K J Maloy

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Intestinal homeostasis and its breakdown in inflammatory bowel disease
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 474:298-306. 2011
  2. ncbi IL-23 and Th17 cytokines in intestinal homeostasis
    K J Maloy
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Mucosal Immunol 1:339-49. 2008
  3. ncbi Intralymphatic immunization enhances DNA vaccination
    K J Maloy
    Department of Dermatology, and Institute of Experimental Immunology, Universitatsspital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:3299-303. 2001
  4. ncbi The Interleukin-23 / Interleukin-17 axis in intestinal inflammation
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    J Intern Med 263:584-90. 2008
  5. ncbi CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Exp Med 197:111-9. 2003
  6. ncbi Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Immunol Lett 97:189-92. 2005
  7. ncbi Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection
    K J Maloy
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:1160-5. 1998
  8. ncbi CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability
    K J Maloy
    Department of Pathology, Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 191:2159-70. 2000
  9. ncbi Control of intestinal homeostasis by regulatory T cells and dendritic cells
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Semin Immunol 19:116-26. 2007
  10. ncbi TLR2-independent induction and regulation of chronic intestinal inflammation
    Olivier Boulard
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 40:516-24. 2010

Collaborators

Detail Information

Publications22

  1. ncbi Intestinal homeostasis and its breakdown in inflammatory bowel disease
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 474:298-306. 2011
    ..Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease...
  2. ncbi IL-23 and Th17 cytokines in intestinal homeostasis
    K J Maloy
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Mucosal Immunol 1:339-49. 2008
    ..Here, we will review the evidence linking the IL-23/Th17 axis to chronic intestinal inflammation and also will discuss its beneficial roles in intestinal protection and homeostasis...
  3. ncbi Intralymphatic immunization enhances DNA vaccination
    K J Maloy
    Department of Dermatology, and Institute of Experimental Immunology, Universitatsspital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:3299-303. 2001
    ..Because injection directly into a lymph node is a rapid and easy procedure in humans, these results have important clinical implications for DNA vaccination...
  4. ncbi The Interleukin-23 / Interleukin-17 axis in intestinal inflammation
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    J Intern Med 263:584-90. 2008
    ..Genome-wide association studies in IBD patients have confirmed the predominant role of the IL-23 pathway, indicating that this could represent an important future therapeutic target...
  5. ncbi CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Exp Med 197:111-9. 2003
    ..Thus, CD4(+)CD25(+) T(R) cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms...
  6. ncbi Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Immunol Lett 97:189-92. 2005
    ..Cure of established pathology was not achieved using subpopulations of CD4+CD25- T cells, further emphasizing the enhanced regulatory activity of CD4+CD25+ T(R) cells...
  7. ncbi Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection
    K J Maloy
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:1160-5. 1998
    ..Thus, during viral infection of alphabeta T cell-deficient mice, gammadelta T cells may provide the signals that are required for isotype switching...
  8. ncbi CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability
    K J Maloy
    Department of Pathology, Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 191:2159-70. 2000
    ..Therefore, the antiviral protective capacity of a given CD4(+) T cell is governed by the effector cytokines it produces and by its migratory capability...
  9. ncbi Control of intestinal homeostasis by regulatory T cells and dendritic cells
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Semin Immunol 19:116-26. 2007
    ..Understanding how these pathways intersect may lead to the development of more specific therapies for the treatment of inflammatory bowel disease...
  10. ncbi TLR2-independent induction and regulation of chronic intestinal inflammation
    Olivier Boulard
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 40:516-24. 2010
    ..Thus, in contrast to their role in acute intestinal inflammation and repair, TLR2 signals may have a limited impact on the induction and regulation of chronic intestinal inflammation...
  11. ncbi Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    Sophie Hue
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 203:2473-83. 2006
    ..These results newly identify IL-23 as a driver of innate immune pathology in the intestine and suggest that selective targeting of IL-23 represents an attractive therapeutic approach in human IBD...
  12. ncbi The interleukin-23 axis in intestinal inflammation
    Philip P Ahern
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 226:147-59. 2008
    ..Here we discuss the dual roles of IL-23 in intestinal immunity and how IL-23 and downstream effector pathways may make novel targets for the treatment of IBD...
  13. ncbi Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    Sofia Buonocore
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Nature 464:1371-5. 2010
    ..These results identify a previously unrecognized IL-23-responsive innate lymphoid population that mediates intestinal immune pathology and may therefore represent a target in inflammatory bowel disease...
  14. ncbi Regulatory T cells and intestinal homeostasis
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunol Rev 204:184-94. 2005
    ..Enhancement of regulatory T-cell activity may be useful to control autoreactive T-cell responses and inhibit harmful inflammatory diseases such as asthma and IBD...
  15. ncbi Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    Ana Izcue
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Immunity 28:559-70. 2008
    ..Taken together, our data indicate that overriding immunosuppressive pathways is an important function of IL-23 in the intestine and could influence not only Th17 cell activity but also other types of immune responses...
  16. ncbi Regulatory T cells in the control of immune pathology
    K J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Immunol 2:816-22. 2001
    ..We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function...
  17. ncbi Induction and regulation of inflammatory bowel disease in immunodeficient mice by distinct CD4+ T-cell subsets
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, UK
    Methods Mol Biol 380:327-35. 2007
    ..The T cell transfer model of IBD is reproducible and easily manipulated and therefore provides an excellent system for the study of immunopathology and immune regulation in the intestine...
  18. ncbi Immunology. Regulating the regulators
    Fiona Powrie
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. ox.ac.uk
    Science 299:1030-1. 2003
  19. ncbi Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease
    Mark J Asquith
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Gastroenterology 139:519-29, 529.e1-2. 2010
    ..We aimed to define the roles of TLR signals in distinct cell types in the induction and regulation of chronic intestinal inflammation...
  20. ncbi Interleukin-23 drives intestinal inflammation through direct activity on T cells
    Philip P Ahern
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK
    Immunity 33:279-88. 2010
    ..Together, these results highlight the multiple functions of IL-23 signaling in T cells that contribute to its colitogenic activity...
  21. ncbi IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2485-94. 2006
    ....
  22. ncbi Fueling regulation: IL-2 keeps CD4+ Treg cells fit
    Kevin J Maloy
    Nat Immunol 6:1071-2. 2005