John C Mathers

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Nutritional modulation of ageing: genomic and epigenetic approaches
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Mech Ageing Dev 127:584-9. 2006
  2. ncbi request reprint Nutrition and DNA repair--potential molecular mechanisms of action
    J C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Curr Cancer Drug Targets 7:425-31. 2007
  3. pmc Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis
    Nicola Hobbs
    Institute of Health and Society, Newcastle University, Baddiley Clark building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
    BMC Med 11:75. 2013
  4. doi request reprint Nutrition and ageing: knowledge, gaps and research priorities
    John C Mathers
    Human Nutrition Research Centre, Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Proc Nutr Soc 72:246-50. 2013
  5. doi request reprint Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John C Mathers
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 13:1242-9. 2012
  6. pmc MYOD-1 in normal colonic mucosa--role as a putative biomarker?
    Ramesh P Arasaradnam
    Department of Gastroenterology, University Hospital Coventry and Warwickshire, Coventry, UK
    BMC Res Notes 5:240. 2012
  7. ncbi request reprint Pulses and carcinogenesis: potential for the prevention of colon, breast and other cancers
    John C Mathers
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle, upon Tyne NE1 7RU, UK
    Br J Nutr 88:S273-9. 2002
  8. pmc Reversal of DNA hypomethylation by folic acid supplements: possible role in colorectal cancer prevention
    J C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Gut 54:579-81. 2005
  9. ncbi request reprint The biological revolution - towards a mechanistic understanding of the impact of diet on cancer risk
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Mutat Res 551:43-9. 2004
  10. ncbi request reprint Can resistant starch and/or aspirin prevent the development of colonic neoplasia? The Concerted Action Polyp Prevention (CAPP) 1 Study
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Proc Nutr Soc 62:51-7. 2003

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Nutritional modulation of ageing: genomic and epigenetic approaches
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Mech Ageing Dev 127:584-9. 2006
    ....
  2. ncbi request reprint Nutrition and DNA repair--potential molecular mechanisms of action
    J C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Curr Cancer Drug Targets 7:425-31. 2007
    ..This review considers possible molecular mechanisms through which such factors could modulate repair...
  3. pmc Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis
    Nicola Hobbs
    Institute of Health and Society, Newcastle University, Baddiley Clark building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
    BMC Med 11:75. 2013
    ..This systematic review adheres to a registered protocol (PROSPERO CRD42011001459)...
  4. doi request reprint Nutrition and ageing: knowledge, gaps and research priorities
    John C Mathers
    Human Nutrition Research Centre, Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Proc Nutr Soc 72:246-50. 2013
    ....
  5. doi request reprint Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John C Mathers
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 13:1242-9. 2012
    ..We assessed the effect of resistant starch on the incidence of colorectal cancer...
  6. pmc MYOD-1 in normal colonic mucosa--role as a putative biomarker?
    Ramesh P Arasaradnam
    Department of Gastroenterology, University Hospital Coventry and Warwickshire, Coventry, UK
    BMC Res Notes 5:240. 2012
    ..In this study, we have determined the frequency of methylation of the MYOD-1 gene in normal colonic mucosa and investigated to see if this is associated with established colorectal cancer risk factors primarily ageing...
  7. ncbi request reprint Pulses and carcinogenesis: potential for the prevention of colon, breast and other cancers
    John C Mathers
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle, upon Tyne NE1 7RU, UK
    Br J Nutr 88:S273-9. 2002
    ..Pulses contain a rich variety of compounds which, if consumed in sufficient quantities, may help to reduce tumour risk...
  8. pmc Reversal of DNA hypomethylation by folic acid supplements: possible role in colorectal cancer prevention
    J C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Gut 54:579-81. 2005
  9. ncbi request reprint The biological revolution - towards a mechanistic understanding of the impact of diet on cancer risk
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Mutat Res 551:43-9. 2004
    ..This is likely to form a significant component of the emerging science of nutrigenomics...
