Research Topics
Genomes and Genes
| Karl MatterSummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell densityMaria S Balda
Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
J Cell Biol 160:423-32. 2003..Although this regulatory process may also involve regulation of transcription by ZONAB, our data suggest that one mechanism by which ZONAB and ZO-1 influence proliferation is by regulating the nuclear accumulation of CDK4...
Tight junctions: molecular architecture and functionSaima Aijaz
Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom
Int Rev Cytol 248:261-98. 2006....- Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpATony Sourisseau
Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, United Kingdom
Mol Cell Biol 26:2387-98. 2006.... - Epithelial tight junctions, gene expression and nucleo-junctional interplayKarl Matter
Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
J Cell Sci 120:1505-11. 2007..In cancer tissues, their expression is often deregulated in a manner that suggests that tight junctions function as suppressors of proliferation and transformation... - Mammalian tight junctions in the regulation of epithelial differentiation and proliferationKarl Matter
Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
Curr Opin Cell Biol 17:453-8. 2005..These signalling proteins include components that affect established signalling cascades and dual localisation proteins that can associate with junctions as well as travel to the nucleus where they regulate gene expression... - Functional analysis of tight junctionsKarl Matter
Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, EC1V 9EL, London, UK
Methods 30:228-34. 2003..Here we describe a set of assays that allow the analysis of tight junctions to determine their integrity and functional state... - Holey barrier: claudins and the regulation of brain endothelial permeabilityKarl Matter
Division of Cell Biology, Institute of Ophthalmology, University College London, UK
J Cell Biol 161:459-60. 2003..This suggests that the BBB can be manipulated to allow selective diffusion of small molecules and makes claudin-5 a possible target for the development of drugs for this purpose... - The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcriptionMei Nie
Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, UK
EMBO Rep 10:1125-31. 2009..Our data thus indicate that GEF-H1 and ZONAB form a signalling module that mediates Rho-regulated cyclin D1 promoter activation and expression... - The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONABAnna Tsapara
Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
Mol Biol Cell 17:1322-30. 2006.... - Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekinEmma Kavanagh
Division of Cell Biology, Institute of Ophthalmology, University College London, London, UK
J Cell Sci 119:5098-105. 2006..Our data thus indicate that symplekin and ZONAB/DbpA cooperate in the regulation of transcription, and that they promote epithelial proliferation and cyclin D1 expression... 
Tight junctions and the regulation of gene expressionMaria S Balda
Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK
Biochim Biophys Acta 1788:761-7. 2009....- Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survivalMei Nie
Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
Proc Natl Acad Sci U S A 109:10897-902. 2012..We thus identify a unique type of stress and Rho signaling activated pathway that drives mRNA stabilization and translation and links the cellular stress response to p21 expression and cell survival... - Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2Saima Aijaz
Division of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
BMC Cell Biol 8:49. 2007..Here, we addressed the question whether Apg-2 is also important for junction formation and epithelial morphogenesis... - Rho signaling and tight junction functionsSteve Terry
Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom
Physiology (Bethesda) 25:16-26. 2010..Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease... - Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin familyEmily Steed
Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
BMC Cell Biol 10:95. 2009..How these components work together to form functional tight junctions is still not well understood and will require a complete understanding of the molecular composition of the junction... - Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherinSarah K Harten
Division of Medicine, Rayne Institute, University College London, WC1E 6JJ, London, United Kingdom
Mol Biol Cell 20:1089-101. 2009..Despite the independent nature of the defects, we show that treatment with the histone deacetylase inhibitor sodium butyrate, which suppresses HIF activation, provides a method for reversing EMT in the context of VHL inactivation... - The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migrationAnna Tsapara
Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
Mol Biol Cell 21:860-70. 2010.... - Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complexAhmed Elbediwy
Department of Cell Biology, Institute of Ophthalmology, University College London, EC1V 9EL London, England, UK
