Karl Matter

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
    Maria S Balda
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    J Cell Biol 160:423-32. 2003
  2. ncbi request reprint Tight junctions: molecular architecture and function
    Saima Aijaz
    Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom
    Int Rev Cytol 248:261-98. 2006
  3. pmc Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA
    Tony Sourisseau
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, United Kingdom
    Mol Cell Biol 26:2387-98. 2006
  4. ncbi request reprint Functional analysis of tight junctions
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, EC1V 9EL, London, UK
    Methods 30:228-34. 2003
  5. ncbi request reprint Mammalian tight junctions in the regulation of epithelial differentiation and proliferation
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    Curr Opin Cell Biol 17:453-8. 2005
  6. ncbi request reprint Epithelial tight junctions, gene expression and nucleo-junctional interplay
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    J Cell Sci 120:1505-11. 2007
  7. pmc Holey barrier: claudins and the regulation of brain endothelial permeability
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, UK
    J Cell Biol 161:459-60. 2003
  8. pmc The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB
    Anna Tsapara
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Mol Biol Cell 17:1322-30. 2006
  9. pmc The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription
    Mei Nie
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, UK
    EMBO Rep 10:1125-31. 2009
  10. doi request reprint Tight junctions and the regulation of gene expression
    Maria S Balda
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Biochim Biophys Acta 1788:761-7. 2009