  10. ncbi request reprint Can resistant starch and/or aspirin prevent the development of colonic neoplasia? The Concerted Action Polyp Prevention (CAPP) 1 Study
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Proc Nutr Soc 62:51-7. 2003
    ..Biopsies of macroscopically-normal rectal mucosa are also being collected for assay of putative biomarkers of CRC risk...
  11. ncbi request reprint Nutrition and cancer prevention: diet-gene interactions
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Proc Nutr Soc 62:605-10. 2003
    ..However, in the absence of a robust body of evidence on which dietary strategies will benefit which individuals, soundly based genetically-targeted nutrition advice to the public on cancer prevention is a little way in the future...
  12. doi request reprint Polymorphisms affecting trace element bioavailability
    John C Mathers
    Human Nutrition Centre, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle, UK
    Int J Vitam Nutr Res 80:314-8. 2010
    ..This may include copy number variants in addition to the more widely studied polymorphisms. Future research on trace element bioavailability should encompass studies of epigenetic variants, including the role of non-coding (micro) RNA...
  13. ncbi request reprint Plant foods for human health: research challenges
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Proc Nutr Soc 65:198-203. 2006
    ....
  14. doi request reprint Session 2: Personalised nutrition. Epigenomics: a basis for understanding individual differences?
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Proc Nutr Soc 67:390-4. 2008
    ..Differences in epigenetic markings may explain some inter-individual variation in disease risk and in response to nutritional interventions...
  15. pmc Folate intake and bowel cancer risk
    John C Mathers
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, William Leech Building, Framlington Place, Newcastle on Tyne, NE2 4HH, UK
    Genes Nutr 4:173-8. 2009
    ....
  16. ncbi request reprint Nutrition in cancer prevention
    J C Mathers
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Curr Opin Oncol 11:402-7. 1999
    ..Targeting initial intervention studies in those with explicit genetic predisposition to cancer may have both greater cost-effectiveness and fewer ethical difficulties than do similar studies in the general public...
  17. ncbi request reprint Dietary carbohydrates and insulin sensitivity
    J C Mathers
    Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Curr Opin Clin Nutr Metab Care 1:553-7. 1998
    ..We conclude that reducing the rate of carbohydrate digestion in the small bowel may be the key stage at which to intervene to reduce insulinaemia and so prevent downregulation of insulin receptors and insulin resistance...
  18. ncbi request reprint Early nutrition: impact on epigenetics
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle, UK
    Forum Nutr 60:42-8. 2007
    ....
  19. ncbi request reprint The biological revolution: understanding the impact of SNPs on diet-cancer interrelationships
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Nutr 137:253S-258S. 2007
    ..Emerging biological science using epigenomics, proteomics, and other molecular technologies appears to offer novel approaches to the discovery and validation of surrogate endpoints...
  20. ncbi request reprint Dietary strategies to reduce the burden of cancer and cardiovascular disease in the UK
    J C Mathers
    Human Nutritrion Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Br J Nutr 84:S211-6. 2000
    ..Ethical exploitation of the rapid growth in interest in 'functional foods' by the food industry will require a level of investment in biomedical research unusual in the past...
  21. ncbi request reprint Chairman's introduction: what can we expect to learn from genomics?
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Proc Nutr Soc 63:1-4. 2004
  22. ncbi request reprint Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype
    Fiona Caple
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Br J Nutr 103:1585-93. 2010
    ..037) between the three genotypes for the Val16Ala single nucleotide polymorphism in manganese superoxide dismutase (rs4880) with individuals homozygous/wild type showing less damage than those carrying the alanine variant...
  23. ncbi request reprint Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex
    Catherine Méplan
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle, United Kingdom
    Am J Clin Nutr 87:1019-27. 2008
    ..Selenium is present as selenocysteine in selenoproteins such as the glutathione peroxidases (GPx). Selenocysteine incorporation requires specific structures in the 3'untranslated region (3'UTR) of selenoprotein mRNAs...
  24. pmc Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Lancet 378:2081-7. 2011
    ....
