Research Topics

John C Mathers


Affiliation: University of Newcastle
Country: UK


  1. Mathers J. Obesity and bowel cancer: from molecular mechanisms to interventions. Nutr Res. 2018;: pubmed publisher
    ..In the meantime, to lower the global CRC burden, it would be prudent to institute effective public measures to reduce the development of obesity and to enable those who are obese to lose weight. ..
  2. Mathers J, Movahedi M, Macrae F, Mecklin J, Moeslein G, Olschwang S, et al. Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol. 2012;13:1242-9 pubmed publisher
  3. Movahedi M, Bishop D, Macrae F, Mecklin J, Moeslein G, Olschwang S, et al. Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study. J Clin Oncol. 2015;33:3591-7 pubmed publisher
    ..79; P = .03). Obesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin. Such patients are likely to benefit from obesity prevention and/or regular aspirin. ..
  4. Mathers J. Folate intake and bowel cancer risk. Genes Nutr. 2009;4:173-8 pubmed publisher
  5. Leslie W, Ford I, Sattar N, Hollingsworth K, Adamson A, Sniehotta F, et al. The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Fam Pract. 2016;17:20 pubmed publisher
    ..Results, available from 2018 onwards, will inform future service strategy. Current Controlled Trials ISRCTN03267836 . Date of Registration 20/12/2013. ..
  6. McKay J, Xie L, Adriaens M, Evelo C, Ford D, Mathers J. Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion. Nutrients. 2016;8: pubmed
    ..Only 25 differentially expressed genes were common between organs. Maternal folate intake during pregnancy influences fetal gene expression in a highly organ specific manner which may reflect organ-specific functions. ..
  7. Langie S, Cameron K, Ficz G, Oxley D, Tomaszewski B, Gorniak J, et al. The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice. Genes (Basel). 2017;8: pubmed publisher
    ..These data indicate that Ogg1 and Neil1 expression can be epigenetically regulated, which may mediate the effects of ageing on DNA repair in the brain. ..
  8. Celis Morales C, Marsaux C, Livingstone K, Navas Carretero S, San Cristobal R, Fallaize R, et al. Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial. Am J Clin Nutr. 2017;105:1204-1213 pubmed publisher
    ..048)].Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at as NCT01530139. ..