Research Topics
Genomes and GenesSpecies | Ali R ManiSummaryAffiliation: University College London Country: UK Publications
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Publications
Heart rate dynamics in iNOS knockout miceAli R Mani
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College Medical School, UCL, London, Rowland Hill Street London NW3 2PF, UK
Life Sci 79:1593-9. 2006..We conclude that disruption of iNOS gene leads to an increase in the low frequency power of HRV consistent with increased cardiac sympathetic activity. These data also demonstrate that LPS-induced decrease of HRV is independent of iNOS...- Endogenous opioids and liver diseaseAli R Mani
Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, London, UK
Scand J Gastroenterol 41:1-11. 2006 
On the origin and the consequences of circadian abnormalities in patients with cirrhosisSara Montagnese
Centre for Hepatology, Department of Medicine, Royal Free Campus, University College London Medical School, University College London, London, UK
Am J Gastroenterol 105:1773-81. 2010..The aims of this study were: (i) to evaluate circadian clock function and hepatic melatonin metabolism in cirrhotic patients, and (ii) to study the relationship between plasma melatonin profiles and sleep-wake behavior...- Nitric oxide-dependent bradycardia in mutant analbuminemic ratsAli R Mani
Division of Medicine, UCL Medical School, University College London UCL, London, UK
Biochem Pharmacol 84:1062-9. 2012..Our data suggest that a NOS/cGMP-dependent mechanism might be involved in increased responsiveness to vagal stimulation and bradycardia in analbuminemic condition... - Nitration of cardiac proteins is associated with abnormal cardiac chronotropic responses in rats with biliary cirrhosisAli R Mani
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, London, UK
Hepatology 43:847-56. 2006..Two independent treatments (N-acetylcysteine and L-NAME) that decrease nitration of cardiac proteins led to normalization of cardiac responses. Nitration of critical proteins in cardiac tissue may lead to abnormal cardiac function... 
Decreased heart rate variability in patients with cirrhosis relates to the presence and degree of hepatic encephalopathyAli R Mani
Centre for Hepatology, Royal Free Campus, University College London Medical School, London, UK
Am J Physiol Gastrointest Liver Physiol 296:G330-8. 2009..The changes observed in HRV and in neuropsychiatric status in patients with cirrhosis are significantly correlated, most likely reflecting a common pathogenic mechanism mediated by inflammatory cytokines...- Role of endogenous hydrogen sulfide in neurogenic relaxation of rat corpus cavernosumMehdi Ghasemi
Department of Medicine, UCL Medical School, University College London, UK
Biochem Pharmacol 83:1261-8. 2012..This suggests that an interaction between endogenously produced H(2)S and nitroxyl (HNO) might be involved in erectile function... - Endotoxemia produces coma and brain swelling in bile duct ligated ratsGavin Wright
Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, 69 75 Chenies Mews, London, UK
Hepatology 45:1517-26. 2007..Although the exact mechanism of how hyperammonemia and LPS facilitate cytotoxic edema and pre-coma in cirrhosis is not clear, our data support an important role for the nitrosation of brain proteins... - Metalloprotein-dependent decomposition of S-nitrosothiols: studies on the stabilization and measurement of S-nitrosothiols in tissuesAli R Mani
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Free Radic Biol Med 40:1654-63. 2006.... - pH-dependent nitration of para-hydroxyphenylacetic acid in the stomachAnanth S Pannala
Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, London, UK
Free Radic Biol Med 41:896-901. 2006.... - The metabolism and dechlorination of chlorotyrosine in vivoAli R Mani
Department of Medicine, Royal Free and University College Medical School, University College London, London NW3 2PF, United Kingdom
J Biol Chem 282:29114-21. 2007..There was approximately 20% decrease in the chlorotyrosine content over 1 h. This study is the first to describe the dechlorination of chlorotyrosine as the major metabolic pathway to eliminate this modified amino acid in vivo... - Dynamic assessment of nitration reactions in vivoAli R Mani
Centre for Hepatology, Department of Medicine, Royal Free Campus, University College London, UK
Methods Enzymol 396:151-9. 2005..Using various animal models, we have shown that measurement of urinary NHPA can be used to assess the formation of reactive nitrogen species in vivo... - Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2Sukhbir S Dhamrait
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JF, UK
Eur Heart J 25:468-75. 2004..Mitochondrial uncoupling protein 2 (UCP2) negatively regulates reactive oxygen species generation. The UCP2 gene demonstrates a common functional promoter variant (-866G>A)... - Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome?Sara Montagnese
Centre for Hepatology, Department of Medicine, Royal Free Campus, University College London Medical School, Rowland Hill Street, London NW3 2PF, UK
Metab Brain Dis 24:427-39. 2009.... - Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosineAli R Mani
Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
Biochem J 374:521-7. 2003..This is the first study to demonstrate that NHPA can be formed by nitration of PHPA in vivo, and that this is the major route for its formation... - Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulumSanjay Kumar
National Heart and Lung Institute, Imperial College, London, UK
Biochem Biophys Res Commun 387:77-82. 2009..3+/-13.5 vs. 73.0+/-15.6 nmol/min/mg protein, p=0.03). The ability of SR calcium ATPase to sequester cytosolic calcium is impaired in stunned myocardium. This is a potential mechanism underlying contractile dysfunction... - d-Serine modulates neurogenic relaxation in rat corpus cavernosumMehdi Ghasemi
Department of Medicine, Royal Free Campus, UCL Medical School, University College London, London, UK
Biochem Pharmacol 79:1791-6. 2010..These observations provide the first evidence for the role of d-serine in modulating the neurogenic relaxation of rat corpus cavernosum, and may open new therapeutic avenues for the treatment of impotence... - Endotoxemia is associated with partial uncoupling of cardiac pacemaker from cholinergic neural control in ratsMasoumeh Gholami
Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran
Shock 37:219-27. 2012..This may lead to partial uncoupling of cardiac pacemaker cells from autonomic neural control and can explain decreased HRV during systemic inflammation... - Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetesJeffrey W Stephens
Diabetes Research Group, The Medical School, Swansea University, Grove Building Swansea University, Swansea SA2 8PP, UK
Nutr Metab Cardiovasc Dis 18:7-14. 2008..The aim of the current study was to test the hypothesis that this variant might interact with smoking (an environmental stress) to influence plasma markers of oxidative stress... - Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infantsThomas Hoehn
Neonatology and Paediatric Intensive Care Medicine, Department of General Paediatrics, Heinrich Heine University, Dusseldorf, Germany
Neonatology 93:73-6. 2008..Nitrative stress is predominantly caused following synthesis of peroxynitrite. Particularly preterm infants with immature defense mechanisms against free radical injury appear at risk... - Dual nitric oxide mechanisms of cholestasis-induced bradycardia in the ratAli R Mani
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Clin Exp Pharmacol Physiol 29:905-8. 2002..A dual role of NO in the regulation of the sinoatrial node may be responsible for this opposite effect and may have a role in the pathophysiology of cholestasis-induced bradycardia...