  25. pmc Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12
    Jill A McKay
    Institute for Ageing and Health, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    PLoS ONE 7:e33290. 2012
    ..In addition, gestational length appears to be an important determinant of infant DNA methylation patterns...
  26. ncbi request reprint Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay
    Joanna P Gorniak
    Centre for Brain Ageing and Vitality, Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Mutagenesis 28:673-81. 2013
    ..In conclusion, the comet-based DNA repair assay can be easily adapted to study a range of mammalian tissues. ..
  27. ncbi request reprint Healthy eating: perceptions and practice (the ASH30 study)
    Amelia A Lake
    Human Nutrition Research Centre, Institute of Health and Society and School of Clinical Medical Sciences, Newcastle University, Medical School, Framlington Place, Newcastle, NE2 4HH, UK
    Appetite 48:176-82. 2007
    ..This paper shows a relationship between perceptions of eating patterns and socio-economic status, adiposity and measured food intake...
  28. ncbi request reprint Postprandial glycaemic, lipaemic and haemostatic responses to ingestion of rapidly and slowly digested starches in healthy young women
    Louisa J Ells
    Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK
    Br J Nutr 94:948-55. 2005
    ..These data confirm that starches characterized as predominantly rapidly digestible versus slowly digestible by the Englyst procedure provoke distinctly different patterns of metabolism postprandially...
  29. doi request reprint Tracking of dietary intake and factors associated with dietary change from early adolescence to adulthood: the ASH30 study
    Amelia A Lake
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, The Medical School, Newcastle upon Tyne, UK
    Obes Facts 2:157-65. 2009
    ..Additionally this paper explores factors associated with change in food intake...
  30. ncbi request reprint Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status
    Catherine Méplan
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle, England
    Antioxid Redox Signal 11:2631-40. 2009
    ..An elevated proportion of the 60-kDa isoform of SePP may increase selenoprotein synthesis and reduce colorectal cancer risk...
  31. doi request reprint Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 55:1026-35. 2011
    ..Given the increased requirement for folate during pregnancy, mothers may be susceptible to aberrant DNA methylation due to folate depletion...
  32. doi request reprint Effects on nutrient intake of a family-based intervention to promote increased consumption of low-fat starchy foods through education, cooking skills and personalised goal setting: the Family Food and Health Project
    PETER J CURTIS
    Institute for Ageing and Health, The Human Nutrition Research Centre, William Leech Building, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Br J Nutr 107:1833-44. 2012
    ....
  33. doi request reprint Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mol Nutr Food Res 55:1717-23. 2011
    ..We reported low folate supply in utero was associated with reduced global DNA methylation in the murine small intestine of adult offspring. We hypothesised that aberrant methylation would be observed during early development...
  34. ncbi request reprint Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study)
    Catherine Méplan
    Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH UK
    FASEB J 21:3063-74. 2007
    ..In conclusion, the data reveal two common functional SNPs within the human SePP gene that may predict behavior of biomarkers of Se status and response to supplementation and thus susceptibility to disease...
  35. doi request reprint Analysis of differential gene-regulatory responses to zinc in human intestinal and placental cell lines
    Kelly A Jackson
    Human Nutrition Research Centre, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Br J Nutr 101:1474-83. 2009
    ....
  36. pmc Effectiveness of dietary interventions among adults of retirement age: a systematic review and meta-analysis of randomized controlled trials
    Jose Lara
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    BMC Med 12:60. 2014
    ..Retirement from work involves significant lifestyle changes and may represent an opportunity to promote healthier eating patterns in later life. However, the effectiveness of dietary interventions during this period has not been evaluated...
  37. doi request reprint Towards measurement of the Healthy Ageing Phenotype in lifestyle-based intervention studies
    Jose Lara
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Maturitas 76:189-99. 2013
    ....
  38. pmc Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations
    Laura C Greaves
    Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 8:e1003082. 2012
    ..These data provide little evidence for any selective constraints on the occurrence and expansion of mtDNA mutations in somatic cells of the human colon during human ageing in contrast to germline mutations seen in the general population...
