David M A Mann

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration
    Penelope Foulds
    Division of Biomedical and Life Sciences, School of Health and Medicine, University of Lancaster, Lancaster, UK
    Acta Neuropathol 116:141-6. 2008
  2. ncbi Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, V5Z 1M9, Vancouver, BC, Canada
    Acta Neuropathol 112:539-49. 2006
  3. ncbi Dementia lacking distinctive histology (DLDH) revisited
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada
    Acta Neuropathol (Berl) 112:551-9. 2006
  4. ncbi Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
    Katerina E Paleologou
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Brain 132:1093-101. 2009
  5. ncbi Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease
    Mark Taylor
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Biochemistry 49:3261-72. 2010
  6. ncbi Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration
    Penelope G Foulds
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Acta Neuropathol 118:647-58. 2009

Collaborators

Detail Information

Publications6

  1. ncbi TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration
    Penelope Foulds
    Division of Biomedical and Life Sciences, School of Health and Medicine, University of Lancaster, Lancaster, UK
    Acta Neuropathol 116:141-6. 2008
    ..As a predictive test, plasma TDP-43 level may have great practical value in directing therapeutic strategies aimed at preventing or removing tau or TDP-43 pathological changes from the brain in FTLD and AD...
  2. ncbi Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, V5Z 1M9, Vancouver, BC, Canada
    Acta Neuropathol 112:539-49. 2006
    ....
  3. ncbi Dementia lacking distinctive histology (DLDH) revisited
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada
    Acta Neuropathol (Berl) 112:551-9. 2006
    ..Hence, we conclude that DLDH is a very rare disorder, and that lack of sensitivity for UBQ immunostaining is likely responsible for the failure to disclose this pathology and to provide a diagnosis of FTLD-U...
  4. ncbi Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
    Katerina E Paleologou
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Brain 132:1093-101. 2009
    ..Furthermore, these findings establish FILA-1 as a very sensitive tool for the detection of oligomeric forms of alpha-syn in human brain lysates...
  5. ncbi Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease
    Mark Taylor
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Biochemistry 49:3261-72. 2010
    ..Thus, RI-OR2 represents a strong candidate for further development as a novel treatment for Alzheimer's disease...
  6. ncbi Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration
    Penelope G Foulds
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Acta Neuropathol 118:647-58. 2009
    ....