M Marsh

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint SFV infection in CHO cells: cell-type specific restrictions to productive virus entry at the cell surface
    M Marsh
    MRC Laboratory for Molecular Cell Biology, University College London, UK
    J Cell Sci 110:95-103. 1997
  2. pmc Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages
    Petra Mlcochova
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK
    BMC Biol 11:89. 2013
  3. ncbi request reprint Virus entry: open sesame
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Cell 124:729-40. 2006
  4. doi request reprint Cell biology. No ESCRTs for exosomes
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 319:1191-2. 2008
  5. ncbi request reprint Endocytosis in viral replication
    M Marsh
    Medical Research Council Laboratory for Molecular Cell Biology, and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
    Traffic 1:525-32. 2000
  6. doi request reprint HIV assembly and budding in macrophages
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem Soc Trans 37:185-9. 2009
  7. ncbi request reprint The structural era of endocytosis
    M Marsh
    Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
    Science 285:215-20. 1999
  8. pmc CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection
    P J Klasse
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    J Virol 73:7453-66. 1999
  9. pmc The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling
    A Fraile-Ramos
    Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 12:1737-49. 2001
  10. ncbi request reprint Trafficking of viral membrane proteins
    R Byland
    MRC LMCB and Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, UK
    Curr Top Microbiol Immunol 285:219-54. 2005