  39. ncbi request reprint Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome
    John Burn
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Pkwy, Newcastle upon Tyne NE1 3BZ, United Kingdom
    N Engl J Med 359:2567-78. 2008
    ..Resistant starch has been associated with an antineoplastic effect on the colon...
  40. pmc Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts
    Laura C Greaves
    Mitochondrial Research Group, Institute for Ageing and Health, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    Exp Gerontol 45:573-9. 2010
    ..Finally we discuss the possible mechanisms by which multiple respiratory chain complex defects may occur in these cells...
  41. doi request reprint Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype
    John Tyson
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Br J Nutr 101:1316-23. 2009
    ..While there was no detectable effect of micronutrient supplementation on NER capacity, there was evidence that the effect of fruit intake on the NER capacity may be modulated by the ERCC2 Lys751Gnl single nucleotide polymorphism...
  42. pmc Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction
    Laura J Ions
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Age (Dordr) 35:1835-49. 2013
    ..Sirt1-mediated effects on DNA methylation and, consequently, gene expression may thus be one of the mechanisms underlying the response to dietary restriction. ..
  43. ncbi request reprint Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Biogerontology 15:317-28. 2014
    ..47 (95 % CI 0.26-0.85); n = 321, p = 0.013]. Overall this study suggests a potential role for age-related changes in CpG island methylation in the development of frailty. ..
  44. doi request reprint Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring
    Sabine A S Langie
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    FASEB J 27:3323-34. 2013
    ..In summary, our data suggest that low-folate supply during early life may leave an epigenetic mark that can predispose the offspring to further dietary insults, causing adverse effects during adult life...
  45. doi request reprint MLH1 Differential allelic expression in mutation carriers and controls
    Mauro Santibanez Koref
    Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Ann Hum Genet 74:479-88. 2010
    ..655G>A; p.I219V) and rs1800734 (c.-93 G>A) that are independently associated with expression. These influences are, however, small compared to the differences associated with pathological variants...
  46. pmc A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Cancer Prev Res (Phila) 4:655-65. 2011
    ..This clinical trial is the largest ever conducted in the setting of FAP and found a trend of reduced polyp load (number and size) with 600 mg of aspirin daily. RS had no clinical effect on adenomas...
  47. pmc Identification of the human zinc transcriptional regulatory element (ZTRE): a palindromic protein-binding DNA sequence responsible for zinc-induced transcriptional repression
    Lisa J Coneyworth
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4NN, United Kingdom
    J Biol Chem 287:36567-81. 2012
    ..These findings provide the basis for elucidating how regulation of a network of genes through this novel mechanism contributes to zinc homeostasis and how the cell orchestrates this response...
  48. doi request reprint Differential antineoplastic effects of butyrate in cells with and without a functioning DNA mismatch repair
    Shridhar S Dronamraju
    Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom
    Nutr Cancer 62:105-15. 2010
    ..Differential expression of key cell cycle regulatory genes may explain some of the molecular mechanisms underlying these effects...
  49. doi request reprint Changing foodscapes 1980-2000, using the ASH30 Study
    Thomas Burgoine
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Leech Building, Framlington Place, Newcastle, NE2 4HH, England, UK
    Appetite 53:157-65. 2009
    ..Adding geographical elements to a dietary study adds an interesting dimension in exploring the change in eating and BMI from adolescence to adulthood...
  50. ncbi request reprint Longitudinal change in food habits between adolescence (11-12 years) and adulthood (32-33 years): the ASH30 Study
    Amelia A Lake
    Human Nutrition Research Centre, University of Newcastle upon Tyne, Framlington Place, Newcastle NE2 4HH, UK
    J Public Health (Oxf) 28:10-6. 2006
    ..Links between diet in childhood and the prevention of disease in adulthood have been established. This longitudinal dietary survey provided quantitative evidence of dietary change from adolescence to adulthood, in Northumberland, England...
