Stephen P Marsden

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint A unified lead-oriented synthesis of over fifty molecular scaffolds
    Richard G Doveston
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 13:859-65. 2015
  2. ncbi request reprint Facile and general synthesis of quaternary 3-aminooxindoles
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:2905-8. 2008
  3. ncbi request reprint Catalytic aza-Wittig cyclizations for heteroaromatic synthesis
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    Org Lett 10:2589-91. 2008
  4. ncbi request reprint Electrophile-directed diastereoselective alkylation of prochiral enediolates
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    J Am Chem Soc 129:12600-1. 2007
  5. ncbi request reprint Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural amino acids
    Paolo Tosatti
    School of Chemistry, University of Leeds, LS2 9JT Leeds, UK
    J Org Chem 76:5495-501. 2011
  6. ncbi request reprint Efficient asymmetric synthesis of quaternary (E)-vinylglycines by deconjugative alkylation of dehydroamino acids
    Matthew C Jones
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 8:5509-12. 2006
  7. ncbi request reprint Recent advances and applications of iridium-catalysed asymmetric allylic substitution
    Paolo Tosatti
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 10:3147-63. 2012
  8. ncbi request reprint Synthesis of benzazoles by hydrogen-transfer catalysis
    A John Blacker
    School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 11:2039-42. 2009
  9. ncbi request reprint A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines
    Ho Yin Li
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Chem Commun (Camb) 50:10222-4. 2014
  10. ncbi request reprint Convergent, regiospecific synthesis of quinolines from o-aminophenylboronates
    Joachim Horn
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:4117-20. 2008

Collaborators

  • Paolo Tosatti
  • A John Blacker
  • Adam Nelson
  • Ian Churcher
  • Jeremy N Harvey
  • David R Glowacki
  • John G Cumming
  • Carlo Sambiagio
  • Ho Yin Li
  • Matthew C Jones
  • David House
  • Duanpen Lertpibulpanya
  • Joachim Horn
  • Richard G Doveston
  • Patrick C McGowan
  • Nicola J Webb
  • J Mikael Hillgren
  • Hayley Jackman
  • John H Cassidy
  • Dulce M Muñoz Subtil
  • Paul A Alexander
  • Tito Akindele
  • Steven M Miles
  • Amanda J Campbell
  • Daniel J Foley
  • Mark Dow
  • Amanda Campbell
  • Steven A Raw
  • Rachel H Munday
  • Gordon G Weingarten
  • Simon Barrett
  • Peter Shapland
  • Anders Pedersen
  • Geoffrey Stemp
  • Mark Slater
  • Ignacio Rodriguez-Garcia
  • Christopher N Farthing
  • Colin A Kilner
  • John C Reader
  • Robin J Leatherbarrow
  • William J Coates

