Luisa Martinez-Pomares

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Lab Invest 85:1238-49. 2005
  2. pmc The mannose receptor mediates dengue virus infection of macrophages
    Joanna L Miller
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e17. 2008
  3. doi request reprint Macrophage mannose receptor on lymphatics controls cell trafficking
    Fumiko Marttila-Ichihara
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, Turku, Finland
    Blood 112:64-72. 2008
  4. ncbi request reprint B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion
    Ping Yu
    Department of Pathology and Committee on Immunology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 168:5117-23. 2002
  5. doi request reprint The mannose receptor
    Luisa Martinez-Pomares
    Faculty of Medicine and Health Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    J Leukoc Biol 92:1177-86. 2012
  6. doi request reprint CD169+ macrophages at the crossroads of antigen presentation
    Luisa Martinez-Pomares
    School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Trends Immunol 33:66-70. 2012
  7. ncbi request reprint Antigen presentation the macrophage way
    Luisa Martinez-Pomares
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Floor A, West Block, Room 1323, Nottingham, NG7 2UH, UK
    Cell 131:641-3. 2007
  8. ncbi request reprint Carbohydrate-independent recognition of collagens by the macrophage mannose receptor
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, UK
    Eur J Immunol 36:1074-82. 2006
  9. ncbi request reprint Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Leukoc Biol 73:604-13. 2003
  10. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Lab Invest 85:1238-49. 2005
    ..Our results suggest an unexpected contribution of MR to splenic function through the recognition of sulphated ligands that could influence the filtering capability of this organ...
  2. pmc The mannose receptor mediates dengue virus infection of macrophages
    Joanna L Miller
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e17. 2008
    ..Our findings indicate a new functional role for the MR in DV infection...
  3. doi request reprint Macrophage mannose receptor on lymphatics controls cell trafficking
    Fumiko Marttila-Ichihara
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, Turku, Finland
    Blood 112:64-72. 2008
    ..Blocking of MR may provide a new approach to controlling inflammation and cancer metastasis by targeting the lymphatic vasculature...
  4. ncbi request reprint B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion
    Ping Yu
    Department of Pathology and Committee on Immunology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 168:5117-23. 2002
    ..In turn, CR-Fc(+) DCs and T cells home to B cell follicles to interact with B cells in the developing germinal center...
  5. doi request reprint The mannose receptor
    Luisa Martinez-Pomares
    Faculty of Medicine and Health Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    J Leukoc Biol 92:1177-86. 2012
    ....
  6. doi request reprint CD169+ macrophages at the crossroads of antigen presentation
    Luisa Martinez-Pomares
    School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Trends Immunol 33:66-70. 2012
    ..Understanding the role of CD169(+) macrophages in the activation of acquired immunity could benefit the design of vaccination strategies, for example those aimed at eliciting cytotoxic T cells...
  7. ncbi request reprint Antigen presentation the macrophage way
    Luisa Martinez-Pomares
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Floor A, West Block, Room 1323, Nottingham, NG7 2UH, UK
    Cell 131:641-3. 2007
    ..Using this technique, Junt et al. (2007) report in a recent issue of Nature that macrophages of the mouse lymph node subcapsular sinus facilitate B cell activation in vivo by collecting and displaying native antigen...
  8. ncbi request reprint Carbohydrate-independent recognition of collagens by the macrophage mannose receptor
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, UK
    Eur J Immunol 36:1074-82. 2006
    ..Furthermore our findings extend the range of endogenous ligands recognised by MR, a molecule firmly placed at the interface between homeostasis and immunity...
  9. ncbi request reprint Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Leukoc Biol 73:604-13. 2003
    ..These data support a role for the MR in T helper cell type 2 cytokine-driven, immune responses and suggest a non-M(phi) contribution to sMR production in vivo...
  10. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
    ..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design...
  11. ncbi request reprint The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    J Immunol 169:3876-82. 2002
    ..These observations imply the existence of an additional mannan-dependent receptor involved in the recognition of zymosan by resident peritoneal Mphi...
  12. ncbi request reprint Mannose receptor expression and function define a new population of murine dendritic cells
    Emma J McKenzie
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 178:4975-83. 2007
    ..In accordance with these observations, ligands highly specific for the MR elicit enhanced humoral responses in vivo only when administered in combination with endotoxin...
  13. ncbi request reprint The mannose receptor: linking homeostasis and immunity through sugar recognition
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
    Trends Immunol 26:104-10. 2005
  14. doi request reprint Influence of the mannose receptor in host immune responses
    Umut Gazi
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Immunobiology 214:554-61. 2009
    ..In this review, we have summarised recent observations relating to MR function in immune responses and focused on its participation in phagocytosis, antigen processing and presentation, cell migration and intracellular signalling...
