Research Topics
Species | S D MarksSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Steroid preservation: the rationale for continued prescribingStephen D Marks
Pediatr Nephrol 21:305-7. 2006..With modern immunosuppressive agents in transplantation, rejection is being traded for infection. The long-term outcome data of PTLD with steroid-free and monoclonal antibody protocols is as yet unknown...- The use of the British Isles Lupus Assessment Group (BILAG) index as a valid tool in assessing disease activity in childhood-onset systemic lupus erythematosusS D Marks
Nephro Urology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Rheumatology (Oxford) 43:1186-9. 2004..The main aim of this study was to correlate the BILAG index with laboratory measures of disease activity in childhood-onset SLE with and without biopsy-proven lupus nephritis... - Successful outcomes with rituximab therapy for refractory childhood systemic lupus erythematosusStephen D Marks
Pediatr Nephrol 21:598-9. 2006 - Evaluation of renal improvement in juvenile systemic lupus erythematosus: Comment on the articles by Ruperto et alStephen D Marks
Arthritis Rheum 55:990-1; author reply 991. 2006 - Glomerular expression of monocyte chemoattractant protein-1 is predictive of poor renal prognosis in pediatric lupus nephritisStephen D Marks
Institute of Child Health, 30 Guilford Street, London, UK
Nephrol Dial Transplant 23:3521-6. 2008..Monocyte chemoattractant protein-1 (MCP-1) is upregulated and it recruits and activates inflammatory cells in murine lupus nephritis (LN)... - Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritisStephen D Marks
Nephro Urology Unit, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
Pediatr Nephrol 25:2283-8. 2010..04). These results provide evidence of increased urinary--but not plasma--MCP-1 levels in children with LN, which correlates well with SLE disease activity as measured by the BILAG index... - Targeted B-cell depletion therapy in childhood-onset systemic lupus erythematosus: progress to dateStephen D Marks
Nephro Urology Unit, Institute of Child Health, London, UK
Paediatr Drugs 9:371-8. 2007.... - Renal tubular dysfunction in children with systemic lupus erythematosusStephen D Marks
Nephro Urology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Pediatr Nephrol 20:141-8. 2005..Evidence of tubular dysfunction in lupus non-nephritis patients may help to identify lupus nephritis prior to the onset of albuminuria... - B lymphocyte depletion therapy in children with refractory systemic lupus erythematosusStephen D Marks
Department of Paediatric Nephrology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
Arthritis Rheum 52:3168-74. 2005..To determine the safety and efficacy of B lymphocyte depletion therapy in patients with refractory childhood-onset systemic lupus erythematosus (SLE)... - Modern therapeutic strategies for paediatric systemic lupus erythematosus and lupus nephritisStephen D Marks
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
Acta Paediatr 99:967-74. 2010..CONCLUSION: Modern therapeutic strategies include reduced doses and use of corticosteroids and intravenous cyclophosphamide respectively, with increased use of azathioprine, MMF and rituximab... - B cell depletion therapy for 19 patients with refractory systemic lupus erythematosusA Podolskaya
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JH, UK
Arch Dis Child 93:401-6. 2008..The safety and efficacy of B cell depletion therapy is evaluated in the the largest series of children to be presented in the literature... - Successful renal transplantation in factor H autoantibody associated HUS with CFHR1 and 3 deficiency and CFH variant G2850TA M Waters
Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, and Faculty of Medicine, Imperial College, London, UK
Am J Transplant 10:168-72. 2010..Furthermore, delineation of the functional significance of CFH-autoantibodies is warranted in individual cases... - Biologic therapy in primary systemic vasculitis of the youngDespina Eleftheriou
Rheumatology Department, Institute of Child Health, London, UK
Rheumatology (Oxford) 48:978-86. 2009..To describe the biologic treatment regimens and report the efficacy and safety of biologic therapies in a multicentre series of children with primary systemic vasculitis (PSV)... - Calcineurin-inhibitor free immunosuppression with mycophenolate mofetil and corticosteroids in paediatric renal transplantation improves renal allograft function without increasing acute rejectionL Krischock
Department of Paediatric Nephrology, Great Ormond Street Hospital, London, UK
Pediatr Transplant 13:475-81. 2009..Complete withdrawal of CNIs after conversion to MMF should be considered in all patients, to preserve renal function as evidenced by improved eGFR... - Multicentre prospective randomised trial of tacrolimus, azathioprine and prednisolone with or without basiliximab: two-year follow-up dataNicholas J A Webb
Department of Paediatric Nephrology, Royal Manchester Children s Hospital, Manchester, M27 4HA, UK