Collaborators

Detail Information

Publications34

  1. pmc The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
    Maria S Balda
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    J Cell Biol 160:423-32. 2003
    ..Although this regulatory process may also involve regulation of transcription by ZONAB, our data suggest that one mechanism by which ZONAB and ZO-1 influence proliferation is by regulating the nuclear accumulation of CDK4...
  2. ncbi request reprint Tight junctions: molecular architecture and function
    Saima Aijaz
    Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom
    Int Rev Cytol 248:261-98. 2006
    ....
  3. pmc Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA
    Tony Sourisseau
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, United Kingdom
    Mol Cell Biol 26:2387-98. 2006
    ....
  4. ncbi request reprint Functional analysis of tight junctions
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, EC1V 9EL, London, UK
    Methods 30:228-34. 2003
    ..Here we describe a set of assays that allow the analysis of tight junctions to determine their integrity and functional state...
  5. ncbi request reprint Mammalian tight junctions in the regulation of epithelial differentiation and proliferation
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    Curr Opin Cell Biol 17:453-8. 2005
    ..These signalling proteins include components that affect established signalling cascades and dual localisation proteins that can associate with junctions as well as travel to the nucleus where they regulate gene expression...
  6. ncbi request reprint Epithelial tight junctions, gene expression and nucleo-junctional interplay
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    J Cell Sci 120:1505-11. 2007
    ..In cancer tissues, their expression is often deregulated in a manner that suggests that tight junctions function as suppressors of proliferation and transformation...
  7. pmc Holey barrier: claudins and the regulation of brain endothelial permeability
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, UK
    J Cell Biol 161:459-60. 2003
    ..This suggests that the BBB can be manipulated to allow selective diffusion of small molecules and makes claudin-5 a possible target for the development of drugs for this purpose...
  8. pmc The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB
    Anna Tsapara
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Mol Biol Cell 17:1322-30. 2006
    ....
  9. pmc The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription
    Mei Nie
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, UK
    EMBO Rep 10:1125-31. 2009
    ..Our data thus indicate that GEF-H1 and ZONAB form a signalling module that mediates Rho-regulated cyclin D1 promoter activation and expression...
  10. doi request reprint Tight junctions and the regulation of gene expression
    Maria S Balda
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Biochim Biophys Acta 1788:761-7. 2009
    ....
  11. ncbi request reprint Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin
    Emma Kavanagh
    Division of Cell Biology, Institute of Ophthalmology, University College London, London, UK
    J Cell Sci 119:5098-105. 2006
    ..Our data thus indicate that symplekin and ZONAB/DbpA cooperate in the regulation of transcription, and that they promote epithelial proliferation and cyclin D1 expression...
  12. pmc Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion
    Stephen J Terry
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 7:e50188. 2012
    ..Our data demonstrate that p114RhoGEF drives cortical myosin activation by stimulating myosin light chain double phosphorylation and, thereby, collective cell migration of epithelial sheets and amoeboid-like motility of tumor cells...
  13. pmc Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival
    Mei Nie
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 109:10897-902. 2012
    ..We thus identify a unique type of stress and Rho signaling activated pathway that drives mRNA stabilization and translation and links the cellular stress response to p21 expression and cell survival...
  14. pmc Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2
    Saima Aijaz
    Division of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    BMC Cell Biol 8:49. 2007
    ..Here, we addressed the question whether Apg-2 is also important for junction formation and epithelial morphogenesis...
  15. doi request reprint Rho signaling and tight junction functions
    Steve Terry
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Physiology (Bethesda) 25:16-26. 2010
    ..Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease...
  16. pmc Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family
    Emily Steed
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    BMC Cell Biol 10:95. 2009
    ..How these components work together to form functional tight junctions is still not well understood and will require a complete understanding of the molecular composition of the junction...
  17. pmc The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration
    Anna Tsapara
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Mol Biol Cell 21:860-70. 2010
    ....
  18. pmc Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin
    Sarah K Harten
    Division of Medicine, Rayne Institute, University College London, WC1E 6JJ, London, United Kingdom
    Mol Biol Cell 20:1089-101. 2009
    ..Despite the independent nature of the defects, we show that treatment with the histone deacetylase inhibitor sodium butyrate, which suppresses HIF activation, provides a method for reversing EMT in the context of VHL inactivation...
  19. pmc Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
    Ahmed Elbediwy
    Department of Cell Biology, Institute of Ophthalmology, University College London, EC1V 9EL London, England, UK
    J Cell Biol 198:677-93. 2012
    ..Epithelial junction formation and morphogenesis thus require a dual activity complex, containing SH3BP1 and CapZ, that is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics...
  20. ncbi request reprint Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition
    Saima Aijaz
    Division of Cell Biology, Institute of Ophthalmology, University College London, UK
    Dev Cell 8:777-86. 2005
    ....
  21. pmc TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein
    Christina F Chakarova
    Institute of Ophthalmology, UCL, London EC1V 9EL, UK
    Hum Mol Genet 20:975-87. 2011
    ..Additionally, it is well known that mutations in other ciliary proteins cause retinal degeneration, which may explain why mutations in TOPORS result in the same phenotype...
  22. pmc The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice
    Anastasios Georgiadis
    Department of Genetics, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 5:e15730. 2010
    ....
  23. pmc Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
    Stephen J Terry
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London, UK
    Nat Cell Biol 13:159-66. 2011
    ....
  24. doi request reprint Dynamics and functions of tight junctions
    Emily Steed
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Trends Cell Biol 20:142-9. 2010
    ..Combining such dynamic properties with existing tight junction models will help us to advance our understanding of the molecular mechanisms that underlie the functional properties of tight junctions...
  25. pmc Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation
    Ceniz Zihni
    Department of Cell Biology and 2 Imaging Unit, Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
    J Cell Biol 204:111-27. 2014
    ..Thus, Dbl3 drives Cdc42 signaling at the apical margin to regulate morphogenesis, apical-lateral border positioning, and apical differentiation. ..
  26. ncbi request reprint Epithelial cell adhesion and the regulation of gene expression
    Maria S Balda
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, UK, EC1V 9EL
    Trends Cell Biol 13:310-8. 2003
    ..Here, we review such signal-transduction pathways and discuss how they influence cell proliferation and differentiation...
  27. pmc RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity
    Paul Frankel
    Oncogene Team, Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    EMBO J 24:54-62. 2005
    ..Additionally, expression of oncogenic Ras alleviates transcriptional repression by ZONAB in a RalA-dependent manner. The data presented here implicate the RalA/ZONAB interaction in the regulation of ZONAB function...
  28. pmc Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis
    G Astrid Limb
    Department of Pathology, Institute of Ophthalmology, University College London and Moorfields Eye Hospital, 11 Bath St, London EC1V 9EL
    Am J Pathol 166:1555-63. 2005
    ..These observations strongly suggest that intracellular association of MMP-1 to mitochondria and nuclei confers resistance to apoptosis and may explain the well-known association of this enzyme with tumor cell survival and spreading...
  29. ncbi request reprint Signalling to and from tight junctions
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, London, UK
    Nat Rev Mol Cell Biol 4:225-36. 2003
    ..They receive and convert signals from the cell interior to regulate junction assembly and function, and transmit signals to the cell interior to modulate gene expression and cell behaviour...
  30. pmc Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting
    J Paul Chapple
    Division of Pathology, Institute of Ophthalmology, University College London, UK
    Biochem J 372:427-33. 2003
    ..These data show that RP2 is present on the membrane of all cell types examined both in vitro and in vivo, and that RP2 associates with lipid rafts, suggesting a potential role for the protein in signal transduction...
  31. pmc Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy
    Christina F Chakarova
    Institute of Ophthalmology, University College London, London, UK
    Am J Hum Genet 81:1098-103. 2007
    ....
  32. pmc The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cells
    Liora Shoshani
    Center for Research and Advanced Studies, Department of Physiology, Biophysics, and Neurosciences, Mexico City 07300, Mexico
    Mol Biol Cell 16:1071-81. 2005
    ..The cell-cell interaction thus established would suffice to account for the polarized expression and positioning of Na+,K+-ATPase in epithelial cells...
  33. pmc Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability
    Gaelle Benais-Pont
    Department of Cell Biology, University of Geneva, 1211 Geneva, Switzerland
    J Cell Biol 160:729-40. 2003
    ..These data indicate that GEF-H1/Lfc is a component of TJs and functions in the regulation of epithelial permeability...
  34. ncbi request reprint Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure
    Julie Pannequin
    Laboratoire de Biochimie, Faculte de Pharmacie, Institut de Genomique Fonctionnelle, B√Ętiment E, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    Mol Cancer Res 5:1147-57. 2007
    ..Our results show that phosphatidylethanol accumulation after chronic ethanol exposure disrupts signals that normally restrict proliferation in highly confluent intestinal cells, thus facilitating abnormal intestinal cell proliferation...