  15. pmc Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity
    Mohamed Emara
    School of Molecular Medical Sciences, Queen s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 286:13033-40. 2011
    ..Our data show for the first time that Fel d 1 is a novel ligand of the cysteine-rich domain of MR and that MR is likely to play a pivotal role in allergic sensitization to airborne allergens in vivo...
  16. ncbi request reprint Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  17. pmc Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e1000218. 2008
    ..albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion...
  18. pmc Fungal recognition enhances mannose receptor shedding through dectin-1 engagement
    Umut Gazi
    School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 286:7822-9. 2011
    ..Thus, MR cleavage could also impact on the magnitude of inflammation during fungal infection...
  19. pmc Development of a specific system for targeting protein to metallophilic macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:1963-8. 2004
    ..This model will allow the dissection of the role of metallophilic M in an immune response in vivo...
  20. ncbi request reprint IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, London, United Kingdom
    Lab Invest 83:1223-31. 2003
    ..We also present evidence that components of schistosome eggs and a fraction of their secretions are ligands of MR, and suggest that MR activity may be of functional significance in the granulomatous response...
  21. ncbi request reprint Divergent roles for C-type lectins expressed by cells of the innate immune system
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford 0X1 3RE, UK
    Mol Immunol 41:1109-21. 2004
    ..We also review more recent data on several members of this family...
  22. doi request reprint The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity
    Pierre Joseph Royer
    School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, United Kingdom
    J Immunol 185:1522-31. 2010
    ..In conclusion, our work demonstrates a major role for MR in glycoallergen recognition and in the development of Th2 responses...
  23. ncbi request reprint The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose
    Eamon P McGreal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
    Glycobiology 16:422-30. 2006
    ....
  24. doi request reprint Exploiting Fc chimaeric proteins for the identification of ligands specific for the mannose receptor
    Luisa Martinez-Pomares
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Methods Mol Biol 531:103-22. 2009
    ..These findings have dramatically changed the way we think about this molecule...
  25. ncbi request reprint The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford, GB
    Eur J Immunol 32:1888-96. 2002
    ..These results demonstrate that mAb209, in addition to its role as an FDC marker, is a valuable reagent for the analysis of complement deposition in vivo...
  26. doi request reprint Murine macrophages: a technical approach
    Luisa Martinez-Pomares
    Institute of Infection, Immunity and Inflammation, Queen s Medical Centre, Nottingham, United Kingdom
    Methods Mol Biol 415:255-72. 2008
    ....
  27. pmc The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer
    Tarek M A Elsaba
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 5:e10714. 2010
    ..We conclude that CD133 expression in CRCs is associated with some features attributable to stemness and that there is plasticity of CD133 expression. Further studies are necessary to delineate the mechanistic basis of these features...
  28. doi request reprint Analysis of the targeting properties of Fc chimeric proteins and antibodies in mice in vivo
    Luisa Martinez-Pomares
    Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom
    Curr Protoc Immunol . 2012
    ..We present procedures to prepare the reagents to be tested under endotoxin-free conditions, suitable injection sites, methodology for tissue collection, and processing, and labeling procedures to detect the injected material in situ...
  29. pmc A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes
    Suryasarathi Dasgupta
    Unite 872, Institut National de la Sante et de la Recherche Medicale, F 75006 Paris, France
    Proc Natl Acad Sci U S A 104:8965-70. 2007
    ..Such a link would be of special relevance in the context of replacement therapy where mechanisms of central and peripheral tolerance have not been established during ontogeny because of the absence of the antigen...
  30. ncbi request reprint Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor
    Susanne Zamze
    Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, United Kingdom
    J Biol Chem 277:41613-23. 2002
    ..The possible involvement of the mannose receptor, either cell surface or soluble, in the innate and adaptive immune responses to bacterial polysaccharides is discussed...
  31. ncbi request reprint Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor
    Jasminka Boskovic
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu, 9, Campus Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 281:8780-7. 2006
    ..We propose a structural model for the mannose receptor family where at least two conformations exist that may serve to regulate differences in ligand selectivity...
  32. ncbi request reprint Glycosylation influences the ligand binding activities of mannose receptor
    Yunpeng Roc Su
    Glycobiology Institute, Oxford University, OX1, 3QU Oxford, UK
    Adv Exp Med Biol 564:25-6. 2005
  33. ncbi request reprint Glycosylation influences the lectin activities of the macrophage mannose receptor
    Yunpeng Su
    Glycobiology Institute and the Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:32811-20. 2005
    ..i) It is required for mannose recognition; and (ii) it modulates the tendency of MR to self-associate, effectively regulating the avidity of the CR domain for sulfated sugar ligands...