J Cell Biol 198:677-93. 2012..Epithelial junction formation and morphogenesis thus require a dual activity complex, containing SH3BP1 and CapZ, that is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics... - Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transitionSaima Aijaz
Division of Cell Biology, Institute of Ophthalmology, University College London, UK
Dev Cell 8:777-86. 2005.... - TOPORS, implicated in retinal degeneration, is a cilia-centrosomal proteinChristina F Chakarova
Institute of Ophthalmology, UCL, London EC1V 9EL, UK
Hum Mol Genet 20:975-87. 2011..Additionally, it is well known that mutations in other ciliary proteins cause retinal degeneration, which may explain why mutations in TOPORS result in the same phenotype... - The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in miceAnastasios Georgiadis
Department of Genetics, UCL Institute of Ophthalmology, University College London, London, United Kingdom
PLoS ONE 5:e15730. 2010.... - Dynamics and functions of tight junctionsEmily Steed
Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
Trends Cell Biol 20:142-9. 2010..Combining such dynamic properties with existing tight junction models will help us to advance our understanding of the molecular mechanisms that underlie the functional properties of tight junctions... - Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesisStephen J Terry
Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London, UK
Nat Cell Biol 13:159-66. 2011.... - Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasionStephen J Terry
Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom
PLoS ONE 7:e50188. 2012..Our data demonstrate that p114RhoGEF drives cortical myosin activation by stimulating myosin light chain double phosphorylation and, thereby, collective cell migration of epithelial sheets and amoeboid-like motility of tumor cells... - Epithelial cell adhesion and the regulation of gene expressionMaria S Balda
Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, UK, EC1V 9EL
Trends Cell Biol 13:310-8. 2003..Here, we review such signal-transduction pathways and discuss how they influence cell proliferation and differentiation... - RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activityPaul Frankel
Oncogene Team, Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
EMBO J 24:54-62. 2005..Additionally, expression of oncogenic Ras alleviates transcriptional repression by ZONAB in a RalA-dependent manner. The data presented here implicate the RalA/ZONAB interaction in the regulation of ZONAB function... - Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosisG Astrid Limb
Department of Pathology, Institute of Ophthalmology, University College London and Moorfields Eye Hospital, 11 Bath St, London EC1V 9EL
Am J Pathol 166:1555-63. 2005..These observations strongly suggest that intracellular association of MMP-1 to mitochondria and nuclei confers resistance to apoptosis and may explain the well-known association of this enzyme with tumor cell survival and spreading... - Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sortingJ Paul Chapple
Division of Pathology, Institute of Ophthalmology, University College London, UK
Biochem J 372:427-33. 2003..These data show that RP2 is present on the membrane of all cell types examined both in vitro and in vivo, and that RP2 associates with lipid rafts, suggesting a potential role for the protein in signal transduction... - Signalling to and from tight junctionsKarl Matter
Division of Cell Biology, Institute of Ophthalmology, University College London, London, UK
Nat Rev Mol Cell Biol 4:225-36. 2003..They receive and convert signals from the cell interior to regulate junction assembly and function, and transmit signals to the cell interior to modulate gene expression and cell behaviour... - Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophyChristina F Chakarova
Institute of Ophthalmology, University College London, London, UK
Am J Hum Genet 81:1098-103. 2007.... - The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cellsLiora Shoshani
Center for Research and Advanced Studies, Department of Physiology, Biophysics, and Neurosciences, Mexico City 07300, Mexico
Mol Biol Cell 16:1071-81. 2005..The cell-cell interaction thus established would suffice to account for the polarized expression and positioning of Na+,K+-ATPase in epithelial cells... - Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeabilityGaelle Benais-Pont
Department of Cell Biology, University of Geneva, 1211 Geneva, Switzerland
J Cell Biol 160:729-40. 2003..These data indicate that GEF-H1/Lfc is a component of TJs and functions in the regulation of epithelial permeability... - Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposureJulie Pannequin
Laboratoire de Biochimie, Faculte de Pharmacie, Institut de Genomique Fonctionnelle, Bâtiment E, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
Mol Cancer Res 5:1147-57. 2007..Our results show that phosphatidylethanol accumulation after chronic ethanol exposure disrupts signals that normally restrict proliferation in highly confluent intestinal cells, thus facilitating abnormal intestinal cell proliferation...