Daniel S Martin

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK University College London, Division of Surgery and Interventional Science, 9th Floor, Royal Free Hospital, Pond Street, London NW3 2QG, UK Electronic address
    Contemp Clin Trials 36:450-9. 2013
  2. doi Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia
    Daniel Stuart Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, United Kingdom
    Crit Care Med 41:423-32. 2013
  3. doi Reduced coagulation at high altitude identified by thromboelastography
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, UK
    Thromb Haemost 107:1066-71. 2012
  4. doi Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Exp Physiol 95:880-91. 2010
  5. pmc Abnormal blood flow in the sublingual microcirculation at high altitude
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, Archway Campus, Highgate Hill, London, N19 5LW, UK
    Eur J Appl Physiol 106:473-8. 2009
  6. pmc The role of nitrogen oxides in human adaptation to hypoxia
    Denny Z Levett
    Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Sci Rep 1:109. 2011
  7. pmc The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude
    Daniel S Martin
    1 Centre for Altitude, Space, and Extreme Environment Medicine CASE Medicine, Portex Unit, Institute of Child Health, University College London, London, United Kingdom
    High Alt Med Biol 14:256-62. 2013
  8. pmc Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia
    Denny Z H Levett
    Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, London, N19 5LW, UK
    BMC Med Res Methodol 10:98. 2010
  9. doi Arterial blood gases and oxygen content in climbers on Mount Everest
    Michael P W Grocott
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London Institute of Human Health and Performance, London, United Kingdom
    N Engl J Med 360:140-9. 2009
  10. doi Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest
    Denny Z Levett
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London UCL Institute of Child Health, University College London, London, UK
    FASEB J 26:1431-41. 2012

Collaborators

  • Can Ince
  • Martin Feelisch
  • S Dhillon
  • A Richardson
  • P Gardiner
  • L Wandrag
  • C Clarke
  • H Montgomery
  • Rick Bezemer
  • Kieran Clarke
  • Andrew J Murray
  • Mark H Wilson
  • Brian J Whipp
  • Denny Z Levett
  • Michael P W Grocott
  • Denny Z H Levett
  • Monty G Mythen
  • Kay Mitchell
  • B Symons
  • M Jonas
  • M Coates
  • J Morgan
  • J Harvey
  • L Evans
  • D Levett
  • A Vercueil
  • C Dougall
  • B Basnyat
  • M Khosravi
  • J Stygal
  • C Stroud
  • P Richards
  • J Simpson
  • M Pun
  • S Newman
  • M Edsell
  • J Milledge
  • M Cox
  • G Morgan
  • J West
  • P Szawarski
  • D Howard
  • V Ahuja
  • C van Tulleken
  • D Coates
  • P Meale
  • P Doyle
  • J Harrington
  • M Mythen
  • N Hart
  • N Kolfschoten
  • J Windsor
  • R Burnham
  • D Cook
  • G Rodway
  • R McMorrow
  • C Holloway
  • P Gunning
  • A Van Tulleken
  • J Pate
  • K Mitchell
  • H Luery
  • C Imray
  • D Hurlbut
  • T Hornbein
  • L Edwards
  • J van der Kaaij
  • M Grocott
  • A Luks
  • M Stroud
  • T Plant
  • A Chisholm
  • P Duncan
  • Hans Hoppeler
  • Elizabeth J Radford
  • E Franziska Graber
  • David A Menassa
  • Andrea J Morash
  • Anne C Ferguson-Smith
  • Mike P Grocott
  • Heather L Riley
  • Carl A Leckstrom
  • Bernadette O Fernandez
  • M O'Dwyer
  • G Aref-Adib
  • Fabio Rigat
  • G Aref Adib
  • Jeremy Windsor
  • Roger McMorrow

Detail Information

Publications14

  1. doi Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK University College London, Division of Surgery and Interventional Science, 9th Floor, Royal Free Hospital, Pond Street, London NW3 2QG, UK Electronic address
    Contemp Clin Trials 36:450-9. 2013
    ..Improved understanding of hypoxaemia in critical illness may provide new therapeutic avenues for interventions that will improve survival in critically ill patients. ..
  2. doi Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia
    Daniel Stuart Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, United Kingdom
    Crit Care Med 41:423-32. 2013
    ..This review sets out to discuss the strengths and limitations of precise control of arterial oxygenation and permissive hypoxemia as candidate management strategies in hypoxemic critically ill patients...
  3. doi Reduced coagulation at high altitude identified by thromboelastography
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, UK
    Thromb Haemost 107:1066-71. 2012
    ..7 (± 8.2) to 51.6 (± 6.4) (p<0.001). There was no change in maximum amplitude (MA) on ascent to altitude. These changes are consistent with an overall pattern of slowed coagulation at high altitude...
  4. doi Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Exp Physiol 95:880-91. 2010
    ..Thus, MFI was reduced whilst GX increased in the sublingual mucosa with prolonged exposure to hypoxia and was exaggerated in those exposed to extreme altitude...
  5. pmc Abnormal blood flow in the sublingual microcirculation at high altitude
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, Archway Campus, Highgate Hill, London, N19 5LW, UK
    Eur J Appl Physiol 106:473-8. 2009
    ..Disruption of blood flow within microcirculatory may explain persistent abnormal oxygen flux to tissues following the normalisation of systemic oxygen delivery that accompanies acclimatisation to high altitude...
  6. pmc The role of nitrogen oxides in human adaptation to hypoxia
    Denny Z Levett
    Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Sci Rep 1:109. 2011
    ....
  7. pmc The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude
    Daniel S Martin
    1 Centre for Altitude, Space, and Extreme Environment Medicine CASE Medicine, Portex Unit, Institute of Child Health, University College London, London, United Kingdom
    High Alt Med Biol 14:256-62. 2013
    ....
  8. pmc Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia
    Denny Z H Levett
    Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, London, N19 5LW, UK
    BMC Med Res Methodol 10:98. 2010
    ..The aim of this study was to describe the spectrum of adaptive responses in humans exposed to graded EHH and identify factors (physiological and genetic) associated with inter-individual variation in these responses...
  9. doi Arterial blood gases and oxygen content in climbers on Mount Everest
    Michael P W Grocott
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London Institute of Human Health and Performance, London, United Kingdom
    N Engl J Med 360:140-9. 2009
    ..We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest...
  10. doi Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest
    Denny Z Levett
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London UCL Institute of Child Health, University College London, London, UK
    FASEB J 26:1431-41. 2012
    ..However, following sustained exposure, mitochondrial biogenesis is deactivated and uncoupling down-regulated, perhaps to improve the efficiency of ATP production...
  11. pmc Concepts in hypoxia reborn
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Crit Care 14:315. 2010
    ....
  12. pmc Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, University College London Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Crit Care 13:S7. 2009
    ..We sought to quantify changes in skeletal muscle oxygenation during exercise using near-infrared spectroscopy (NIRS) in healthy volunteers ascending to high altitude...