med 19:527-34. 2002..Caution should be exercised when making comparisons between studies due to variations in infusion protocols, sampling procedures and hormone assays used in different studies... - Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational studyI M Stratton
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
BMJ 321:405-12. 2000..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes... - Effects of three months' diet after diagnosis of Type 2 diabetes on plasma lipids and lipoproteins (UKPDS 45). UK Prospective Diabetes Study GroupS E Manley
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
Diabet Med 17:518-23. 2000..To assess the effect of diet on fasting plasma lipids and lipoproteins in patients with newly diagnosed Type 2 diabetes... - Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?A Clark
Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, UK
Diabetes 50:S169-71. 2001..Increasing the function of unresponsive beta-cells rather than the mass of cells may be a more effective therapeutic target for type 2 diabetes... - Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66Richard J Stevens
Diabetes Trials Unit and the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U K
Diabetes Care 27:201-7. 2004..We investigated whether the risk of MI or stroke being fatal in type 2 diabetes can be estimated using information available around the time diabetes is diagnosed... - Normal reference range for mean tissue glucose and glycemic variability derived from continuous glucose monitoring for subjects without diabetes in different ethnic groupsNathan R Hill
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom
Diabetes Technol Ther 13:921-8. 2011..For treatment targets and clinical research we present normative ranges for published measures of glycemic variability... - An assessment of lifestyle video education for people newly diagnosed with type 2 diabetesP A Dyson
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, UK
J Hum Nutr Diet 23:353-9. 2010..Conclusions: A brief video intervention increased diabetes knowledge amongst those newly diagnosed with type 2 diabetes and may comprise an effective way of directing education to such individuals... - A method for assessing quality of control from glucose profilesN R Hill
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Diabet Med 24:753-8. 2007.... - The hospital and home use of a 30-second hand-held blood ketone meter: guidelines for clinical practiceT M Wallace
Oxford Centre for Diabetes, Endocrinology and Metabolism, The Radcliffe Infirmary, UK
Diabet Med 18:640-5. 2001..The data suggest that beta-OHB levels > or = 1 mmol/l require further action and levels > 3 mmol/l necessitate medical review. In addition, the rate of fall of beta-OHB in DKA can be used as an indicator of the adequacy of treatment... - Coefficient of failure: a methodology for examining longitudinal beta-cell function in Type 2 diabetesT M Wallace
Oxford Centre for Diabetes, Endocrinology and Metabolism, The Radcliffe Infirmary, Oxford, UK
Diabet Med 19:465-9. 2002..In contrast, the coefficient of failure includes all data in the analysis and takes into account improvement of glycaemia as well as deterioration of glycaemia... - Networks offer new opportunities for diabetes researchEleanor D Kennedy
Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford Biomedical Research Centre NIHR, Old Road, Headington, Oxford OX3 7LJ, United Kingdom
Prim Care Diabetes 4:3-8. 2010..An essential element for success is the involvement of primary care where benefits can accrue to patients and healthcare professionals alike... - Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patternsGaya W Katulanda
Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK
Ann Clin Biochem 47:29-34. 2010..Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians... - The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fatL K Summers
Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK
Int J Obes Relat Metab Disord 25:1294-9. 2001..014). CONCLUSION: Adipose tissue blood flow may be 'carbohydrate-stimulated' rather than 'fat-stimulated', with insulin having a vasodilatory role in adipose tissue as in skeletal muscle... - Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjectsT J Ulahannan
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
Horm Metab Res 34:499-503. 2002..We conclude that alpha1 -adrenoceptor activity may be more important in regulation of human lipid metabolism than previously recognized... - Higher body mass index is associated with irregular and suppressed insulin pulsatilityN R Hill
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, UK
Diabetes Obes Metab 9:603-4. 2007 - Use and abuse of HOMA modelingTara M Wallace
Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Old Road, Oxford OX3 7LJ, U.K
Diabetes Care 27:1487-95. 2004..However, as with all models, the primary input data need to be robust, and the data need to be interpreted carefully... - Apolipoprotein E genotype, islet amyloid deposition and severity of Type 2 diabetesD S Powell
Diabetes Research Laboratories, Oxford Centre for Diabetes Endocrinology and Metabolism, Radcliffe Infirmary, UK
Diabetes Res Clin Pract 60:105-10. 2003..It is unlikely that the common polymorphisms for the ApoE gene are linked to amyloid formation or progression of islet dysfunction in Type 2 diabetes... - Prevalence and clinical characteristics of maternally inherited diabetes and deafness caused by the mt3243A > G mutation in young adult diabetic subjects in Sri LankaP Katulanda
Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, UK, and Faculty of Medicine, University of Columbo, Sri Lanka
Diabet Med 25:370-4. 2008..We aimed to determine the prevalence and clinical characteristics of MIDD in a large South Asian cohort of young adult-onset diabetic patients from Sri Lanka... - Ergotamine use in severe diabetic autonomic neuropathyV Toh
Oxford Centre of Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Diabet Med 23:574-6. 2006..When it does occur, it can prove debilitating and difficult to treat. We report here the therapeutic challenges encountered in managing a patient with severe postural hypotension secondary to diabetes-related autonomic neuropathy... - Safety and tolerability of pioglitazone, metformin, and gliclazide in the treatment of type 2 diabetesGlyn Belcher
Takeda Europe R and D Centre, Savannah House, 11 12 Charles II Street, London, UK
Diabetes Res Clin Pract 70:53-62. 2005..The results show that all three drugs are safe, but that tolerability profiles vary. Each treatment provides an alternative therapy for type 2 diabetes, dependent on the particular needs of individual patients... - One-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetesMarkolf Hanefeld
Centre for Clinical Studies, GWT Technical University, Dresden, Germany
Diabetes Care 27:141-7. 2004..The goal was to assess the 1-year efficacy and safety of the addition of pioglitazone or metformin to existing sulfonylurea (SU) therapy in patients with inadequately controlled type 2 diabetes... - Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trialSten Madsbad
Department of Endocrinology, Hvidovre Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Denmark
Diabetes Care 27:1335-42. 2004..Liraglutide is a long-acting glucagon-like peptide 1 analog designed for once daily injection. This study assessed the efficacy and safety of liraglutide after 12 weeks of treatment in type 2 diabetic patients... - Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) studyMark Peyrot
Department of Sociology, Loyola College, Baltimore, MD 21210 2699, USA
Diabetes Care 28:2673-9. 2005..To examine the correlates of patient and provider attitudes toward insulin therapy... - Diabetes and the global burden of non-communicable diseaseDavid R Matthews
Lancet 362:1763-4. 2003 - Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selectionUlrik Pedersen-Bjergaard
Department of Internal Medicine F, Hillerød Hospital, Helsevej, Hillerød, Denmark
Diabetes Metab Res Rev 20:479-86. 2004..The purpose of this study was to assess the frequency of severe hypoglycaemia in unselected patients treated in different secondary care centres and to evaluate the influence of risk markers, clinical setting and selection... - The regulation of growth in glycogen storage disease type 1Helen R Mundy
The London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, London, UK
Clin Endocrinol (Oxf) 58:332-9. 2003..To study endocrine and metabolic variables that affect growth in patients with glycogen storage disease type 1 (GSD-1) receiving standard dietary therapy... - Grand challenges in chronic non-communicable diseasesAbdallah S Daar
Program on Life Sciences, Ethics and Policy, McLaughlin-Rotman Centre for Global Health, University Health Network/University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
Nature 450:494-6. 2007