  51. doi request reprint Mechanisms of mammalian zinc-regulated gene expression
    Kelly A Jackson
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Biochem Soc Trans 36:1262-6. 2008
    ....
  52. ncbi request reprint Changes over 20 years in macronutrient intake and body mass index in 11- to 12-year-old adolescents living in Northumberland
    E S Fletcher
    Human Nutrition Research Centre, University of Newcastle upon Tyne, NE1 4LP, UK
    Br J Nutr 92:321-33. 2004
    ..The number of overweight and obese children increased from 11 % to 30 % between 1980 and 2000. Positive changes have occurred in the Northumbrian adolescent diet but social inequalities, reported in previous surveys, remain...
  53. doi request reprint Raised adolescent body mass index predicts the development of adiposity and a central distribution of body fat in adulthood: a longitudinal study
    Angela M Craigie
    Institute of Health and Society, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Obes Facts 2:150-6. 2009
    ..To test the hypothesis that adolescent body mass index (BMI) tracks into adulthood and can be used as a predictor of obesity and/or central adiposity in adulthood...
  54. ncbi request reprint ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells
    Ruth A Valentine
    The Human Nutrition Research Centre, School of Dental Sciences, Institute for Cell and Molecular Biosciences, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    J Biol Chem 282:14389-93. 2007
    ....
  55. pmc Quantification of mitochondrial DNA mutation load
    Laura C Greaves
    Mitochondrial Research Group, Institute for Ageing and Health, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Aging Cell 8:566-72. 2009
    ..We assess the procedures and practicalities involved in each of these three assays and discuss the results obtained by investigation of mutation loads in colonic mucosal biopsies from ten human subjects...
  56. ncbi request reprint Intestinal tumours, colonic butyrate and sleep in exercised Min mice
    Laura Basterfield
    Faculty of Medical Sciences, Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Br J Nutr 104:355-63. 2010
    ..001) and tumour burden (P = 0.001). More studies of the effects of sleep and of colonic butyrate in mediating the effects of physical activity on intestinal tumourigenesis are warranted...
  57. ncbi request reprint Effecting dietary change
    Ashley J Adamson
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 4LP, UK
    Proc Nutr Soc 63:537-47. 2004
    ..There is a need for further theory-based research on which to develop more effective strategies to enable individuals to adopt healthier lifestyles...
  58. pmc Comparison of methods for quantification of global DNA methylation in human cells and tissues
    Sofia Lisanti
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e79044. 2013
    ....
  59. ncbi request reprint Chemoprevention in Lynch syndrome
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Fam Cancer 12:707-18. 2013
    ..CAPP3 will involve a double blind dose non-inferiority trial comparing 100, 300 or 600 mg daily in 3,000 gene carriers. We can now recommend aspirin in people at high risk of colorectal cancer...
  60. pmc Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Int J Epidemiol 41:210-7. 2012
    ..The hypothesis that Long Interspersed Nucleotide Element 1 (LINE-1) DNA methylation (an index of global DNA methylation) is associated with biomarkers of metabolic health was investigated in this study...
  61. pmc Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK
    Linda Penn
    Public Health Research Programme, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 9:342. 2009
    ..In the Newcastle arm of this study (EDIPS-Newcastle), we tested the hypothesis that T2D can be prevented by lifestyle intervention and explored secondary outcomes in relation to diabetes incidence...
  62. pmc Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass
    Alexandra Groom
    Institute of Genetic Medicine and Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 61:391-400. 2012
    ..Noncausal methylation patterns may still be useful predictors of later adiposity...
  63. ncbi request reprint Gender-specific modulation of tumorigenesis by folic acid supply in the Apc mouse during early neonatal life
    Jill A McKay
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, NE2 4HH, UK
    Br J Nutr 99:550-8. 2008
    ....
  64. doi request reprint Induction of epigenetic alterations by dietary and other environmental factors
    John C Mathers
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    Adv Genet 71:3-39. 2010
    ....
