Research Topics
Genomes and Genes | P MartinSummaryAffiliation: University College London Country: UK Publications
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Publications
Epithelial fusions in the embryoPaul Martin
Department Anatomy and Developmental Biology, University College London, UK
Curr Opin Cell Biol 14:569-74. 2002..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates...- Development. May the force be with youPaul Martin
Department of Anatomy, University College London, Gower Street, London WC1E 6BT, UK
Science 300:63-5. 2003 - Wound healing--aiming for perfect skin regenerationP Martin
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Science 276:75-81. 1997.... - Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cellsPaul Martin
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Curr Biol 13:1122-8. 2003..We also show that hyperinnervation of the wound site, previously believed to be a consequence of inflammation, is present in the PU.1 null wound, too... - Mechanisms of epithelial fusion and repairA Jacinto
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Nat Cell Biol 3:E117-23. 2001..We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam... - Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closureA Jacinto
Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
Curr Biol 10:1420-6. 2000..Although many components of the signalling cascade directing this process have been identified, the precise cell-biological events upon which these signals act remain poorly described... - Conserved mechanisms of repair: from damaged single cells to wounds in multicellular tissuesK Woolley
Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
Bioessays 22:911-9. 2000.... - Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryosW Wood
Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
Development 127:5245-52. 2000.... 
The remarkable cochlear amplifierJ Ashmore
Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
Hear Res 266:1-17. 2010..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...- Morphogenesis: unravelling the cell biology of hole closureA Jacinto
Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
Curr Biol 11:R705-7. 2001..Recent studies show that the underlying amnioserosa works actively to help bring together the two epithelial sheets and close the embryonic hole during dorsal closure in fruitfly development... - A reciprocal relationship between cutaneous nerves and repairing skin wounds in the developing chick embryoS Harsum
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
Dev Biol 238:27-39. 2001.... - The role of macrophages in clearing programmed cell death in the developing kidneyV Camp
Department of Anatomy and Developmental Biology, University College London, UK
Anat Embryol (Berl) 194:341-8. 1996.... - Rapid induction and clearance of TGF beta 1 is an early response to wounding in the mouse embryoP Martin
Department of Anatomy and Developmental Biology, University College, London, England, UK
Dev Genet 14:225-38. 1993..These data are discussed in terms of the molecular mechanisms underlying embryonic wound healing and the significance of the results to an understanding of scarring following adult tissue repair... - Dynamic analysis of actin cable function during Drosophila dorsal closureAntonio Jacinto
Department of Anatomy andDevelopmental Biology, University College London, United Kingdom
Curr Biol 12:1245-50. 2002.... - Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouseSheena A Linehan
Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
Histochem Cell Biol 123:365-76. 2005..1 null mouse. This study provides the first evidence of apparently compensatory alterations in the microvasculature of the Mphi-deficient PU.1 null mouse... - The small GTPase Rac plays multiple roles in epithelial sheet fusion--dynamic studies of Drosophila dorsal closureSarah Woolner
Department of Anatomy, University College London, Gower Street, London WC1E 6BT, United Kingdom
Dev Biol 282:163-73. 2005.... - Inflammatory cells during wound repair: the good, the bad and the uglyPaul Martin
Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK BS8 1TD
Trends Cell Biol 15:599-607. 2005.... - Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammationMichael J Redd
Cell Motility Group, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
Cell Motil Cytoskeleton 63:415-22. 2006..Taken together, these results suggest that destabilizing microtubules activates Rho kinase and that this increase in Rho kinase activity interferes with leukocyte recruitment in vivo... - Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesisSergio Simoes
Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Portugal
Development 133:4257-67. 2006.... - Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migrationRyoichi Mori
Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
J Cell Sci 119:5193-203. 2006.... - Morphoregulation by acetylcholinesterase in fibroblasts and astrocytesAlexandra A Anderson
Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, South Kensington Campus, London, UK
J Cell Physiol 215:82-100. 2008..These findings suggest that cell surface AChE, possibly in a novel signalling complex containing APP and perlecan, contributes to a generalised mechanism for polarised membrane protrusion and migration in all adherent cells... 