Pediatr Nephrol 24:177-82. 2009..These data provide further evidence of a lack of benefit associated with the addition of basiliximab to a TAS regimen for European paediatric renal transplant recipients at low immunological risk... - Clinicopathological correlations of paediatric lupus nephritisStephen D Marks
Nephro Urology Unit, Institute of Child Health, London, UK
Pediatr Nephrol 22:77-83. 2007..73 m(2) in patients with diffuse global sclerosing [class IV-G(C)] LN. The new classification allows expanded histopathological grading of LN with further delineation of classes III and IV with activity and chronicity indices... - Chronic kidney disease in children following lung and heart-lung transplantationChristian Benden
Cardio Respiratory and Critical Care Division, Great Ormond Street Hospital for Children NHS Trust, London, UK
Pediatr Transplant 13:104-10. 2009..Unlike in adults, we were unable to detect any predictors of renal impairment in pediatric lung transplant recipients... - Dense B cell infiltrates in paediatric renal transplant biopsies are predictive of allograft lossMordi R Muorah
Departments of Paediatric Nephrology, Great Ormond Street Hospital for Childrens NHS Trust, Great Ormond Street, London, UK
Pediatr Transplant 13:217-22. 2009..This observation raises the possibility of future studies examining the efficacy of B cell depletion therapy in this clinical context... - Rituximab in refractory nephrotic syndromeAgnieszka Prytuła
Department of Paediatric Nephrology, Great Ormond Street Hospital NHS Trust, London, UK
Pediatr Nephrol 25:461-8. 2010..The good initial response in group 3 can be biased by the accompanying treatments that were administered at the same time as rituximab. Controlled prospective trials are required to establish the value of rituximab in idiopathic NS... - Induction therapy: why, when, and which agent?Leah Krischock
Department of Paediatric Nephrology, Royal Hospital for Sick Children, Glasgow, UK
Pediatr Transplant 14:298-313. 2010..The aim of this review is to summarize the current literature relating to the use of antibody agents for induction in paediatric solid organ transplantation... - Prevalence and complications of chronic kidney disease in paediatric renal transplantation: a K/DOQI perspectiveRajiv Sinha
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
Nephrol Dial Transplant 25:1313-20. 2010..Further multi-centre prospective studies are required to substantiate our findings and to explore whether early identification and intervention can improve renal allograft outcome... - Vasculitis in children and adolescents: clinical presentation, etiopathogenesis, and treatmentKjell Tullus
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
Paediatr Drugs 11:375-80. 2009..The more rare vasculitides are generally much more severe, often needing treatment with high doses of corticosteroids and immunosuppressant agents such as cyclophosphamide, azathioprine, and mycophenolate mofetil... - Renovascular hypertension in childrenKjell Tullus
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
Lancet 371:1453-63. 2008..Modern treatment provided by a multidisciplinary team of paediatric nephrologists, interventional radiologists, and vascular surgeons offers good long-term treatment results... - Imaging in childhood urinary tract infections: time to reduce investigationsStephen D Marks
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
Pediatr Nephrol 23:9-17. 2008.... - Current issues in pediatric lupus nephritis: role of revised histopathological classificationStephen D Marks
Nephro-Urology Unit, Institute of Child Health, London, UK
Fetal Pediatr Pathol 25:297-309. 2006..However, we are many years away from completely understanding the etiopathogenesis of LN and the predictive role of the revised histological classification for direction of patient management... - What is the value of magnetic resonance venography in children before renal transplantation?Mark G Meister
Department of Paediatric Radiology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, England, UK
Pediatr Nephrol 23:1157-62. 2008..MRV infrequently contributes beneficial information, is difficult to justify as a screening tool, and due to the risks of gadolinium in uraemia, should only be used on an individual patient basis... - Standard dosing of tacrolimus leads to overexposure in pediatric renal transplantation recipientsJoshua Y Kausman
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
Pediatr Transplant 12:329-35. 2008..We therefore outline a regimen restricting tacrolimus dosage given to larger/older patients, but emphasize the need for a prospective randomized trial to define optimal dosing... - Neonatal renal venous thrombosis: clinical outcomes and prevalence of prothrombotic disordersStephen D Marks
Division of Nephrology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada
J Pediatr 146:811-6. 2005..Twelve of the 28 patients (43%) examined had prothrombotic abnormalities. CONCLUSION: Neonatal RVT is associated with significant renal morbidity and a high prevalence of prothrombotic abnormalities... - Does rituximab treat recurrent focal segmental glomerulosclerosis post-renal transplantation?Stephen D Marks
Pediatr Nephrol 22:158-60. 2007