Paul Martin

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, The University of Manchester, Manchester M139PT, UK
    Arthritis Res Ther 13:R12. 2011
  2. ncbi Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
    Stephen Eyre
    Arthritis Research UK, Epidemiology Unit, Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 12:R175. 2010
  3. ncbi ASSIMILATOR: a new tool to inform selection of associated genetic variants for functional studies
    Paul Martin
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Bioinformatics 27:144-6. 2011
  4. ncbi Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure
    Thomas H Millard
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
    Development 135:621-6. 2008
  5. ncbi Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1395-400. 2011
  6. ncbi A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
  7. ncbi Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2169-72. 2010
  8. ncbi Association of the CCR5 gene with juvenile idiopathic arthritis
    A Hinks
    Manchester Academy of Health Sciences, The University of Manchester, UK
    Genes Immun 11:584-9. 2010
  9. ncbi Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
  10. ncbi Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
    Anne Hinks
    Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1049-53. 2010

Detail Information

Publications15

  1. ncbi Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, The University of Manchester, Manchester M139PT, UK
    Arthritis Res Ther 13:R12. 2011
    ..We, therefore, hypothesized that two well-established susceptibility loci for AS and Ps, ERAP1 and IL23R, could also confer susceptibility to these JIA subtypes...
  2. ncbi Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
    Stephen Eyre
    Arthritis Research UK, Epidemiology Unit, Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 12:R175. 2010
    ..Here we have attempted to define overlapping genetic variants between rheumatoid arthritis (RA), type 1 diabetes (T1D) and coeliac disease (CeD)...
  3. ncbi ASSIMILATOR: a new tool to inform selection of associated genetic variants for functional studies
    Paul Martin
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Bioinformatics 27:144-6. 2011
    ..AVAILABILITY: http://www.medicine.manchester.ac.uk/musculoskeletal/research/arc/genetics/bioinformatics/assimilator/...
  4. ncbi Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure
    Thomas H Millard
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
    Development 135:621-6. 2008
    ..Finally, we characterise the behaviour of a patched-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence that this cell contributes to cell matching...
  5. ncbi Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1395-400. 2011
    ..Using a candidate gene approach, single nucleotide polymorphisms (SNPs) within genes in the metabolic pathway of MTX, were investigated for association with response to treatment in JIA cases...
  6. ncbi A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
    ..Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression...
  7. ncbi Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2169-72. 2010
    ..There is strong evidence suggesting that juvenile idiopathic arthritis (JIA) shares many susceptibility loci with other autoimmune diseases...
  8. ncbi Association of the CCR5 gene with juvenile idiopathic arthritis
    A Hinks
    Manchester Academy of Health Sciences, The University of Manchester, UK
    Genes Immun 11:584-9. 2010
    ....
  9. ncbi Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
    ..All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed...
  10. ncbi Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
    Anne Hinks
    Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1049-53. 2010
    ..Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci...
  11. ncbi Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
    ..This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for...
  12. ncbi Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes
    Anne Barton
    University of Manchester, Manchester, UK
    Hum Mol Genet 18:2518-22. 2009
    ..94, P = 1.1 x 10(-4) and OR 0.86, 95% CI 0.79-0.94, P = 5.4 x 10(-4), respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases...
  13. ncbi The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    Darren Plant
    ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 50:78-84. 2011
    ..We therefore sought to investigate the role of recently identified RA susceptibility SNP markers in predicting erosive outcome in patients with recent-onset inflammatory polyarthritis (IP)...
  14. ncbi High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
    Steve Eyre
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Nat Genet 44:1336-40. 2012
    ..Bioinformatic analyses generated strong hypotheses for the causal SNP at seven loci. This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations...
  15. ncbi Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Ann Rheum Dis 71:1117-21. 2012
    ..A plethora of newly validated RA loci has been reported in the past year. Therefore, the aim of this study was to investigate these single nucleotide polymorphisms (SNP) to determine if they were also associated with JIA...