Carylyn J Marek

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics
    Carylyn J Marek
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Comp Hepatol 8:1. 2009
  2. ncbi request reprint Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro
    Emma L Haughton
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland
    Gastroenterology 131:194-209. 2006
  3. ncbi request reprint Expression of CYP2S1 in human hepatic stellate cells
    Carylyn J Marek
    School of Medical Sciences, Institute of Medical Science, University of Aberdeen, Aberdeen, UK
    FEBS Lett 581:781-6. 2007
  4. pmc Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
    Carylyn J Marek
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Biochem J 387:601-8. 2005
  5. ncbi request reprint Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells
    James G Orr
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Hepatology 40:232-42. 2004

Collaborators

  • Matthew C Wright
  • Val Leel
  • Bryan Goodwin
  • Emma L Haughton
  • Julie E Trim
  • James G Orr
  • Derek A Mann
  • Steven J Tucker
  • Elaina Collie-Duguid
  • Zainab Bascal
  • Tanya Monaghan
  • Elaine Durward
  • Matthew Koruth
  • Andrew P Halestrap
  • Lucy J Elrick
  • Gary A Cameron
  • Gabrielle M Hawksworth

Detail Information

Publications5

  1. pmc Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics
    Carylyn J Marek
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Comp Hepatol 8:1. 2009
    ..The data also demonstrate that the anti-fibrogenic effects of PCN in vivo are likely mediated entirely via the PXR...
  2. ncbi request reprint Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro
    Emma L Haughton
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland
    Gastroenterology 131:194-209. 2006
    ..The aim of this study was to determine the effects of human pregnane X receptor activators on human hepatic stellate cell transdifferentiation to a profibrogenic phenotype in vitro...
  3. ncbi request reprint Expression of CYP2S1 in human hepatic stellate cells
    Carylyn J Marek
    School of Medical Sciences, Institute of Medical Science, University of Aberdeen, Aberdeen, UK
    FEBS Lett 581:781-6. 2007
    ..The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1...
  4. pmc Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
    Carylyn J Marek
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Biochem J 387:601-8. 2005
    ..These data suggest that the PXR is antifibrogenic in rodents in vivo and that a PXR-independent target for PXR activators exists in hepatic stellate cells that also functions to inhibit fibrosis...
  5. ncbi request reprint Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells
    James G Orr
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Hepatology 40:232-42. 2004
    ..Further understanding of this mechanism of cell death will aid in finding therapeutics that specifically stimulate HSC apoptosis in the liver, a promising approach to antifibrotic therapy...