Stephen J Martin
Affiliation: University of Edinburgh
- The relationship between tetanus intensity and the magnitude of hippocampal long-term potentiation in vivoS J Martin
Centre for Cognitive and Neural Systems, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK
Neuroscience 231:363-72. 2013..In conclusion, while tetanus intensity must exceed the LTP induction threshold, intensities above 500 μA should be avoided; in the present study, tetanization at 250-500 μA yielded maximal levels of LTP...
- Retrograde amnesia: neither partial nor complete hippocampal lesions in rats result in preferential sparing of remote spatial memory, even after remindingStephen J Martin
Laboratory for Cognitive Neuroscience, Division of Neuroscience, University of Edinburgh, Crichton Street, Edinburgh EH8 9LE, Scotland, UK
Neuropsychologia 43:609-24. 2005..The nature of this role--in the storage, retrieval, or expression of memory--is discussed...
- Synaptic plasticity and memory: an evaluation of the hypothesisS J Martin
Department and Centre for Neuroscience, University of Edinburgh, United Kingdom
Annu Rev Neurosci 23:649-711. 2000..We conclude that a wealth of data supports the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency...
- Cortical plasticity: It's all the range!S J Martin
Department of Neuroscience, University of Edinburgh, Crichton Street, EH8 9LE, Edinburgh, UK
Curr Biol 11:R57-9. 2001..These findings support the view that activity-dependent synaptic plasticity is the brain's memory mechanism...
- Activation of metabotropic glutamate receptors induces gamma frequency oscillations in the rat dentate gyrus in vivoS J Martin
Department of Neuroscience, University of Edinburgh, Crichton Street, Edinburgh EH8 9LE, UK
Neuropharmacology 40:634-7. 2001..The present study reveals that pharmacological activation of mGluRs in vivo induces dentate EEG oscillations at the low end of the gamma frequency range, with peak activity just below 30 Hz...
- New life in an old idea: the synaptic plasticity and memory hypothesis revisitedS J Martin
Hippocampus 12:609-36. 2002..A major challenge will be to determine whether such changes constitute the memory trace itself or play a less specific supporting role in the information processing that accompanies memory formation...
- The rodent hippocampus and spatial memory: from synapses to systemsS J Martin
Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK
Cell Mol Life Sci 64:401-31. 2007....
- Faster forgetting contributes to impaired spatial memory in the PDAPP mouse: deficit in memory retrieval associated with increased sensitivity to interference?Stephanie Daumas
Centre for Cognitive and Neural Systems University of Edinburgh, Edinburgh EH8 9JZ, Scotland
Learn Mem 15:625-32. 2008..This interpretation of one aspect of the cognitive deficit in human mutant APP mice has parallels to deficits observed in patients with Alzheimer's disease, further supporting the validity of transgenic models of the disease...
- SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptorNoboru H Komiyama
Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
J Neurosci 22:9721-32. 2002..A comparison of SynGAP and PSD-95 mutants suggests that PSD-95 couples NMDARs to multiple downstream signaling pathways with very different roles in LTP and learning...
- The postsubiculum and spatial learning: the role of postsubicular synaptic activity and synaptic plasticity in hippocampal place cell, object, and object-location memoryDavid Bett
Centre for Cognitive and Neural Systems, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
J Neurosci 33:6928-43. 2013..However, plasticity in the postsubiculum is not necessary for the formation of new spatial maps...
- Forgetting, reminding, and remembering: the retrieval of lost spatial memoryLivia de Hoz
Laboratory for Cognitive Neuroscience, Centre and Division of Neuroscience, University of Edinburgh, Edinburgh, Scotland, United Kingdom
PLoS Biol 2:E225. 2004....
- Functional connectivity between the thalamus and postsubiculum: analysis of evoked responses elicited by stimulation of the laterodorsal thalamic nucleus in anesthetized ratsKate L Shires
The University of Edinburgh, Centre for Cognitive and Neural Systems CCNS, 1 George Square, Edinburgh, EH8 9JZ, United Kingdom
Hippocampus 23:559-69. 2013..Infusion of CNQX almost completely abolished postsubicular fEPSPs, whereas D-AP5 had little effect. However, 60-Hz LTD was blocked by D-AP5 infusion, revealing that this form of synaptic plasticity is NMDA-receptor dependent...
- Upstairs/downstairs revisited: spatial pretraining-induced rescue of normal spatial learning during selective blockade of hippocampal N-methyl-d-aspartate receptorsJennifer Inglis
Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK
Eur J Neurosci 37:718-27. 2013..The implication of this paradoxical dissociation between hippocampal NMDA receptor-dependent plasticity and spatial learning is discussed with reference to two rival hypotheses of the impact of pretraining...
- Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memoryColin M O'Carroll
Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, The University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
Learn Mem 13:760-9. 2006..The complementary effects of D1/D5 receptor blockade on the persistence of LTP and the duration of memory are consistent with the idea that changes in synaptic strength underlie memory...
- Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memoryR G M Morris
Division of Centre for Neuroscience, The University of Edingurgh, Edinburgh, UK
Philos Trans R Soc Lond B Biol Sci 358:773-86. 2003....
- (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivoS J Martin
Centre for Neuroscience and Department of Pharmacology, University of Edinburgh, UK
Neuropharmacology 36:1339-54. 1997....
- Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloidGuiquan Chen
Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, Edinburgh EH8 9JZ, United Kingdom
J Neurosci 27:2654-62. 2007....
- A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's diseaseG Chen
Department of Neuroscience, University of Edinburgh, UK
Nature 408:975-9. 2000....
- Interrogating rodents regarding their object and spatial memoryRobert E Clark
Department of Psychiatry, 0603 University of California San Diego and Veterans Affairs Medical Center, San Diego, La Jolla, CA 92093, USA
Curr Opin Neurobiol 15:593-8. 2005..Relevant to these issues, there have been substantial developments in the methods used to evaluate two of the most frequently studied forms of memory in the rodent -- recognition memory and spatial memory...