A G Marson

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. pmc The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1000-15. 2007
  2. ncbi request reprint Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures
    A G Marson
    Division of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Liverpool, L9 7LJ, UK
    Neurology 67:1872-5. 2006
  3. pmc The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1016-26. 2007
  4. ncbi request reprint Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review
    A G Marson
    Department of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Epilepsy Res 46:259-70. 2001
  5. ncbi request reprint Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis
    Anthony G Marson
    Department of Neurological Science, Faculty of Medicine, University of Liverpool, Liverpool, England, UK
    Epilepsia 43:505-13. 2002
  6. doi request reprint Interpreting regulatory trials in epilepsy
    A G Marson
    The University of Liverpool, Liverpool, UK
    Curr Opin Neurol 22:167-73. 2009
  7. doi request reprint When to start antiepileptic drug treatment and with what evidence?
    Anthony G Marson
    The University of Liverpool, The Walton Centre, Liverpool, UK
    Epilepsia 49:3-6. 2008
  8. doi request reprint Reporting and analysis of open-label extension studies of anti-epileptic drugs
    M J Maguire
    Department of Neuroscience, University of Liverpool, Liverpool, UK
    Epilepsy Res 81:24-9. 2008
  9. pmc New antiepileptic drugs: a systematic review of their efficacy and tolerability
    A G Marson
    Department of Neurological Science, University of Liverpool
    BMJ 313:1169-74. 1996
  10. ncbi request reprint A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial
    A G Marson
    Division of Neurological Science, University of Liverpool, UK
    Health Technol Assess 11:iii-iv, ix-x, 1-134. 2007