  65. ncbi request reprint A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane
    Ruth A Cragg
    Department of Biological and Nutritional Sciences, University of Newcastle, Kings Rd, Newcastle upon Tyne, NE1 7RU, United Kingdom
    J Biol Chem 277:22789-97. 2002
    ..The localization, regulatory properties, and function of hZTL1 indicate a role in regulating the absorption of dietary zinc across the apical enterocyte membrane...
  66. ncbi request reprint Changes in consumption of sugars by English adolescents over 20 years
    A J Rugg-Gunn
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 4LP, UK
    Public Health Nutr 10:354-63. 2007
    ..This study reports dietary sugars consumption in 2000 and compares it with data collected in 1980 and 1990, using identical methods...
  67. doi request reprint Do age-related changes in DNA methylation play a role in the development of age-related diseases?
    Sanne D van Otterdijk
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE1 4LP, UK
    Biochem Soc Trans 41:803-7. 2013
    ..We focus especially on the extent to which the acquisition of aberrant methylation changes during aging could underlie the development of a number of important age-related pathological conditions...
  68. ncbi request reprint DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC)
    Ramesh P Arasaradnam
    Human Nutrition Research Centre, Newcastle University, Newcastle, UK
    Epigenetics 5:422-6. 2010
    ..Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and no studies exist that assess its relationship with lifestyle exposures...
  69. pmc Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT
    Linda Penn
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e57143. 2013
    ..We report pooled analyses of data from three European trial cohorts: to analyse T2D incidence, sustained weight loss and utility of risk predictors...
  70. ncbi request reprint Anti-cancer effects of butyrate: use of micro-array technology to investigate mechanisms
    Elizabeth A Williams
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK
    Proc Nutr Soc 62:107-15. 2003
    ....
  71. ncbi request reprint Accuracy of estimates of food portion size using food photographs--the importance of using age-appropriate tools
    Emma Foster
    Human Nutrition Research Centre, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Public Health Nutr 9:509-14. 2006
    ..Tools are available to assist subjects in providing an estimate of portion size and these include food photographs. The application of these tools in improving portion size estimation by children has not been investigated systematically...
  72. doi request reprint Sources of total, non-milk extrinsic, and intrinsic and milk sugars in the diets of older adults living in sheltered accommodation
    Jane Bradbury
    Human Nutrition Research Centre, School of Dental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
    Br J Nutr 99:649-52. 2008
    ..9 %), 'soft drinks' (13.1 %) and 'table sugar' (11.1 %) made the greatest contributions to intakes of NMES. Interventions to reduce NMES intake should focus on limiting quantity and frequency of intake of these food groups...
  73. ncbi request reprint Quantitative kinetics of glucose appearance and disposal following a 13C-labelled starch-rich meal: comparison of male and female subjects
    M Denise Robertson
    Human Nutrition Research Centre, Dept Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Br J Nutr 87:569-77. 2002
    ..05) carbohydrate oxidation rate obtained by indirect calorimetry. The present study suggests that during the ingestion of a starchy meal, females exhibit higher glucose flux and greater whole-body insulin sensitivity than males...
  74. doi request reprint Packaged food intake by British children aged 0 to 6 years
    E Foster
    Human Nutrition Research Centre, Medical School, William Leech Building, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:380-8. 2010
    ..65 dm(2) kg(-1) for the infants under 1 year, 0.81 dm(2) kg(-1) for the 1-4-year-olds, and 0.66 dm(2) kg(-1) for the 4-6-year-olds. All 297 children had intakes that exceeded 0.1 dm(2) of packaging per kg of body weight assumption...
  75. doi request reprint Nutrition in advanced age: dietary assessment in the Newcastle 85+ study
    A J Adamson
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Nutr 63:S6-18. 2009
    ..This paper describes a comparison of two different methods of dietary assessment within the Newcastle 85+ Study; a UK cohort study of health and ageing in the oldest old...
  76. doi request reprint Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass
    L Basterfield
    Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Int J Obes (Lond) 33:212-8. 2009
    ..To examine the impact of two diets differing in fat content and of wheel-running exercise on body mass...