Collaborators

Detail Information

Publications31

  1. ncbi request reprint SFV infection in CHO cells: cell-type specific restrictions to productive virus entry at the cell surface
    M Marsh
    MRC Laboratory for Molecular Cell Biology, University College London, UK
    J Cell Sci 110:95-103. 1997
    ..Moreover, they suggest the endocytic pathway provides a mechanism for bringing viral particles to a site, or sites, in the cell where replication can proceed...
  2. pmc Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages
    Petra Mlcochova
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK
    BMC Biol 11:89. 2013
    ..Despite their clear role in virus formation, little is known of the organization, composition, dynamics or function of these compartments...
  3. ncbi request reprint Virus entry: open sesame
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Cell 124:729-40. 2006
    ..In addition, such insights reveal new targets for attacking viruses before they can usurp the host-cell machinery for replication...
  4. doi request reprint Cell biology. No ESCRTs for exosomes
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 319:1191-2. 2008
  5. ncbi request reprint Endocytosis in viral replication
    M Marsh
    Medical Research Council Laboratory for Molecular Cell Biology, and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
    Traffic 1:525-32. 2000
    ..Here we consider several aspects of this association and recent results that have emerged to support this view...
  6. doi request reprint HIV assembly and budding in macrophages
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem Soc Trans 37:185-9. 2009
    ..The events that take place at these intracellular assembly sites may endow the virus with unique biochemical characteristics and allow virus release to be co-ordinated through the formation of infectious synapses...
  7. ncbi request reprint The structural era of endocytosis
    M Marsh
    Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
    Science 285:215-20. 1999
    ..Together, these data provide an initial three-dimensional framework for understanding the clathrin endocytic machinery...
  8. pmc CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection
    P J Klasse
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    J Virol 73:7453-66. 1999
    ..Thus single-molecule hybrid constructs that mimic receptor-coreceptor complexes can be used to dissect coreceptor function and its inhibition...
  9. pmc The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling
    A Fraile-Ramos
    Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 12:1737-49. 2001
    ..In addition, the distribution of US28 mainly on endosomal membranes may allow it to be incorporated into the viral envelope during HCMV assembly...
  10. ncbi request reprint Trafficking of viral membrane proteins
    R Byland
    MRC LMCB and Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, UK
    Curr Top Microbiol Immunol 285:219-54. 2005
    ..Importantly, loss or modification of these signals can influence virus infectivity and pathogenesis...
  11. pmc Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck)
    M J Bijlmakers
    Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, London, WC1E 6BT, United Kingdom
    Mol Biol Cell 11:1585-95. 2000
    ..Together these data suggest that interaction with Hsp90 is necessary for the correct synthesis and subsequent membrane binding of Lck. However, Hsp90 does not appear to play a direct role in Lck membrane, or CD4, association...
  12. pmc Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
    S C Ley
    National Institute for Medical Research, London, United Kingdom
    J Cell Biol 125:639-49. 1994
    ..Furthermore, the distribution of fyn in mitotic cells raises the possibility that it functions at the M phase of the cell cycle...
  13. ncbi request reprint Dendritic cells: new roles for Cdc42 and Rac in antigen uptake?
    C Nobes
    MRC Laboratory for Molecular Cell Biology, University College London, UK
    Curr Biol 10:R739-41. 2000
    ..In dendritic cells, macropinocytosis is downregulated during maturation and antigen presentation. New studies indicate a key role for Rho-family GTPases in this regulation, but what these proteins are actually doing remains a mystery...
  14. ncbi request reprint HIV's great escape
    Mark Marsh
    Nat Med 9:1262-3. 2003
  15. pmc CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages
    Ezequiel Ruiz-Mateos
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Virol 82:4751-61. 2008
    ..Together, our results indicate that at least in tissue culture, CD63 expression is not required for either the production or the infectivity of HIV-1...
  16. ncbi request reprint Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes
    Alberto Fraile-Ramos
    Department of Biochemistry and Molecular Biology, Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    Traffic 3:218-32. 2002
    ....
  17. ncbi request reprint ALIX catches HIV
    Juan Martin-Serrano
    Department of Infectious Diseases, King s College London School of Medicine, Second Floor, New Guy s House, Guy s Hospital, London SE1 9RT, United Kingdom
    Cell Host Microbe 1:5-7. 2007
    ..One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered...
  18. ncbi request reprint The ESCRT machinery is not required for human cytomegalovirus envelopment
    Alberto Fraile-Ramos
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, Madrid 28049, Spain
    Cell Microbiol 9:2955-67. 2007
    ..Treatment of infected cells with protease inhibitors also increased viral production. These studies indicate that, in contrast to some enveloped RNA viruses, HCMV does not require the cellular ESCRT machinery to complete its envelopment...
  19. pmc In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53
    Magdalena Deneka
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 177:329-41. 2007
    ..These results indicate that, in macrophages, HIV-1 exploits a previously undescribed intracellular plasma membrane domain to assemble infectious particles...
  20. pmc Bluetongue virus entry into cells
    Mario Forzan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, United Kingdom
    J Virol 81:4819-27. 2007
    ..Together, our data indicate that BTV undergoes low-pH-induced penetration in early endosomes following clathrin-mediated endocytosis from the plasma membrane, supporting a stepwise model for BTV entry and penetration...
  21. pmc A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein
    Rahel Byland
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 18:414-25. 2007
    ....
  22. pmc Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent
    Nathalie Signoret
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 16:902-17. 2005
    ..However, sequestration of cholesterol with filipin interferes with agonist binding to CCR5, suggesting that cholesterol and/or lipid raft domains play some role in the events required for CCR5 activation before internalization...
  23. ncbi request reprint HIV interaction with endosomes in macrophages and dendritic cells
    Beatrice Kramer
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Blood Cells Mol Dis 35:136-42. 2005
    ....
  24. ncbi request reprint pH-independent endocytic cycling of the chemokine receptor CCR5
    Nathalie Signoret
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    Traffic 5:529-43. 2004
    ..Our data show that exposure to low pH is not required for RANTES or MIP-1beta dissociation from CCR5, or for recycling of internalised CCR5 to the cell surface...
  25. ncbi request reprint HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse
    Eduardo Garcia
    Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland
    Traffic 6:488-501. 2005
    ....
  26. ncbi request reprint Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway
    Alberto Fraile-Ramos
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK
    Traffic 4:243-53. 2003
    ..Antibody-feeding experiments and biochemical analysis showed that US28 internalization was also inhibited. Together, these data indicate that US28 endocytosis occurs via a clathrin-mediated mechanism but is independent of beta-arrestins...
  27. ncbi request reprint Endosomes, exosomes and Trojan viruses
    Annegret Pelchen-Matthews
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Microbiol 12:310-6. 2004
    ..Here we discuss this concept and the emerging evidence that compartments of the endocytic pathway play important roles in the biogenesis of both the internal vesicles of MVB and viruses...
  28. pmc Infectious HIV-1 assembles in late endosomes in primary macrophages
    Annegret Pelchen-Matthews
    Cell Biology Unit, Medical Research MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
    J Cell Biol 162:443-55. 2003
    ..This notion has significant implications for understanding the biology of HIV and its cell-cell transmission...
  29. ncbi request reprint NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype
    Lene Martini
    Laboratory for Molecular Pharmacology, Department of Pharmacology, The Panum Institute, University of Copenhagen, Denmark
    Mol Pharmacol 62:30-7. 2002
    ....
  30. ncbi request reprint Electron microscopy analysis of viral morphogenesis
    Annegret Pelchen-Matthews
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
    Methods Cell Biol 79:515-42. 2007
  31. pmc Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions
    Marion Peter
    Randall Division of Cell and Molecular Biophysics, Guy s Campus, King s College London, London, United Kingdom
    Biophys J 88:1224-37. 2005
    ..The EGFP-mRFP1 couple should be widely applicable, particularly to live-cell quantitative FRET assays...