Natasha K Martin

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. doi request reprint Hepatitis C virus treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals
    Natasha K Martin
    School of Social and Community Medicine, University of Bristol, Bristol, UK Social and Mathematical Epidemiology Group, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK
    Hepatology 58:1598-609. 2013
  2. pmc Combination interventions to prevent HCV transmission among people who inject drugs: modeling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy
    Natasha K Martin
    School of Social and Community Medicine, University of Bristol, UK
    Clin Infect Dis 57:S39-45. 2013
  3. pmc Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study
    N K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford OX1 3LB, UK
    Br J Cancer 106:1280-7. 2012
  4. pmc Leaky vessels as a potential source of stromal acidification in tumours
    Natasha K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford OX1 3LB, UK
    J Theor Biol 267:454-60. 2010
  5. doi request reprint Cost-effectiveness of hepatitis C virus antiviral treatment for injection drug user populations
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    Hepatology 55:49-57. 2012
  6. pmc Optimal control of hepatitis C antiviral treatment programme delivery for prevention amongst a population of injecting drug users
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e22309. 2011
  7. pmc Tumour-stromal interactions in acid-mediated invasion: a mathematical model
    Natasha K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford OX1 3LB, UK
    J Theor Biol 267:461-70. 2010
  8. doi request reprint Can antiviral therapy for hepatitis C reduce the prevalence of HCV among injecting drug user populations? A modeling analysis of its prevention utility
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    J Hepatol 54:1137-44. 2011
  9. pmc A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system
    Natasha K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford, OX1 3LB, UK
    Math Biosci 230:1-11. 2011
  10. doi request reprint Mathematical modelling of hepatitis C treatment for injecting drug users
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    J Theor Biol 274:58-66. 2011

Detail Information

Publications17

  1. doi request reprint Hepatitis C virus treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals
    Natasha K Martin
    School of Social and Community Medicine, University of Bristol, Bristol, UK Social and Mathematical Epidemiology Group, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK
    Hepatology 58:1598-609. 2013
    ..Conclusion: Interferon-free DAAs could enable increased HCV treatment uptake among PWID, which could have a major preventative impact. However, treatment costs may limit scale-up, and should be addressed...
  2. pmc Combination interventions to prevent HCV transmission among people who inject drugs: modeling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy
    Natasha K Martin
    School of Social and Community Medicine, University of Bristol, UK
    Clin Infect Dis 57:S39-45. 2013
    ..HCV antiviral treatment may prevent onward transmission. We project the impact of combining OST, HCNSP, and antiviral treatment on HCV prevalence/incidence among PWID...
  3. pmc Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study
    N K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford OX1 3LB, UK
    Br J Cancer 106:1280-7. 2012
    ..Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts...
  4. pmc Leaky vessels as a potential source of stromal acidification in tumours
    Natasha K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford OX1 3LB, UK
    J Theor Biol 267:454-60. 2010
    ..Nevertheless, tumour destruction of vasculature could result in enhanced stromal acidification and invasion, hence current therapies aimed at buffering tumour pH should also examine the possibility of preventing vessel disruption...
  5. doi request reprint Cost-effectiveness of hepatitis C virus antiviral treatment for injection drug user populations
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    Hepatology 55:49-57. 2012
    ..A sensitivity analysis indicates these rankings hold even when IDU sustained viral response rates as compared with ex/non-IDUs are halved...
  6. pmc Optimal control of hepatitis C antiviral treatment programme delivery for prevention amongst a population of injecting drug users
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e22309. 2011
    ..By contrast, if the objective is only to minimise costs to the health service while attaining the 20% prevalence reduction, the programme is deferred until the final years of the decade, and is the least cost-effective of the scenarios...
  7. pmc Tumour-stromal interactions in acid-mediated invasion: a mathematical model
    Natasha K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford OX1 3LB, UK
    J Theor Biol 267:461-70. 2010
    ..These results suggest, counterintuitively, that increasing tumour acidity may, in some cases, prevent tumour invasion...
  8. doi request reprint Can antiviral therapy for hepatitis C reduce the prevalence of HCV among injecting drug user populations? A modeling analysis of its prevention utility
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    J Hepatol 54:1137-44. 2011
    ..Hepatitis C virus antiviral treatment is effective for individual patients but few active injecting drug users are treated. We considered the utility of antiviral treatment for primary prevention of hepatitis C...
  9. pmc A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system
    Natasha K Martin
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford, OX1 3LB, UK
    Math Biosci 230:1-11. 2011
    ..In addition, numerical simulations are performed, validating the model against well-known metabolic/respiratory disorders and predicting how these disorders could change tumour pHe...
  10. doi request reprint Mathematical modelling of hepatitis C treatment for injecting drug users
    Natasha K Martin
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    J Theor Biol 274:58-66. 2011
    ..We conclude by discussing the public health implications of this work, and comment on the importance and feasibility of utilising treatment as prevention for HCV spread amongst IDUs...
  11. doi request reprint Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?
    Peter Vickerman
    Social and Mathematical Epidemiology Group London School of Hygiene and Tropical Medicine, London, UK
    Drug Alcohol Depend 132:172-81. 2013
    ..We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection prevalence) and consider whether it proxies the degree of sexual HIV transmission amongst IDUs...
  12. doi request reprint Hepatitis C virus reinfection incidence and treatment outcome among HIV-positive MSM
    Thomas C S Martin
    aHIV Department, Chelsea and Westminster Hospital, London bSchool of Social and Community Medicine, University of Bristol, Bristol cSocial and Mathematical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
    AIDS 27:2551-7. 2013
    ..We calculate and compare HCV reinfection rates among HIV-positive MSM after spontaneous clearance and successful medical treatment of infection...
  13. doi request reprint Modeling the impact of early antiretroviral therapy for adults coinfected with HIV and hepatitis B or C in South Africa
    Natasha K Martin
    aSchool of Social and Community Medicine, University of Bristol, Bristol bSocial and Mathematical Epidemiology Group, London School of Hygiene and Tropical Medicine cDepartment of Health Services Research and Policy, London School of Hygiene and Tropical Medicine dDepartment of Infectious Disease Epidemiology, Imperial College London eBlizard Institute of Molecular Medicine, Queen Mary s University of London, London, UK fKirby Institute, University of New South Wales, Sydney, Australia gDepartment of HIV AIDS, World Health Organization, Geneva, Switzerland
    AIDS 28:S35-46. 2014
    ..We evaluate individual outcomes (HIV/liver disease progression) and preventive benefits in a generalized HIV epidemic setting...
  14. ncbi request reprint Atraumatic splenic rupture secondary to chronic HIV infection
    Thomas C S Martin
    HIV Department, Chelsea and Westminster Hospital, London, UK
    Int J STD AIDS 24:989-91. 2013
    ..Given the high mortality associated with atraumatic splenic rupture, we believe it should be included in the differential diagnosis of HIV-positive patients presenting with acute abdominal pain. ..
  15. doi request reprint Understanding the trends in HIV and hepatitis C prevalence amongst injecting drug users in different settings--implications for intervention impact
    Peter Vickerman
    London School of Hygiene and Tropical Medicine, London, UK
    Drug Alcohol Depend 123:122-31. 2012
    ..We explore whether a model can reproduce these trends, what determines different epidemiological profiles and how this affects intervention impact...
  16. doi request reprint A general reaction-diffusion model of acidity in cancer invasion
    Jessica B McGillen
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford, OX1 3LB, UK
    J Math Biol 68:1199-224. 2014
    ..Comparison with conclusions drawn under the original system--a special case of our generalised system--allows us to comment on the structural stability and predictive power of the modelling framework...