  77. pmc Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation
    J A McKay
    Human Nutrition Research Centre, Medical School, Newcastle University, Framlington Place, Newcastle, NE2 4HH, UK
    Genes Nutr 3:167-71. 2008
    ....
  78. ncbi request reprint Comparative gastrointestinal and plasma cholesterol responses of rats fed on cholesterol-free diets supplemented with guar gum and sodium alginate
    C J Seal
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Br J Nutr 85:317-24. 2001
    ....
  79. ncbi request reprint Dietary and genetic modulation of DNA repair in healthy human adults
    J Tyson
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Proc Nutr Soc 66:42-51. 2007
    ....
  80. ncbi request reprint DNA mismatch repair status may influence anti-neoplastic effects of butyrate
    J M Coxhead
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Agriculture Building, University of Newcastle, Kings Road, Newcastle upon Tyne NE1 7RU, UK
    Biochem Soc Trans 33:728-9. 2005
    ..5-2 mM) may have more potent anti-neoplastic effects in CRC cell lines deficient in MMR, but mechanisms for such a differential response remain to be established...
  81. ncbi request reprint Children's estimates of food portion size: the effect of timing of dietary interview on the accuracy of children's portion size estimates
    E Foster
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Room M1151, 1st Floor, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Br J Nutr 99:185-90. 2008
    ..Under these conditions many children were able to estimate food portion size utilising perception, conceptualisation and memory skills...
  82. ncbi request reprint Randomised controlled trial evaluating the effectiveness of behavioural interventions to modify cardiovascular risk factors in men and women with impaired glucose tolerance: outcomes at 6 months
    J C Oldroyd
    Department of Epidemiology and Public Health, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Diabetes Res Clin Pract 52:29-43. 2001
    ..To evaluate the efficacy of interventions to promote a healthy diet and physical activity in people with impaired glucose tolerance (IGT)...
  83. ncbi request reprint Children's estimates of food portion size: the development and evaluation of three portion size assessment tools for use with children
    E Foster
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Room M1151, 1st Floor, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Br J Nutr 99:175-84. 2008
    ..Before practical application in assessment of dietary intake of children the tool would need to be expanded to cover a wider range of foods and to be validated in a 'real-life' situation...
  84. ncbi request reprint Evidence for altered control of glucose disposal after total colectomy
    M D Robertson
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Br J Nutr 84:813-9. 2000
    ..The present study indicates that loss of the colon is associated with several characteristics of the insulin resistance syndrome, and favours a view that the colon has a role in the control of postprandial glucose...
  85. ncbi request reprint The nutrition knowledge of older adults living in sheltered housing accommodation
    P J Moynihan
    School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK
    J Hum Nutr Diet 20:446-58. 2007
    ..Nutrition knowledge enables informed dietary choices. This paper reports on the nutrition knowledge of older adults residing in sheltered housing accommodation in socially deprived areas of north-east England...
  86. ncbi request reprint A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49-51 years
    L Parker
    Paediatric and Lifecourse Epidemiology Research Group, University of Newcastle upon Tyne, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Diabet Med 20:406-15. 2003
    ..A central metabolic syndrome (CMS) has been identified comprising obesity, dyslipidaemia and insulin resistance. This study was designed to investigate determinants of risk for CMS...
  87. ncbi request reprint Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch diet
    M E Daly
    Human Nutrition Research Centre, the Department of Biological and Nutritional Sciences, University of Newcastle upon Tyne, United Kingdom
    Am J Clin Nutr 67:1186-96. 1998
    ..001). Plasma fatty acid concentrations showed a late postprandial rise with the sucrose-rich diet relative to the starch-rich diet, which was mirrored with a fractionally later peak in triacylglycerol concentrations...
  88. ncbi request reprint Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months
    S L Williamson
    Department of Histopathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Carcinogenesis 20:805-10. 1999
    ..However, it remains possible that any increased risk is restricted to carriers of germline mutations in APC...