Detail Information

Publications23

  1. ncbi request reprint A unified lead-oriented synthesis of over fifty molecular scaffolds
    Richard G Doveston
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 13:859-65. 2015
    ..Crucially, after derivatisation, these scaffolds would target significant lead-like chemical space, and complement commercially-available compounds. ..
  2. ncbi request reprint Facile and general synthesis of quaternary 3-aminooxindoles
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:2905-8. 2008
    ..The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines...
  3. ncbi request reprint Catalytic aza-Wittig cyclizations for heteroaromatic synthesis
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    Org Lett 10:2589-91. 2008
    ..Catalyst loadings down to 1 mol % have been used with little or no loss in reaction efficiency. The intimate involvement of the phosphine oxide in the catalytic cycle has been verified by in situ infrared spectroscopy...
  4. ncbi request reprint Electrophile-directed diastereoselective alkylation of prochiral enediolates
    Stephen P Marsden
    School of Chemistry, University of Leeds, Leeds, UK
    J Am Chem Soc 129:12600-1. 2007
  5. ncbi request reprint Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural amino acids
    Paolo Tosatti
    School of Chemistry, University of Leeds, LS2 9JT Leeds, UK
    J Org Chem 76:5495-501. 2011
    ....
  6. ncbi request reprint Efficient asymmetric synthesis of quaternary (E)-vinylglycines by deconjugative alkylation of dehydroamino acids
    Matthew C Jones
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 8:5509-12. 2006
    ..The products can be converted to valuable quaternary beta-amino alcohols by chemoselective reduction. [reaction: see text]...
  7. ncbi request reprint Recent advances and applications of iridium-catalysed asymmetric allylic substitution
    Paolo Tosatti
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Org Biomol Chem 10:3147-63. 2012
    ....
  8. ncbi request reprint Synthesis of benzazoles by hydrogen-transfer catalysis
    A John Blacker
    School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 11:2039-42. 2009
    ..Transition-metal-catalyzed hydrogen-transfer reactions have been used for the conversion of alcohols into benzimidazoles and aldehydes into benzoxazoles and benzothiazoles...
  9. ncbi request reprint A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines
    Ho Yin Li
    School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK
    Chem Commun (Camb) 50:10222-4. 2014
    ..In both cases, combinatorial variation of the substitution of the tetrahydroquinoline ring system was possible. ..
  10. ncbi request reprint Convergent, regiospecific synthesis of quinolines from o-aminophenylboronates
    Joachim Horn
    School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
    Org Lett 10:4117-20. 2008
    ..Quinolines substituted in the benzenoid ring can be accessed by using substituted o-aminophenylboronates prepared by direct palladium-catalyzed borylation of the corresponding o-bromoanilines...
  11. ncbi request reprint Isotopic labeling for determination of enantiomeric purity by 2H NMR spectroscopy
    Hayley Jackman
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    Org Lett 9:5179-82. 2007
    ..The assays allow for simple semiquantitative analysis of asymmetric transformations...
  12. ncbi request reprint Picolinamides as effective ligands for copper-catalysed aryl ether formation: structure-activity relationships, substrate scope and mechanistic investigations
    Carlo Sambiagio
    iPRD, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT UK
    Chemistry 20:17606-15. 2014
    ..An understanding of these effects is important for the development of new efficient and tunable ligands for copper-based chemistry. ..
  13. ncbi request reprint Deconjugation of dehydroamino acids: stereoselective synthesis of racemic (E)-vinylglycines
    Paul A Alexander
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    Org Lett 7:5433-6. 2005
    ..The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids...
  14. ncbi request reprint Alkene hydroboration: hot intermediates that react while they are cooling
    David R Glowacki
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Am Chem Soc 132:13621-3. 2010
    ....
  15. ncbi request reprint Total synthesis of the immunosuppressants myriocin and 2-epi-myriocin
    Matthew C Jones
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    Org Lett 10:4125-8. 2008
    ..The key transformations are the efficient synthesis of a quaternary (E)-vinylglycine by asymmetric deconjugative alkylation of a dehydroamino acid and an unusually highly diastereoselective dihydroxylation of the vinylglycine alkene...
  16. ncbi request reprint Convenient synthesis of 3-alkoxy-3-aryloxindoles by intramolecular arylation of mandelic amides
    J Mikael Hillgren
    School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Org Chem 73:6459-61. 2008
    ..Medicinally important 3-alkoxy-3-aryloxindoles are conveniently prepared by the rapid microwave-promoted palladium-catalyzed intramolecular enolate arylation of mandelate-derived anilides...
  17. ncbi request reprint Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent
    Nicola J Webb
    School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds, LS2 9JT, U K
    Org Lett 16:4718-21. 2014
    ..The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed. ..
  18. ncbi request reprint Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development
    Carlo Sambiagio
    iPRD, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK
    Chem Soc Rev 43:3525-50. 2014
    ..Finally, recent developments in green chemistry for these reactions, such as reactions in aqueous media and heterogeneous catalysis, have also been reviewed...
  19. ncbi request reprint Stereocontrolled assembly of tetrasubstituted tetrahydrofurans: a concise synthesis of virgatusin
    Tito Akindele
    School of Chemistry, University of Leeds, Leeds LS2 9JT, U K
    Org Lett 7:3685-8. 2005
    ..The reaction has been applied to a concise (nine step) synthesis of (+)-virgatusin (ent-1). [reaction: see text]..
  20. ncbi request reprint A concise, convergent total synthesis of monocerin
    John H Cassidy
    Department of Chemistry, Imperial College, London, SW7 2AY, UK
    Org Biomol Chem 4:4118-26. 2006
    ..The synthesis was ultimately completed by a strategy involving stepwise oxidative cleavage of the C3-ethenyl substituent...
  21. ncbi request reprint Asymmetric aza-Wittig reactions: enantioselective synthesis of beta-quaternary azacycles
    Duanpen Lertpibulpanya
    Department of Chemistry, Imperial College London, London SW72AY, UK
    Angew Chem Int Ed Engl 45:5000-2. 2006
  22. ncbi request reprint Concise access to indolizidine and pyrroloazepine skeleta via intramolecular Schmidt reactions of azido 1,3-diketones
    Duanpen Lertpibulpanya
    Department of Chemistry, Imperial College, London, UK SW7 2AY
    Org Biomol Chem 4:3498-504. 2006
    ..Chiral aluminium-based Lewis acids could also be used to mediate this symmetry-breaking transformation, but no significant asymmetric induction was observed...
  23. ncbi request reprint Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues
    Steven M Miles
    Department of Chemistry, Imperial College London, South Kensington Campus, London, UKSW7 2AZ
    Org Biomol Chem 2:281-3. 2004
    ....