Stephen P Marsden

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. doi request reprint A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
    Daniel J Foley
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Chem Commun (Camb) 51:11174-7. 2015
  2. doi request reprint A unified lead-oriented synthesis of over fifty molecular scaffolds
    Richard G Doveston
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 13:859-65. 2015
  3. doi request reprint Facile and general synthesis of quaternary 3-aminooxindoles
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:2905-8. 2008
  4. doi request reprint Catalytic aza-Wittig cyclizations for heteroaromatic synthesis
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    Org Lett 10:2589-91. 2008
  5. ncbi request reprint Electrophile-directed diastereoselective alkylation of prochiral enediolates
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    J Am Chem Soc 129:12600-1. 2007
  6. doi request reprint Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural amino acids
    Paolo Tosatti
    School of Chemistry, University of Leeds, LS2 9JT Leeds, UK
    J Org Chem 76:5495-501. 2011
  7. ncbi request reprint Efficient asymmetric synthesis of quaternary (E)-vinylglycines by deconjugative alkylation of dehydroamino acids
    Matthew C Jones
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 8:5509-12. 2006
  8. doi request reprint Recent advances and applications of iridium-catalysed asymmetric allylic substitution
    Paolo Tosatti
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 10:3147-63. 2012
  9. doi request reprint Synthesis of benzazoles by hydrogen-transfer catalysis
    A John Blacker
    School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 11:2039-42. 2009
  10. doi request reprint Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries
    Ignacio Colomer
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Bioorg Med Chem 23:2736-40. 2015

Collaborators

  • Paolo Tosatti
  • A John Blacker
  • Adam Nelson
  • Ian Churcher
  • Tuomo Kalliokoski
  • Ignacio Colomer
  • Jeremy N Harvey
  • David R Glowacki
  • John G Cumming
  • Carlo Sambiagio
  • Daniel J Foley
  • Richard G Doveston
  • Ho Yin Li
  • Matthew C Jones
  • David House
  • Duanpen Lertpibulpanya
  • Joachim Horn
  • Philip Craven
  • Mark Dow
  • Patrick C McGowan
  • Nicola J Webb
  • J Mikael Hillgren
  • Hayley Jackman
  • John H Cassidy
  • Dulce M Muñoz Subtil
  • Paul A Alexander
  • Tito Akindele
  • Steven M Miles
  • Amanda J Campbell
  • Richard Foster
  • Anthony Aimon
  • Nicolas Fleury-Brégeot
  • Rachel Guilleux
  • Didier Roche
  • Remy Morgentin
  • Amanda Campbell
  • Rachel H Munday
  • Steven A Raw
  • Gordon G Weingarten
  • Peter Shapland
  • Simon Barrett
  • Colin A Kilner
  • Ignacio Rodriguez-Garcia
  • Geoffrey Stemp
  • Mark Slater
  • Anders Pedersen
  • Christopher N Farthing
  • John C Reader
  • William J Coates
  • Robin J Leatherbarrow