  89. ncbi request reprint A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis
    R P Arasaradnam
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle, UK
    Epigenetics 3:193-8. 2008
    ..Such interactions are likely to have a mechanistic impact on CRC carcinogenesis through the methylation pathway but also, may offer possible therapeutic potential as nutraceuticals...
  90. ncbi request reprint Kill and cure: dietary augmentation of immune defences against colon cancer
    F Armstrong
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Proc Nutr Soc 59:215-20. 2000
    ..Effective chemopreventative agents will include dietary components that enhance the immune system's ability to identify transformed cells and to target them for apoptosis...
  91. ncbi request reprint Changes in water intake of Northumbrian adolescents 1980 to 2000
    F V Zohouri
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Br Dent J 196:547-52; discussion 537. 2004
    ..To determine: total water intake in young English adolescents; the relative importance of sources of water intake; and changes in water intake and sources of water between 1980 and 2000...
  92. ncbi request reprint Folate and DNA methylation during in utero development and aging
    J A McKay
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle upon Tyne, NE1 7RU, UK
    Biochem Soc Trans 32:1006-7. 2004
    ..This review describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging...
  93. ncbi request reprint Bioavailability of fluoride in drinking water: a human experimental study
    A Maguire
    Faculty of Medical Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    J Dent Res 84:989-93. 2005
    ..e., F concentration of individual waters); T(max), time of c(max)...
  94. pmc Supporting well-being in retirement through meaningful social roles: systematic review of intervention studies
    Ben Heaven
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
    Milbank Q 91:222-87. 2013
    ..After retiring from work, people may lose roles that provide purpose and social contacts. The outcomes of interventions to promote social roles in retirement have not been systematically reviewed...
  95. ncbi request reprint Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance
    John C Oldroyd
    School of Population and Health Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Diabetes Res Clin Pract 72:117-27. 2006
    ..To evaluate the effectiveness of lifestyle interventions in people with impaired glucose tolerance (IGT)...
  96. doi request reprint Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a comet-based in vitro repair assay
    Sabine A S Langie
    Centre for Brain Ageing and Vitality, Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Mutagenesis 26:461-71. 2011
    ....
  97. ncbi request reprint Postprandial carbohydrate metabolism in healthy subjects and those with type 2 diabetes fed starches with slow and rapid hydrolysis rates determined in vitro
    Chris J Seal
    Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Faculty of Science, Agriculture and Engineering, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK
    Br J Nutr 90:853-64. 2003
    ..Data from the hydrolysis of novel starch products in vitro, therefore, are useful in predicting glycaemic responses in vivo...
  98. doi request reprint Does promoter methylation of the SLC30A5 (ZnT5) zinc transporter gene contribute to the ageing-related decline in zinc status?
    L J Coneyworth
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Proc Nutr Soc 68:142-7. 2009
    ..This premise is being investigated by analysis of additional samples from a human adult cohort to test the hypothesis that methylation of the SLC30A5 promoter region contributes to the age-related decline in Zn status...
  99. pmc Effect of maternal and post-weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult apc and wild type mice
    Jill A McKay
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University Newcastle upon Tyne, UK
    Front Genet 2:23. 2011
    ....
  100. ncbi request reprint Starch digestion, large-bowel fermentation and intestinal mucosal cell proliferation in rats treated with the alpha-glucosidase inhibitor acarbose
    Mahshid Dehghan-Kooshkghazi
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Br J Nutr 91:357-65. 2004
    ..In conclusion, apart from the increased faecal loss of starch, there was no evidence of adverse effects of acarbose on the aspects of large-bowel function investigated...
  101. doi request reprint Epigenetics - potential contribution to fetal programming
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, William Leech Building, Newcastle on Tyne, UK
    Adv Exp Med Biol 646:119-23. 2009
    ..Studies of altered epigenetic marking will be of profound importance for mechanistic understanding of the role of nutrition in health but especially for studies of the developmental origins of health...