Ruth C Massey

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. pmc Interference competition and parasite virulence
    Ruth C Massey
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Proc Biol Sci 271:785-8. 2004
  2. pmc Staphylococcus aureus extracellular adherence protein triggers TNFα release, promoting attachment to endothelial cells via protein A
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 7:e43046. 2012
  3. doi request reprint From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?
    Nicholas K Priest
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Nat Rev Microbiol 10:791-7. 2012
  4. pmc Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 6:e18899. 2011
  5. pmc Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system
    Justine K Rudkin
    Department of Biology and Biochemistry, University of Bath, UK
    J Infect Dis 205:798-806. 2012
  6. pmc Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells
    Ruth C Massey
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Infect Immun 75:5711-5. 2007
  7. doi request reprint How does Staphylococcus aureus escape the bloodstream?
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Trends Microbiol 19:184-90. 2011
  8. pmc Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 6:e1000964. 2010
  9. pmc Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence
    Vicki Fleming
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 188:7686-8. 2006
  10. pmc Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media
    Ruth C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 70:5339-45. 2002

Collaborators

Detail Information

Publications19

  1. pmc Interference competition and parasite virulence
    Ruth C Massey
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Proc Biol Sci 271:785-8. 2004
    ..The ubiquity and diversity of bacteriocins among pathogenic bacteria suggest mixed infections will be, on average, less virulent than single infections...
  2. pmc Staphylococcus aureus extracellular adherence protein triggers TNFα release, promoting attachment to endothelial cells via protein A
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 7:e43046. 2012
    ..Using a murine bacteraemia model we found that Eap expressing strains cause a more severe infection, demonstrating its role in invasive disease...
  3. doi request reprint From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?
    Nicholas K Priest
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Nat Rev Microbiol 10:791-7. 2012
    ..aureus genomic sequences using existing technology...
  4. pmc Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 6:e18899. 2011
    ..aureus for both colonisation and infection, may have provided the selective pressure for the multiple binding repeats within FnBPA...
  5. pmc Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system
    Justine K Rudkin
    Department of Biology and Biochemistry, University of Bath, UK
    J Infect Dis 205:798-806. 2012
    ..CA-MRSA typically express less penicillin-binding protein 2a (encoded by mecA), allowing them to maintain full virulence and succeed in the community environment...
  6. pmc Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells
    Ruth C Massey
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Infect Immun 75:5711-5. 2007
    ..aureus Eap protein does not block MHC-T-cell receptor interactions and is not a superantigen. Instead, it has nonspecific cross-linking activity that is dependent upon having at least two of its six 110-amino-acid repeats...
  7. doi request reprint How does Staphylococcus aureus escape the bloodstream?
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Trends Microbiol 19:184-90. 2011
    ..aureus can escape the bloodstream. In this article we review these new developments and set them in the context of strategies used by other established pathogens to traverse cellular barriers...
  8. pmc Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 6:e1000964. 2010
    ..In conclusion, multiple FnBRs within FnBPA facilitate efficient Fn adhesion, trigger rapid bacterial uptake and are required for pathogenesis...
  9. pmc Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence
    Vicki Fleming
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 188:7686-8. 2006
    ..Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population...
  10. pmc Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media
    Ruth C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 70:5339-45. 2002
    ..These findings have important implications for future studies of S. aureus adhesins...
  11. pmc Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus
    Angus Buckling
    Department of Zoology, University of Oxford, South Parks Rd, Oxford OX1 3PS, UK
    J Bacteriol 187:2917-9. 2005
    ..This study demonstrates that mapW is an allelic variant of the map/eap genes found in other strains and that the variation in the length of this poly(A) tract suggests that it is a contingency locus...
  12. ncbi request reprint Antibiotic-resistant sub-populations of the pathogenic bacterium Staphylococcus aureus confer population-wide resistance
    Ruth C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Level 4, John Radcliffe Hospital, UK
    Curr Biol 12:R686-7. 2002
  13. ncbi request reprint Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization
    Louise M O'Brien
    Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Cell Microbiol 4:759-70. 2002
    ..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
  14. ncbi request reprint Genes encoding a cellulosic polymer contribute toward the ecological success of Pseudomonas fluorescens SBW25 on plant surfaces
    Micaela Gal
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK
    Mol Ecol 12:3109-21. 2003
    ....
  15. pmc Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates
    James Collins
    Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
    J Clin Microbiol 46:2112-4. 2008
    ..We found that the beta and delta hemolysins are involved and that methicillin-resistant S. aureus strains are less toxic than methicillin-susceptible S. aureus strains...
  16. pmc The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines
    Thomas J Scriba
    Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Infect Immun 76:2164-8. 2008
    ..The activation of CD14(+) cells by Eap suggests that it could play a significant role in both septic shock and fever, two of the major pathological features of S. aureus infections...
  17. doi request reprint Interspecific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa
    Freya Harrison
    Department of Zoology, University of Oxford, Oxford, UK
    ISME J 2:49-55. 2008
    ..This is probably because the S. aureus had the net effect of competing for iron, rather than acting as an iron source. This study demonstrates that interspecific competition can have a marked effect on intraspecific social interactions...
  18. ncbi request reprint The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?
    Ruth C Massey
    Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK
    Nat Rev Microbiol 4:953-8. 2006
    ..aureus. In the case of S. epidermidis, where skin contact affords easier transmission between hosts, high levels of virulence do not offer an advantage to this pathogen...
  19. pmc Antagonistic coevolution with parasites increases the cost of host deleterious mutations
    Angus Buckling
    Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Proc Biol Sci 273:45-9. 2006
    ..These data suggest that coevolution with parasites increases the rate at which deleterious mutations are purged from host populations...