Detail Information

Publications26

  1. doi request reprint A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
    Daniel J Foley
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Chem Commun (Camb) 51:11174-7. 2015
    ..Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space. ..
  2. doi request reprint A unified lead-oriented synthesis of over fifty molecular scaffolds
    Richard G Doveston
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 13:859-65. 2015
    ..Crucially, after derivatisation, these scaffolds would target significant lead-like chemical space, and complement commercially-available compounds. ..
  3. doi request reprint Facile and general synthesis of quaternary 3-aminooxindoles
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:2905-8. 2008
    ..The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines...
  4. doi request reprint Catalytic aza-Wittig cyclizations for heteroaromatic synthesis
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    Org Lett 10:2589-91. 2008
    ..Catalyst loadings down to 1 mol % have been used with little or no loss in reaction efficiency. The intimate involvement of the phosphine oxide in the catalytic cycle has been verified by in situ infrared spectroscopy...
  5. ncbi request reprint Electrophile-directed diastereoselective alkylation of prochiral enediolates
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    J Am Chem Soc 129:12600-1. 2007
  6. doi request reprint Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural amino acids
    Paolo Tosatti
    School of Chemistry, University of Leeds, LS2 9JT Leeds, UK
    J Org Chem 76:5495-501. 2011
    ....
  7. ncbi request reprint Efficient asymmetric synthesis of quaternary (E)-vinylglycines by deconjugative alkylation of dehydroamino acids
    Matthew C Jones
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 8:5509-12. 2006
    ..The products can be converted to valuable quaternary beta-amino alcohols by chemoselective reduction. [reaction: see text]...
  8. doi request reprint Recent advances and applications of iridium-catalysed asymmetric allylic substitution
    Paolo Tosatti
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 10:3147-63. 2012
    ....
  9. doi request reprint Synthesis of benzazoles by hydrogen-transfer catalysis
    A John Blacker
    School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 11:2039-42. 2009
    ..Transition-metal-catalyzed hydrogen-transfer reactions have been used for the conversion of alcohols into benzimidazoles and aldehydes into benzoxazoles and benzothiazoles...
  10. doi request reprint Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries
    Ignacio Colomer
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Bioorg Med Chem 23:2736-40. 2015
    ..For one scaffold, the synthesis of exemplar screening compounds was undertaken to demonstrate potential value in small molecule library production. ..
  11. doi request reprint Convergent, regiospecific synthesis of quinolines from o-aminophenylboronates
    Joachim Horn
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:4117-20. 2008
    ..Quinolines substituted in the benzenoid ring can be accessed by using substituted o-aminophenylboronates prepared by direct palladium-catalyzed borylation of the corresponding o-bromoanilines...
  12. doi request reprint A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines
    Ho Yin Li
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Chem Commun (Camb) 50:10222-4. 2014
    ..In both cases, combinatorial variation of the substitution of the tetrahydroquinoline ring system was possible. ..
  13. ncbi request reprint Isotopic labeling for determination of enantiomeric purity by 2H NMR spectroscopy
    Hayley Jackman
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    Org Lett 9:5179-82. 2007
    ..The assays allow for simple semiquantitative analysis of asymmetric transformations...
  14. doi request reprint Picolinamides as effective ligands for copper-catalysed aryl ether formation: structure-activity relationships, substrate scope and mechanistic investigations
    Carlo Sambiagio
    iPRD, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT UK
    Chemistry 20:17606-15. 2014
    ..An understanding of these effects is important for the development of new efficient and tunable ligands for copper-based chemistry. ..
  15. ncbi request reprint Deconjugation of dehydroamino acids: stereoselective synthesis of racemic (E)-vinylglycines
    Paul A Alexander
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    Org Lett 7:5433-6. 2005
    ..The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids...
  16. doi request reprint Alkene hydroboration: hot intermediates that react while they are cooling
    David R Glowacki
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Am Chem Soc 132:13621-3. 2010
    ....
  17. doi request reprint Total synthesis of the immunosuppressants myriocin and 2-epi-myriocin
    Matthew C Jones
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    Org Lett 10:4125-8. 2008
    ..The key transformations are the efficient synthesis of a quaternary (E)-vinylglycine by asymmetric deconjugative alkylation of a dehydroamino acid and an unusually highly diastereoselective dihydroxylation of the vinylglycine alkene...
  18. doi request reprint Convenient synthesis of 3-alkoxy-3-aryloxindoles by intramolecular arylation of mandelic amides
    J Mikael Hillgren
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Org Chem 73:6459-61. 2008
    ..Medicinally important 3-alkoxy-3-aryloxindoles are conveniently prepared by the rapid microwave-promoted palladium-catalyzed intramolecular enolate arylation of mandelate-derived anilides...
  19. doi request reprint Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries
    Philip Craven
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Bioorg Med Chem 23:2629-35. 2015
    ..In total, the research has led to the successful synthesis of >2500 novel alkaloid-like compounds for addition to the screening collection (the Joint European Compound Library, JECL) of the European Lead Factory. ..
  20. doi request reprint Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent
    Nicola J Webb
    School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds, LS2 9JT, U K
    Org Lett 16:4718-21. 2014
    ..The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed. ..
  21. doi request reprint Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development
    Carlo Sambiagio
    iPRD, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK
    Chem Soc Rev 43:3525-50. 2014
    ..Finally, recent developments in green chemistry for these reactions, such as reactions in aqueous media and heterogeneous catalysis, have also been reviewed...
  22. ncbi request reprint Stereocontrolled assembly of tetrasubstituted tetrahydrofurans: a concise synthesis of virgatusin
    Tito Akindele
    School of Chemistry, University of Leeds, Leeds LS2 9JT, U K
    Org Lett 7:3685-8. 2005
    ..The reaction has been applied to a concise (nine step) synthesis of (+)-virgatusin (ent-1). [reaction: see text]..
  23. ncbi request reprint A concise, convergent total synthesis of monocerin
    John H Cassidy
    Department of Chemistry, Imperial College, London, SW7 2AY, UK
    Org Biomol Chem 4:4118-26. 2006
    ..The synthesis was ultimately completed by a strategy involving stepwise oxidative cleavage of the C3-ethenyl substituent...
  24. ncbi request reprint Asymmetric aza-Wittig reactions: enantioselective synthesis of beta-quaternary azacycles
    Duanpen Lertpibulpanya
    Department of Chemistry, Imperial College London, London SW72AY, UK
    Angew Chem Int Ed Engl 45:5000-2. 2006
  25. ncbi request reprint Concise access to indolizidine and pyrroloazepine skeleta via intramolecular Schmidt reactions of azido 1,3-diketones
    Duanpen Lertpibulpanya
    Department of Chemistry, Imperial College, London, UK SW7 2AY
    Org Biomol Chem 4:3498-504. 2006
    ..Chiral aluminium-based Lewis acids could also be used to mediate this symmetry-breaking transformation, but no significant asymmetric induction was observed...
  26. ncbi request reprint Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues
    Steven M Miles
    Department of Chemistry, Imperial College London, South Kensington Campus, London, UKSW7 2AZ
    Org Biomol Chem 2:281-3. 2004
    ....