Collaborators

Detail Information

Publications25

  1. pmc The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1000-15. 2007
    ..We aimed to assess efficacy with regards to longer-term outcomes, quality of life, and health economic outcomes...
  2. ncbi request reprint Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures
    A G Marson
    Division of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Liverpool, L9 7LJ, UK
    Neurology 67:1872-5. 2006
    ..For time to first seizure recurrence, MESS provides strong evidence of an effect for carbamazepine as monotherapy but mixed evidence of an effect for valproate...
  3. pmc The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1016-26. 2007
    ..The SANAD study aimed to compare the longer-term effects of these drugs in patients with generalised onset seizures or seizures that are difficult to classify...
  4. ncbi request reprint Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review
    A G Marson
    Department of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Epilepsy Res 46:259-70. 2001
    ..To undertake a systematic review and meta-analysis of placebo controlled add-on trials of levetiracetam, oxcarbazepine, remacemide and zonisamide for patients with drug resistant localization related epilepsy...
  5. ncbi request reprint Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis
    Anthony G Marson
    Department of Neurological Science, Faculty of Medicine, University of Liverpool, Liverpool, England, UK
    Epilepsia 43:505-13. 2002
    ....
  6. doi request reprint Interpreting regulatory trials in epilepsy
    A G Marson
    The University of Liverpool, Liverpool, UK
    Curr Opin Neurol 22:167-73. 2009
    ....
  7. doi request reprint When to start antiepileptic drug treatment and with what evidence?
    Anthony G Marson
    The University of Liverpool, The Walton Centre, Liverpool, UK
    Epilepsia 49:3-6. 2008
    ..They may wish to start antiepileptic drug treatment if they are in a medium or high recurrence risk group as defined by a prognostic model...
  8. doi request reprint Reporting and analysis of open-label extension studies of anti-epileptic drugs
    M J Maguire
    Department of Neuroscience, University of Liverpool, Liverpool, UK
    Epilepsy Res 81:24-9. 2008
    ..We propose an alternative method of analysis, in line with that recommended in the analysis of RCTs, the intention to treat (ITT) approach, in which it is assumed that all patients who discontinue treatment are non-responders...
  9. pmc New antiepileptic drugs: a systematic review of their efficacy and tolerability
    A G Marson
    Department of Neurological Science, University of Liverpool
    BMJ 313:1169-74. 1996
    ..To evaluate the efficacy and tolerability of the newly developed antiepileptic drugs gabapentin, lamotrigine, tiagabine, topiramate, vigabatrin, and zonisamide in patients with refractory partial epilepsy...
  10. ncbi request reprint A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial
    A G Marson
    Division of Neurological Science, University of Liverpool, UK
    Health Technol Assess 11:iii-iv, ix-x, 1-134. 2007
    ..To compare clinicians' choice of one of the standard epilepsy drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs...
  11. ncbi request reprint A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy
    C Gamble
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, UK
    Neurology 66:1310-7. 2006
    ..To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures...
  12. doi request reprint Overwhelming heterogeneity in systematic reviews of observational anti-epileptic studies
    M J Maguire
    The Department of Neuroscience, University of Liverpool, Liverpool, UK
    Epilepsy Res 80:201-12. 2008
    ..These issues were investigated in a systematic review of non-randomised add-on anti-epileptic drug studies...
  13. ncbi request reprint Quality-of-life and behavioral outcome measures in randomized controlled trials of antiepileptic drugs: a systematic review of methodology and reporting standards
    G A Baker
    Department of Neurological Science, The Walton Centre, Liverpool, United Kingdom
    Epilepsia 41:1357-63. 2000
    ..To review the methodology and use of quality-of-life and behavioral measures used in randomized controlled trials (RCTs) of antiepileptic drugs in patients with epilepsy...
  14. doi request reprint Joint modelling of longitudinal and competing risks data
    P R Williamson
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Shelley s Cottage, Brownlow Street, Liverpool L69 3GS, UK
    Stat Med 27:6426-38. 2008
    ..Adjustment for the titration rate of LTG relative to CBZ resulted in an unchanged effect of the former on drug withdrawals due to inadequate seizure control. LTG remains the AED of choice from this analysis...
  15. ncbi request reprint Cognitive and behavioural assessments in clinical trials: what type of measure?
    G A Baker
    University Department of Neurosciences, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, L9 7LJ, Liverpool, UK
    Epilepsy Res 45:163-7; discussion 169-70. 2001
    ..A much more standardised approach to assessing these effects is necessary...
  16. doi request reprint HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review
    V L Yip
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Clin Pharmacol Ther 92:757-65. 2012
    ..Our findings suggest that HLA testing before carbamazepine therapy would be effective at identifying individuals at risk of hypersensitivity and applicable to multiple populations providing hope for prevention in the future...
  17. ncbi request reprint Statistical issues in the assessment of the evidence for an interaction between factors in epilepsy trials
    Paula R Williamson
    Division of Statistics and Operational Research, Department of Mathematical Sciences, University of Liverpool, Liverpool, L69 3BX, UK
    Stat Med 21:2613-22. 2002
    ..We suggest that in any context where misclassification is likely, it is worth considering the use of an explicit 'unclassified' group, and investigating whether additional covariates can answer the substantive question...
  18. ncbi request reprint Aggregate data meta-analysis with time-to-event outcomes
    Paula R Williamson
    Department of Mathematical Sciences, University of Liverpool, UK
    Stat Med 21:3337-51. 2002
    ..A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration...
  19. ncbi request reprint Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes
    Catrin Tudur Smith
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool L69 3BX, UK
    Stat Med 24:1307-19. 2005
    ..The models are further applied to simulated data examples in which the degree of heterogeneity and magnitude of treatment effect are varied. The behaviour of each model in each situation is explored and compared...
  20. ncbi request reprint A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine
    Ewa B Posner
    Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Seizure 14:117-22. 2005
    ..To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS)...
  21. ncbi request reprint An overview of methods and empirical comparison of aggregate data and individual patient data results for investigating heterogeneity in meta-analysis of time-to-event outcomes
    Catrin Tudur Smith
    Centre for Medical Statistics and Health Evaluation, Shelley s Cottage, University of Liverpool, Liverpool, UK
    J Eval Clin Pract 11:468-78. 2005
    ..Time from first ever seizure to randomization is only identified by some AD models. A more thorough explanation of heterogeneity is obtained from the model using IPD but further empirical evidence comparing IPD and AD results are needed...
  22. ncbi request reprint Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial
    Lois G Kim
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Lancet Neurol 5:317-22. 2006
    ..This will enable decision-making on the basis of the perceived risk of treatment compared with the benefit of reducing the risk of further seizures in the initial years after diagnosis...
  23. ncbi request reprint New statistical method for analyzing time to first seizure: example using data comparing carbamazepine and valproate monotherapy
    Benjamin J Cowling
    Department of Community Medicine and School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Epilepsia 48:1173-8. 2007
    ..Methods: Individual patient data were available on 1,265 patients from a meta-analysis of five trials. The outcome measure was time to first seizure after randomization, adjusted for background variables and baseline seizure rate...
  24. ncbi request reprint Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study
    Guy Leschziner
    Division of Neurosciences, Imperial College London, London, UK
    Lancet Neurol 5:668-76. 2006
    ..We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes...
  25. ncbi request reprint The association between polymorphisms in RLIP76 and drug response in epilepsy
    Guy D Leschziner
    Imperial College London, Division of Neuroscience, Charing Cross Campus, Room 10E07, St Dunstan s Road, London W6 8RF, UK
    Pharmacogenomics 8:1715-22. 2007
    ..We aimed to look for an association with outcomes reflecting drug response in a larger prospective cohort, with gene-wide coverage...