P Martin

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Epithelial fusions in the embryo
    Paul Martin
    Department Anatomy and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 14:569-74. 2002
  2. ncbi Development. May the force be with you
    Paul Martin
    Department of Anatomy, University College London, Gower Street, London WC1E 6BT, UK
    Science 300:63-5. 2003
  3. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
  4. ncbi Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells
    Paul Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 13:1122-8. 2003
  5. ncbi Mechanisms of epithelial fusion and repair
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 3:E117-23. 2001
  6. ncbi Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Biol 10:1420-6. 2000
  7. ncbi Conserved mechanisms of repair: from damaged single cells to wounds in multicellular tissues
    K Woolley
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Bioessays 22:911-9. 2000
  8. ncbi Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos
    W Wood
    Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
    Development 127:5245-52. 2000
  9. doi The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
  10. ncbi Morphogenesis: unravelling the cell biology of hole closure
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Biol 11:R705-7. 2001

Collaborators

Detail Information

Publications39

  1. ncbi Epithelial fusions in the embryo
    Paul Martin
    Department Anatomy and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 14:569-74. 2002
    ..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates...
  2. ncbi Development. May the force be with you
    Paul Martin
    Department of Anatomy, University College London, Gower Street, London WC1E 6BT, UK
    Science 300:63-5. 2003
  3. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
    ....
  4. ncbi Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells
    Paul Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 13:1122-8. 2003
    ..We also show that hyperinnervation of the wound site, previously believed to be a consequence of inflammation, is present in the PU.1 null wound, too...
  5. ncbi Mechanisms of epithelial fusion and repair
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 3:E117-23. 2001
    ..We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam...
  6. ncbi Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Biol 10:1420-6. 2000
    ..Although many components of the signalling cascade directing this process have been identified, the precise cell-biological events upon which these signals act remain poorly described...
  7. ncbi Conserved mechanisms of repair: from damaged single cells to wounds in multicellular tissues
    K Woolley
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Bioessays 22:911-9. 2000
    ....
  8. ncbi Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos
    W Wood
    Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
    Development 127:5245-52. 2000
    ....
  9. doi The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
    ..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...
  10. ncbi Morphogenesis: unravelling the cell biology of hole closure
    A Jacinto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Biol 11:R705-7. 2001
    ..Recent studies show that the underlying amnioserosa works actively to help bring together the two epithelial sheets and close the embryonic hole during dorsal closure in fruitfly development...
  11. ncbi A reciprocal relationship between cutaneous nerves and repairing skin wounds in the developing chick embryo
    S Harsum
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Dev Biol 238:27-39. 2001
    ....
  12. ncbi The role of macrophages in clearing programmed cell death in the developing kidney
    V Camp
    Department of Anatomy and Developmental Biology, University College London, UK
    Anat Embryol (Berl) 194:341-8. 1996
    ....
  13. ncbi Rapid induction and clearance of TGF beta 1 is an early response to wounding in the mouse embryo
    P Martin
    Department of Anatomy and Developmental Biology, University College, London, England, UK
    Dev Genet 14:225-38. 1993
    ..These data are discussed in terms of the molecular mechanisms underlying embryonic wound healing and the significance of the results to an understanding of scarring following adult tissue repair...
  14. ncbi Dynamic analysis of actin cable function during Drosophila dorsal closure
    Antonio Jacinto
    Department of Anatomy andDevelopmental Biology, University College London, United Kingdom
    Curr Biol 12:1245-50. 2002
    ....
  15. ncbi Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouse
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Histochem Cell Biol 123:365-76. 2005
    ..1 null mouse. This study provides the first evidence of apparently compensatory alterations in the microvasculature of the Mphi-deficient PU.1 null mouse...
  16. ncbi The small GTPase Rac plays multiple roles in epithelial sheet fusion--dynamic studies of Drosophila dorsal closure
    Sarah Woolner
    Department of Anatomy, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Biol 282:163-73. 2005
    ....
  17. ncbi Inflammatory cells during wound repair: the good, the bad and the ugly
    Paul Martin
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK BS8 1TD
    Trends Cell Biol 15:599-607. 2005
    ....
  18. ncbi Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation
    Michael J Redd
    Cell Motility Group, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    Cell Motil Cytoskeleton 63:415-22. 2006
    ..Taken together, these results suggest that destabilizing microtubules activates Rho kinase and that this increase in Rho kinase activity interferes with leukocyte recruitment in vivo...
  19. ncbi Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis
    Sergio Simoes
    Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Portugal
    Development 133:4257-67. 2006
    ....
  20. ncbi Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 119:5193-203. 2006
    ....
  21. ncbi Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes
    Alexandra A Anderson
    Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, South Kensington Campus, London, UK
    J Cell Physiol 215:82-100. 2008
    ..These findings suggest that cell surface AChE, possibly in a novel signalling complex containing APP and perlecan, contributes to a generalised mechanism for polarised membrane protrusion and migration in all adherent cells...
  22. pmc Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Exp Med 205:43-51. 2008
    ..Thus, OPN and PDGF are potential targets for therapeutic modulation of skin repair to improve healing rate and quality...
  23. pmc Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure
    Thomas H Millard
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
    Development 135:621-6. 2008
    ..Finally, we characterise the behaviour of a patched-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence that this cell contributes to cell matching...
  24. pmc Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    EMBO Rep 9:465-71. 2008
    ....
  25. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
    ..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
  26. pmc Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice
    Lisa Cooper
    Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R5. 2005
    ..Tissue damage also triggers a robust influx of inflammatory leukocytes to the wound site that play key roles in clearing the wound of invading microbes but also release signals that may be detrimental to repair and lead to fibrosis...
  27. ncbi Wound healing recapitulates morphogenesis in Drosophila embryos
    William Wood
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 4:907-12. 2002
    ..Our data suggest a more complex model for epithelial repair than previously envisaged and highlight remarkable similarities with the well-characterized morphogenetic movement of dorsal closure in Drosophila...
  28. ncbi Dynamic analysis of dorsal closure in Drosophila: from genetics to cell biology
    Antonio Jacinto
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, 2780 156, Oeiras, Portugal
    Dev Cell 3:9-19. 2002
    ....
  29. ncbi Structures in focus--filopodia
    William Wood
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Int J Biochem Cell Biol 34:726-30. 2002
    ..As this field improves, the number of tissues in which filopodia are seen to be playing key roles is fast increasing...
  30. ncbi Targeting connexin43 expression accelerates the rate of wound repair
    Cindy Qiu
    Department of Anatomy and Developmental Biology, University College London, Gower St, WC1E 6BT London, UK
    Curr Biol 13:1697-703. 2003
    ..This approach is likely to have widespread therapeutic applications in other injured tissues and opens up new avenues of research into improving the wound healing process...
  31. ncbi Morphogenesis: shroom in to close the neural tube
    Paul Martin
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, UK
    Curr Biol 14:R150-1. 2004
    ....
  32. ncbi Parallels between tissue repair and embryo morphogenesis
    Paul Martin
    Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Development 131:3021-34. 2004
    ..In the embryo, both morphogenesis and repair are achieved with a perfect end result, whereas repair of adult tissues leads to scarring. We discuss whether this may be due to the adult inflammatory response, which is absent in the embryo...
  33. pmc Wound healing and inflammation: embryos reveal the way to perfect repair
    Michael J Redd
    Department of Anatomny and Developmental Biology, University College London, Gower Street, London WCIE 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 359:777-84. 2004
    ....
  34. ncbi Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse
    Richard Grose
    Institute of Cell Biology, HPM D25, ETH Zurich, Honggerberg, Zurich, Switzerland
    Dev Dyn 223:371-8. 2002
    ..Despite the dramatic up-regulation of these genes in response to injury, our studies reveal that neither of them on their own is essential for repair...
  35. ncbi The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair
    Brian M Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    J Invest Dermatol 127:1009-17. 2007
    ....
  36. ncbi Cell biology: master regulators of sealing and healing
    Brian Stramer
    Department of Physiology and Biochemistry, University of Bristol, UK
    Curr Biol 15:R425-7. 2005
    ..Yet new evidence suggests a conserved transcription factor, Grainyhead, controls both their development and the means by which both structures repair themselves...
  37. ncbi Role for keratins 6 and 17 during wound closure in embryonic mouse skin
    Stacy Mazzalupo
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Dev Dyn 226:356-65. 2003
    ....
  38. ncbi Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease
    Stephen A Geller
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 28:1204-11. 2004
    ..6-TG-related hepatotoxicity, including liver biochemistry value elevations, sinusoidal collagen deposition on electron microscopy, and veno-occlusive disease, have been described related to its use as therapy for neoplastic disease...
  39. ncbi The role of actin cables in directing the morphogenesis of the pharyngeal pouches
    Robyn Quinlan
    MRC Centre for Developmental Neurobiology, 4th Floor New Hunts House, Guys Campus, Kings College London, London SE1 1UL, UK
    Development 131:593-9. 2004
    ..They also give evidence, for the first time, of actin cables functioning as constraints during complex vertebrate morphogenetic episodes...