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarringRyoichi Mori
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Exp Med 205:43-51. 2008..Thus, OPN and PDGF are potential targets for therapeutic modulation of skin repair to improve healing rate and quality...- Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closureThomas H Millard
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
Development 135:621-6. 2008..Finally, we characterise the behaviour of a patched-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence that this cell contributes to cell matching... - Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryosBrian Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, UK
EMBO Rep 9:465-71. 2008.... - Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migrationBrian Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
J Cell Biol 168:567-73. 2005..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues... - Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null miceLisa Cooper
Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, UK
Genome Biol 6:R5. 2005..Tissue damage also triggers a robust influx of inflammatory leukocytes to the wound site that play key roles in clearing the wound of invading microbes but also release signals that may be detrimental to repair and lead to fibrosis... - Wound healing recapitulates morphogenesis in Drosophila embryosWilliam Wood
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Nat Cell Biol 4:907-12. 2002..Our data suggest a more complex model for epithelial repair than previously envisaged and highlight remarkable similarities with the well-characterized morphogenetic movement of dorsal closure in Drosophila... - Dynamic analysis of dorsal closure in Drosophila: from genetics to cell biologyAntonio Jacinto
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, 2780 156, Oeiras, Portugal
Dev Cell 3:9-19. 2002.... - Structures in focus--filopodiaWilliam Wood
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Int J Biochem Cell Biol 34:726-30. 2002..As this field improves, the number of tissues in which filopodia are seen to be playing key roles is fast increasing... - Targeting connexin43 expression accelerates the rate of wound repairCindy Qiu
Department of Anatomy and Developmental Biology, University College London, Gower St, WC1E 6BT London, UK
Curr Biol 13:1697-703. 2003..This approach is likely to have widespread therapeutic applications in other injured tissues and opens up new avenues of research into improving the wound healing process... - Morphogenesis: shroom in to close the neural tubePaul Martin
Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, UK
Curr Biol 14:R150-1. 2004.... - Parallels between tissue repair and embryo morphogenesisPaul Martin
Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Development 131:3021-34. 2004..In the embryo, both morphogenesis and repair are achieved with a perfect end result, whereas repair of adult tissues leads to scarring. We discuss whether this may be due to the adult inflammatory response, which is absent in the embryo... - Wound healing and inflammation: embryos reveal the way to perfect repairMichael J Redd
Department of Anatomny and Developmental Biology, University College London, Gower Street, London WCIE 6BT, UK
Philos Trans R Soc Lond B Biol Sci 359:777-84. 2004.... - Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouseRichard Grose
Institute of Cell Biology, HPM D25, ETH Zurich, Honggerberg, Zurich, Switzerland
Dev Dyn 223:371-8. 2002..Despite the dramatic up-regulation of these genes in response to injury, our studies reveal that neither of them on their own is essential for repair... - The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repairBrian M Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
J Invest Dermatol 127:1009-17. 2007.... - Cell biology: master regulators of sealing and healingBrian Stramer
Department of Physiology and Biochemistry, University of Bristol, UK
Curr Biol 15:R425-7. 2005..Yet new evidence suggests a conserved transcription factor, Grainyhead, controls both their development and the means by which both structures repair themselves... - Role for keratins 6 and 17 during wound closure in embryonic mouse skinStacy Mazzalupo
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Dev Dyn 226:356-65. 2003.... - Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel diseaseStephen A Geller
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 28:1204-11. 2004..6-TG-related hepatotoxicity, including liver biochemistry value elevations, sinusoidal collagen deposition on electron microscopy, and veno-occlusive disease, have been described related to its use as therapy for neoplastic disease... - The role of actin cables in directing the morphogenesis of the pharyngeal pouchesRobyn Quinlan
MRC Centre for Developmental Neurobiology, 4th Floor New Hunts House, Guys Campus, Kings College London, London SE1 1UL, UK
Development 131:593-9. 2004..They also give evidence, for the first time, of actin cables functioning as constraints during complex vertebrate morphogenetic episodes...